Phenoxyethanol (BioDeep_00000858361)

   

natural product Volatile Flavor Compounds


代谢物信息卡片


Phenoxyethanol

化学式: C8H10O2 (138.06807600000002)
中文名称: 乙二醇苯醚, 2-苯氧基乙醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)OCCO
InChI: InChI=1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D000890 - Anti-Infective Agents

同义名列表

2 个代谢物同义名

Phenoxyethanol; 2-Phenoxyethanol



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li-Dan Zhou, Yi-Na Lu, Qing Liu, Xue-Mei Shi, Jun Tian. Modulation of TRPV1 function by Citrus reticulata (tangerine) fruit extract for the treatment of sensitive skin. Journal of cosmetic dermatology. 2023 Apr; 22(4):1369-1376. doi: 10.1111/jocd.15578. [PMID: 36575892]
  • Nannaphat Sukkasam, Aran Incharoensakdi, Tanakarn Monshupanee. Chemicals Affecting Cyanobacterial Poly(3-hydroxybutyrate) Accumulation: 2-Phenylethanol Treatment Combined with Nitrogen Deprivation Synergistically Enhanced Poly(3-hydroxybutyrate) Storage in Synechocystis sp. PCC6803 and Anabaena sp. TISTR8076. Plant & cell physiology. 2022 Sep; 63(9):1253-1272. doi: 10.1093/pcp/pcac100. [PMID: 35818829]
  • Nicola J Hewitt, John Troutman, Julia Przibilla, Andreas Schepky, Gladys Ouédraogo, Catherine Mahony, Gerry Kenna, Mustafa Varçin, Mathew P Dent. Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment. Regulatory toxicology and pharmacology : RTP. 2022 Jun; 131(?):105132. doi: 10.1016/j.yrtph.2022.105132. [PMID: 35217105]
  • F Zhang, M J LeBaron, M S Marty. Prediction of tissue and urine concentrations of 2-phenoxyethanol and its metabolite 2-phenoxyacetic acid in rat and human after oral and dermal exposures via GastroPlusTM physiologically based pharmacokinetic modelling. SAR and QSAR in environmental research. 2022 May; 33(5):323-339. doi: 10.1080/1062936x.2022.2049866. [PMID: 35301938]
  • T Rairat, Y Chi, S-K Chang, C-Y Hsieh, N Chuchird, C-C Chou. Differential effects of aquatic anaesthetics on the pharmacokinetics of antibiotics: Examples using florfenicol in Nile tilapia (Oreochromis niloticus). Journal of fish diseases. 2021 Oct; 44(10):1579-1586. doi: 10.1111/jfd.13480. [PMID: 34152617]
  • Mihye Kwon, Jung Bae Park, Miwha Kwon, Jinho Song, Chang Su Yeo, Soo Hyeon Bae. Pharmacokinetics of 2-phenoxyethanol and its major metabolite, phenoxyacetic acid, after dermal and inhaled routes of exposure: application to development PBPK model in rats. Archives of toxicology. 2021 06; 95(6):2019-2036. doi: 10.1007/s00204-021-03041-z. [PMID: 33844041]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Jingyi Wang, Yang Liu, Wendy R Kam, Ying Li, David A Sullivan. Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells. Experimental eye research. 2020 07; 196(?):108057. doi: 10.1016/j.exer.2020.108057. [PMID: 32387382]
  • Mehmet Çağrı Akgündüz, Kültiğin Çavuşoğlu, Emine Yalçın. The Potential Risk Assessment of Phenoxyethanol with a Versatile Model System. Scientific reports. 2020 Jan; 10(1):1209. doi: 10.1038/s41598-020-58170-9. [PMID: 31988350]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Kamila Szostak, Aleksander Czogalla, Magdalena Przybyło, Marek Langner. New lipid formulation of octenidine dihydrochloride. Journal of liposome research. 2018 Jun; 28(2):106-111. doi: 10.1080/08982104.2016.1275678. [PMID: 28006995]
  • Douglas J Fort, Michael B Mathis, Patrick D Guiney, John A Weeks. Inhibition of germinal vesicle breakdown in Xenopus oocytes in vitro by a series of substituted glycol ethers. Journal of applied toxicology : JAT. 2018 05; 38(5):628-637. doi: 10.1002/jat.3567. [PMID: 29205417]
  • N Kapalschinski, H M Seipp, M Kückelhaus, K K Harati, J J Kolbenschlag, A Daigeler, F Jacobsen, M Lehnhardt, T Hirsch. Albumin reduces the antibacterial efficacy of wound antiseptics against Staphylococcus aureus. Journal of wound care. 2017 Apr; 26(4):184-187. doi: 10.12968/jowc.2017.26.4.184. [PMID: 28379100]
  • Rémi Béranger, Ronan Garlantézec, Gaïd Le Maner-Idrissi, Agnès Lacroix, Florence Rouget, Jessica Trowbridge, Charline Warembourg, Christine Monfort, Florent Le Gléau, Marylène Jourdin, Luc Multigner, Sylvaine Cordier, Cécile Chevrier. Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study. Environmental health perspectives. 2017 04; 125(4):684-690. doi: 10.1289/ehp39. [PMID: 27740510]
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  • Tae Hwan Kim, Min Gi Kim, Min Gyu Kim, Beom Soo Shin, Kyu-Bong Kim, Jong Bong Lee, Soo Heui Paik, Sun Dong Yoo. Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS with polarity switching: Application to ADME studies. Talanta. 2015 Nov; 144(?):29-38. doi: 10.1016/j.talanta.2015.05.075. [PMID: 26452788]
  • M Javadi Moosavi, M M Salahi Ardekani, A Pirbeigi, S Ghazi. The effects of exposure duration to optimal concentration of 2-phenoxyethanol on primary and secondary stress responses in kutum (Rutilus frisii kutum). Journal of animal physiology and animal nutrition. 2015 Aug; 99(4):661-7. doi: 10.1111/jpn.12281. [PMID: 25545544]
  • Bartosz Pomierny, Weronika Krzyżanowska, Irena Smaga, Lucyna Pomierny-Chamioło, Piotr Stankowicz, Bogusława Budziszewska. Ethylene glycol ethers induce oxidative stress in the rat brain. Neurotoxicity research. 2014 Nov; 26(4):422-9. doi: 10.1007/s12640-014-9486-8. [PMID: 25085197]
  • Ronan Garlantézec, Charline Warembourg, Christine Monfort, Laurence Labat, Juha Pulkkinen, Nathalie Bonvallot, Luc Multigner, Cécile Chevrier, Sylvaine Cordier. Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohort. Environmental health perspectives. 2013 Oct; 121(10):1167-73. doi: 10.1289/ehp.1206103. [PMID: 23838187]
  • Fardin Shaluei, Aliakbar Hedayati, Abdolreza Jahanbakhshi, Maryam Baghfalaki. Physiological responses of great sturgeon (Huso huso) to different concentrations of 2-phenoxyethanol as an anesthetic. Fish physiology and biochemistry. 2012 Dec; 38(6):1627-1634. doi: 10.1007/s10695-012-9659-4. [PMID: 22660890]
  • Erik Hoffmann, Anders Walstad, Johnny Karlsson, Per-Erik Olsson, Bertil Borg. Androgen receptor-beta mRNA levels in different tissues in breeding and post-breeding male and female sticklebacks, Gasterosteus aculeatus. Reproductive biology and endocrinology : RB&E. 2012 Mar; 10(?):23. doi: 10.1186/1477-7827-10-23. [PMID: 22455382]
  • Jueun Oh, Tao Yu, Soo Jeong Choi, Yanyan Yang, Heung Soo Baek, Soon Ae An, Lee Kyoung Kwon, Jinsol Kim, Ho Sik Rho, Song Seok Shin, Wahn Soo Choi, Sungyoul Hong, Jae Youl Cho. Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid. Mediators of inflammation. 2012; 2012(?):781375. doi: 10.1155/2012/781375. [PMID: 22577255]
  • J Lademann, H Richter, S Schanzer, A Patzelt, G Thiede, A Kramer, K-D Weltmann, B Hartmann, B Lange-Asschenfeldt. Comparison of the antiseptic efficacy of tissue-tolerable plasma and an octenidine hydrochloride-based wound antiseptic on human skin. Skin pharmacology and physiology. 2012; 25(2):100-6. doi: 10.1159/000335558. [PMID: 22301799]
  • Subramanian Saravanan, Johan W Schrama, A Claudia Figueiredo-Silva, Sadasivam J Kaushik, Johan A J Verreth, Inge Geurden. Constraints on energy intake in fish: the link between diet composition, energy metabolism, and energy intake in rainbow trout. PloS one. 2012; 7(4):e34743. doi: 10.1371/journal.pone.0034743. [PMID: 22496852]
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  • Neelakanteswar Aluru, John F Leatherland, Mathilakath M Vijayan. Bisphenol A in oocytes leads to growth suppression and altered stress performance in juvenile rainbow trout. PloS one. 2010 May; 5(5):e10741. doi: 10.1371/journal.pone.0010741. [PMID: 20505776]
  • Qiong Ming Xu, Yan Li Liu, Xiao Ran Li, Yu Lin Feng, Shi Lin Yang. Two new phenylglycol derivatives isolated from Syringa reticulata var. mandshurica and their antifungal activities. Chemical & pharmaceutical bulletin. 2009 Aug; 57(8):863-6. doi: 10.1248/cpb.57.863. [PMID: 19652414]
  • Catherine-Ines Kolditz, Gilles Paboeuf, Maïena Borthaire, Diane Esquerré, Magali SanCristobal, Florence Lefèvre, Françoise Médale. Changes induced by dietary energy intake and divergent selection for muscle fat content in rainbow trout (Oncorhynchus mykiss), assessed by transcriptome and proteome analysis of the liver. BMC genomics. 2008 Oct; 9(?):506. doi: 10.1186/1471-2164-9-506. [PMID: 18959775]
  • Stanislava Macova, Petra Dolezelova, Vladimira Pistekova, Zdenka Svobodova, Iveta Bedanova, Eva Voslarova. Comparison of acute toxicity of 2-phenoxyethanol and clove oil to juvenile and embryonic stages of Danio rerio. Neuro endocrinology letters. 2008 Oct; 29(5):680-4. doi: ". [PMID: 18987607]
  • Eva Klimánková, Katerina Riddellová, Jana Hajslová, Jan Poustka, Jitka Kolárová, Vladimír Kocourek. Development of an SPME-GC-MS/MS procedure for the monitoring of 2-phenoxyethanol in anaesthetised fish. Talanta. 2008 May; 75(4):1082-8. doi: 10.1016/j.talanta.2008.01.035. [PMID: 18585187]
  • Sylvain Milla, Xavier Terrien, Armin Sturm, Fidaa Ibrahim, Franck Giton, Jean Fiet, Patrick Prunet, Florence Le Gac. Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: implication with 17alpha, 20beta-dihydroxyprogesterone on the milt fluidity?. Reproductive biology and endocrinology : RB&E. 2008 May; 6(?):19. doi: 10.1186/1477-7827-6-19. [PMID: 18489781]
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