(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (BioDeep_00000838887)

   


代谢物信息卡片


(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid

化学式: C21H18O3 (318.12558779999995)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(C(=O)O)OC2=CC=C(C=C2)C3=CC=CC=C3
InChI: InChI=1S/C21H18O3/c22-21(23)20(15-16-7-3-1-4-8-16)24-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20H,15H2,(H,22,23)/t20-/m0/s1

描述信息

LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].

同义名列表

2 个代谢物同义名

(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid; LT175



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文献列表

  • Antonio Laghezza, Luca Piemontese, Carmen Cerchia, Roberta Montanari, Davide Capelli, Marco Giudici, Maurizio Crestani, Paolo Tortorella, Franck Peiretti, Giorgio Pochetti, Antonio Lavecchia, Fulvio Loiodice. Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. Journal of medicinal chemistry. 2018 09; 61(18):8282-8298. doi: 10.1021/acs.jmedchem.8b00835. [PMID: 30199253]
  • Federica Gilardi, Marco Giudici, Nico Mitro, Omar Maschi, Uliano Guerrini, Gianpaolo Rando, Adriana Maggi, Gaia Cermenati, Antonio Laghezza, Fulvio Loiodice, Giorgio Pochetti, Antonio Lavecchia, Donatella Caruso, Emma De Fabiani, Krister Bamberg, Maurizio Crestani. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. The Journal of biological chemistry. 2014 Mar; 289(10):6908-6920. doi: 10.1074/jbc.m113.506394. [PMID: 24451380]
  • Roberta Montanari, Fulvio Saccoccia, Elena Scotti, Maurizio Crestani, Cristina Godio, Federica Gilardi, Fulvio Loiodice, Giuseppe Fracchiolla, Antonio Laghezza, Paolo Tortorella, Antonio Lavecchia, Ettore Novellino, Fernando Mazza, Massimiliano Aschi, Giorgio Pochetti. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. Journal of medicinal chemistry. 2008 Dec; 51(24):7768-76. doi: 10.1021/jm800733h. [PMID: 19053776]
  • Alessandra Pinelli, Cristina Godio, Antonio Laghezza, Nico Mitro, Giuseppe Fracchiolla, Vincenzo Tortorella, Antonio Lavecchia, Ettore Novellino, Jean-Charles Fruchart, Bart Staels, Maurizio Crestani, Fulvio Loiodice. Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity. Journal of medicinal chemistry. 2005 Aug; 48(17):5509-19. doi: 10.1021/jm0502844. [PMID: 16107150]