Neurotensin (BioDeep_00000796493)
Chemicals and Drugs
代谢物信息卡片
Neurotensin acetate salt
化学式: C78H121N21O20 (1671.9096306000001)
中文名称: 神经降压素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(C)C)NC(=O)C5CCC(=O)N5
InChI: InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
描述信息
A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinsons disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.
Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:7542
- PubChem: 25077406
- ChEMBL: CHEMBL407196
- MeSH: Neurotensin
- CAS: 39379-15-2
- CAS: 55508-42-4
- MetaboLights: MTBLC7542
- medchemexpress: HY-P0234
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing Li, Liping Yang, Jun Song, Baoxiang Yan, Andrew J Morris, Hunter Moseley, Robert Flight, Chi Wang, Jinpeng Liu, Heidi L Weiss, Edward F Morris, Ilyes Abdelhamid, Mathias J Gerl, Olle Melander, Susan Smyth, B Mark Evers. Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides.
Atherosclerosis.
2024 May; 392(?):117479. doi:
10.1016/j.atherosclerosis.2024.117479. [PMID: 38423808] - Sonia Srivastava, Swarnima Mishra, Gyan Babu, Banalata Mohanty. Neurotensin agonist PD149163 modulates lipopolysaccharide induced inflammation and oxidative stress in the female reproductive system of mice.
Reproductive biology.
2023 Nov; 24(1):100828. doi:
10.1016/j.repbio.2023.100828. [PMID: 38029502] - Francesca De Vito, Velia Cassano, Elettra Mancuso, Elena Succurro, Marta Letizia Hribal, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Teresa Vanessa Fiorentino. Higher circulating levels of proneurotensin are associated with increased risk of incident NAFLD.
Journal of internal medicine.
2023 09; 294(3):336-346. doi:
10.1111/joim.13651. [PMID: 37157165] - Gyan Babu, Banalata Mohanty. Neurotensin modulation of lipopolysaccharide induced inflammation of gut-liver axis: Evaluation using neurotensin receptor agonist and antagonist.
Neuropeptides.
2023 Feb; 97(?):102297. doi:
10.1016/j.npep.2022.102297. [PMID: 36368076] - Ankit Mishra, K P Singh. Protective effect of neurotensin receptor-1 agonist PD 149163 against lipopolysaccharide-induced gut toxicity in mice.
Drug and chemical toxicology.
2022 Nov; 45(6):2399-2410. doi:
10.1080/01480545.2021.1954698. [PMID: 34334065] - X Ke, L Duan, F Gong, Y Zhang, K Deng, Y Yao, L Wang, F Feng, B Xing, H Pan, H Zhu. A study on serum pro-neurotensin (PNT), furin, and zinc alpha-2-glycoprotein (ZAG) levels in patients with acromegaly.
Journal of endocrinological investigation.
2022 Oct; 45(10):1945-1954. doi:
10.1007/s40618-022-01827-1. [PMID: 35670958] - Ankit Mishra, K P Singh. Neurotensin agonist PD 149163 modulates the neuroinflammation induced by bacterial endotoxin lipopolysaccharide in mice model.
Immunopharmacology and immunotoxicology.
2022 Apr; 44(2):216-226. doi:
10.1080/08923973.2022.2037628. [PMID: 35166614] - Ayesha Fawad, Andreas Bergmann, Janin Schulte, Zahra A Butt, Peter M Nilsson, Louise Bennet, Marju Orho-Melander, Olle Melander. Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up.
The Journal of clinical endocrinology and metabolism.
2022 02; 107(3):e1204-e1211. doi:
10.1210/clinem/dgab755. [PMID: 34665860] - Ilaria Barchetta, Marco Giorgio Baroni, Olle Melander, Maria Gisella Cavallo. New Insights in the Control of Fat Homeostasis: The Role of Neurotensin.
International journal of molecular sciences.
2022 Feb; 23(4):. doi:
10.3390/ijms23042209. [PMID: 35216326] - Daniel B Andersen, Jens J Holst. Peptides in the regulation of glucagon secretion.
Peptides.
2022 02; 148(?):170683. doi:
10.1016/j.peptides.2021.170683. [PMID: 34748791] - Maria S Svane, Caroline C Øhrstrøm, Astrid Plamboeck, Nils B Jørgensen, Kirstine N Bojsen-Møller, Carsten Dirksen, Christoffer Martinussen, Tina Vilsbøll, Bolette Hartmann, Carolyn F Deacon, Viggo B Kristiansen, Filip K Knop, Lars B Svendsen, Sten Madsbad, Jens J Holst, Simon Veedfald. Neurotensin secretion after Roux-en-Y gastric bypass, sleeve gastrectomy, and truncal vagotomy with pyloroplasty.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2022 01; 34(1):e14210. doi:
10.1111/nmo.14210. [PMID: 34378827] - Flavia Agata Cimini, Ilaria Barchetta, Laura Bertoccini, Valentina Ceccarelli, Marco Giorgio Baroni, Olle Melander, Maria Gisella Cavallo. High pro-neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow-up.
Acta diabetologica.
2022 Jan; 59(1):49-56. doi:
10.1007/s00592-021-01783-x. [PMID: 34455471] - Gonca Özyurt, Gülten Cingöz, Yusuf Öztürk, Tuncay Küme, Bumin Nuri Dündar, Ali Evren Tufan, Gönül Çatlı. Elevated neurotensin levels among obese adolescents may be related to emotion dysregulation and impulsivity: a cross-sectional, case-control study.
The Turkish journal of pediatrics.
2022; 64(2):255-264. doi:
10.24953/turkjped.2021.1437. [PMID: 35611414] - Takenori Onaga, Hideaki Hayashi, Yumiko Yasui. Effects of xenin-25 on insulin and glucagon secretions in healthy conscious sheep.
Domestic animal endocrinology.
2021 10; 77(?):106635. doi:
10.1016/j.domaniend.2021.106635. [PMID: 34111624] - Daneng Li, Megan Minnix, Rebecca Allen, James Bading, Junie Chea, Patty Wong, Nicole Bowles, Erasmus Poku, John E Shively. Preclinical PET Imaging of NTSR-1-Positive Tumors with 64Cu- and 68Ga-DOTA-Neurotensin Analogs and Therapy with an 225Ac-DOTA-Neurotensin Analog.
Cancer biotherapy & radiopharmaceuticals.
2021 Oct; 36(8):651-661. doi:
10.1089/cbr.2020.3926. [PMID: 32822229] - Gülten Cingöz, Gonca Özyurt, Hamide Uzun, Özlem Gürsoy Doruk, Tuncay Küme, Bumin Nuri Dündar, Gönül Çatlı. High serum neurotensin level in obese adolescents is not associated with metabolic parameters, hyperphagia or food preference.
Journal of pediatric endocrinology & metabolism : JPEM.
2021 Aug; 34(8):971-978. doi:
10.1515/jpem-2021-0031. [PMID: 34147046] - Charles D Nicoli, April P Carson, Timothy B Plante, D Leann Long, Leslie A McClure, Janin Schulte, Mary Cushman. Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort.
The Journal of clinical endocrinology and metabolism.
2021 08; 106(9):e3483-e3494. doi:
10.1210/clinem/dgab355. [PMID: 34013344] - S L Craig, V A Gault, C E Shiels, G Hamscher, N Irwin. Comparison of independent and combined effects of the neurotensin receptor agonist, JMV-449, and incretin mimetics on pancreatic islet function, glucose homeostasis and appetite control.
Biochimica et biophysica acta. General subjects.
2021 08; 1865(8):129917. doi:
10.1016/j.bbagen.2021.129917. [PMID: 33964357] - Mélanie Vivancos, Roberto Fanelli, Élie Besserer-Offroy, Sabrina Beaulieu, Magali Chartier, Martin Resua-Rojas, Christine E Mona, Santo Previti, Emmanuelle Rémond, Jean-Michel Longpré, Florine Cavelier, Philippe Sarret. Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia.
Behavioural brain research.
2021 05; 405(?):113189. doi:
10.1016/j.bbr.2021.113189. [PMID: 33607165] - Jing Li, Jun Song, Baoxiang Yan, Heidi L Weiss, L Todd Weiss, Tianyan Gao, B Mark Evers. Neurotensin differentially regulates bile acid metabolism and intestinal FXR-bile acid transporter axis in response to nutrient abundance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 05; 35(5):e21371. doi:
10.1096/fj.202001692r. [PMID: 33811694] - Genevieve E Campbell, Hannah R Bender, Grace A Parker, Thomas E Curry, Diane M Duffy. Neurotensin: A novel mediator of ovulation?.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 04; 35(4):e21481. doi:
10.1096/fj.202002547rr. [PMID: 33710668] - Ilaria Barchetta, Laura Bertoccini, Federica Sentinelli, Diego Bailetti, Giacomo Marini, Flavia Agata Cimini, Valentina Ceccarelli, Joachim Struck, Janin Schulte, Sandro Loche, Efisio Cossu, Olle Melander, Maria G Cavallo, Marco G Baroni. Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2021 03; 31(3):902-910. doi:
10.1016/j.numecd.2020.11.025. [PMID: 33549442] - Meng Zhang, Miao Gui, Zi-Fu Wang, Christoph Gorgulla, James J Yu, Hao Wu, Zhen-Yu J Sun, Christoph Klenk, Lisa Merklinger, Lena Morstein, Franz Hagn, Andreas Plückthun, Alan Brown, Mahmoud L Nasr, Gerhard Wagner. Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nature structural & molecular biology.
2021 03; 28(3):258-267. doi:
10.1038/s41594-020-00554-6. [PMID: 33633398] - Neil Tanday, R Charlotte Moffett, Victor A Gault, Peter R Flatt, Nigel Irwin. Enzymatically stable analogue of the gut-derived peptide xenin on beta-cell transdifferentiation in high fat fed and insulin-deficient Ins1Cre/+ ;Rosa26-eYFP mice.
Diabetes/metabolism research and reviews.
2021 03; 37(3):e3384. doi:
10.1002/dmrr.3384. [PMID: 32662136] - Terry W Moody, Irene Ramos-Alvarez, Robert T Jensen. Bombesin, endothelin, neurotensin and pituitary adenylate cyclase activating polypeptide cause tyrosine phosphorylation of receptor tyrosine kinases.
Peptides.
2021 03; 137(?):170480. doi:
10.1016/j.peptides.2020.170480. [PMID: 33385499] - Vardan T Karamyan. Between two storms, vasoactive peptides or bradykinin underlie severity of COVID-19?.
Physiological reports.
2021 03; 9(5):e14796. doi:
10.14814/phy2.14796. [PMID: 33687143] - Isabella Jonsson, Kirstine N Bojsen-Møller, Viggo B Kristiansen, Simon Veedfald, Nicolai J Wewer Albrechtsen, Trine R Clausen, Rune E Kuhre, Jens F Rehfeld, Jens J Holst, Sten Madsbad, Maria S Svane. Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass.
Frontiers in endocrinology.
2021; 12(?):681116. doi:
10.3389/fendo.2021.681116. [PMID: 34084153] - Zherui Wu, Nicolas Stadler, Amazigh Abbaci, Jin Liu, Agnès Boullier, Nicolas Marie, Olivier Biondi, Marthe Moldes, Romain Morichon, Bruno Feve, Olle Melander, Patricia Forgez. Effect of Monoclonal Antibody Blockade of Long Fragment Neurotensin on Weight Loss, Behavior, and Metabolic Traits After High-Fat Diet Induced Obesity.
Frontiers in endocrinology.
2021; 12(?):739287. doi:
10.3389/fendo.2021.739287. [PMID: 34690932] - Sarah L Craig, Victor A Gault, Peter R Flatt, Nigel Irwin. The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin.
Biochemical pharmacology.
2021 01; 183(?):114355. doi:
10.1016/j.bcp.2020.114355. [PMID: 33279496] - Niki Christou, Sabrina Blondy, Valentin David, Mireille Verdier, Fabrice Lalloué, Marie-Odile Jauberteau, Muriel Mathonnet, Aurélie Perraud. Neurotensin pathway in digestive cancers and clinical applications: an overview.
Cell death & disease.
2020 12; 11(12):1027. doi:
10.1038/s41419-020-03245-8. [PMID: 33268796] - Li Li, Heidi L Weiss, Jing Li, Zhengyi Chen, Leslie Donato, B Mark Evers. High plasma levels of pro-NT are associated with increased colon cancer risk.
Endocrine-related cancer.
2020 11; 27(11):641-646. doi:
10.1530/erc-20-0310. [PMID: 33055301] - Luana Palazzi, Antonella Pasquato, Mattia Vicario, Alexandre Roulin, Patrizia Polverino de Laureto, Laura Cendron. C-terminal tails mimicking bioactive intermediates cause different plasma degradation patterns and kinetics in neuropeptides γ-MSH, α-MSH, and neurotensin.
Journal of peptide science : an official publication of the European Peptide Society.
2020 Nov; 26(11):e3279. doi:
10.1002/psc.3279. [PMID: 32812282] - Andrew English, Sarah L Craig, Peter R Flatt, Nigel Irwin. Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes.
Biological chemistry.
2020 10; 401(11):1293-1303. doi:
10.1515/hsz-2020-0195. [PMID: 32769216] - Roberto Fanelli, Adrien Chastel, Santo Previti, Elif Hindié, Delphine Vimont, Paolo Zanotti-Fregonara, Philippe Fernandez, Philippe Garrigue, Frédéric Lamare, Romain Schollhammer, Laure Balasse, Benjamin Guillet, Emmanuelle Rémond, Clément Morgat, Florine Cavelier. Silicon-Containing Neurotensin Analogues as Radiopharmaceuticals for NTS1-Positive Tumors Imaging.
Bioconjugate chemistry.
2020 10; 31(10):2339-2349. doi:
10.1021/acs.bioconjchem.0c00419. [PMID: 32887526] - Paola Dongiovanni, Marica Meroni, Salvatore Petta, Miriam Longo, Anna Alisi, Giorgio Soardo, Luca Valenti, Luca Miele, Stefania Grimaudo, Grazia Pennisi, Grieco Antonio, Dario Consonni, Silvia Fargion, Anna Ludovica Fracanzani. Neurotensin up-regulation is associated with advanced fibrosis and hepatocellular carcinoma in patients with MAFLD.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 10; 1865(10):158765. doi:
10.1016/j.bbalip.2020.158765. [PMID: 32663609] - Anke Tönjes, Annett Hoffmann, Susan Kralisch, Abdul Rashid Qureshi, Nora Klöting, Markus Scholz, Dorit Schleinitz, Anette Bachmann, Jürgen Kratzsch, Marcin Nowicki, Sabine Paeschke, Kerstin Wirkner, Cornelia Enzenbach, Ronny Baber, Joachim Beige, Matthias Anders, Ingolf Bast, Matthias Blüher, Peter Kovacs, Markus Löffler, Ming-Zhi Zhang, Raymond C Harris, Peter Stenvinkel, Michael Stumvoll, Mathias Fasshauer, Thomas Ebert. Pro-neurotensin depends on renal function and is related to all-cause mortality in chronic kidney disease.
European journal of endocrinology.
2020 Sep; 183(3):233-244. doi:
10.1530/eje-20-0087. [PMID: 32508317] - Ayesha Fawad, Celine Fernandez, Andreas Bergmann, Joachim Struck, Peter M Nilsson, Louise Bennet, Marju Orho-Melander, Olle Melander. Magnitude of rise in proneurotensin is related to amount of triglyceride appearance in blood after standardized oral intake of both saturated and unsaturated fat.
Lipids in health and disease.
2020 Aug; 19(1):191. doi:
10.1186/s12944-020-01361-0. [PMID: 32825823] - Napatsorn Saiyasit, Titikorn Chunchai, Nattayaporn Apaijai, Wasana Pratchayasakul, Jirapas Sripetchwandee, Nipon Chattipakorn, Siriporn C Chattipakorn. Chronic high-fat diet consumption induces an alteration in plasma/brain neurotensin signaling, metabolic disturbance, systemic inflammation/oxidative stress, brain apoptosis, and dendritic spine loss.
Neuropeptides.
2020 Aug; 82(?):102047. doi:
10.1016/j.npep.2020.102047. [PMID: 32327191] - Irene Tsilioni, Harry Pantazopoulos, Pio Conti, Susan E Leeman, Theoharis C Theoharides. IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder.
Proceedings of the National Academy of Sciences of the United States of America.
2020 07; 117(28):16475-16480. doi:
10.1073/pnas.2004666117. [PMID: 32601180] - Jing Li, Xian Li, Jun Song, Baoxiang Yan, Stephanie A Rock, Jianhang Jia, Jinpeng Liu, Chi Wang, Todd Weiss, Heidi L Weiss, Tianyan Gao, Ashfaqul Alam, B Mark Evers. Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 06; 34(6):8596-8610. doi:
10.1096/fj.201902374rr. [PMID: 32359121] - Christian Zinck Jensen, Kirstine N Bojsen-Møller, Maria S Svane, Line M Holst, Kjeld Hermansen, Bolette Hartmann, Nicolai Jacob Wewer Albrechtsen, Rune Ehrenreich Kuhre, Viggo B Kristiansen, Jens Frederik Rehfeld, Trine R Clausen, Jens J Holst, Sten Madsbad. Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery.
American journal of physiology. Gastrointestinal and liver physiology.
2020 04; 318(4):G661-G672. doi:
10.1152/ajpgi.00265.2019. [PMID: 32068442] - Lin-Jie Wang, Mei-Juan Liu, Tian-Shu Zhai, Hui-Juan Zhu, Feng-Ying Gong, Hong-Bo Yang, Ke-Min Yan, Hui Pan, Yong Zeng. Identification of U-shaped curve relation between proneurotensin and risk of coronary artery disease (CAD) in patients with premature CAD.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2020 03; 30(3):483-491. doi:
10.1016/j.numecd.2019.10.009. [PMID: 31926821] - Arezou M Farahani, Fariba Maleki, Nourollah Sadeghzadeh. The Influence of Different Spacers on Biological Profile of Peptide Radiopharmaceuticals for Diagnosis and Therapy of Human Cancers.
Anti-cancer agents in medicinal chemistry.
2020; 20(4):402-416. doi:
10.2174/1871520620666191231161227. [PMID: 31889492] - Ismail Bolat, Hamdi Pusuroglu, Ali Rıza Demir, Vesile Ornek, Mehmet Erturk. Decreased neurotensin levels as a biomarker in resistant hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2020; 42(3):266-270. doi:
10.1080/10641963.2019.1632340. [PMID: 31204518] - Diane J Kim, Sarah J Blossom, Pedro L Delgado, Jessica M Carbajal, Ricardo Cáceda. Examination of pain threshold and neuropeptides in patients with acute suicide risk.
Progress in neuro-psychopharmacology & biological psychiatry.
2019 12; 95(?):109705. doi:
10.1016/j.pnpbp.2019.109705. [PMID: 31326514] - Terry W Moody, Lingaku Lee, Irene Ramos-Alvarez, Robert T Jensen. Neurotensin receptors regulate transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.
European journal of pharmacology.
2019 Dec; 865(?):172735. doi:
10.1016/j.ejphar.2019.172735. [PMID: 31614143] - Aneta Lidia Zygulska, Agata Furgala, Jolanta Kaszuba-Zwoińska, Krzysztof Krzemieniecki, Krzysztof Gil. Changes in plasma levels of cholecystokinin, neurotensin, VIP and PYY in gastric and colorectal cancer - Preliminary results.
Peptides.
2019 12; 122(?):170148. doi:
10.1016/j.peptides.2019.170148. [PMID: 31541684] - Emilie Eiselt, Simon Gonzalez, Charlotte Martin, Magali Chartier, Cecilia Betti, Jean-Michel Longpré, Florine Cavelier, Dirk Tourwé, Louis Gendron, Steven Ballet, Philippe Sarret. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia.
ACS chemical neuroscience.
2019 11; 10(11):4535-4544. doi:
10.1021/acschemneuro.9b00390. [PMID: 31589400] - Yusuf Adnan Guclu, Ebru Sahin, Murat Aksit. The relationship between elevated serum xenin and insulin resistance in women with polycystic ovary syndrome: a case-control study.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2019 Nov; 35(11):960-964. doi:
10.1080/09513590.2019.1604663. [PMID: 31010340] - S L Craig, V A Gault, S McClean, G Hamscher, N Irwin. Effects of an enzymatically stable C-terminal hexapseudopeptide fragment peptide of xenin-25, ψ-xenin-6, on pancreatic islet function and metabolism.
Molecular and cellular endocrinology.
2019 10; 496(?):110523. doi:
10.1016/j.mce.2019.110523. [PMID: 31352038] - A Fawad, P M Nilsson, J Struck, A Bergmann, O Melander, L Bennet. The association between plasma proneurotensin and glucose regulation is modified by country of birth.
Scientific reports.
2019 09; 9(1):13640. doi:
10.1038/s41598-019-50040-3. [PMID: 31541150] - E B Lohman, G R Pacheco, L Gharibvand, N Daher, K Devore, G Bains, M AlAmeri, L S Berk. The immediate effects of cervical spine manipulation on pain and biochemical markers in females with acute non-specific mechanical neck pain: a randomized clinical trial.
The Journal of manual & manipulative therapy.
2019 09; 27(4):186-196. doi:
10.1080/10669817.2018.1553696. [PMID: 30935335] - Vassiliki Magafa, Minos-Timotheos Matsoukas, Vlasios Karageorgos, Eirini Dermitzaki, Revekka Exarchakou, Evgenios Κ Stylos, Michail Pardalos, Andrew N Margioris, George Varvounis, Andreas G Tzakos, Georgios A Spyroulias, George Liapakis. Novel stable analogues of the neurotensin C-terminal hexapeptide containing unnatural amino acids.
Amino acids.
2019 Jul; 51(7):1009-1022. doi:
10.1007/s00726-019-02741-2. [PMID: 31079216] - Shengyang Qiu, Stella Nikolaou, Francesca Fiorentino, Shahnawaz Rasheed, Ara Darzi, David Cunningham, Paris Tekkis, Christos Kontovounisios. Exploratory Analysis of Plasma Neurotensin as a Novel Biomarker for Early Detection of Colorectal Polyp and Cancer.
Hormones & cancer.
2019 06; 10(2-3):128-135. doi:
10.1007/s12672-019-00364-3. [PMID: 31093954] - A Tönjes, S Kralisch, A Hoffmann, D Schleinitz, J Kratzsch, M Blüher, M Stumvoll, P Kovacs, M Fasshauer, T Ebert. Circulating Pro-Neurotensin in gestational diabetes mellitus.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2019 01; 29(1):23-29. doi:
10.1016/j.numecd.2018.09.011. [PMID: 30527352] - Christian von Loeffelholz, Lidia Castagneto Gissey, Tina Schumann, Christine Henke, Anica Kurzbach, Joachim Struck, Andreas Bergmann, Markolf Hanefeld, Ulrike Schatz, Stefan R Bornstein, Giovanni Casella, Geltrude Mingrone, Andreas L Birkenfeld. The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery.
International journal of obesity (2005).
2018 12; 42(12):2057-2061. doi:
10.1038/s41366-018-0084-3. [PMID: 29795470] - I Barchetta, G Ciccarelli, F A Cimini, V Ceccarelli, M Orho-Melander, O Melander, M G Cavallo. Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus.
Journal of endocrinological investigation.
2018 Oct; 41(10):1159-1163. doi:
10.1007/s40618-018-0845-9. [PMID: 29417469] - Yongtao Xiao, Weihui Yan, Ying Lu, Kejun Zhou, Wei Cai. Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.
EBioMedicine.
2018 Sep; 35(?):133-141. doi:
10.1016/j.ebiom.2018.08.006. [PMID: 30104181] - Marc Sousbie, Mélanie Vivancos, Rebecca L Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Richard Leduc, Philippe Sarret, Éric Marsault. Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13).
Journal of medicinal chemistry.
2018 08; 61(16):7103-7115. doi:
10.1021/acs.jmedchem.8b00175. [PMID: 30035538] - Jing Li, Jun Song, Xian Li, Stephanie B Rock, Heather F Sinner, Heidi L Weiss, Todd Weiss, Courtney M Townsend, Tianyan Gao, B Mark Evers. FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice.
Endocrinology.
2018 08; 159(8):2939-2952. doi:
10.1210/en.2018-00284. [PMID: 29796668] - Ilaria Barchetta, Flavia Agata Cimini, Frida Leonetti, Danila Capoccia, Claudio Di Cristofano, Gianfranco Silecchia, Marju Orho-Melander, Olle Melander, Maria Gisella Cavallo. Increased Plasma Proneurotensin Levels Identify NAFLD in Adults With and Without Type 2 Diabetes.
The Journal of clinical endocrinology and metabolism.
2018 06; 103(6):2253-2260. doi:
10.1210/jc.2017-02751. [PMID: 29590379] - Ayesha Fawad, Andreas Bergmann, Joachim Struck, Peter M Nilsson, Marju Orho-Melander, Olle Melander. Proneurotensin Predicts Cardiovascular Disease in an Elderly Population.
The Journal of clinical endocrinology and metabolism.
2018 05; 103(5):1940-1947. doi:
10.1210/jc.2017-02424. [PMID: 29546332] - Paul Denver, Victor A Gault, Paula L McClean. Sustained high-fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high-fat model.
Diabetes, obesity & metabolism.
2018 05; 20(5):1166-1175. doi:
10.1111/dom.13210. [PMID: 29316242] - Patricia M Dijkman, Oliver K Castell, Alan D Goddard, Juan C Munoz-Garcia, Chris de Graaf, Mark I Wallace, Anthony Watts. Dynamic tuneable G protein-coupled receptor monomer-dimer populations.
Nature communications.
2018 04; 9(1):1710. doi:
10.1038/s41467-018-03727-6. [PMID: 29703992] - Ilaria Barchetta, Flavia Agata Cimini, Danila Capoccia, Laura Bertoccini, Valentina Ceccarelli, Caterina Chiappetta, Frida Leonetti, Claudio Di Cristofano, Gianfranco Silecchia, Marju Orho-Melander, Olle Melander, Maria Gisella Cavallo. Neurotensin Is a Lipid-Induced Gastrointestinal Peptide Associated with Visceral Adipose Tissue Inflammation in Obesity.
Nutrients.
2018 Apr; 10(4):. doi:
10.3390/nu10040526. [PMID: 29690638] - Sharma Bhavya, Pei San Lew, Tooru M Mizuno. Stimulation of white adipose tissue lipolysis by xenin, a neurotensin-related peptide.
Biochemical and biophysical research communications.
2018 04; 498(4):842-848. doi:
10.1016/j.bbrc.2018.03.067. [PMID: 29530527] - Pedro F Teixeira, Geoffrey Masuyer, Catarina M Pinho, Rui M M Branca, Beata Kmiec, Cecilia Wallin, Sebastian K T S Wärmländer, Ronnie P-A Berntsson, Maria Ankarcrona, Astrid Gräslund, Janne Lehtiö, Pål Stenmark, Elzbieta Glaser. Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
Journal of molecular biology.
2018 02; 430(3):348-362. doi:
10.1016/j.jmb.2017.11.011. [PMID: 29183787] - L Lénárd, K László, E Kertes, T Ollmann, L Péczely, A Kovács, V Kállai, O Zagorácz, R Gálosi, Z Karádi. Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation.
Neuroscience and biobehavioral reviews.
2018 02; 85(?):1-20. doi:
10.1016/j.neubiorev.2017.09.003. [PMID: 28887225] - Teresa Auguet, Gemma Aragonès, Alba Berlanga, Salomé Martínez, Fàtima Sabench, Carmen Aguilar, Beatriz Villar, Joan Josep Sirvent, Daniel Del Castillo, Cristóbal Richart. Low Circulating Levels of Neurotensin in Women with Nonalcoholic Fatty Liver Disease Associated with Severe Obesity.
Obesity (Silver Spring, Md.).
2018 02; 26(2):274-278. doi:
10.1002/oby.22058. [PMID: 29276861] - Songyan Wang, Lauren Z Oestricker, Michael J Wallendorf, Karin Sterl, Judit Dunai, C Rachel Kilpatrick, Bruce W Patterson, Dominic N Reeds, Burton M Wice. Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance.
PloS one.
2018; 13(2):e0192441. doi:
10.1371/journal.pone.0192441. [PMID: 29466430] - Dawood Khan, Srividya Vasu, R Charlotte Moffett, Victor A Gault, Peter R Flatt, Nigel Irwin. Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival.
Biological chemistry.
2017 12; 399(1):79-92. doi:
10.1515/hsz-2017-0136. [PMID: 28822218] - Christos Kontovounisios, Shengyang Qiu, Shahnawaz Rasheed, Ara Darzi, Paris Tekkis. The role of neurotensin as a novel biomarker in the endoscopic screening of high-risk population for developing colorectal neoplasia.
Updates in surgery.
2017 Sep; 69(3):397-402. doi:
10.1007/s13304-017-0464-6. [PMID: 28560510] - Stefan Acosta, Soumia Taimour, Anders Gottsäter, Margaretha Persson, Gunnar Engström, Olle Melander, Moncef Zarrouk, Peter M Nilsson, J Gustav Smith. Lp-PLA2 activity and mass for prediction of incident abdominal aortic aneurysms: A prospective longitudinal cohort study.
Atherosclerosis.
2017 07; 262(?):14-18. doi:
10.1016/j.atherosclerosis.2017.04.014. [PMID: 28475940] - Sharma Bhavya, Pei San Lew, Tooru M Mizuno. Central action of xenin affects the expression of lipid metabolism-related genes and proteins in mouse white adipose tissue.
Neuropeptides.
2017 Jun; 63(?):67-73. doi:
10.1016/j.npep.2017.01.007. [PMID: 28190525] - Annie Hasib, Ming T Ng, Victor A Gault, Dawood Khan, Vadivel Parthsarathy, Peter R Flatt, Nigel Irwin. An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.
Diabetologia.
2017 03; 60(3):541-552. doi:
10.1007/s00125-016-4186-y. [PMID: 28004148] - Majlinda Kullolli, Dan A Rock, Ji Ma. Immuno-affinity Capture Followed by TMPP N-Terminus Tagging to Study Catabolism of Therapeutic Proteins.
Journal of proteome research.
2017 02; 16(2):911-919. doi:
10.1021/acs.jproteome.6b00863. [PMID: 28152598] - Manuel Tena-Sempere. Neuroendocrinology in 2016: Neuroendocrine control of metabolism and reproduction.
Nature reviews. Endocrinology.
2017 02; 13(2):67-68. doi:
10.1038/nrendo.2016.216. [PMID: 28059155] - Giuseppe Riezzo, Guglielmina Chimienti, Caterina Clemente, Benedetta D'Attoma, Antonella Orlando, Caterina Mammone Rinaldi, Francesco Russo. Colonic Transit Time and Gut Peptides in Adult Patients with Slow and Normal Colonic Transit Constipation.
BioMed research international.
2017; 2017(?):3178263. doi:
10.1155/2017/3178263. [PMID: 29082242] - C Montén, Å Torinsson Naluai, D Agardh. Role of proneurotensin as marker of paediatric coeliac disease.
Clinical and experimental immunology.
2016 Dec; 186(3):387-392. doi:
10.1111/cei.12864. [PMID: 27612962] - Yinnong Jia, Wenting Zhang, Wei Fan, Susan Brusnahan, Jered Garrison. Investigation of the Biological Impact of Charge Distribution on a NTR1-Targeted Peptide.
Bioconjugate chemistry.
2016 Nov; 27(11):2658-2668. doi:
10.1021/acs.bioconjchem.6b00418. [PMID: 27661393] - Robert P Sparks, Jermaine L Jenkins, Gregory E Miner, Yan Wang, Wayne C Guida, Charles E Sparks, Rutilio A Fratti, Janet D Sparks. Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding.
Biochemical and biophysical research communications.
2016 Oct; 479(3):551-556. doi:
10.1016/j.bbrc.2016.09.108. [PMID: 27666481] - Jayanta K Chakrabarty, Aishwarya G Naik, Michael B Fessler, Gerhard R Munske, Saiful M Chowdhury. Differential Tandem Mass Spectrometry-Based Cross-Linker: A New Approach for High Confidence in Identifying Protein Cross-Linking.
Analytical chemistry.
2016 10; 88(20):10215-10222. doi:
10.1021/acs.analchem.6b02886. [PMID: 27649375] - Katarzyna Kaczyńska, Ewelina Kogut, Dominika Zając, Monika Jampolska, Kryspin Andrzejewski, Dorota Sulejczak, Andrzej W Lipkowski, Patrycja Kleczkowska. Neurotensin-based hybrid peptide's anti-inflammatory activity in murine model of a contact sensitivity response.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Oct; 93(?):84-9. doi:
10.1016/j.ejps.2016.08.012. [PMID: 27509866] - Cecilia Ratner, Louise J Skov, Zindy Raida, Thomas Bächler, Kathrin Bellmann-Sickert, Christelle Le Foll, Bjørn Sivertsen, Louise S Dalbøge, Bolette Hartmann, Annette G Beck-Sickinger, Andreas N Madsen, Jacob Jelsing, Jens J Holst, Thomas A Lutz, Zane B Andrews, Birgitte Holst. Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.
Endocrinology.
2016 09; 157(9):3482-92. doi:
10.1210/en.2016-1329. [PMID: 27580810] - Karin Sterl, Songyan Wang, Lauren Oestricker, Michael J Wallendorf, Bruce W Patterson, Dominic N Reeds, Burton M Wice. Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgery.
Peptides.
2016 08; 82(?):76-84. doi:
10.1016/j.peptides.2016.06.001. [PMID: 27288245] - T C Theoharides, I Tsilioni, A B Patel, R Doyle. Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders.
Translational psychiatry.
2016 06; 6(6):e844. doi:
10.1038/tp.2016.77. [PMID: 27351598] - Jing Li, Jun Song, Yekaterina Y Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E Starr, Ji Tae Kim, Jennifer W Harris, Frederique B Yiannikouris, Wendy S Katz, Peter M Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M Higashi, Tianyan Gao, Andrew J Morris, Lisa A Cassis, Teresa W-M Fan, Heidi L Weiss, Paul R Dobner, Olle Melander, Jianhang Jia, B Mark Evers. An obligatory role for neurotensin in high-fat-diet-induced obesity.
Nature.
2016 05; 533(7603):411-5. doi:
10.1038/nature17662. [PMID: 27193687] - Vadivel Parthsarathy, Nigel Irwin, Annie Hasib, Christine M Martin, Stephen McClean, Vikas K Bhat, Ming T Ng, Peter R Flatt, Victor A Gault. A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties.
Biochimica et biophysica acta.
2016 Apr; 1860(4):757-64. doi:
10.1016/j.bbagen.2016.01.015. [PMID: 26802310] - Ivy Ka Man Law, Dane Jensen, Nigel W Bunnett, Charalabos Pothoulakis. Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin.
Scientific reports.
2016 Feb; 6(?):22195. doi:
10.1038/srep22195. [PMID: 26902265] - Yun Yang, Pai-di Xu, Yu Xin, Zhao-xia Kang, Hong-xing Zhang, Li Zhou. [Involvement of Neurotensin-mediated Brain-gut Axis in Electroacupuncture Intervention Induced Improvement of Functional Dyspepsia in Rats].
Zhen ci yan jiu = Acupuncture research.
2016 Feb; 41(1):35-9, 50. doi:
NULL. [PMID: 27141618] - Sara Chowdhury, Songyan Wang, Judit Dunai, Rachel Kilpatrick, Lauren Z Oestricker, Michael J Wallendorf, Bruce W Patterson, Dominic N Reeds, Burton M Wice. Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus.
PloS one.
2016; 11(6):e0156852. doi:
10.1371/journal.pone.0156852. [PMID: 27304975] - Christine M Martin, Vadivel Parthsarathy, Annie Hasib, Ming T Ng, Stephen McClean, Peter R Flatt, Victor A Gault, Nigel Irwin. Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin.
PloS one.
2016; 11(3):e0152818. doi:
10.1371/journal.pone.0152818. [PMID: 27032106] - Jing Li, Jun Song, Heidi L Weiss, Todd Weiss, Courtney M Townsend, B Mark Evers. Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells.
Molecular endocrinology (Baltimore, Md.).
2016 Jan; 30(1):26-36. doi:
10.1210/me.2015-1094. [PMID: 26528831] - I Tsilioni, A Taliou, K Francis, T C Theoharides. Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6.
Translational psychiatry.
2015 Sep; 5(?):e647. doi:
10.1038/tp.2015.142. [PMID: 26418275] - Mette J Mandøe, Katrine B Hansen, Bolette Hartmann, Jens F Rehfeld, Jens J Holst, Harald S Hansen. The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans.
The American journal of clinical nutrition.
2015 Sep; 102(3):548-55. doi:
10.3945/ajcn.115.106799. [PMID: 26178726] - Merlin G Butler, Tommy A Nelson, Daniel J Driscoll, Ann M Manzardo. High plasma neurotensin levels in children with Prader-Willi syndrome.
American journal of medical genetics. Part A.
2015 Aug; 167A(8):1773-8. doi:
10.1002/ajmg.a.37103. [PMID: 25847417] - Hafeza Akter, Min Park, Oh-Seung Kwon, Eun Joo Song, Won-Sang Park, Min-Jung Kang. Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2015 Aug; 36(8):6053-62. doi:
10.1007/s13277-015-3282-9. [PMID: 25724188] - Huan-rong Hu, Zhen Dong, Liang Yi, Xiao-yan He, Yan-li Zhang, Ya-ling Liu, Hong-juan Cui. Function and mechanism of neurotensin (NTS) and its receptor 1 (NTSR1) in occurrence and development of tumors.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2015 Jul; 40(13):2524-36. doi:
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The journal of physical chemistry. B.
2015 Apr; 119(15):4917-28. doi:
10.1021/jp510735f. [PMID: 25807267]