Asitribin (BioDeep_00000006845)

 

Secondary id: BioDeep_00000640721

human metabolite Endogenous


代谢物信息卡片


3-(13-{5-[5-(1,5-dihydroxyundecyl)oxolan-2-yl]oxolan-2-yl}-13-hydroxytridecyl)-5-methyl-2,5-dihydrofuran-2-one

化学式: C37H66O7 (622.4808286)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCC(CCCC(C1CCC(O1)C2CCC(O2)C(CCCCCCCCCCCCC3=CC(OC3=O)C)O)O)O
InChI: InChI=1S/C37H66O7/c1-3-4-5-15-19-30(38)20-17-22-32(40)34-24-26-36(44-34)35-25-23-33(43-35)31(39)21-16-13-11-9-7-6-8-10-12-14-18-29-27-28(2)42-37(29)41/h27-28,30-36,38-40H,3-26H2,1-2H3/t28-,30-,31+,32-,33+,34+,35+,36+/m0/s1

描述信息

Asiminacin is found in fruits. Asiminacin is a constituent of Asimina triloba (pawpaw) and Annona squamosa (sugar apple).
Constituent of the seeds of Asimina triloba (pawpaw). Asitribin is found in fruits.

同义名列表

4 个代谢物同义名

3-(13-{5-[5-(1,5-dihydroxyundecyl)oxolan-2-yl]oxolan-2-yl}-13-hydroxytridecyl)-5-methyl-2,5-dihydrofuran-2-one; 3-(13-{5-[5-(1,5-dihydroxyundecyl)oxolan-2-yl]oxolan-2-yl}-13-hydroxytridecyl)-5-methyl-5H-furan-2-one; Squamocin; Asitribin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

47 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kevin Tran, Sean Ryan, Miranda McDonald, Andrew L Thomas, José Guilherme S Maia, Robert E Smith. Annonacin and Squamocin Contents of Pawpaw (Asimina triloba) and Marolo (Annona crassiflora) Fruits and Atemoya (A. squamosa × A. cherimola) Seeds. Biological trace element research. 2021 06; 199(6):2320-2329. doi: 10.1007/s12011-020-02320-7. [PMID: 32761515]
  • Y Miao, X Xu, F Yuan, Y Shi, Y Chen, J Chen, X Li. Four cytotoxic annonaceous acetogenins from the seeds of Annona squamosa. Natural product research. 2016 Jun; 30(11):1273-9. doi: 10.1080/14786419.2015.1055490. [PMID: 26181648]
  • Jing-Fang Shi, Ping Wu, Zi-Hua Jiang, Xiao-Yi Wei. Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. European journal of medicinal chemistry. 2014 Jan; 71(?):219-28. doi: 10.1016/j.ejmech.2013.11.012. [PMID: 24308999]
  • Haijun Yang, Ning Zhang, Xiang Li, Jianwei Chen, Baochang Cai. Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells. Bioorganic & medicinal chemistry letters. 2009 Apr; 19(8):2199-202. doi: 10.1016/j.bmcl.2009.02.105. [PMID: 19285863]
  • Séverine Derbré, Erwan Poupon, Christophe Gleye, Reynald Hocquemiller. Biogenetic relationships between Annonaceous acetogenins: squamocin is not a precursor of chamuvarinin based on a semisynthetic study. Journal of natural products. 2007 Feb; 70(2):300-3. doi: 10.1021/np060376b. [PMID: 17279796]
  • Shyng-Shiou F Yuan, Hsueh-Ling Chang, Hsiao-Wen Chen, Fu-Chen Kuo, Chih-Chuang Liaw, Jinu-Huang Su, Yang-Chang Wu. Selective cytotoxicity of squamocin on T24 bladder cancer cells at the S-phase via a Bax-, Bad-, and caspase-3-related pathways. Life sciences. 2006 Jan; 78(8):869-74. doi: 10.1016/j.lfs.2005.05.068. [PMID: 16154156]
  • Djibril Fall, Romain A Duval, Christophe Gleye, Alain Laurens, Reynald Hocquemiller. Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae. Journal of natural products. 2004 Jun; 67(6):1041-3. doi: 10.1021/np030521a. [PMID: 15217292]
  • Yuka Nakanishi, Fang-Rong Chang, Chih-Chuang Liaw, Yang-Chang Wu, Kenneth F Bastow, Kuo-Hsiung Lee. Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line. Journal of medicinal chemistry. 2003 Jul; 46(15):3185-8. doi: 10.1021/jm020548b. [PMID: 12852747]
  • Li-Da Wang, De-You Qiu, Ji-Yun Chen, Yi-Fan Han, Jun-Hua Zheng, De-An Guo. Callus cultures of Annona squamosa for the production of annonaceous acetogenins. Journal of Asian natural products research. 2002 Sep; 4(3):171-4. doi: 10.1080/1028602021000000062. [PMID: 12118503]
  • L Sun, J G Yu, D Y Li, J Li, X D Yang, S L Yang. [Determination of annonaceous acetogenins in annonaceae plants by HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 2001 Sep; 36(9):683-5. doi: . [PMID: 12580108]
  • E F Queiroz, F Roblot, P Duret, B Figadère, A Gouyette, O Laprévote, L Serani, R Hocquemiller. Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy. Journal of medicinal chemistry. 2000 Apr; 43(8):1604-10. doi: 10.1021/jm990568m. [PMID: 10780917]
  • S Raynaud, C Fourneau, A Laurens, R Hocquemiller, P Loiseau, C Bories. Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts. Planta medica. 2000 Mar; 66(2):173-5. doi: 10.1055/s-0029-1243125. [PMID: 10763595]
  • E F Queiroz, F Roblot, A Cavé, R Hocquemiller, L Serani, O Laprévote, M Q Paulo. A new bistetrahydrofuran acetogenin from the roots of Annona salzmanii. Journal of natural products. 1999 May; 62(5):710-3. doi: 10.1021/np980482g. [PMID: 10346951]
  • B Akendengue, E Ngou-Milama, A Laurens, R Hocquemiller. Recent advances in the fight against leishmaniasis with natural products. Parasite (Paris, France). 1999 Mar; 6(1):3-8. doi: 10.1051/parasite/1999061003. [PMID: 10229931]
  • V Padmaja, V Thankamany, A Hisham. Antibacterial, antifungal and anthelmintic activities of root barks of Uvaria hookeri and Uvaria narum. Journal of ethnopharmacology. 1993 Dec; 40(3):181-6. doi: 10.1016/0378-8741(93)90066-e. [PMID: 8145573]