Ulixertinib (BioDeep_00000771873)
代谢物信息卡片
化学式: C21H22Cl2N4O2 (432.11197319999997)
中文名称: 优立替尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)Cl
InChI: InChI=1S/C21H22Cl2N4O2/c1-12(2)26-20-8-16(17(23)10-25-20)14-7-18(24-9-14)21(29)27-19(11-28)13-4-3-5-15(22)6-13/h3-10,12,19,24,28H,11H2,1-2H3,(H,25,26)(H,27,29)/t19-/m1/s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line[1][2].
同义名列表
4 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D11038
- PubChem: 11719003
- DrugBank: DB13930
- ChEMBL: CHEMBL3590106
- CAS: 869886-67-9
- medchemexpress: HY-15816
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yahui Zhu, Li Gu, Xi Lin, Xinyi Zhou, Bingjun Lu, Cheng Liu, Caoqi Lei, Feng Zhou, Qiu Zhao, Edward V Prochownik, Youjun Li. USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1.
Cell reports.
2021 12; 37(13):110174. doi:
10.1016/j.celrep.2021.110174. [PMID: 34965422] - Bin Yu, Jie Duan, Hong Ning, Yi-Lan Huang, Bao-Dong Ling, Fei Lin. Pharmacokinetics and metabolism of ulixertinib in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Journal of separation science.
2020 Apr; 43(7):1275-1283. doi:
10.1002/jssc.201901139. [PMID: 31970927] - Ponnayyan Sulochana Suresh, Ravi Kumar Jairam, Devaraj V Chandrasekhar, Anera Balakrishna Vinod, Rakesh A Hiremath, Anusha Raj, Mohd Zainuddin, Ravi Kanth Bhamidipati, Ramesh Mullangi. Prediction of Human Pharmacokinetics of Ulixertinib, a Novel ERK1/2 Inhibitor from Mice, Rats, and Dogs Pharmacokinetics.
European journal of drug metabolism and pharmacokinetics.
2018 Aug; 43(4):453-460. doi:
10.1007/s13318-018-0465-y. [PMID: 29470718] - Rajinish Kumar, P S Suresh, G Rudresh, Mohd Zainuddin, Purushottam Dewang, Ragahava Reddy Kethiri, Sriram Rajagopal, Ramesh Mullangi. Determination of ulixertinib in mice plasma by LC-MS/MS and its application to a pharmacokinetic study in mice.
Journal of pharmaceutical and biomedical analysis.
2016 Jun; 125(?):140-4. doi:
10.1016/j.jpba.2016.03.036. [PMID: 27017572] - H Ebihara. [Extraction of urinary gonadotropin and determination of luteinizing hormone].
Nihon Sanka Fujinka Gakkai zasshi.
1970 Mar; 22(3):221-9. doi:
NULL. [PMID: 5463350]