Trimegestone (BioDeep_00000815685)
代谢物信息卡片
Trimegestone
化学式: C22H30O3 (342.21948299999997)
中文名称: 曲美孕酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)C1(CCC2C1(CCC3=C4CCC(=O)C=C4CCC23)C)C)O
InChI: InChI=1S/C22H30O3/c1-13(23)20(25)22(3)11-9-19-18-6-4-14-12-15(24)5-7-16(14)17(18)8-10-21(19,22)2/h12-13,18-19,23H,4-11H2,1-3H3/t13-,18+,19-,21-,22+/m0/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C389 - Oral Contraceptive
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:136027
- KEGGdrug: D06235
- PubChem: 68926
- DrugBank: DB13129
- ChEMBL: CHEMBL2104765
- CAS: 74513-62-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Natalícia de Jesus Antunes, Raimundo Vieira de Oliveira Filho, Jaime de Oliveira Ilha, Ronilson A Moreno, André Felipe Nahoum, Ralph-Steven Wedemeyer, André Warnke, Gilberto De Nucci. Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2021 Jun; 26(3):184-194. doi:
10.1080/13625187.2021.1884219. [PMID: 33645377] - Ingrid J M Duijkers, Christine Klipping, Corinna Draeger, Barbara S Schug, Annika Dax, Maika Friedrich, Klaus Nickisch. Ovulation inhibition with a new vaginal ring containing trimegestone.
Contraception.
2020 10; 102(4):237-242. doi:
10.1016/j.contraception.2020.06.006. [PMID: 32569678] - Donita Africander, Nicolette Verhoog, Janet P Hapgood. Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception.
Steroids.
2011 Jun; 76(7):636-52. doi:
10.1016/j.steroids.2011.03.001. [PMID: 21414337] - Regine Sitruk-Ware, Anita Nath. Metabolic effects of contraceptive steroids.
Reviews in endocrine & metabolic disorders.
2011 Jun; 12(2):63-75. doi:
10.1007/s11154-011-9182-4. [PMID: 21538049] - M Hellgren, J Conard, L Norris, C Kluft. Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone.
Maturitas.
2009 Mar; 62(3):287-93. doi:
10.1016/j.maturitas.2009.01.004. [PMID: 19268506] - Regine Sitruk-Ware. New progestagens for contraceptive use.
Human reproduction update.
2006 Mar; 12(2):169-78. doi:
10.1093/humupd/dmi046. [PMID: 16291771] - R Sitruk-Ware. Pharmacology of different progestogens: the special case of drospirenone.
Climacteric : the journal of the International Menopause Society.
2005 Oct; 8 Suppl 3(?):4-12. doi:
10.1080/13697130500330382. [PMID: 16203650] - Rebecca A Shirk, Zhiming Zhang, Richard C Winneker. Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat.
The Journal of steroid biochemistry and molecular biology.
2005 Mar; 94(4):361-8. doi:
10.1016/j.jsbmb.2004.12.026. [PMID: 15857755] - F Al-Azzawi, M Wahab, S Sami, A J Proudler, J Thompson, J Stevenson. Randomized trial of effects of estradiol in combination with either norethisterone acetate or trimegestone on lipids and lipoproteins in postmenopausal women.
Climacteric : the journal of the International Menopause Society.
2004 Sep; 7(3):292-300. doi:
10.1080/13697130400001364. [PMID: 15669554] - Lise Warming, Pernille Ravn, Danièle Spielman, Pierre Delmas, Claus Christiansen. Trimegestone in a low-dose, continuous-combined hormone therapy regimen prevents bone loss in osteopenic postmenopausal women.
Menopause (New York, N.Y.).
2004 May; 11(3):337-42. doi:
10.1097/01.gme.0000097846.95550.aa. [PMID: 15167314] - Régine Sitruk-Ware. New progestogens: a review of their effects in perimenopausal and postmenopausal women.
Drugs & aging.
2004; 21(13):865-83. doi:
10.2165/00002512-200421130-00004. [PMID: 15493951] - Marinka S Post, Marieke O Verhoeven, Marius J van der Mooren, Peter Kenemans, Coen D A Stehouwer, Tom Teerlink. Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women.
The Journal of clinical endocrinology and metabolism.
2003 Sep; 88(9):4221-6. doi:
10.1210/jc.2003-030584. [PMID: 12970290] - J H J M Meuwissen, L Beijers-De Bie, T Vihtamaki, R Tuimala, N Siseles, C Magaril, H S The, P W H Houben, M Murga, D Spielmann, T J De Villiers. Assessment of the metabolic tolerance in postmenopausal women over a 1-year period of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2002 Apr; 16(2):155-62. doi:
. [PMID: 12012627] - M S Post, D F Hendriks, M J Van Der Mooren, W M Van Baal, J R Leurs, J J Emeis, P Kenemans, C D A Stehouwer. Oral oestradiol/trimegestone replacement reduces procarboxypeptidase U (TAFI): a randomized, placebo- controlled, 12-week study in early postmenopausal women.
Journal of internal medicine.
2002 Mar; 251(3):245-51. doi:
10.1046/j.1365-2796.2002.00960.x. [PMID: 11886484] - Régine Sitruk-Ware. Progestogens in hormonal replacement therapy: new molecules, risks, and benefits.
Menopause (New York, N.Y.).
2002 Jan; 9(1):6-15. doi:
10.1097/00042192-200201000-00003. [PMID: 11791081] - W M Van Baal, J J Emeis, P Kenemans, H Kessel, E R Peters-Muller, C G Schalkwijk, M J van der Mooren, C D Stehouwer. Short-term hormone replacement therapy: reduced plasma levels of soluble adhesion molecules.
European journal of clinical investigation.
1999 Nov; 29(11):913-21. doi:
10.1046/j.1365-2362.1999.00565.x. [PMID: 10583435] - W M van Baal, R G Smolders, M J van der Mooren, T Teerlink, P Kenemans. Hormone replacement therapy and plasma homocysteine levels.
Obstetrics and gynecology.
1999 Oct; 94(4):485-91. doi:
10.1016/s0029-7844(99)00412-3. [PMID: 10511346]