(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-Dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone (BioDeep_00000843791)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-Dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone

化学式: C52H76N4O12 (948.5459)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 93.22%

分子结构信息

SMILES: CC1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC(C)C)C)CC2=CC=CC=C2)CC(C)C)C)C)CC(C)C)C)CC3=CC=CC=C3)CC(C)C)C
InChI: InChI=1S/C52H76N4O12/c1-31(2)25-39-49(61)65-35(9)45(57)53(11)42(28-34(7)8)52(64)68-44(30-38-23-19-16-20-24-38)48(60)56(14)40(26-32(3)4)50(62)66-36(10)46(58)54(12)41(27-33(5)6)51(63)67-43(47(59)55(39)13)29-37-21-17-15-18-22-37/h15-24,31-36,39-44H,25-30H2,1-14H3/t35-,36-,39+,40+,41+,42+,43-,44-/m1/s1

描述信息

PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research[1][2][3].

同义名列表

2 个代谢物同义名

(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-Dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone; PF 1022A



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Daniel Kulke, Jürgen Krücken, Achim Harder, Ralph Krebber, Kristine Fraatz, Heinz Mehlhorn, Georg VON Samson-Himmelstjerna. In vivo efficacy of PF1022A and nicotinic acetylcholine receptor agonists alone and in combination against Nippostrongylus brasiliensis. Parasitology. 2013 Sep; 140(10):1252-65. doi: 10.1017/s0031182013000632. [PMID: 23742764]
  • Uzoma Nwosu, Mireille Vargas, Achim Harder, Jennifer Keiser. Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. Parasitology. 2011 Aug; 138(9):1193-201. doi: 10.1017/s003118201100076x. [PMID: 21756418]
  • R Jeschke, K Iinuma, A Harder, M Schindler, T Murakami. Influence of the cyclooctadepsipeptides PF1022A and PF1022E as natural products on the design of semi-synthetic anthelmintics such as emodepside. Parasitology research. 2005 Oct; 97 Suppl 1(?):S11-S16. doi: 10.1007/s00436-005-1439-y. [PMID: 16228266]
  • Achim Harder, Hans-Peter Schmitt-Wrede, Jürgen Krücken, Predrag Marinovski, Frank Wunderlich, James Willson, Kiran Amliwala, Lindy Holden-Dye, Robert Walker. Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action. International journal of antimicrobial agents. 2003 Sep; 22(3):318-31. doi: 10.1016/s0924-8579(03)00219-x. [PMID: 13678839]
  • Byung H Lee, Fred E Dutton, David P Thompson, Eileen M Thomas. Generation of a small library of cyclodepsipeptide PF1022A analogues using a cyclization-cleavage method with oxime resin. Bioorganic & medicinal chemistry letters. 2002 Feb; 12(3):353-6. doi: 10.1016/s0960-894x(01)00748-x. [PMID: 11814795]
  • G von Samson-Himmelstjerna, A Harder, T Schnieder, J Kalbe, N Mencke. In vivo activities of the new anthelmintic depsipeptide PF 1022A. Parasitology research. 2000 Mar; 86(3):194-9. doi: 10.1007/s004360050031. [PMID: 10726989]
  • J Scherkenbeck, A Harder, A Plant, H Dyker. PF1022A--a novel anthelmintic cyclooctadepsipeptide. Modification and exchange of the N-methyl leucine residues. Bioorganic & medicinal chemistry letters. 1998 May; 8(9):1035-40. doi: 10.1016/s0960-894x(98)00156-5. [PMID: 9871703]
  • M L Rodrick, C H Tempelis. Protein-induced neonatal specific and non-specific immunosuppression. Advances in experimental medicine and biology. 1977; 88(?):137-45. doi: 10.1007/978-1-4613-4169-7_12. [PMID: 72493]