1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-tricyclo(3.3.1.13,7)dec-1-yl-, (1R,3S)- (BioDeep_00000843905)
代谢物信息卡片
化学式: C20H27NO3 (329.1991)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2CC3CC1CC(C2)(C3)C4CC5=C(C=CC(=C5O)O)C(O4)CN
InChI: InChI=1S/C20H27NO3/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20/h1-2,11-13,17-18,22-23H,3-10,21H2/t11?,12?,13?,17-,18-,20?/m0/s1
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Junliang Hao, James P Beck, John M Schaus, Joseph H Krushinski, Qi Chen, Christopher D Beadle, Paloma Vidal, Matthew R Reinhard, Bruce A Dressman, Steven M Massey, Serge L Boulet, Michael P Cohen, Brian M Watson, David Tupper, Kevin M Gardinier, Jason Myers, Anette M Johansson, Jeffery Richardson, Daniel S Richards, Erik J Hembre, David M Remick, David A Coates, Rajni M Bhardwaj, Benjamin A Diseroad, David Bender, Greg Stephenson, Craig D Wolfangel, Nuria Diaz, Brian G Getman, Xu-Shan Wang, Beverly A Heinz, Jeff W Cramer, Xin Zhou, Deanna L Maren, Julie F Falcone, Rebecca A Wright, Stephen N Mitchell, Guy Carter, Charles R Yang, Robert F Bruns, Kjell A Svensson. Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor.
Journal of medicinal chemistry.
2019 10; 62(19):8711-8732. doi:
10.1021/acs.jmedchem.9b01234
. [PMID: 31532644] - Jennifer E Davoren, Deane Nason, Jotham Coe, Keith Dlugolenski, Christopher Helal, Anthony R Harris, Erik LaChapelle, Sidney Liang, Yue Liu, Rebecca O'Connor, Christine C Orozco, Brajesh K Rai, Michelle Salafia, Brian Samas, Wenjian Xu, Rouba Kozak, David Gray. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization.
Journal of medicinal chemistry.
2018 12; 61(24):11384-11397. doi:
10.1021/acs.jmedchem.8b01622
. [PMID: 30431269] - Kjell A Svensson, Beverly A Heinz, John M Schaus, James P Beck, Junliang Hao, Joseph H Krushinski, Matthew R Reinhard, Michael P Cohen, Sarah L Hellman, Brian G Getman, Xushan Wang, Michelle M Menezes, Deanna L Maren, Julie F Falcone, Wesley H Anderson, Rebecca A Wright, S Michelle Morin, Kelly L Knopp, Benjamin L Adams, Borys Rogovoy, Ilya Okun, Todd M Suter, Michael A Statnick, Donald R Gehlert, David L Nelson, Virginia L Lucaites, Renee Emkey, Neil W DeLapp, Todd R Wiernicki, Jeffrey W Cramer, Charles R Yang, Robert F Bruns. An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.
The Journal of pharmacology and experimental therapeutics.
2017 Jan; 360(1):117-128. doi:
10.1124/jpet.116.236372
. [PMID: 27811173] - Jessica P Ryman-Rasmussen, David E Nichols, Richard B Mailman. Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists.
Molecular pharmacology.
2005 Oct; 68(4):1039-48. doi:
10.1124/mol.105.012153
. [PMID: 15985612] - J Grider, E Kilpatrick, C Ott, B Jackson. Effect of dopamine on NaCl transport in the medullary thick ascending limb of the rat.
European journal of pharmacology.
1998 Jan; 342(2-3):281-4. doi:
10.1016/s0014-2999(97)01564-1
. [PMID: 9548397] - E Acquas, H C Fibiger. Chronic lithium attenuates dopamine D1-receptor mediated increases in acetylcholine release in rat frontal cortex.
Psychopharmacology.
1996 May; 125(2):162-7. doi:
10.1007/bf02249415
. [PMID: 8783390]