Acetyldigitoxin (BioDeep_00000000723)

 

Secondary id: BioDeep_00000614959

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs


代谢物信息卡片


[(2R,3R,4S,6S)-3-hydroxy-6-[(2R,3S,4S,6S)-4-hydroxy-6-[(2R,3S,4S,6R)-4-hydroxy-6-[[(3S,5R,8R,9S,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-2-methyloxan-3-yl]oxy-2-methyloxan-3-yl]oxy-2-methyloxan-4-yl] acetate

化学式: C43H66O14 (806.4452336)
中文名称: 乙酰洋地黄毒甙
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: CC(=O)OC1CC(OC2C(O)CC(OC3C(O)CC(OC4CCC5(C)C(CCC6C5CCC5(C)C(C7=CC(=O)OC7)CCC65O)C4)OC3C)OC2C)OC(C)C1O
InChI: InChI=1S/C43H66O14/c1-21-38(48)33(54-24(4)44)19-37(51-21)57-40-23(3)53-36(18-32(40)46)56-39-22(2)52-35(17-31(39)45)55-27-9-12-41(5)26(16-27)7-8-30-29(41)10-13-42(6)28(11-14-43(30,42)49)25-15-34(47)50-20-25/h15,21-23,26-33,35-40,45-46,48-49H,7-14,16-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29+,30-,31+,32+,33+,35+,36+,37+,38-,39-,40-,41+,42-,43+/m1/s1

描述信息

Acetyldigitoxin is only found in individuals that have used or taken this drug. It is a cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.Acetyldigitoxin binds to a site on the extracellular aspect of the α-subunit of the Na+/K+ ATPase pump in the membranes of heart cells (myocytes). This causes an increase in the level of sodium ions in the myocytes, which then leads to a rise in the level of calcium ions. The proposed mechanism is the following: inhibition of the Na+/K+ pump leads to increased Na+ levels, which in turn slows down the extrusion of Ca2+ via the Na+/Ca2+ exchange pump. Increased amounts of Ca2+ are then stored in the sarcoplasmic reticulum and released by each action potential, which is unchanged by acetyldigitoxin. This is a different mechanism from that of catecholamines. Acetyldigitoxin also increases vagal activity via its central action on the central nervous system, thus decreasing the conduction of electrical impulses through the AV node. This is important for its clinical use in different arrhythmias.
3-O-acetyldigitoxin is a cardenolide glycoside compound consisting of digitoxin having an acetyl substituent at the 3-position on the D-ribo-hexopyranosyl residue at the non-reducing end. It has a role as an anti-arrhythmia drug, a cardiotonic drug and an enzyme inhibitor. It is functionally related to a digitoxin.
Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.
Acetyldigitoxin is a natural product found in Digitalis grandiflora and Digitalis lanata with data available.
Cardioactive derivatives of lanatoside A or of DIGITOXIN. They are used for fast digitalization in congestive heart failure.
See also: Digitoxin (has active moiety) ... View More ...
C - Cardiovascular system > C01 - Cardiac therapy > C01A - Cardiac glycosides > C01AA - Digitalis glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D004071 - Digitalis Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D000112 - Acetyldigitoxins
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D004791 - Enzyme Inhibitors

同义名列表

70 个代谢物同义名

[(2R,3R,4S,6S)-3-hydroxy-6-[(2R,3S,4S,6S)-4-hydroxy-6-[(2R,3S,4S,6R)-4-hydroxy-6-[[(3S,5R,8R,9S,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-2-methyloxan-3-yl]oxy-2-methyloxan-3-yl]oxy-2-methyloxan-4-yl] acetate; (2R,3R,4S,6S)-6-{[(2R,3S,4S,6S)-6-{[(2R,3S,4S,6R)-6-{[(1R,3aS,3bR,5aR,7S,9aS,9bS,11aR)-3a-hydroxy-9a,11a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-3-hydroxy-2-methyloxan-4-yl acetate; (2R,3R,4S,6S)-3-hydroxy-6-{[(2R,3S,4S,6S)-4-hydroxy-6-{[(2R,3S,4S,6R)-4-hydroxy-6-{[(1S,2S,5S,7R,10R,11S,14R,15R)-11-hydroxy-2,15-dimethyl-14-(5-oxo-2,5-dihydrofuran-3-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-yl]oxy}-2-methyloxan-3-yl]oxy}-2-methyloxan-3-yl]oxy}-2-methyloxan-4-yl acetate; (2R,3R,4S,6S)-3-hydroxy-6-{[(2R,3S,4S,6S)-4-hydroxy-6-{[(2R,3S,4S,6R)-4-hydroxy-6-{[(1S,2S,5S,7R,10R,11S,14R,15R)-11-hydroxy-2,15-dimethyl-14-(5-oxo-2,5-dihydrofuran-3-yl)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-yl]oxy}-2-methyloxan-3-yl]oxy}-2-methyloxan-3-yl]oxy}-2-methyloxan-4-yl acetate; (2R,3R,4S,6S)-6-{[(2R,3S,4S,6S)-6-{[(2R,3S,4S,6R)-6-{[(1R,3aS,3bR,5aR,7S,9aS,9bS,11aR)-3a-hydroxy-9a,11a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2-methyloxan-3; (3.BETA.,5.BETA.)-3-((O-3-O-ACETYL-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXYCARD-20(22)-ENOLIDE; Card-20(22)-enolide, 3-((O-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-; (3beta,5beta)-3-((O-3-O-Acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide; (3beta,5beta)-3-((O-3-O-Acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide; (3beta,5beta)-3-{[3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide; 3beta-[3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyloxy]-14-hydroxy-5beta-card-20(22)-enolide; 3beta-(3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyloxy)-14-hydroxy-5beta-card-20(22)-enolide; ACETYLDIGITOXINS .ALPHA.-FORM [MI]; Acetildigitoxina (INN-Spanish); Acetildigitoxina [INN-Spanish]; Acetyldigitoxinum [INN-Latin]; ACETYLDIGITOXIN [ORANGE BOOK]; Acetyldigitoxins .alpha.-form; Acetyldigitoxinum (INN-Latin); ACETYLDIGITOXINS alpha-FORM; Digitoxin, acetate, alpha-; alpha-Monoacetyldigitoxin; Digitoxin, alpha-acetyl-; Acetyldigitoxin [INN:NF]; ACETYLDIGITOXIN [WHO-DD]; ACETYLDIGITOXIN (MART.); Digitoxin 3-acetic acid; ACETYLDIGITOXIN [MART.]; Monoacetate, Digitoxin; alpha-Acetyldigitoxins; Acetyl-digitoxin-alpha; alpha-Acetylgitaloxin; alpha Acetyldigitoxin; a-Monoacetyldigitoxin; alpha-Acetyldigitoxin; Α-monoacetyldigitoxin; Acetyldigitoxin [INN]; Acetyldigitoxin (INN); Digitoxin Monoacetate; Desglucolanatosides A; Digitoxin, 3-acetate; Desglucolanatoside A; 3-O-acetyldigitoxin; Digitoxin 3-acetate; Acetyl-digitoxin-α; Acetyl-digitoxin-a; a-Acetylgitaloxin; Acetyldigitoxinum; Α-acetylgitaloxin; Α-acetyldigitoxin; acetildigitossina; a-Acetyldigitoxin; Acetyldigitoxins; Acetildigitoxina; acetyldigitoxine; UNII-0ZV4Q4L2FU; Acetyldiginatin; Acetylgitaloxin; Acetyldigitoxin; Acetylgitoxin; Acylanid (TN); 0ZV4Q4L2FU; Acylanide; Acylanid; Acedigal; Acedoxin; C01AA02; C01AA01; Adicin; NCGC00521080-01



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18 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • D S Hage, A Sengupta. Characterisation of the binding of digitoxin and acetyldigitoxin to human serum albumin by high-performance affinity chromatography. Journal of chromatography. B, Biomedical sciences and applications. 1999 Mar; 724(1):91-100. doi: 10.1016/s0378-4347(98)00589-1. [PMID: 10202961]
  • A Tracqui, P Kintz, B Ludes, P Mangin. High-performance liquid chromatography-ionspray mass spectrometry for the specific determination of digoxin and some related cardiac glycosides in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1997 Apr; 692(1):101-9. doi: 10.1016/s0378-4347(96)00462-8. [PMID: 9187389]
  • J Kuhlmann, S Marcin, K H Frank. [Pharmacokinetics and cardiac effect of beta-acetyldigoxin and digitoxin in combination therapy with nifedipine]. Klinische Wochenschrift. 1984 May; 62(10):451-7. doi: 10.1007/bf01726906. [PMID: 6748559]
  • N Rietbrock, B G Woodcock. [Are non-kidney-dependent digitalis glycosides therapeutically safer?]. ZFA. Zeitschrift fur Allgemeinmedizin. 1983 Aug; 59(24):1290-5. doi: NULL. [PMID: 6636996]
  • K O Haustein. Measurement of plasma glycoside level following pengitoxin administration. European journal of clinical pharmacology. 1978 Jul; 13(5):389-91. doi: 10.1007/bf00644614. [PMID: 668799]
  • K O Haustein. Pharmacokinetic investigations in man of two acetyl derivatives of 16alpha-gitoxin. European journal of clinical pharmacology. 1977 Dec; 12(6):445-50. doi: 10.1007/bf00561064. [PMID: 598419]
  • G Bodem, K Wirth, H J Dengler. [Studies on metabolism and pharmacokinetics of alpha-acetyldigitoxin in man (author's transl)]. Arzneimittel-Forschung. 1975 Sep; 25(9):1448-52. doi: . [PMID: 1242671]
  • G G Belz, H Nübling, M Strauch. [Effect and plasma level of methylproscillaridin and beta-acetyldigitoxin following long term administration in man]. Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung. 1975; 41(?):315-9. doi: NULL. [PMID: 821263]
  • T Bogdanik, E Tydelska, A Sosin, J Zambrzycki. [Principles of therapeutic algorithm used in the determination of optimal dosage of digitalis derivatives]. Polski tygodnik lekarski (Warsaw, Poland : 1960). 1974 Oct; 29(43):1849-51. doi: NULL. [PMID: 4608627]
  • K Buchtela, K Drexler, H Hackl, M Königstein, H Sazovsky. [Intestinal resorption and excretion of alpha-acetyldigoxin-3H]. Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete. 1973; 54(7):324-31. doi: NULL. [PMID: 4803609]
  • O GISVOLD. Isolation of acetyldigitoxin. Journal of pharmaceutical sciences. 1963 Jan; 52(?):83-5. doi: 10.1002/jps.2600520119. [PMID: 13948234]
  • S J DAMANY, G R KAMAT. Clinical observations on acetyl digitoxin. Indian journal of medical sciences. 1960 Jul; 14(?):619-23. doi: ". [PMID: 13813876]
  • L I VELLES AGUIRRE, D AZAR, H BALPARDA, J I GONZALEZ GARCIA, L E LEONE, C D VOZZI. [Clinical experience with acetyldigitoxin]. La Semana medica. 1960 May; 116(?):760-2. doi: ". [PMID: 13841628]
  • J F MARTIN, S E WRIGHT. The metabolism of acetyl digitoxin in the rat. The Journal of pharmacology and experimental therapeutics. 1960 Apr; 128(?):329-32. doi: ". [PMID: 14421694]
  • G ARMIJO, I MELEDA, J SAAVEDRA, R ARMAS CRUZ, J HARNECKER. [Treatment of cardiac insufficiency with acetyl-digitoxin]. Revista medica de Chile. 1960 Feb; 88(?):113-6. doi: ". [PMID: 13794292]
  • G FINARDI, D STORTI. [Clinical evaluation and therapeutic value of a new digitalic drug, acetyl-digitoxin]. La Clinica terapeutica. 1959 Nov; 17(?):499-514. doi: . [PMID: 13822809]
  • L MECIANI. [Clinical data on the combined acetyldigitoxin & reserpine therapy of circulatory decompensation]. La Clinica terapeutica. 1959 Mar; 16(3):229-53. doi: ". [PMID: 13652429]
  • F COCUZZA, A ZINNARI, A MISTRETTA. [Use of acetyldigitoxin in non-compensated heart disease]. La Riforma medica. 1959 Jan; 73(5):134-40. doi: . [PMID: 13634845]
  • V TORMO ALFONSO, R BAGUENA CANDELA. [Effect of acetyldigitoxin on the electrocardiogram]. Medicina espanola. 1958 Dec; 40(237):504-16. doi: ". [PMID: 13632285]
  • L MATHIEU, C PERNOT, J METZ, F STREIFF. [Acetyldigitoxin in cardiovascular therapy: elective indications & contraindications]. Revue medicale de Nancy. 1958 Dec; 83(?):1103-24. doi: ". [PMID: 13624369]
  • D LAMAS, A DUENAS. [Acetyldigitoxin in the treatment of cardiac insufficiency]. Revista medica de Chile. 1958 Oct; 86(10):619-24. doi: ". [PMID: 13614913]
  • J B VACCA, J M SCHUSTER, W A KNIGHT. Clinical evaluation of acetyldigitoxin. The American journal of cardiology. 1958 Jun; 1(6):717-22. doi: 10.1016/0002-9149(58)90161-9. [PMID: 13533294]
  • F C LU, A LAVALLEE, M G ALLMARK, M A HOSSAIN. A comparative study on some pharmacological effects of digitoxin, acetyldigitoxin and gitalin (amorphous) in cats. The Journal of pharmacy and pharmacology. 1958 Jun; 10(6):375-9. doi: 10.1111/j.2042-7158.1958.tb10318.x. [PMID: 13550078]
  • E HELLMAN, M PORT. Rapid digitalization of ambulatory patients with atrial fibrillation; use of intramuscularly given deslanoside followed by orally given acetyldigitoxin. Journal of the American Medical Association. 1958 May; 167(2):215-6. doi: 10.1001/jama.1958.72990190002015a. [PMID: 13538696]
  • L LANGERON, G ROUTIER. [Acetyldigitoxin; clinical study in 26 patients]. Concours medical. 1958 Apr; 80(16):1941-2 passim. doi: ". [PMID: 13537562]
  • S B HUMERFELT, R JORDE. [Acetyldigitoxin; clinical evaluation]. Nordisk medicin. 1958 Mar; 59(10):351-3. doi: ". [PMID: 13517641]
  • J C KING, J R LAADT. Acetyldigitoxin for cardiac decompensation in the elderly patient; a study of its effect in 33 ambulatory patients. Geriatrics. 1958 Feb; 13(2):75-9. doi: ". [PMID: 13501427]
  • R ARMAS CRUZ, J HARNECKER, J JALIL MUSSA, I MELEDA. [Acetyldigitoxin, a new cardiotonic preparation]. Revista medica de Chile. 1958 Jan; 86(1):18-25. doi: . [PMID: 13542980]
  • F DREYFUSS, A ZLOTNICK, J MENCZEL. Clinical use of acetyl-digitoxin. Cardiologia. 1958; 32(4):220-31. doi: 10.1159/000165819. [PMID: 13547066]
  • P MULLER-BRUNOTTE, E MANNHEIMER. [Digitalis therapy in childhood with special regard to acetyl-digitoxin (acylanid)]. Cardiologia. 1958; 33(5):371-83. doi: ". [PMID: 13597002]
  • G HACHMANN. [Clinical experiences with the cardiac glycoside acylanid (acetyl-digitoxin Sandoz)]. Arztliche Forschung. 1957 Dec; 11(12):I/601-5. doi: ". [PMID: 13497873]
  • D SATOH, Y OYAMA, T OKUMURA. Studies on digitalis glycoside; acetyldigitoxin-alpha from digitoxin. Pharmaceutical bulletin. 1957 Dec; 5(6):627. doi: 10.1248/cpb1953.5.627. [PMID: 13527160]
  • O STORSTEIN, R ROKSETH. [Effects of acetyldigitoxin; a clinicophysiological study]. Nordisk medicin. 1957 Nov; 58(45):1728-30. doi: ". [PMID: 13493833]
  • D SATOH, Y OYAMA, H ISHII. Studies on digitalis glycosides: acetylgitoxin-alpha from gitoxin. Pharmaceutical bulletin. 1957 Oct; 5(5):493. doi: 10.1248/cpb1953.5.493. [PMID: 13505076]
  • M A GOLD. Acetyldigitoxin in clinical practice. A.M.A. archives of internal medicine. 1957 Aug; 100(2):209-13. doi: 10.1001/archinte.1957.00260080035008. [PMID: 13443540]
  • P J SANAZARO. Acetyldigitoxin in therapy of ambulatory patients with congestive heart failure. Journal of the American Medical Association. 1957 Jun; 164(7):743-5. doi: 10.1001/jama.1957.02980070025005. [PMID: 13428547]
  • H GOLD, S BELLET. Acetyldigitoxin in the treatment of heart failure. The New England journal of medicine. 1957 Mar; 256(12):536-40. doi: 10.1056/nejm195703212561202. [PMID: 13419037]
  • I CHAVEZ, F MENDOZA, C GUZMAN GARCIA, M CARDENAS LOAEZA. [Studies of a new digitalic preparation, acetyldigitoxin]. Archivos del Instituto de Cardiologia de Mexico. 1957 Mar; 27(2):111-36. doi: . [PMID: 13436253]
  • F DREYFUSS, A ZLOTNICK, J MENCZEL. Clinical use of acetyl-digitoxin. Harefuah. 1957 Feb; 52(4):90-4. doi: ". [PMID: 13428171]
  • A M PETERSEN. [alpha-Acetyldigitoxin: clinical experience with a new digitalis glycoside]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 1957 Feb; 77(4):156-7; passim. doi: ". [PMID: 13422417]
  • A R BERGER, A BERNSTEIN, S DANN, L B GUTNER, H S KUPPERMAN. Clinical evaluation of acetyldigitoxin alpha, a new cardiac glycoside. New York state journal of medicine. 1957 Jan; 57(2):239-50. doi: ". [PMID: 13388069]
  • M CARDENAS LOAEZA, I CHAVEZ, C GUZMAN GARCIA, F MENDOZA. [Studies on acetyldigitoxin, a new digitalis preparation]. Cardiologia. 1957; 30(1):62-85. doi: ". [PMID: 13396718]
  • M ERMAN. [Treatment of congestive heart failure with acetyl digitoxin]. Turk Tip Cemiyeti mecmuasi. 1956 Nov; 22(11):579-90. doi: ". [PMID: 13433824]
  • A BERNSTEIN, I E COHEN, E KOGAN. Acetyl-digitoxin; a clinical study. The Journal-lancet. 1956 Aug; 76(8):228-36. doi: ". [PMID: 13367611]
  • H B GILLIS. Acetyl digitoxin; a new cardiac glycoside. Northwest medicine. 1956 Apr; 55(4):418-21. doi: ". [PMID: 13309831]
  • I C BRILL, P R BURGNER, N A DAVID. Acetyl-digitoxin (acylanid): rapid digitalization and maintenance by oral administration. Annals of internal medicine. 1956 Apr; 44(4):707-16. doi: 10.7326/0003-4819-44-4-707. [PMID: 13303040]
  • F KAZMEIER, H LOHSE, W SCHILD. [Clinical experiences with acetyldigitoxin (acylanid) treatment of heart insufficiency]. Arztliche Wochenschrift. 1956 Mar; 11(11):233-6. doi: ". [PMID: 13326735]
  • M GOLDFARB, M C THORNER, G C GRIFFITH. Clinical experience with acetyldigitoxin; preliminary report. The American journal of the medical sciences. 1956 Feb; 231(2):186-91. doi: 10.1097/00000441-195602000-00010. [PMID: 13282901]
  • J E DOHERTY. A clinical study of acetyl digitoxin. American practitioner and digest of treatment. 1955 Dec; 6(12):1836-40. doi: ". [PMID: 13268836]
  • S BOBER, W GRZEDA. [New preparation of Digitalis lanta acetyldigitoxin]. Polski tygodnik lekarski. 1955 Nov; 10(45):1464-7. doi: ". [PMID: 13289458]
  • P BROUSTET, R CASTAING, H BRICAUD, D COTTIN. [Hemodynamic effects of acetyldigitoxin in mitral stenosis]. Archives des maladies du coeur et des vaisseaux. 1955 Sep; 48(9):859-71. doi: . [PMID: 13276061]
  • C C MAHER, C W PULLEN. Acetyl-digitoxin; a new cardiac glycoside. Rocky Mountain medical journal. 1955 May; 52(5):436-7. doi: ". [PMID: 14372870]
  • F LASCH, K THEINL. [Clinical experience with acetyl-digitoxin treatment (acylanid)]. Wiener klinische Wochenschrift. 1955 Apr; 67(15):258-62. doi: ". [PMID: 14374450]
  • H J SCHMID. [Rectal digitalis therapy with acetyl-digitoxin-alpha]. Schweizerische medizinische Wochenschrift. 1955 Mar; 85(10):228-30. doi: ". [PMID: 14358640]
  • A SANABRIA. [Clinical research on the effect of acetyl-digitoxin (acylanid)]. Cardiologia. 1955; 26(5):287-91. doi: ". [PMID: 14390065]
  • A ZILLI, A A LUISADA. Effects of acetyl-digitoxin alpha in ambulatory patients with congestive failure. Experimental medicine and surgery. 1955; 13(2):118-23. doi: ". [PMID: 14391324]
  • J U DE CASTRO, C A S DUARTE. [Therapeutic trial with the new cardiotonic acetyl digitoxin]. Jornal do medico. 1954 Dec; 25(621):781-4. doi: . [PMID: 13232906]
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