5-(diaminomethylideneamino)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-2-[[2-[1-[2-oxo-2-[4-(6-oxo-5,11-dihydrobenzo[c][1]benzazepin-11-yl)piperazin-1-yl]ethyl]cyclopentyl]acetyl]amino]pentanamide (BioDeep_00000842870)
代谢物信息卡片
5-(diaminomethylideneamino)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-2-[[2-[1-[2-oxo-2-[4-(6-oxo-5,11-dihydrobenzo[c][1]benzazepin-11-yl)piperazin-1-yl]ethyl]cyclopentyl]acetyl]amino]pentanamide
化学式: C49H57N11O6 (895.4493061999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(C1)(CC(=O)NC(CCCN=C(N)N)C(=O)NCCN2C(=O)N(N(C2=O)C3=CC=CC=C3)C4=CC=CC=C4)CC(=O)N5CCN(CC5)C6C7=CC=CC=C7C(=O)NC8=CC=CC=C68
InChI: InChI=1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)
相关代谢途径
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Abigail C Lay, A Fern Barrington, Jenny A Hurcombe, Raina D Ramnath, Mark Graham, Philip A Lewis, Marieangela C Wilson, Kate J Heesom, Matthew J Butler, Rebecca M Perrett, Chris R Neal, Eleanor Herbert, Edward Mountjoy, Denize Atan, Viji Nair, Wenjun Ju, Robert G Nelson, Matthias Kretzler, Simon C Satchell, Craig A McArdle, Gavin I Welsh, Richard J M Coward. A role for NPY-NPY2R signaling in albuminuric kidney disease.
Proceedings of the National Academy of Sciences of the United States of America.
2020 07; 117(27):15862-15873. doi:
10.1073/pnas.2004651117. [PMID: 32561647] - Sachiko Mogami, Chihiro Yamada, Naoki Fujitsuka, Tomohisa Hattori. Peptide YY induces characteristic meal patterns of aged mice.
Hormones and behavior.
2017 11; 96(?):62-68. doi:
10.1016/j.yhbeh.2017.09.003. [PMID: 28916138] - Hui-Fang Niu, Ling Xu, Yan Yan, Fang Xie, Bao-Feng Yang, Jing Ai. Inhibition of peripheral NPY Y1 and Y2 receptors ameliorates the aberrant baroreceptor reflex sensitivity in streptozotocin induced diabetic rats.
Sheng li xue bao : [Acta physiologica Sinica].
2013 Aug; 65(4):370-80. doi:
. [PMID: 23963068] - Vanessa V dos Santos, Danúbia B Santos, Gilliard Lach, Ana Lúcia S Rodrigues, Marcelo Farina, Thereza C M De Lima, Rui Daniel Prediger. Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-β (Aβ(1-40)) administration in mice.
Behavioural brain research.
2013 May; 244(?):107-15. doi:
10.1016/j.bbr.2013.01.039. [PMID: 23396168] - Jing Liu, Ning Wang, Fang Xie, Li-Hua Sun, Qing-Xin Chen, Jian-Han Ye, Ben-Zhi Cai, Bao-Feng Yang, Jing Ai. Blockage of peripheral NPY Y1 and Y2 receptors modulates barorefex sensitivity of diabetic rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 31(2-3):421-31. doi:
10.1159/000343379. [PMID: 23548582] - Brenna M Flannery, Erica S Clark, James J Pestka. Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Dec; 130(2):289-97. doi:
10.1093/toxsci/kfs255. [PMID: 22903826] - Joana Rosmaninho-Salgado, Vera Cortez, Marta Estrada, Magda M Santana, Alexandra Gonçalves, Ana Patrícia Marques, Cláudia Cavadas. Intracellular mechanisms coupled to NPY Y2 and Y5 receptor activation and lipid accumulation in murine adipocytes.
Neuropeptides.
2012 Dec; 46(6):359-66. doi:
10.1016/j.npep.2012.08.006. [PMID: 22981159] - Astrid A Ortiz, Lucinda F Milardo, Lynn B DeCarr, Thomas M Buckholz, Michelle R Mays, Thomas H Claus, James N Livingston, Cathy D Mahle, Kevin J Lumb. A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents.
The Journal of pharmacology and experimental therapeutics.
2007 Nov; 323(2):692-700. doi:
10.1124/jpet.107.125211. [PMID: 17671099] - Hisahito Ishida, Yukihiko Shirayama, Masaaki Iwata, Seiji Katayama, Ayaka Yamamoto, Ryuzou Kawahara, Kazuyuki Nakagome. Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor.
Hippocampus.
2007; 17(4):271-80. doi:
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The Journal of physiology.
2005 Oct; 568(Pt 2):573-81. doi:
10.1113/jphysiol.2005.092700. [PMID: 16081487] - Caroline R Abbott, Caroline J Small, Adam R Kennedy, Nicola M Neary, Arshia Sajedi, Mohammad A Ghatei, Stephen R Bloom. Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake.
Brain research.
2005 May; 1043(1-2):139-44. doi:
10.1016/j.brainres.2005.02.065. [PMID: 15862527] - Eckhard Schwertfeger, Thomas Klein, Oliver Vonend, Vitus Oberhauser, Johannes Stegbauer, Lars Christian Rump. Neuropeptide Y inhibits acetylcholine release in human heart atrium by activation of Y2-receptors.
Naunyn-Schmiedeberg's archives of pharmacology.
2004 May; 369(5):455-61. doi:
10.1007/s00210-004-0930-9. [PMID: 15103451] - Michael H Ossipov, En-Tan Zhang, Cristina Carvajal, Luis Gardell, Remi Quirion, Yvan Dumont, Josephine Lai, Frank Porreca. Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002 Nov; 22(22):9858-67. doi:
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European journal of pharmacology.
2002 Mar; 439(1-3):113-9. doi:
10.1016/s0014-2999(02)01371-7. [PMID: 11937100] - Rickard E Malmström, Jon N Lundberg, Eddie Weitzberg. Effects of the neuropeptide Y Y2 receptor antagonist BIIE0246 on sympathetic transmitter release in the pig in vivo.
Naunyn-Schmiedeberg's archives of pharmacology.
2002 Feb; 365(2):106-11. doi:
10.1007/s00210-001-0516-8. [PMID: 11819028] - R E Malmström. Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y(2) receptor antagonist, in vivo.
British journal of pharmacology.
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