Sangivamycin (BioDeep_00000731646)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C12H15N5O5 (309.10731400000003)
中文名称: 桑霉素
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 92.31%
分子结构信息
SMILES: C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)C(=O)N
InChI: InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)/t5-,7-,8-,12-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000970 - Antineoplastic Agents
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].
同义名列表
3 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:85997
- PubChem: 14978
- ChEMBL: CHEMBL101892
- CAS: 18417-89-5
- medchemexpress: HY-118384
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ryan P Bennett, Elena N Postnikova, Brett P Eaton, Yingyun Cai, Shuiqing Yu, Charles O Smith, Janie Liang, Huanying Zhou, Gregory A Kocher, Michael J Murphy, Harold C Smith, Jens H Kuhn. Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties.
JCI insight.
2022 01; 7(1):. doi:
10.1172/jci.insight.153165. [PMID: 34807849] - Ryan P Bennett, Courtney L Finch, Elena N Postnikova, Ryan A Stewart, Yingyun Cai, Shuiqing Yu, Janie Liang, Julie Dyall, Jason D Salter, Harold C Smith, Jens H Kuhn. A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures.
Viruses.
2020 Dec; 13(1):. doi:
10.3390/v13010052. [PMID: 33396288] - Luke H Stockwin, Sherry X Yu, Howard Stotler, Melinda G Hollingshead, Dianne L Newton. ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.
BMC cancer.
2009 Feb; 9(?):63. doi:
10.1186/1471-2407-9-63. [PMID: 19232100] - N M Greene, D S Williams, A C Newton. Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C.
The Journal of biological chemistry.
1995 Mar; 270(12):6710-7. doi:
10.1074/jbc.270.12.6710. [PMID: 7896814] - M S Simonson, J A Wolfe, M Konieczkowski, J R Sedor, M J Dunn. Regulation of prostaglandin endoperoxide synthase gene expression in cultured rat mesangial cells: induction by serum via a protein kinase-C-dependent mechanism.
Molecular endocrinology (Baltimore, Md.).
1991 Mar; 5(3):441-51. doi:
10.1210/mend-5-3-441. [PMID: 1653896] - C R Loomis, R M Bell. Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.
The Journal of biological chemistry.
1988 Feb; 263(4):1682-92. doi:
". [PMID: 3338987] - D E Bergstrom, A J Brattesani, M K Ogawa, P A Reddy, M J Schweickert, J Balzarini, E De Clercq. Antiviral activity of C-5 substituted tubercidin analogues.
Journal of medicinal chemistry.
1984 Mar; 27(3):285-92. doi:
10.1021/jm00369a010. [PMID: 6699874] - H Christensen, S Felby. Dibenzepine and its metabolites in blood, muscle, liver, vitreous body and urine from fatal poisoning.
Acta pharmacologica et toxicologica.
1975 Nov; 37(5):393-401. doi:
10.1111/j.1600-0773.1975.tb00858.x. [PMID: 888]
