formycin A (BioDeep_00000731636)

   

Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


formycin A

化学式: C10H13N5O4 (267.09674980000005)
中文名称: 间型霉素A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](c2c3c(c(N)ncn3)[nH]n2)O1)O)O)O
InChI: InChI=1S/C10H13N5O4/c11-10-6-4(12-2-13-10)5(14-15-6)9-8(18)7(17)3(1-16)19-9/h2-3,7-9,16-18H,1H2,(H,14,15)(H2,11,12,13)/t3-,7-,8-,9+/m1/s1

描述信息

D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D005573 - Formycins

同义名列表

1 个代谢物同义名

formycin A



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yoshikazu Miura, Yuichi Hori, Shinzo Kimura, Hiroyuki Hachiya, Yuichirou Sakurai, Kenichi Inoue, Tokihiko Sawada, Keiichi Kubota. Triphenyltin impairs insulin secretion by decreasing glucose-induced NADP(H) and ATP production in hamster pancreatic β-cells. Toxicology. 2012 Sep; 299(2-3):165-71. doi: 10.1016/j.tox.2012.05.021. [PMID: 22664483]
  • Karen K W Siu, Jeffrey E Lee, Janice R Sufrin, Barbara A Moffatt, Martin McMillan, Kenneth A Cornell, Chelsea Isom, P Lynne Howell. Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases. Journal of molecular biology. 2008 Apr; 378(1):112-28. doi: 10.1016/j.jmb.2008.01.088. [PMID: 18342331]
  • Jeffrey E Lee, Ethan C Settembre, Kenneth A Cornell, Michael K Riscoe, Janice R Sufrin, Steven E Ealick, P Lynne Howell. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 2004 May; 43(18):5159-69. doi: 10.1021/bi035492h. [PMID: 15122881]
  • Philippe Lawton, Carine Hejl, Roselyne Mancassola, Muriel Naciri, Anne Françoise Petavy. Effects of purine nucleosides on the in vitro growth of Cryptosporidium parvum. FEMS microbiology letters. 2003 Sep; 226(1):39-43. doi: 10.1016/s0378-1097(03)00555-x. [PMID: 13129605]
  • B Paw, G Misztal, K Dzwonnik. Thin-layer chromatographic analysis of fludarabine and formycin A in human plasma. Acta poloniae pharmaceutica. 2000 Sep; 57(5):341-3. doi: NULL. [PMID: 11126023]
  • G Misztal, B Paw, J S Skierski, E Jagiełło-Wójtowicz. High-performance liquid chromatographic assay of formycin A in plasma after solid-phase extraction. Journal of chromatography. B, Biomedical sciences and applications. 1999 Aug; 731(2):383-7. doi: 10.1016/s0378-4347(99)00210-8. [PMID: 10510793]
  • X Y Chen, T M Link, V L Schramm. Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors. Biochemistry. 1998 Aug; 37(33):11605-13. doi: 10.1021/bi980990p. [PMID: 9708998]
  • A Rosowsky, V C Solan, L J Gudas. Improved synthesis of 2'-deoxyformycin A and studies of its in vitro activity against mouse lymphoma of T-cell origin. Journal of medicinal chemistry. 1985 Aug; 28(8):1096-9. doi: 10.1021/jm00146a020. [PMID: 3874961]
  • J D Berman, C M Keenan, S R Lamb, W L Hanson, V B Waits. Leishmania donovani: oral efficacy and toxicity of formycin B in the infected hamster. Experimental parasitology. 1983 Oct; 56(2):215-21. doi: 10.1016/0014-4894(83)90065-6. [PMID: 6617804]