Amn082 dihydrochloride (BioDeep_00000843804)

   


代谢物信息卡片


Amn082 dihydrochloride

化学式: C28H30Cl2N2 (464.178592)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
InChI: 2*1H

描述信息

AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects[1][2].

同义名列表

2 个代谢物同义名

Amn082 dihydrochloride; AMN082



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5 个数据库交叉引用编号

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代谢反应

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • K Gawel, M Jenda-Wojtanowska, E Gibula-Bruzda, E Kedzierska, J Filarowska, M Marszalek-Grabska, K K Wojtanowski, L Komsta, S Talarek, J H Kotlinska. The influence of AMN082, metabotropic glutamate receptor 7 (mGlu7) allosteric agonist on the acute and chronic antinociceptive effects of morphine in the tail-immersion test in mice: Comparison with mGlu5 and mGlu2/3 ligands. Physiology & behavior. 2018 03; 185(?):112-120. doi: 10.1016/j.physbeh.2017.12.035. [PMID: 29294304]
  • E M Guimarães-Souza, K C Calaza. Selective activation of group III metabotropic glutamate receptor subtypes produces different patterns of γ-aminobutyric acid immunoreactivity and glutamate release in the retina. Journal of neuroscience research. 2012 Dec; 90(12):2349-61. doi: 10.1002/jnr.23123. [PMID: 22987212]
  • A Bahi. The pre-synaptic metabotropic glutamate receptor 7 "mGluR7" is a critical modulator of ethanol sensitivity in mice. Neuroscience. 2011 Dec; 199(?):13-23. doi: 10.1016/j.neuroscience.2011.10.029. [PMID: 22056957]
  • Stacey J Sukoff Rizzo, Sarah K Leonard, Adam Gilbert, Paul Dollings, Deborah L Smith, Mei-Yi Zhang, Li Di, Brian J Platt, Sarah Neal, Jason M Dwyer, Corey N Bender, Jean Zhang, Tim Lock, Dianne Kowal, Angela Kramer, Andrew Randall, Christine Huselton, Karthick Vishwanathan, Susanna Y Tse, John Butera, Robert H Ring, Sharon Rosenzweig-Lipson, Zoë A Hughes, John Dunlop. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?. The Journal of pharmacology and experimental therapeutics. 2011 Jul; 338(1):345-52. doi: 10.1124/jpet.110.177378. [PMID: 21508084]
  • M Julio-Pieper, N P Hyland, J A Bravo, T G Dinan, J F Cryan. A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse. British journal of pharmacology. 2010 May; 160(2):367-75. doi: 10.1111/j.1476-5381.2010.00713.x. [PMID: 20423346]
  • Michael C Salling, Sara Faccidomo, Clyde W Hodge. Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082. Pharmacology, biochemistry, and behavior. 2008 Nov; 91(1):14-20. doi: 10.1016/j.pbb.2008.06.006. [PMID: 18593591]
  • Kayo Mitsukawa, Rina Yamamoto, Silvio Ofner, Joachim Nozulak, Oliver Pescott, Snezana Lukic, Natacha Stoehr, Cedric Mombereau, Rainer Kuhn, Kevin H McAllister, Herman van der Putten, John F Cryan, Peter J Flor. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2005 Dec; 102(51):18712-7. doi: 10.1073/pnas.0508063102. [PMID: 16339898]