Daytrana (BioDeep_00000843673)
代谢物信息卡片
化学式: C14H19NO2 (233.1415714)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)C(C1CCCCN1)C2=CC=CC=C2
InChI: InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m0/s1
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:51857
- PubChem: 10657292
- ChEMBL: CHEMBL542556
- ChEMBL: CHEMBL290634
- MeSH: Methylphenidate
- CAS: 40431-62-7
- CAS: 20748-11-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Susu Qu, Xiangyu Zhou, Zhicheng Wang, Yi Wei, Han Zhou, Xinshuang Zhang, Qingjie Zhu, Yanmin Wang, Quanjun Yang, Likun Jiang, Yuan Ma, Yuan Gao, Lei Kong, Li Zhang. The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment.
Molecular psychiatry.
2023 Nov; ?(?):. doi:
10.1038/s41380-023-02314-6
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Journal of neural transmission (Vienna, Austria : 1996).
2023 04; 130(4):597-609. doi:
10.1007/s00702-022-02583-5
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Journal of attention disorders.
2023 02; 27(4):394-409. doi:
10.1177/10870547221149198
. [PMID: 36642920] - Jing Wang, Xin-Qiang Ni, Li-Min Li, Ying-Zhao Liao, Yao Chen, Chun-Ling Huang. [Effect of Rehmanniae Radix Praeparata on energy metabolism in prefrontal cortex of rats with attention deficit hyperactivity disorder based on "static Yin and dynamic Yang" theory].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jul; 47(13):3554-3561. doi:
10.19540/j.cnki.cjcmm.20220412.402
. [PMID: 35850809] - Majid Motaghinejad, Manijeh Motevalian. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus.
Neurotoxicity research.
2022 Jun; 40(3):689-713. doi:
10.1007/s12640-021-00454-7
. [PMID: 35446003] - Vincent Chin-Hung Chen, Yao-Hsu Yang, Charles Tzu-Chi Lee, Yi-Lung Chen, Michael E Dewey, Michael Gossop. Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study.
European child & adolescent psychiatry.
2022 Feb; 31(2):361-368. doi:
10.1007/s00787-020-01694-2
. [PMID: 33389157] - Hang Thi Nguyet Pham, Hong Nguyen Tran, Xoan Thi Le, Ha Thi Do, Tue Trong Nguyen, Chien Le Nguyen, Hideki Yoshida, Masamistu Yamaguchi, Folk R William, Kinzo Matsumoto. Ilex kudingcha C.J. Tseng Mitigates Phenotypic Characteristics of Human Autism Spectrum Disorders in a Drosophila Melanogaster Rugose Mutant.
Neurochemical research.
2021 Aug; 46(8):1995-2007. doi:
10.1007/s11064-021-03337-7
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Progress in neuro-psychopharmacology & biological psychiatry.
2021 03; 106(?):110069. doi:
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Epidemiology and psychiatric sciences.
2021 Feb; 30(?):e14. doi:
10.1017/s2045796021000032
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The Cochrane database of systematic reviews.
2021 01; 1(?):CD013011. doi:
10.1002/14651858.cd013011.pub2
. [PMID: 33460048] - Anibah Khalid, Umme Aimen Abbasi, Sanila Amber, Sumera, Fatima Javed Mirza, Muhammad Asif, Aneela Javed, Saadia Zahid. Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl3-induced neurotoxicity mouse model.
Molecular biology reports.
2020 Oct; 47(10):7861-7870. doi:
10.1007/s11033-020-05864-y
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Drug metabolism and disposition: the biological fate of chemicals.
2020 10; 48(10):993-1007. doi:
10.1124/dmd.120.000065
. [PMID: 32591414] - Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting Yu Kuo, Mong-Liang Lu, Wei-Ting Tseng, Tsai-Yu Hou, Jia-Ying Yeh, Charles Tzu-Chi Lee, Yi-Lung Chen, Min-Jing Lee, Michael E Dewey, Michael Gossop. Methylphenidate and the risk of burn injury among children with attention-deficit/hyperactivity disorder.
Epidemiology and psychiatric sciences.
2020 Jul; 29(?):e146. doi:
10.1017/s2045796020000608
. [PMID: 32686635] - Shiho Suzuki, Ryo Kimura, Shingo Maegawa, Masatoshi Nakata, Masatoshi Hagiwara. Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish.
Molecular brain.
2020 05; 13(1):70. doi:
10.1186/s13041-020-00614-4
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Neurobiology of disease.
2020 05; 138(?):104789. doi:
10.1016/j.nbd.2020.104789
. [PMID: 32032728] - Tianyi Chen, Haixia Yuan, Yu-Bo Sun, Yu-Chen Song, Manqi Lu, Xinqiang Ni, Xinmin Han. Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior.
Biochemical and biophysical research communications.
2020 03; 523(2):315-321. doi:
10.1016/j.bbrc.2019.12.016
. [PMID: 31864712] - Mai Hoang Philipsen, Nhu T N Phan, John Stephen Fletcher, Andrew G Ewing. Interplay between Cocaine, Drug Removal, and Methylphenidate Reversal on Phospholipid Alterations in Drosophila Brain Determined by Imaging Mass Spectrometry.
ACS chemical neuroscience.
2020 03; 11(5):806-813. doi:
10.1021/acschemneuro.0c00014
. [PMID: 32045198] - Hajra Mazhar, Brian C Foster, Candace Necyk, Paula M Gardiner, Cory S Harris, Philippe Robaey. Natural Health Product-Drug Interaction Causality Assessment in Pediatric Adverse Event Reports Associated with Attention-Deficit/Hyperactivity Disorder Medication.
Journal of child and adolescent psychopharmacology.
2020 02; 30(1):38-47. doi:
10.1089/cap.2019.0102
. [PMID: 31670573] - Stephanie Maxine Ross. Saffron (Crocus sativus L.): A Phytomedicine as Effective as Methylphenidate in Treating ADHD in Children.
Holistic nursing practice.
2020 Jan; 34(1):65-67. doi:
10.1097/hnp.0000000000000365
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European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2019 12; 29(2):195-210. doi:
10.1016/j.euroneuro.2018.12.007
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109033. doi:
10.1016/j.biopha.2019.109033
. [PMID: 31545235] - Lixia Yan, Siyuan Wang, Yang Yuan, Junhua Zhang. Effects of neurofeedback versus methylphenidate for the treatment of ADHD: systematic review and meta-analysis of head-to-head trials.
Evidence-based mental health.
2019 08; 22(3):111-117. doi:
10.1136/ebmental-2019-300088
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Complementary therapies in clinical practice.
2019 Aug; 36(?):170-175. doi:
10.1016/j.ctcp.2019.07.008
. [PMID: 31383435] - Shu-Cheng Chen, Branda Yee-Man Yu, Lorna Kwai-Ping Suen, Juan Yu, Fiona Yan-Yee Ho, Jun-Jun Yang, Wing-Fai Yeung. Massage therapy for the treatment of attention deficit/hyperactivity disorder (ADHD) in children and adolescents: A systematic review and meta-analysis.
Complementary therapies in medicine.
2019 Feb; 42(?):389-399. doi:
10.1016/j.ctim.2018.12.011
. [PMID: 30670272] - Danielly Chierrito, Camila B Villas-Boas, Fernanda S Tonin, Fernando Fernandez-Llimos, Andréia C C Sanches, João C P de Mello. Using Cell Cultures for the Investigation of Treatments for Attention Deficit Hyperactivity Disorder: A Systematic Review.
Current neuropharmacology.
2019; 17(10):916-925. doi:
10.2174/1570159x17666190409143155
. [PMID: 31079591] - Lixia Yan, Junhua Zhang, Yang Yuan, Samuele Cortese. Effects of neurofeedback versus methylphenidate for the treatment of attention-deficit/hyperactivity disorder protocol for a systematic review and meta-analysis of head-to-head trials.
Medicine.
2018 Sep; 97(39):e12623. doi:
10.1097/md.0000000000012623
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Sep; 43(17):3539-3544. doi:
10.19540/j.cnki.cjcmm.20180522.004
. [PMID: 30347924] - Mai H Philipsen, Nhu T N Phan, John S Fletcher, Per Malmberg, Andrew G Ewing. Mass Spectrometry Imaging Shows Cocaine and Methylphenidate Have Opposite Effects on Major Lipids in Drosophila Brain.
ACS chemical neuroscience.
2018 06; 9(6):1462-1468. doi:
10.1021/acschemneuro.8b00046
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Metabolic brain disease.
2018 06; 33(3):693-704. doi:
10.1007/s11011-017-0177-z
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European child & adolescent psychiatry.
2018 Mar; 27(3):279-288. doi:
10.1007/s00787-017-1042-7
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Zeitschrift fur Gerontologie und Geriatrie.
2018 Feb; 51(2):143-148. doi:
10.1007/s00391-017-1351-y
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Research in developmental disabilities.
2018 Jan; 72(?):96-105. doi:
10.1016/j.ridd.2017.10.023
. [PMID: 29121517] - Majid Motaghinejad, Manijeh Motevalian, Sulail Fatima, Tabassom Beiranvand, Shiva Mozaffari. Topiramate via NMDA, AMPA/kainate, GABAA and Alpha2 receptors and by modulation of CREB/BDNF and Akt/GSK3 signaling pathway exerts neuroprotective effects against methylphenidate-induced neurotoxicity in rats.
Journal of neural transmission (Vienna, Austria : 1996).
2017 11; 124(11):1369-1387. doi:
10.1007/s00702-017-1771-2
. [PMID: 28795276] - Majid Motaghinejad, Manijeh Motevalian, Sulai Fatima. Mediatory role of NMDA, AMPA/kainate, GABAA and Alpha2 receptors in topiramate neuroprotective effects against methylphenidate induced neurotoxicity in rat.
Life sciences.
2017 Jun; 179(?):37-53. doi:
10.1016/j.lfs.2017.01.002
. [PMID: 28082019] - Majid Motaghinejad, Manijeh Motevalian, Fatemeh Babalouei, Mohammad Abdollahi, Mansour Heidari, Zahra Madjd. Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences.
Brain research bulletin.
2017 06; 132(?):82-98. doi:
10.1016/j.brainresbull.2017.05.011
. [PMID: 28552672] - Majid Motaghinejad, Manijeh Motevalian, Behnaz Shabab. Possible involvements of glutamate and adrenergic receptors on acute toxicity of methylphenidate in isolated hippocampus and cerebral cortex of adult rats.
Fundamental & clinical pharmacology.
2017 Apr; 31(2):208-225. doi:
10.1111/fcp.12250
. [PMID: 27739173] - Majid Motaghinejad, Manijeh Motevalian, Mohammad Abdollahi, Mansour Heidari, Zahra Madjd. Topiramate Confers Neuroprotection Against Methylphenidate-Induced Neurodegeneration in Dentate Gyrus and CA1 Regions of Hippocampus via CREB/BDNF Pathway in Rats.
Neurotoxicity research.
2017 04; 31(3):373-399. doi:
10.1007/s12640-016-9695-4
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Trials.
2017 03; 18(1):145. doi:
10.1186/s13063-017-1879-6
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Pharmacoepidemiology and drug safety.
2017 Mar; 26(3):320-326. doi:
10.1002/pds.4127
. [PMID: 27862608] - Luiz K S Kanazawa, Débora D Vecchia, Etiéli M Wendler, Palloma de A S Hocayen, Paulo S Beirão, Manuela L de Mélo, Francislaine A Dos Reis Lívero, Claudia Rita Corso, Maria Carolina Stipp, Alexandra Acco, Roberto Andreatini. Effects of acute and chronic quercetin administration on methylphenidate-induced hyperlocomotion and oxidative stress.
Life sciences.
2017 Feb; 171(?):1-8. doi:
10.1016/j.lfs.2017.01.007
. [PMID: 28104366] - Vincent Chin-Hung Chen, Yao-Hsu Yang, Yin-To Liao, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Tzu-Chin Lin. The association between methylphenidate treatment and the risk for fracture among young ADHD patients: A nationwide population-based study in Taiwan.
PloS one.
2017; 12(3):e0173762. doi:
10.1371/journal.pone.0173762
. [PMID: 28296941] - Majid Motaghinejad, Manijeh Motevalian, Behnaz Shabab, Sulail Fatima. Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats.
Journal of neural transmission (Vienna, Austria : 1996).
2017 01; 124(1):121-131. doi:
10.1007/s00702-016-1623-5
. [PMID: 27682635] - Majid Motaghinejad, Manijeh Motevalian, Reza Falak, Mansour Heidari, Mahshid Sharzad, Elham Kalantari. Neuroprotective effects of various doses of topiramate against methylphenidate-induced oxidative stress and inflammation in isolated rat amygdala: the possible role of CREB/BDNF signaling pathway.
Journal of neural transmission (Vienna, Austria : 1996).
2016 12; 123(12):1463-1477. doi:
10.1007/s00702-016-1619-1
. [PMID: 27665547] - Majid Motaghinejad, Zeinab Seyedjavadein, Manijeh Motevalian, Majid Asadi. The neuroprotective effect of lithium against high dose methylphenidate: Possible role of BDNF.
Neurotoxicology.
2016 09; 56(?):40-54. doi:
10.1016/j.neuro.2016.06.010
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European journal of pharmacology.
2016 Aug; 784(?):181-91. doi:
10.1016/j.ejphar.2016.04.036
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Neuroscience letters.
2016 Apr; 619(?):106-13. doi:
10.1016/j.neulet.2015.12.015
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Clinical and experimental pharmacology & physiology.
2016 Mar; 43(3):360-71. doi:
10.1111/1440-1681.12538
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Complementary therapies in clinical practice.
2015 May; 21(2):61-7. doi:
10.1016/j.ctcp.2015.04.001
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Analytical chemistry.
2015 Apr; 87(8):4063-71. doi:
10.1021/acs.analchem.5b00555
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Explore (New York, N.Y.).
2014 Nov; 10(6):398-403. doi:
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Forensic science international.
2014 Oct; 243(?):1-13. doi:
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Indian journal of physiology and pharmacology.
2014 Jul; 58(3):240-50. doi:
"
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Neuroscience letters.
2014 May; 569(?):6-11. doi:
10.1016/j.neulet.2014.03.011
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Journal of ethnopharmacology.
2013 Sep; 149(2):583-9. doi:
10.1016/j.jep.2013.07.029
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Metabolic brain disease.
2012 Dec; 27(4):605-12. doi:
10.1007/s11011-012-9335-5
. [PMID: 22968482] - Donald R Mattison, Tony M Plant, Hui-Min Lin, Hung-Chia Chen, James J Chen, Nathan C Twaddle, Daniel Doerge, William Slikker, Ralph E Patton, Charlotte E Hotchkiss, Ralph J Callicott, Steven M Schrader, Terry W Turner, James S Kesner, Benedetto Vitiello, Dayton M Petibone, Suzanne M Morris. Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate.
Proceedings of the National Academy of Sciences of the United States of America.
2011 Sep; 108(39):16301-6. doi:
10.1073/pnas.1102187108
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Psychopharmacology.
2011 Aug; 216(4):501-9. doi:
10.1007/s00213-011-2238-z
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Chemosphere.
2010 Dec; 81(11):1416-22. doi:
10.1016/j.chemosphere.2010.09.018
. [PMID: 20932550] - Bahman Salehi, Reza Imani, Mohammad Reza Mohammadi, Jalil Fallah, Mohammad Mohammadi, Ahmad Ghanizadeh, Ali Akbar Tasviechi, Ardalan Vossoughi, Shams-Ali Rezazadeh, Shahin Akhondzadeh. Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents: a double blind, randomized controlled trial.
Progress in neuro-psychopharmacology & biological psychiatry.
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