Sizofilan (BioDeep_00000836661)
代谢物信息卡片
(2R,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol
化学式: C24H42O21 (666.2218482000001)
中文名称: 裂裥菌素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O)O
InChI: InChI=1S/C24H42O21/c25-1-5-9(28)13(32)15(34)22(41-5)39-4-8-12(31)20(45-23-16(35)14(33)10(29)6(2-26)42-23)18(37)24(43-8)44-19-11(30)7(3-27)40-21(38)17(19)36/h5-38H,1-4H2
描述信息
D000970 - Antineoplastic Agents
D007155 - Immunologic Factors
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ketlin Cristine Batista Mancinelli, Nicole Dalonso, Ana Paula Testa Pezzin, Guilherme Lanzi Sassaki, Carmen Lúcia de Oliveira Petkowicz, Daniela Delwing-de Lima, Ana Helena Loos Moritz, Michele Debiasi Alberton, Gilmar Sidnei Erzinger. Schizophyllan from Schizophyllum commune BRM 060008: Potential application as an inhibitor of lipase.
International journal of biological macromolecules.
2023 Dec; 259(Pt 1):129108. doi:
10.1016/j.ijbiomac.2023.129108. [PMID: 38158055] - Maki Saito, Sachiko Nameda, Noriko N Miura, Yoshiyuki Adachi, Naohito Ohno. SPG/IND-induced septic shock in a LPS-low responder strain, C3H/HeJ mice.
Microbial pathogenesis.
2008 May; 44(5):402-9. doi:
10.1016/j.micpath.2007.11.003. [PMID: 18093793] - M Kukan, Z Szatmáry, M Lutterová, D Kuba, K Vajdová, J Horecký. Effects of sizofiran on endotoxin-enhanced cold ischemia-reperfusion injury of the rat liver.
Physiological research.
2004; 53(4):431-7. doi:
NULL. [PMID: 15312003] - Yoshihito Hayashi, Naoki Shinyashiki, Shin Yagihara, Kazuto Yoshiba, Akio Teramoto, Naotake Nakamura, Yuji Miyazaki, Michio Sorai, Qi Wang. Ordering in aqueous polysaccharide solutions. I. Dielectric relaxation in aqueous solutions of a triple-helical polysaccharide schizophyllan.
Biopolymers.
2002 Jan; 63(1):21-31. doi:
10.1002/bip.1059. [PMID: 11754345] - B H Falch, T Espevik, L Ryan, B T Stokke. The cytokine stimulating activity of (1-->3)-beta-D-glucans is dependent on the triple helix conformation.
Carbohydrate research.
2000 Nov; 329(3):587-96. doi:
10.1016/s0008-6215(00)00222-6. [PMID: 11128587] - Y Ding, S S Alkan, G Baschang, J Defaye. Synthesis of the HSA-conjugate of the S-linked thiomimetic of the branched tetrasaccharide repeating unit of the immunostimulant polysaccharide, schizophyllan. Evaluation as potential immunomodulator.
Carbohydrate research.
2000 Aug; 328(1):71-6. doi:
10.1016/s0008-6215(00)00082-3. [PMID: 11005577] - T Kumae, Y Saburi, M Nasu. In vivo and in vitro effects of Sizofiran on the human neutrophils and the serum opsonic activity.
Biotherapy (Dordrecht, Netherlands).
1997; 10(2):121-7. doi:
10.1007/bf02678539. [PMID: 9373734] - H Shibuya, N Ohkohchi, K Seya, S Satomi, S Mori. Modulation of mitochondrial ATP synthesis and lipid peroxidation by Kupffer cells in liver grafts.
Transplantation proceedings.
1996 Feb; 28(1):321-3. doi:
". [PMID: 8644241] - A Hirata, M Komoda, W Itoh, K Tabata, I Sugawara. Epitope analysis using anti-oligosaccharide (G4) monoclonal antibody.
Microbiology and immunology.
1995; 39(1):43-7. doi:
10.1111/j.1348-0421.1995.tb02166.x. [PMID: 7540250] - A Hirata, M Komoda, W Itoh, K Tabata, S Itoyama, I Sugawara. An improved sandwich ELISA method for the determination of immunoreactive schizophyllan (SPG).
Biological & pharmaceutical bulletin.
1994 Nov; 17(11):1437-40. doi:
10.1248/bpb.17.1437. [PMID: 7703958] - S Kitamura, T Hori, K Kurita, K Takeo, C Hara, W Itoh, K Tabata, A Elgsaeter, B T Stokke. An antitumor, branched (1-->3)-beta-D-glucan from a water extract of fruiting bodies of Cryptoporus volvatus.
Carbohydrate research.
1994 Oct; 263(1):111-21. doi:
10.1016/0008-6215(94)00156-1. [PMID: 7982226] - S Usui, K Murashima, M Sakai, T Kiho, S Ukai. Preparation and antitumor activities of mitomycin C beta-(1-->6)-branched (1-->3)-beta-D-glucan conjugate.
Biological & pharmaceutical bulletin.
1994 Sep; 17(9):1165-70. doi:
10.1248/bpb.17.1165. [PMID: 7841935] - A Hirata, W Itoh, M Komoda, K Tabata, S Itoyama, I Sugawara. Detection of immunoreactive schizophyllan by solid-phase enzyme-linked immunosorbent assay.
Biological & pharmaceutical bulletin.
1993 Nov; 16(11):1091-3. doi:
10.1248/bpb.16.1091. [PMID: 8312861] - H Hotta, K Hagiwara, K Tabata, W Ito, M Homma. Augmentation of protective immune responses against Sendai virus infection by fungal polysaccharide schizophyllan.
International journal of immunopharmacology.
1993 Jan; 15(1):55-60. doi:
10.1016/0192-0561(93)90031-s. [PMID: 7679379] - T Suzuki, N Ohno, K Saito, T Yadomae. Activation of the complement system by (1----3)-beta-D-glucans having different degrees of branching and different ultrastructures.
Journal of pharmacobio-dynamics.
1992 Jun; 15(6):277-85. doi:
10.1248/bpb1978.15.277. [PMID: 1432567] - H Sakagami, Y Kuroiwa, M Takeda, H Ota, K Kazama, T Naoe, Y Kawazoe, S Ichikawa, H Kondo, T Yokokura. Distribution of TNF endogenously induced by various immunopotentiators and Lactobacillus casei in mice.
In vivo (Athens, Greece).
1992 May; 6(3):247-53. doi:
NULL. [PMID: 1327255] - K Yoneda, E Ueta, T Yamamoto, T Osaki. Immunoregulatory effects of sizofiran (SPG) on lymphocytes and polymorphonuclear leukocytes.
Clinical and experimental immunology.
1991 Nov; 86(2):229-35. doi:
10.1111/j.1365-2249.1991.tb05801.x. [PMID: 1657462] - A Horii, M Kyo, M Asakawa, R Yasumoto, M Maekawa. Multidisciplinary treatment for bladder carcinoma--biological response modifiers and kampo medicines.
Urologia internationalis.
1991; 47 Suppl 1(?):108-12. doi:
10.1159/000282266. [PMID: 1949364] - I Sekiguchi, M Suzuki, A Izumi, I Aida, T Tamada. [The study on the immunological effect of sizofilan combined with radiotherapy in patients with uterine cervical cancer].
Nihon Gan Chiryo Gakkai shi.
1990 Nov; 25(11):2659-64. doi:
NULL. [PMID: 2126027] - S Tanji, K Akima, M Horiba, K Amemiya, T Aimoto. [Studies on metabolism and disposition of sizofiran (SPG), an anti-tumor polysaccharide. III. Degradation and excretion of SPG in rats].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1990 Nov; 110(11):869-75. doi:
10.1248/yakushi1947.110.11_869. [PMID: 2127945] - D C Rau, V A Parsegian. Direct measurement of forces between linear polysaccharides xanthan and schizophyllan.
Science (New York, N.Y.).
1990 Sep; 249(4974):1278-81. doi:
10.1126/science.2144663. [PMID: 2144663] - K Tabata, W Itoh, A Hirata, I Sugawara, S Mori. Preparation of polyclonal antibodies to an anti-tumor (1----3)-beta-D-glucan, schizophyllan.
Agricultural and biological chemistry.
1990 Aug; 54(8):1953-9. doi:
NULL. [PMID: 1368605] - Y Tsuchiya, M Igarashi, M Inoue, K Kumagai. Cytokine-related immunomodulating activities of an anti-tumor glucan, sizofiran (SPG).
Journal of pharmacobio-dynamics.
1989 Oct; 12(10):616-25. doi:
10.1248/bpb1978.12.616. [PMID: 2534316] - H Itoh. [Changes in serum protein in cancer].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1986 Aug; 83(8):1435-43. doi:
NULL. [PMID: 3097354] - K Akima, K Amemiya, K Hosaka, H Sugimoto, H Suzuki, K Kawai, Y Akasaka, G Uozumi. [Effects of schizophyllan (SPG), an antitumor polysaccharide, on serum proteins--in ENNG induced canine gastric cancer].
Nihon Gan Chiryo Gakkai shi.
1985 Jul; 20(6):1098-106. doi:
NULL. [PMID: 2933478] - K Akima, T Arika, K Amemiya. Purification, physicochemical characterization, and antitumor activity of a cancer-associated human serum protein that is increased by treatment with schizophyllan, an antitumor polysaccharide.
Japanese journal of cancer research : Gann.
1985 Jun; 76(6):541-8. doi:
NULL. [PMID: 3926585] - K Akima, M Yoshioka, C Imai, M Horiba, T Honma, K Ishitani. [Analysis of human sera obtained from lung cancer patients by two-dimensional electrophoresis after schizophyllan (SPG) treatment].
Gan to kagaku ryoho. Cancer & chemotherapy.
1985 Jun; 12(6):1278-85. doi:
NULL. [PMID: 2988458] - Y Hamazaki, M Kuramoto, K Okamura, A Yajima, H Higashiiwai, M Suzuki. [Studies on immunotherapy of uterine cervical cancer by administration of schizophyllan (SPG) (author's transl)].
Nihon Sanka Fujinka Gakkai zasshi.
1980 Jul; 32(7):929-35. doi:
NULL. [PMID: 6453913] - M Suzuki, N Komatsu, S Nomura. [Interaction of antithymocyte globulin and immunopotentiating activity of schizophyllan (author's transl)].
The Japanese journal of antibiotics.
1979 Mar; 32(3):369-74. doi:
NULL. [PMID: 155747] - N Komatsu, H Nagaoka, A Fukutome, Z Ri, H Amano. [Influence of schizophyllan, streptomycin and rifampicin on histopathological changes in mice infected with tubercle bacilli (author's transl)].
The Japanese journal of antibiotics.
1975 Aug; 28(4):549-57. doi:
NULL. [PMID: 125808]