Homobrassinolide (BioDeep_00000771372)
Main id: BioDeep_00000027259
PANOMIX_OTCML-2023
代谢物信息卡片
22S,23S-Homobrassinolide
化学式: C29H50O6 (494.36072)
中文名称: 28-高油菜素内酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C(C)C)C(C(C(C)C1CCC2C1(CCC3C2COC(=O)C4C3(CC(C(C4)O)O)C)C)O)O
InChI: InChI=1S/C29H50O6/c1-7-17(15(2)3)26(33)25(32)16(4)19-8-9-20-18-14-35-27(34)22-12-23(30)24(31)13-29(22,6)21(18)10-11-28(19,20)5/h15-26,30-33H,7-14H2,1-6H3
描述信息
28-Homobrassinolide is a phytosteroid. 28-Homobrassinolide can be used for the research of cholesterol and glucose homeostasis[1].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:180809
- PubChem: 11038340
- PubChem: 4285635
- ChEMBL: CHEMBL1801924
- CAS: 82373-95-3
- CAS: 74174-44-0
- medchemexpress: HY-N9435
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3369 - Cryptomeria japonica: 10.3184/030823400103165734
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Muhammad Ashfaq Aslam, Shakil Ahmed, Muhammad Saleem, Rehana Sardar, Anis Ali Shah, Manzer H Siddiqui, Zunera Shabbir. Mitigation of chromium-induced phytotoxicity in 28-homobrassinolide treated Trigonella corniculata L. by modulation of oxidative biomarkers and antioxidant system.
Ecotoxicology and environmental safety.
2023 Aug; 263(?):115354. doi:
10.1016/j.ecoenv.2023.115354. [PMID: 37595348] - Junpeng Huang, Biaodi Shen, Xiao Rao, Xuehua Cao, Jianjun Zhang, Linchuan Liu, Jianming Li, Juan Mao. Assessment of Biological Activity of 28-Homobrassinolide via a Multi-Level Comparative Analysis.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119377. [PMID: 37298328] - Victor Mukherjee, Premalatha Ramakrishna, Sushmita Bora, Srikumar Kotteazeth. Phytosteroid 28-homobrassinolide targets cholesterol and glucose homeostasis implicating ABCA1 and SREBP role in regulation.
Steroids.
2021 01; 165(?):108756. doi:
10.1016/j.steroids.2020.108756. [PMID: 33171131] - Husna Siddiqui, Khan Bilal Mukhtar Ahmed, Shamsul Hayat. Comparative effect of 28-homobrassinolide and 24-epibrassinolide on the performance of different components influencing the photosynthetic machinery in Brassica juncea L.
Plant physiology and biochemistry : PPB.
2018 Aug; 129(?):198-212. doi:
10.1016/j.plaphy.2018.05.027. [PMID: 29894860] - Harpreet Kaur, Geetika Sirhindi, Renu Bhardwaj, M N Alyemeni, Kadambot H M Siddique, Parvaiz Ahmad. 28-homobrassinolide regulates antioxidant enzyme activities and gene expression in response to salt- and temperature-induced oxidative stress in Brassica juncea.
Scientific reports.
2018 06; 8(1):8735. doi:
10.1038/s41598-018-27032-w. [PMID: 29880861] - Victor Mukherjee, D Vijayalaksmi, Jagadeesh Gulipalli, R Premalatha, Shamim A Sufi, Athithan Velan, Kotteazeth Srikumar. A plant oxysterol, 28-homobrassinolide binds HMGCoA reductase catalytic cleft: stereoselective avidity affects enzyme function.
Molecular biology reports.
2016 Oct; 43(10):1049-58. doi:
10.1007/s11033-016-4052-5. [PMID: 27585573] - Tanveer Alam Khan, Qazi Fariduddin, Mohammad Yusuf. Lycopersicon esculentum under low temperature stress: an approach toward enhanced antioxidants and yield.
Environmental science and pollution research international.
2015 Sep; 22(18):14178-88. doi:
10.1007/s11356-015-4658-5. [PMID: 25966887] - R Premalatha, K Srikumar, D Vijayalaksmi, G N Kumar, P P Mathur. 28-Homobrassinolide: a novel oxysterol transactivating LXR gene expression.
Molecular biology reports.
2014 Nov; 41(11):7447-61. doi:
10.1007/s11033-014-3632-5. [PMID: 25091941] - Shamsul Hayat, Gulshan Khalique, Arif Shafi Wani, Mohammed Nasser Alyemeni, Aqil Ahmad. Protection of growth in response to 28-homobrassinolide under the stress of cadmium and salinity in wheat.
International journal of biological macromolecules.
2014 Mar; 64(?):130-6. doi:
10.1016/j.ijbiomac.2013.11.021. [PMID: 24296402] - R Premalatha, Rajamanickam Jubendradass, S Judith Amala Rani, K Srikumar, Premendu Prakash Mathur. A phytooxysterol, 28-homobrassinolide modulates rat testicular steroidogenesis in normal and diabetic rats.
Reproductive sciences (Thousand Oaks, Calif.).
2013 May; 20(5):589-96. doi:
10.1177/1933719112459241. [PMID: 23012313] - Yu-Ping Jiang, Fei Cheng, Yan-Hong Zhou, Xiao-Jian Xia, Wei-Hua Mao, Kai Shi, Zhixiang Chen, Jing-Quan Yu. Cellular glutathione redox homeostasis plays an important role in the brassinosteroid-induced increase in CO2 assimilation in Cucumis sativus.
The New phytologist.
2012 Jun; 194(4):932-943. doi:
10.1111/j.1469-8137.2012.04111.x. [PMID: 22432590] - Shamsul Hayat, Pragya Maheshwari, Arif Shafi Wani, Mohd Irfan, Mohammed Nasser Alyemeni, Aqil Ahmad. Comparative effect of 28 homobrassinolide and salicylic acid in the amelioration of NaCl stress in Brassica juncea L.
Plant physiology and biochemistry : PPB.
2012 Apr; 53(?):61-8. doi:
10.1016/j.plaphy.2012.01.011. [PMID: 22322250] - Mohammad Yusuf, Qazi Fariduddin, Aqil Ahmad. 28-Homobrassinolide mitigates boron induced toxicity through enhanced antioxidant system in Vigna radiata plants.
Chemosphere.
2011 Nov; 85(10):1574-84. doi:
10.1016/j.chemosphere.2011.08.004. [PMID: 21899875] - Debora Esposito, Slavko Komarnytsky, Sue Shapses, Ilya Raskin. Anabolic effect of plant brassinosteroid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2011 Oct; 25(10):3708-19. doi:
10.1096/fj.11-181271. [PMID: 21746867] - Syed Aiman Hasan, Shamsul Hayat, Aqil Ahmad. Brassinosteroids protect photosynthetic machinery against the cadmium induced oxidative stress in two tomato cultivars.
Chemosphere.
2011 Sep; 84(10):1446-51. doi:
10.1016/j.chemosphere.2011.04.047. [PMID: 21565386] - Debora Esposito, Thirumurugan Rathinasabapathy, Alexander Poulev, Slavko Komarnytsky, Ilya Raskin. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells.
Journal of medicinal chemistry.
2011 Jun; 54(12):4057-66. doi:
10.1021/jm200028h. [PMID: 21491949] - Indu Sharma, Pratap Kumar Pati, Renu Bhardwaj. Effect of 28-homobrassinolide on antioxidant defence system in Raphanus sativus L. under chromium toxicity.
Ecotoxicology (London, England).
2011 Jun; 20(4):862-74. doi:
10.1007/s10646-011-0650-0. [PMID: 21448625] - Mohammad Yusuf, Qazi Fariduddin, Shamsul Hayat, Syed Aiman Hasan, Aqil Ahmad. Protective response of 28-homobrassinolide in cultivars of Triticum aestivum with different levels of nickel.
Archives of environmental contamination and toxicology.
2011 Jan; 60(1):68-76. doi:
10.1007/s00244-010-9535-0. [PMID: 20464550] - P Muthuraman, K Srikumar. Induction of hexokinase I expression in normal and diabetic rats by a brassinosteroid isoform.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Sep; 41(1):1-9. doi:
10.1016/j.ejps.2010.05.008. [PMID: 20570616] - Indu Sharma, Pratap Kumar Pati, Renu Bhardwaj. Regulation of growth and antioxidant enzyme activities by 28-homobrassinolide in seedlings of Raphanus sativus L. under cadmium stress.
Indian journal of biochemistry & biophysics.
2010 Jun; 47(3):172-7. doi:
". [PMID: 20653289] - Shamsul Hayat, S Aiman Hasan, Qaiser Hayat, Aqil Ahmad. Brassinosteroids protect Lycopersicon esculentum from cadmium toxicity applied as shotgun approach.
Protoplasma.
2010 Mar; 239(1-4):3-14. doi:
10.1007/s00709-009-0075-2. [PMID: 19842014] - P Muthuraman, S Ravikumar, K Srikumar. Enhanced expression of hexokinase I mRNA in male rat tissues by homobrassinolide.
Preparative biochemistry & biotechnology.
2010; 40(4):256-62. doi:
10.1080/10826068.2010.488980. [PMID: 21108129] - P Muthuraman, K Srikumar. A comparative study on the effect of homobrassinolide and gibberellic acid on lipid peroxidation and antioxidant status in normal and diabetic rats.
Journal of enzyme inhibition and medicinal chemistry.
2009 Oct; 24(5):1122-7. doi:
10.1080/14756360802667563. [PMID: 19619070] - S A Hasan, S Hayat, B Ali, A Ahmad. 28-homobrassinolide protects chickpea (Cicer arietinum) from cadmium toxicity by stimulating antioxidants.
Environmental pollution (Barking, Essex : 1987).
2008 Jan; 151(1):60-6. doi:
10.1016/j.envpol.2007.03.006. [PMID: 17481788] - Margarita Romero-Avila, Guadalupe de Dios-Bravo, Jóse M Mendez-Stivalet, Rogelio Rodríguez-Sotres, Martin A Iglesias-Arteaga. Synthesis and biological activity of furostanic analogues of brassinosteroids bearing the 5alpha-hydroxy-6-oxo moiety.
Steroids.
2007 Dec; 72(14):955-9. doi:
10.1016/j.steroids.2007.08.007. [PMID: 17905389] - O L Kandelinskaia, A F Topunov, E R Grishchenko. [Biochemical aspects of growth-stimulating effects of steroid phytohormones on lupine plants].
Prikladnaia biokhimiia i mikrobiologiia.
2007 May; 43(3):358-65. doi:
". [PMID: 17619585] - M Catterou, F Dubois, H Schaller, L Aubanelle, B Vilcot, B S Sangwan-Norreel, R S Sangwan. Brassinosteroids, microtubules and cell elongation in Arabidopsis thaliana. I. Molecular, cellular and physiological characterization of the Arabidopsis bull mutant, defective in the delta 7-sterol-C5-desaturation step leading to brassinosteroid biosynthesis.
Planta.
2001 Apr; 212(5-6):659-72. doi:
10.1007/s004250000466. [PMID: 11346939] - M Catterou, F Dubois, H Schaller, L Aubanelle, B Vilcot, B S Sangwan-Norreel, R S Sangwan. Brassinosteroids, microtubules and cell elongation in Arabidopsis thaliana. II. Effects of brassinosteroids on microtubules and cell elongation in the bul1 mutant.
Planta.
2001 Apr; 212(5-6):673-83. doi:
10.1007/s004250000467. [PMID: 11346940] - T C McMorris. Recent developments in the field of plant steroid hormones.
Lipids.
1997 Dec; 32(12):1303-8. doi:
10.1007/s11745-006-0168-z. [PMID: 9438241] - J L Zhu, W S Zhou. Studies on steroidal plant-growth regulators (XVII)--a new synthesis of homobrassinolide and (22S, 23S)-22, 23-epi-homobrassinolide.
Science in China. Series B, Chemistry, life sciences & earth sciences.
1991 Jun; 34(6):706-11. doi:
". [PMID: 1888437]