Piericidin A (BioDeep_00000829214)

   


代谢物信息卡片


Piericidin A1

化学式: C25H37NO4 (415.27224420000005)
中文名称: 抗生素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C(=C(N1)OC)OC)C)C)O
InChI: InChI=1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-10,12-13,15,19,22,27H,11,14H2,1-8H3,(H,26,28)/b12-10+,16-13+,17-15+,18-9+/t19-,22+/m1/s1

描述信息

A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

2 个代谢物同义名

Piericidin A1; Piericidin A



数据库引用编号

6 个数据库交叉引用编号

分类词条

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Traci E LaMoia, Gina M Butrico, Hasini A Kalpage, Leigh Goedeke, Brandon T Hubbard, Daniel F Vatner, Rafael C Gaspar, Xian-Man Zhang, Gary W Cline, Keita Nakahara, Seungwan Woo, Atsuhiro Shimada, Maik Hüttemann, Gerald I Shulman. Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2022 03; 119(10):e2122287119. doi: 10.1073/pnas.2122287119. [PMID: 35238637]
  • Xuefeng Zhou, Zhi Liang, Kunlong Li, Wei Fang, Yuanxin Tian, Xiaowei Luo, Yulian Chen, Zhikun Zhan, Tao Zhang, Shengrong Liao, Shuwen Liu, Yonghong Liu, William Fenical, Lan Tang. Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. Journal of medicinal chemistry. 2019 08; 62(15):7058-7069. doi: 10.1021/acs.jmedchem.9b00598. [PMID: 31298537]
  • Ji Eun Kang, Jae Woo Han, Byeong Jun Jeon, Beom Seok Kim. Efficacies of quorum sensing inhibitors, piericidin A and glucopiericidin A, produced by Streptomyces xanthocidicus KPP01532 for the control of potato soft rot caused by Erwinia carotovora subsp. atroseptica. Microbiological research. 2016 Mar; 184(?):32-41. doi: 10.1016/j.micres.2015.12.005. [PMID: 26856451]
  • Christian Meesters, Timon Mönig, Julian Oeljeklaus, Daniel Krahn, Corey S Westfall, Bettina Hause, Joseph M Jez, Markus Kaiser, Erich Kombrink. A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana. Nature chemical biology. 2014 Oct; 10(10):830-6. doi: 10.1038/nchembio.1591. [PMID: 25129030]
  • Takehiko Yoshida, Masatoshi Murai, Masato Abe, Naoya Ichimaru, Toshiyuki Harada, Takaaki Nishioka, Hideto Miyoshi. Crucial structural factors and mode of action of polyene amides as inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I). Biochemistry. 2007 Sep; 46(36):10365-72. doi: 10.1021/bi7010306. [PMID: 17685634]
  • T Satoh, H Miyoshi, K Sakamoto, H Iwamura. Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases. Biochimica et biophysica acta. 1996 Jan; 1273(1):21-30. doi: 10.1016/0005-2728(95)00131-x. [PMID: 8573592]
  • R R Ramsay, T P Singer. Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoreductase by rotenone, piericidin A, and MPP+. Biochemical and biophysical research communications. 1992 Nov; 189(1):47-52. doi: 10.1016/0006-291x(92)91523-s. [PMID: 1333196]
  • I L Sun, E E Sun, F L Crane, D J Morré. Evidence for coenzyme Q function in transplasma membrane electron transport. Biochemical and biophysical research communications. 1990 Nov; 172(3):979-84. doi: 10.1016/0006-291x(90)91542-z. [PMID: 2244922]