Trodusquemine (BioDeep_00000858783)

   

natural product


代谢物信息卡片


Trodusquemine

化学式: C37H72N4O5S (684.5223142)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(CCC(C)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)NCCCNCCCCNCCCN)C)O)C)OS(=O)(=O)O
InChI: InChI=1S/C37H72N4O5S/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38/h26-35,39-42H,6-25,38H2,1-5H3,(H,43,44,45)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-/m1/s1

描述信息

C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

同义名列表

1 个代谢物同义名

Trodusquemine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Beatrice Barletti, Giacomo Lucchesi, Stefano Muscat, Silvia Errico, Denise Barbut, Andrea Danani, Michael Zasloff, Gianvito Grasso, Fabrizio Chiti, Gabriella Caminati. Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol. Colloids and surfaces. B, Biointerfaces. 2023 Feb; 222(?):113115. doi: 10.1016/j.colsurfb.2022.113115. [PMID: 36603410]
  • Chao Liang, Louise Kjaerulff, Paul Robert Hansen, Kenneth T Kongstad, Dan Staerk. Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from Rhododendron capitatum. Journal of natural products. 2021 09; 84(9):2454-2467. doi: 10.1021/acs.jnatprod.1c00454. [PMID: 34460246]
  • Silvia Errico, Hassan Ramshini, Claudia Capitini, Claudio Canale, Martina Spaziano, Denise Barbut, Martino Calamai, Michael Zasloff, Reinier Oropesa-Nuñez, Michele Vendruscolo, Fabrizio Chiti. Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine. ACS chemical neuroscience. 2021 09; 12(17):3189-3202. doi: 10.1021/acschemneuro.1c00327. [PMID: 34382791]
  • Silvia Errico, Giacomo Lucchesi, Davide Odino, Stefano Muscat, Claudia Capitini, Chiara Bugelli, Claudio Canale, Riccardo Ferrando, Gianvito Grasso, Denise Barbut, Martino Calamai, Andrea Danani, Michael Zasloff, Annalisa Relini, Gabriella Caminati, Michele Vendruscolo, Fabrizio Chiti. Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine. Nanoscale. 2020 Nov; 12(44):22596-22614. doi: 10.1039/d0nr05285j. [PMID: 33150350]
  • Hans Albert Pedersen, Chi Ndi, Susan J Semple, Bevan Buirchell, Birger Lindberg Møller, Dan Staerk. PTP1B-Inhibiting Branched-Chain Fatty Acid Dimers from Eremophila oppositifolia subsp. angustifolia Identified by High-Resolution PTP1B Inhibition Profiling and HPLC-PDA-HRMS-SPE-NMR Analysis. Journal of natural products. 2020 05; 83(5):1598-1610. doi: 10.1021/acs.jnatprod.0c00070. [PMID: 32255628]
  • Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco A Aprile, Céline Galvagnion, Gabriella T Heller, Georg Meisl, Serene W Chen, Janet R Kumita, Pavan K Challa, Julius B Kirkegaard, Samuel I A Cohen, Benedetta Mannini, Denise Barbut, Ellen A A Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P J Knowles, Fabrizio Chiti, Michael Zasloff, Michele Vendruscolo, Christopher M Dobson. Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology. 2018 08; 13(8):2308-2319. doi: 10.1021/acschembio.8b00466. [PMID: 29953201]
  • Mitchell F Roitman, Seth Wescott, Jackson J Cone, Michael P McLane, Henry R Wolfe. MSI-1436 reduces acute food intake without affecting dopamine transporter activity. Pharmacology, biochemistry, and behavior. 2010 Nov; 97(1):138-43. doi: 10.1016/j.pbb.2010.05.010. [PMID: 20478327]
  • Kristen A Lantz, Susan G Emeigh Hart, Sonia L Planey, Mitchell F Roitman, Inez A Ruiz-White, Henry R Wolfe, Michael P McLane. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring, Md.). 2010 Aug; 18(8):1516-23. doi: 10.1038/oby.2009.444. [PMID: 20075852]
  • M Zasloff, J I Williams, Q Chen, M Anderson, T Maeder, K Holroyd, S Jones, W Kinney, K Cheshire, M McLane. A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2001 May; 25(5):689-97. doi: 10.1038/sj.ijo.0801599. [PMID: 11360152]