selenocysteine (BioDeep_00000729635)

   


代谢物信息卡片


3-Selenoalanine

化学式: C3H6NO2Se (167.9563726)
中文名称: 硒氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(=O)O)N)[Se]
InChI: InChI=1S/C3H6NO2Se/c4-2(1-7)3(5)6/h2H,1,4H2,(H,5,6)

描述信息

同义名列表

2 个代谢物同义名

3-Selenoalanine; selenocysteine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

44 个相关的代谢反应过程信息。

Reactome(44)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yongli Xie, Xiaoshan Ke, Zhencong Ye, Xuexia Li, Zetao Chen, Jiantao Liu, Ziyi Wu, Qiong Liu, Xiubo Du. Se-methylselenocysteine ameliorates mitochondrial function by targeting both mitophagy and autophagy in the mouse model of Alzheimer's disease. Food & function. 2024 Apr; 15(8):4310-4322. doi: 10.1039/d4fo00520a. [PMID: 38529619]
  • Yu Cao, Bin Wu, Ying Xu, Mingchen Wang, Xinyu Wu, Xiaochen Liang, Jin Lin, Zhihai Li, Hua Lin, Cheng Luo, Shijie Chen. Discovery of GPX4 inhibitors through FP-based high-throughput screening. European journal of medicinal chemistry. 2024 Feb; 265(?):116044. doi: 10.1016/j.ejmech.2023.116044. [PMID: 38145603]
  • Yuxiang Fei, Tao Li, Ruoyu Wu, Xuejiao Xu, Sheng Hu, Ya Yang, Chenchen Jin, Wenlian Tang, Xu Zhang, Qianming Du, Chao Liu. Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner. Psychopharmacology. 2024 Feb; 241(2):379-399. doi: 10.1007/s00213-023-06495-4. [PMID: 38019326]
  • Robert J Hondal. Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine. Current opinion in chemical biology. 2023 May; 75(?):102328. doi: 10.1016/j.cbpa.2023.102328. [PMID: 37236134]
  • Chenyu Sun, Qiao Guo, Muhammad Zeeshan, Paul Milham, Shengfeng Qin, Junqing Ma, Yisen Yang, Hangxian Lai, Jinghua Huang. Dual RNA and 16S ribosomal DNA sequencing reveal arbuscular mycorrhizal fungi-mediated mitigation of selenate stress in Zea mays L. and reshaping of soil microbiota. Ecotoxicology and environmental safety. 2022 Dec; 247(?):114217. doi: 10.1016/j.ecoenv.2022.114217. [PMID: 36306613]
  • Lance G A Nunes, Matthew W Pitts, Peter R Hoffmann. Selenoprotein I (selenoi) as a critical enzyme in the central nervous system. Archives of biochemistry and biophysics. 2022 10; 729(?):109376. doi: 10.1016/j.abb.2022.109376. [PMID: 36007576]
  • Yihong Zheng, Ziyan Wang, Dengfeng Xue, Ming Tao, Fajun Jiang, Bin Jia, Youhao Li, Guanqin Huang, Zhangli Hu. Characterization of a new selenoprotein methionine sulfoxide reductase from Haematococcus pluvialis and its antioxidant activity in response to high light intensity, hydrogen peroxide, glyphosate, and cadmium exposure. Ecotoxicology and environmental safety. 2022 Sep; 242(?):113903. doi: 10.1016/j.ecoenv.2022.113903. [PMID: 35870349]
  • Diane E Handy, Joseph Loscalzo. The role of glutathione peroxidase-1 in health and disease. Free radical biology & medicine. 2022 08; 188(?):146-161. doi: 10.1016/j.freeradbiomed.2022.06.004. [PMID: 35691509]
  • Jinping Cao, Xin Liu, Yuanzhi Cheng, Yizhen Wang, Fengqin Wang. Selenium-enriched Polysaccharide: an Effective and Safe Selenium Source of C57 Mice to Improve Growth Performance, Regulate Selenium Deposition, and Promote Antioxidant Capacity. Biological trace element research. 2022 May; 200(5):2247-2258. doi: 10.1007/s12011-021-02832-w. [PMID: 34476677]
  • Valentina N Mal'tseva, Michael V Goltyaev, Egor A Turovsky, Elena G Varlamova. Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042360. [PMID: 35216476]
  • Lutz Schomburg. Selenium Deficiency in COVID-19-A Possible Long-Lasting Toxic Relationship. Nutrients. 2022 Jan; 14(2):. doi: 10.3390/nu14020283. [PMID: 35057464]
  • Jin Wang, Jiayu Zhang, Yuting Zhong, Liqiang Qin, Jianxiang Li. Sex-dimorphic distribution and anti-oxidative effects of selenomethionine and Se-methylselenocysteine supplementation. Journal of food science. 2021 Dec; 86(12):5424-5438. doi: 10.1111/1750-3841.15970. [PMID: 34796490]
  • Liping Luo, Jinping Zhang, Kangyi Zhang, Qingyu Wen, Kang Ming, Hua Xiong, Fangjian Ning. Peanut selenium distribution, concentration, speciation, and effects on proteins after exogenous selenium biofortification. Food chemistry. 2021 Aug; 354(?):129515. doi: 10.1016/j.foodchem.2021.129515. [PMID: 33756318]
  • Jordan Sonet, Anne-Laure Bulteau, Zahia Touat-Hamici, Maurine Mosca, Katarzyna Bierla, Sandra Mounicou, Ryszard Lobinski, Laurent Chavatte. Selenoproteome Expression Studied by Non-Radioactive Isotopic Selenium-Labeling in Human Cell Lines. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147308. [PMID: 34298926]
  • Jia Ma, Jing Huang, Jinli Sun, Yanfeng Zhou, Xiaoyuan Ji, Daoxia Guo, Chang Liu, Jiyu Li, Jiye Zhang, Haiyun Song. L-Se-methylselenocysteine sensitizes lung carcinoma to chemotherapy. Cell proliferation. 2021 May; 54(5):e13038. doi: 10.1111/cpr.13038. [PMID: 33793020]
  • Akbar Hossain, Milan Skalicky, Marian Brestic, Sagar Maitra, Sukamal Sarkar, Zahoor Ahmad, Hindu Vemuri, Sourav Garai, Mousumi Mondal, Rajan Bhatt, Pardeep Kumar, Pradipta Banerjee, Saikat Saha, Tofazzal Islam, Alison M Laing. Selenium Biofortification: Roles, Mechanisms, Responses and Prospects. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26040881. [PMID: 33562416]
  • George D Vavougios, Konstantinos T Ntoskas, Triantafyllos K Doskas. Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients. Medical hypotheses. 2021 Feb; 147(?):110475. doi: 10.1016/j.mehy.2020.110475. [PMID: 33421689]
  • Tapan Kumar Mohanta, Awdhesh Kumar Mishra, Abeer Hashem, Elsayed Fathi Abd Allah, Abdul Latif Khan, Ahmed Al-Harrasi. Construction of anti-codon table of the plant kingdom and evolution of tRNA selenocysteine (tRNASec). BMC genomics. 2020 Nov; 21(1):804. doi: 10.1186/s12864-020-07216-3. [PMID: 33213362]
  • Romina López, Roberto D'Amato, Massimo Trabalza-Marinucci, Luca Regni, Primo Proetti, Ariel Maratta, Soledad Cerutti, Pablo Pacheco. Green and simple extraction of free seleno-amino acids from powdered and lyophilized milk samples with natural deep eutectic solvents. Food chemistry. 2020 Oct; 326(?):126965. doi: 10.1016/j.foodchem.2020.126965. [PMID: 32413755]
  • Xueyun Mao, Chen Hua, Liang Yang, Yuhui Zhang, Zhengxi Sun, Lei Li, Tao Li. The Effects of Selenium on Wheat Fusarium Head Blight and DON Accumulation Were Selenium Compound-Dependent. Toxins. 2020 09; 12(9):. doi: 10.3390/toxins12090573. [PMID: 32899906]
  • A Arias-Borrego, B Callejón-Leblic, G Rodríguez-Moro, I Velasco, J L Gómez-Ariza, T García-Barrera. A novel HPLC column switching method coupled to ICP-MS/QTOF for the first determination of selenoprotein P (SELENOP) in human breast milk. Food chemistry. 2020 Aug; 321(?):126692. doi: 10.1016/j.foodchem.2020.126692. [PMID: 32251923]
  • John K Eaton, Laura Furst, Richard A Ruberto, Dieter Moosmayer, André Hilpmann, Matthew J Ryan, Katja Zimmermann, Luke L Cai, Michael Niehues, Volker Badock, Anneke Kramm, Sixun Chen, Roman C Hillig, Paul A Clemons, Stefan Gradl, Claire Montagnon, Kiel E Lazarski, Sven Christian, Besnik Bajrami, Roland Neuhaus, Ashley L Eheim, Vasanthi S Viswanathan, Stuart L Schreiber. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nature chemical biology. 2020 05; 16(5):497-506. doi: 10.1038/s41589-020-0501-5. [PMID: 32231343]
  • Maggie-Anne Harvey, Peter D Erskine, Hugh H Harris, Gillian K Brown, Elizabeth A H Pilon-Smits, Lachlan W Casey, Guillaume Echevarria, Antony van der Ent. Distribution and chemical form of selenium in Neptunia amplexicaulis from Central Queensland, Australia. Metallomics : integrated biometal science. 2020 04; 12(4):514-527. doi: 10.1039/c9mt00244h. [PMID: 32055807]
  • Daniel Gabriel Pons, Carmen Moran, Marina Alorda-Clara, Jordi Oliver, Pilar Roca, Jorge Sastre-Serra. Micronutrients Selenomethionine and Selenocysteine Modulate the Redox Status of MCF-7 Breast Cancer Cells. Nutrients. 2020 Mar; 12(3):. doi: 10.3390/nu12030865. [PMID: 32213883]
  • Carmine Rocca, Teresa Pasqua, Loubna Boukhzar, Youssef Anouar, Tommaso Angelone. Progress in the emerging role of selenoproteins in cardiovascular disease: focus on endoplasmic reticulum-resident selenoproteins. Cellular and molecular life sciences : CMLS. 2019 Oct; 76(20):3969-3985. doi: 10.1007/s00018-019-03195-1. [PMID: 31218451]
  • Kyle S Hoffman, Oscar Vargas-Rodriguez, Daniel W Bak, Takahito Mukai, Laura K Woodward, Eranthie Weerapana, Dieter Söll, Noah M Reynolds. A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation. The Journal of biological chemistry. 2019 08; 294(34):12855-12865. doi: 10.1074/jbc.ra119.008219. [PMID: 31296657]
  • Tapan Kumar Mohanta, Abdullatif Khan, Abeer Hashem, Elsayed Fathi Abd Allah, Ahmed Al-Harrasi. The molecular mass and isoelectric point of plant proteomes. BMC genomics. 2019 Aug; 20(1):631. doi: 10.1186/s12864-019-5983-8. [PMID: 31382875]
  • Ning Sun, Sakina Petiwala, Charles Lu, Jessica E Hutti, Min Hu, Mufeng Hu, Marc H Domanus, Diya Mitra, Sadiya N Addo, Christopher P Miller, Namjin Chung. VHL Synthetic Lethality Signatures Uncovered by Genotype-Specific CRISPR-Cas9 Screens. The CRISPR journal. 2019 08; 2(?):230-245. doi: 10.1089/crispr.2019.0018. [PMID: 31436504]
  • A Castañeda-Ovando, J A Segovia-Cruz, J F Flores-Aguilar, G M Rodríguez-Serrano, V Salazar-Pereda, J Ramírez-Godínez, E Contreras-López, J Jaimez-Ordaz, L G González-Olivares. Serine-enriched minimal medium enhances conversion of selenium into selenocysteine by Streptococcus thermophilus. Journal of dairy science. 2019 Aug; 102(8):6781-6789. doi: 10.3168/jds.2019-16365. [PMID: 31155253]
  • Mengjiao Bi, Hao Zhang, Lin Yuan, Lining Zhao, Rutao Liu. Molecular mechanisms of lead-induced changes of selenium status in mice livers through interacting with selenoprotein P. Ecotoxicology and environmental safety. 2019 Jul; 175(?):282-288. doi: 10.1016/j.ecoenv.2019.03.059. [PMID: 30921565]
  • Hongping Liang, Tong Wei, Yan Xu, Linzhou Li, Sunil Kumar Sahu, Hongli Wang, Haoyuan Li, Xian Fu, Gengyun Zhang, Michael Melkonian, Xin Liu, Sibo Wang, Huan Liu. Phylogenomics Provides New Insights into Gains and Losses of Selenoproteins among Archaeplastida. International journal of molecular sciences. 2019 Jun; 20(12):. doi: 10.3390/ijms20123020. [PMID: 31226841]
  • Stephen O Evans, Gregory M Jacobson, Hugh J B Goodman, Steve Bird, Michael B Jameson. Comparative Safety and Pharmacokinetic Evaluation of Three Oral Selenium Compounds in Cancer Patients. Biological trace element research. 2019 Jun; 189(2):395-404. doi: 10.1007/s12011-018-1501-0. [PMID: 30187284]
  • Isabelle Rohn, Nina Kroepfl, Julia Bornhorst, Doris Kuehnelt, Tanja Schwerdtle. Side-Directed Transfer and Presystemic Metabolism of Selenoneine in a Human Intestinal Barrier Model. Molecular nutrition & food research. 2019 06; 63(12):e1900080. doi: 10.1002/mnfr.201900080. [PMID: 30939220]
  • Youcef M Rustum, Sreenivasulu Chintala, Farukh A Durrani, Arup Bhattacharya. Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy. International journal of molecular sciences. 2018 Oct; 19(11):. doi: 10.3390/ijms19113378. [PMID: 30380599]
  • Kazuaki Takahashi, Noriyuki Suzuki, Yasumitsu Ogra. Effect of administration route and dose on metabolism of nine bioselenocompounds. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2018 Sep; 49(?):113-118. doi: 10.1016/j.jtemb.2018.05.007. [PMID: 29895359]
  • Yong Fang, Yingyue Zhang, Mingyang Wang, Fei Pei, Minhao Xie, Peng Li, Qiuhui Hu. In vitro bioaccessibility and speciation changes of selenium in Pleurotus eryngii during the growing stage. Food & function. 2018 Aug; 9(8):4493-4499. doi: 10.1039/c8fo00566d. [PMID: 30083671]
  • Xiaoling Li, Haobin Zhang, Leung Chan, Chang Liu, Tianfeng Chen. Nutritionally Available Selenocysteine Derivative Antagonizes Cisplatin-Induced Toxicity in Renal Epithelial Cells through Inhibition of Reactive Oxygen Species-Mediated Signaling Pathways. Journal of agricultural and food chemistry. 2018 Jun; 66(23):5860-5870. doi: 10.1021/acs.jafc.8b01876. [PMID: 29779385]
  • Antonín Bednařík, Jan Kuta, Dai Long Vu, Karolína Ranglová, Pavel Hrouzek, Viktor Kanický, Jan Preisler. Thin-layer chromatography combined with diode laser thermal vaporization inductively coupled plasma mass spectrometry for the determination of selenomethionine and selenocysteine in algae and yeast. Journal of chromatography. A. 2018 Jan; 1533(?):199-207. doi: 10.1016/j.chroma.2017.12.017. [PMID: 29248347]
  • Erik Schoenmakers, Krishna Chatterjee. Identification of Genetic Disorders Causing Disruption of Selenoprotein Biosynthesis. Methods in molecular biology (Clifton, N.J.). 2018; 1661(?):325-335. doi: 10.1007/978-1-4939-7258-6_23. [PMID: 28917055]
  • Moritz A N Pohl, Tiehui Wang, Thitiya Pohl, John Sweetman, Samuel A M Martin, Christopher J Secombes. Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection. PloS one. 2018; 13(12):e0209381. doi: 10.1371/journal.pone.0209381. [PMID: 30571741]
  • Sun Hee Yim, Ryuta Tobe, Anton A Turanov, Bradley A Carlson. Radioactive 75Se Labeling and Detection of Selenoproteins. Methods in molecular biology (Clifton, N.J.). 2018; 1661(?):177-192. doi: 10.1007/978-1-4939-7258-6_13. [PMID: 28917045]
  • Véronique Vacchina, Katarzyna Bierla, Joanna Szpunar, Ryszard Lobinski. Quantification of SeMet and SeCys in Biological Fluids and Tissues by Liquid Chromatography Coupled to Inductively Coupled Plasma Mass Spectrometry (HPLC-ICP MS). Methods in molecular biology (Clifton, N.J.). 2018; 1661(?):153-162. doi: 10.1007/978-1-4939-7258-6_11. [PMID: 28917043]
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