Melevodopa (BioDeep_00000692401)

   

PANOMIX_OTCML-2025


代谢物信息卡片


(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid methyl ester

  化学式: C10H13NO4 (211.0845)
中文名称: 盐酸左旋多巴甲酯
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: COC(=O)C(CC1=CC(=C(C=C1)O)O)N
InChI: InChI=1S/C10H13NO4/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6/h2-3,5,7,12-13H,4,11H2,1H3/t7-/m0/s1


描述信息

N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BA - Dopa and dopa derivatives
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist

同义名列表

18 个代谢物同义名

Melevodopa; (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid methyl ester; (2S)-2-amino-3-(3,4-dihydroxyphenyl)propionic acid methyl ester; methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate; ALANINE, 3-(3,4-DIHYDROXYPHENYL)-, METHYL ESTER, L-; L-3-(3,4-Dihydroxyphenyl)alanine methyl ester; 4-14-00-02494 (Beilstein Handbook Reference); L-Tyrosine, 3-hydroxy-, methyl ester (9CI); 3-Hydroxy-L-tyrosine methyl ester; Levodopa methyl ester; L-Dopa methyl ester; Melevodopa [INN]; NCGC00015327-01; Lopac0_000356; Lopac-D-1507; BRN 3056415; 7101-51-1; Melevodopa



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Anna Lisa Scaturro, Viviana De Caro, Giuseppina Campisi, Libero Italo Giannola. Potential transbuccal delivery of l-DOPA methylester prodrug: stability in the environment of the oral cavity and ability to cross the mucosal tissue. Drug delivery. 2016 Sep; 23(7):2355-2362. doi: 10.3109/10717544.2014.987332. [PMID: 25533875]
  • Yeon Hong Lee, Kyung Hee Kim, In Kyung Yoon, Kyung Eun Lee, In Koo Chun, Jeong Yeon Rhie, Hye Sun Gwak. Pharmacokinetic evaluation of formulated levodopa methyl ester nasal delivery systems. European journal of drug metabolism and pharmacokinetics. 2014 Dec; 39(4):237-42. doi: 10.1007/s13318-013-0171-8. [PMID: 24363125]
  • Alfonso Fasano, Francesco Bove, Maurizio Gabrielli, Enzo Ragazzoni, Serena Fortuna, Annalisa Tortora, Maria Assunta Zocco, Stefano Marconi, Antonio Gasbarrini, Anna Rita Bentivoglio. Liquid melevodopa versus standard levodopa in patients with Parkinson disease and small intestinal bacterial overgrowth. Clinical neuropharmacology. 2014 Jul; 37(4):91-5. doi: 10.1097/wnf.0000000000000034. [PMID: 24992085]
  • Alba Minelli, Carmela Conte, Elvira Prudenzi, Ivana Cacciatore, Catia Cornacchia, Elena Taha, Francesco Pinnen. N-acetyl-L-methionyl-L-Dopa-methyl ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity. Free radical biology & medicine. 2010 Jul; 49(1):31-9. doi: 10.1016/j.freeradbiomed.2010.03.011. [PMID: 20307650]
  • Soichi Itoh, Charles Oo. A feasibility study of differential delivery of levodopa ester and benserazide using site-specific intestinal loops in rats. Journal of pharmaceutical sciences. 2010 Jan; 99(1):227-33. doi: 10.1002/jps.21822. [PMID: 19455628]
  • A Vinuela, P J Hallett, C Reske-Nielsen, M Patterson, T D Sotnikova, M G Caron, R R Gainetdinov, O Isacson. Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. Brain : a journal of neurology. 2008 Dec; 131(Pt 12):3361-79. doi: 10.1093/brain/awn192. [PMID: 18988638]
  • J Wang, Y Zhou, A F Wang, S H Zhang, L Ning, P G He, Y Z Fang. Determination of levodopa methyl ester and its metabolites in rat serum by CZE with amperometric detection. Analytical and bioanalytical chemistry. 2005 May; 382(1):198-203. doi: 10.1007/s00216-005-3202-8. [PMID: 15900472]
  • R Bettini, D Acerbi, G Caponetti, R Musa, N Magi, P Colombo, D Cocconi, P Santi, P L Catellani, P Ventura. Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2002 Mar; 53(2):227-32. doi: 10.1016/s0939-6411(01)00238-7. [PMID: 11880007]
  • S Rose, P Jenner, C D Marsden. Chronic administration does not alter the accumulation of L-dopa into muscle. Movement disorders : official journal of the Movement Disorder Society. 1994 Mar; 9(2):167-72. doi: 10.1002/mds.870090207. [PMID: 8196677]
  • I Rondelli, D Acerbi, F Mariotti, P Ventura. Simultaneous determination of levodopa methyl ester, levodopa, 3-O-methyldopa and dopamine in plasma by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical applications. 1994 Feb; 653(1):17-23. doi: 10.1016/0378-4347(93)e0411-i. [PMID: 8012555]
  • F Stocchi, S Ruggieri, A Carta, J Ryatt, N Quinn, P Jenner, C D Marsden, A Agnoli. Intravenous boluses and continuous infusions of L-dopa methyl ester in fluctuating patients with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 1992; 7(3):249-56. doi: 10.1002/mds.870070311. [PMID: 1620143]
  • G G Meadows, H F Pierson, R M Abdallah. Ascorbate in the treatment of experimental transplanted melanoma. The American journal of clinical nutrition. 1991 12; 54(6 Suppl):1284S-1291S. doi: 10.1093/ajcn/54.6.1284s. [PMID: 1962584]
  • J L Juncos, M M Mouradian, G Fabbrini, C Serrati, T N Chase. Levodopa methyl ester treatment of Parkinson's disease. Neurology. 1987 Jul; 37(7):1242-5. doi: 10.1212/wnl.37.7.1242. [PMID: 3601092]
  • H F Pierson, G G Meadows. Modulation of peroxidation in murine melanoma by dietary tyrosine-phenylalanine restriction, levodopa methylester chemotherapy, and sodium ascorbate supplementation. Journal of the National Cancer Institute. 1985 Sep; 75(3):507-16. doi: NULL. [PMID: 3861901]