cefuroxime axetil (BioDeep_00000006662)
代谢物信息卡片
cefuroxime axetil
化学式: C20H22N4O10S (510.1056592)
中文名称: 头孢呋辛酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(OC(=O)C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CC=CO3)COC(=O)N
InChI: InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:3516
- KEGG: C08107
- KEGGdrug: D00914
- PubChem: 6321416
- PubChem: 3379942
- Metlin: METLIN1629
- ChEMBL: CHEMBL1095930
- CAS: 64544-07-6
- PMhub: MS000019738
- MetaboLights: MTBLC3516
- PubChem: 10307
- NIKKAJI: J111.110H
- KNApSAcK: 3516
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nishat Bhatia, Asha Kumari, Nitika Thakur, Gaurav Sharma, Ragini Raj Singh, Rahul Sharma. Phytochemically stabilized chitosan encapsulated Cu and Ag nanocomposites to remove cefuroxime axetil and pathogens from the environment.
International journal of biological macromolecules.
2022 Jul; 212(?):451-464. doi:
10.1016/j.ijbiomac.2022.05.143. [PMID: 35618089] - Gabriela A Albarellos, Sabrina M Passini, Martín P Lupi, Silvia Aramayona, Paula M Lorenzini, Laura Montoya, Maria F Landoni. Effect of food on the pharmacokinetics of oral cefuroxime axetil in dogs.
Journal of veterinary pharmacology and therapeutics.
2020 May; 43(3):297-302. doi:
10.1111/jvp.12854. [PMID: 32157713] - Rahul Lalge, Priyanka Thipsay, Vijay Kumar Shankar, Abhijeet Maurya, Manjeet Pimparade, Suresh Bandari, Feng Zhang, S Narasimha Murthy, Michael A Repka. Preparation and evaluation of cefuroxime axetil gastro-retentive floating drug delivery system via hot melt extrusion technology.
International journal of pharmaceutics.
2019 Jul; 566(?):520-531. doi:
10.1016/j.ijpharm.2019.06.021. [PMID: 31185262] - Maria Daniel, Hania Szajewska, Małgorzata Pańczyk-Tomaszewska. 7-day compared with 10-day antibiotic treatment for febrile urinary tract infections in children: protocol of a randomised controlled trial.
BMJ open.
2018 03; 8(3):e019479. doi:
10.1136/bmjopen-2017-019479. [PMID: 29500209] - Tetyana O Kryuchko, Vira P Kharshman, Inna M Nesina, Nataliia V Kuzmenko, Jaroslava M Oleksiienko. Regional features of the microbial landscape of urine and comparative evaluation of antimicrobial therapy in children with cystitis.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2017 ; 70(3 pt 2):566-570. doi:
. [PMID: 28713083] - Mohammad Awwad, Fuad Al-Rimawi, Khuloud Jamal Khayyat Dajani, Mustafa Khamis, Shlomo Nir, Rafik Karaman. Removal of amoxicillin and cefuroxime axetil by advanced membranes technology, activated carbon and micelle-clay complex.
Environmental technology.
2015 Jul; 36(13-16):2069-78. doi:
10.1080/09593330.2015.1019935. [PMID: 25686519] - Sruti Jammula, Ch Niranjan Patra, Suryakanta Swain, Kanhu Charan Panigrahi, Sabita Nayak, Subas Chandra Dinda, Muddana Eswara Bhanoji Rao. Design and characterization of cefuroxime axetil biphasic floating minitablets.
Drug delivery.
2015 Jan; 22(1):125-35. doi:
10.3109/10717544.2013.871603. [PMID: 24417642] - Bhupender Singh, Parameswara Rao Vuddanda, Vijayakumar M R, Vinod Kumar, Preeti S Saxena, Sanjay Singh. Cefuroxime axetil loaded solid lipid nanoparticles for enhanced activity against S. aureus biofilm.
Colloids and surfaces. B, Biointerfaces.
2014 Sep; 121(?):92-8. doi:
10.1016/j.colsurfb.2014.03.046. [PMID: 24945607] - Ahmet Emre Eskazan, Ayse Salihoglu, Emine Gulturk, Seniz Ongoren, Teoman Soysal. Thrombotic thrombocytopenic purpura after prophylactic cefuroxime axetil administered in relation to a liposuction procedure.
Aesthetic plastic surgery.
2012 Apr; 36(2):464-7. doi:
10.1007/s00266-011-9794-9. [PMID: 21853406] - Y A Asiri, B M Al-Hadiya, A A Kadi, K I Al-Khamis, H A Mowafy, Y M El-Sayed. Comparative bioavailability study of cefuroxime axetil (equivalent to 500 mg cefuroxime/tablet) tablets (Zednad® versus Zinnat®) in healthy male volunteers.
International journal of clinical pharmacology and therapeutics.
2011 Sep; 49(9):571-6. doi:
10.5414/cp201376. [PMID: 21888870] - Gustavo D Mendes, André Borges, Ligia de Cássia Val, Anil K Patni, Simrit Reyar, Tausif Monif, Daiene Sereno, Ana Maria M Orellana, Gilberto De Nucci. Comparative bioavailability of cefuroxime axetil suspension formulations administered with food in healthy subjects.
Arzneimittel-Forschung.
2010; 60(2):101-5. doi:
10.1055/s-0031-1296256. [PMID: 20329659] - J B Bulitta, C B Landersdorfer, M Kinzig, U Holzgrabe, F Sorgel. New semiphysiological absorption model to assess the pharmacodynamic profile of cefuroxime axetil using nonparametric and parametric population pharmacokinetics.
Antimicrobial agents and chemotherapy.
2009 Aug; 53(8):3462-71. doi:
10.1128/aac.00054-09. [PMID: 19528278] - Nikolaos Bilanakis, Vaios Peritogiannis, Georgios Kalampokis. Infections as complications of neuroleptic malignant syndrome.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2009; 10(4 Pt 3):973-6. doi:
10.1080/15622970801935578. [PMID: 18609425] - Gang-ke Wu, Cheng-nong Yan, Yi Liu. [Studies on the action features between cefuroxime axetil and bovine serum albumin].
Guang pu xue yu guang pu fen xi = Guang pu.
2008 Sep; 28(9):2139-43. doi:
NULL. [PMID: 19093579] - Iliana González-Hernández, Helgi Jung-Cook, Angela Sotelo. Effect of malnutrition on the pharmacokinetics of cefuroxime axetil in young rats.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2008; 11(1):9-21. doi:
10.18433/j3z59s. [PMID: 18445361] - Ivica Grgurević, Vlatko Pejsa, Jadranka Morović-Vergles, Ivan Dobrić, Vladimir Gasparović, Neven Tudorić. Fatal toxic epidermal necrolysis and severe granulocytopenia following therapy with cefuroxime.
Acta dermatovenerologica Croatica : ADC.
2008; 16(3):133-7. doi:
. [PMID: 18812062] - C Pistos, S Michalea, M Kalovidouris, G Kontopoulos, M Georgarakis. Bioequivalence evaluation of 2 brands of cefuroxime axetil 250 mg tablets in healthy human volunteers.
International journal of clinical pharmacology and therapeutics.
2004 Jul; 42(7):367-72. doi:
10.5414/cpp42367. [PMID: 15605688] - P Ruiz-Carretero, M Merino-Sanjuán, A Nácher, V G Casabó. Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2004 Feb; 21(2-3):217-23. doi:
10.1016/j.ejps.2003.10.006. [PMID: 14757493] - Noppamas Rojanasthien, Chayanontchaimongkol Boonchaliew, Boonyium Kumsorn, Chaichan Sangdee. A bioequivalence study of the cefuroxime axetil in healthy volunteers.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2003 Nov; 86(11):1063-72. doi:
NULL. [PMID: 14696789] - A J White, S Gompertz, D L Bayley, S L Hill, C O'Brien, I Unsal, R A Stockley. Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitis.
Thorax.
2003 Aug; 58(8):680-5. doi:
10.1136/thorax.58.8.680. [PMID: 12885984] - G Colmenarejo, A Alvarez-Pedraglio, J L Lavandera. Cheminformatic models to predict binding affinities to human serum albumin.
Journal of medicinal chemistry.
2001 Dec; 44(25):4370-8. doi:
10.1021/jm010960b. [PMID: 11728183] - S Vasu, C Adithan, C H Shashindran, M Asad, K Koumaravelou, I Topno. Effect of two types of Indian breakfast on bioavailability of cefuroxime axetil.
The Indian journal of medical research.
2000 Sep; 112(?):104-8. doi:
NULL. [PMID: 11094856] - P Ruiz-Carretero, A Nacher, M Merino-Sanjuan, V G Casabo. Pharmacokinetics and absolute bioavailability of oral cefuroxime axetil in the rat.
International journal of pharmaceutics.
2000 Jul; 202(1-2):89-96. doi:
10.1016/s0378-5173(00)00420-8. [PMID: 10915930] - M Ortega Calvo, R Delgado Zamora, P Fernández Arance, L J Elgorriaga Guillén, L Del Valle Vázquez, J Gutiérrez Caracuel. [Kluyvera cryocrescens: a positive urine culture in a young girl with persistent proteinuria].
Actas urologicas espanolas.
1999 Jun; 23(6):528-31. doi:
NULL. [PMID: 10464962] - M K Lacy, R C Owens, X Xu, D P Nicolau, R Quintiliani, C H Nightingale. Comparison of bactericidal activity after multidose administration of clarithromycin, azithromycin, and ceruroxime axetil against Streptococcus pneumoniae.
International journal of antimicrobial agents.
1998 Nov; 10(4):279-83. doi:
10.1016/s0924-8579(98)00057-0. [PMID: 9916901] - E Thoroddsen. Measuring antibiotic levels in otitis media.
Ear, nose, & throat journal.
1998 Jun; 77(6 Suppl):13-5. doi:
. [PMID: 9674329] - E Pérez-Trallero, M Alkorta, J M García-Arenzana, A Iturzaeta, M Gomariz. In-vitro, in-vivo and ex-vivo studies with oral beta-lactams against Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy.
1998 Jun; 41(6):629-34. doi:
10.1093/jac/41.6.629. [PMID: 9687101] - M Dan, F Poch, A Edelman, J Asherov, H Hafely, Y Atzmon. Serum bactericidal activity of newer oral cephalosporins in healthy volunteers.
The Journal of antimicrobial chemotherapy.
1998 Apr; 41(4):485-8. doi:
10.1093/jac/41.4.485. [PMID: 9598780] - H J Manley, G R Bailie, G Eisele. Bilateral renal cortical necrosis associated with cefuroxime axetil.
Clinical nephrology.
1998 Apr; 49(4):268-70. doi:
NULL. [PMID: 9582561] - C Edlund, L Barkholt, B Olsson-Liljequist, C E Nord. Effect of vancomycin on intestinal flora of patients who previously received antimicrobial therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
1997 Sep; 25(3):729-32. doi:
10.1086/513755. [PMID: 9314469] - M Ghia, R Lotti, C Traverso, F Mattioli, A Martelli. Penetration of oral cefuroxime axetil into the human aqueous humor.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.
1997; 211(4):229-31. doi:
10.1159/000310796. [PMID: 9216013] - D E Nix, W T Symonds, J M Hyatt, J H Wilton, M A Teal, P Reidenberg, M B Affrime. Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers.
Pharmacotherapy.
1997 Jan; 17(1):121-5. doi:
. [PMID: 9017772] - A F Bierkens, A J Hendrikx, K E Ezz el Din, J J de la Rosette, A Horrevorts, W Doesburg, F M Debruyne. The value of antibiotic prophylaxis during extracorporeal shock wave lithotripsy in the prevention of urinary tract infections in patients with urine proven sterile prior to treatment.
European urology.
1997; 31(1):30-5. doi:
10.1159/000474414. [PMID: 9032531] - A K Deshpande, S R Joshi, H M Lal, N D Cooverji, S Ajay. Cefuroxime axetil in the treatment of Salmonella typhi infection (enteric fever) in adults.
The Journal of the Association of Physicians of India.
1996 Nov; 44(11):786-9. doi:
. [PMID: 9251454] - K Stoeckel, M Harell, M Dan. Penetration of cefetamet pivoxil and cefuroxime axetil into the maxillary sinus mucosa at steady state.
Antimicrobial agents and chemotherapy.
1996 Mar; 40(3):780-3. doi:
10.1128/aac.40.3.780. [PMID: 8851611] - A Novelli, T Mazzei, S Fallani, R Dei, M I Cassetta, S Conti. Betalactam therapy and intestinal flora.
Journal of chemotherapy (Florence, Italy).
1995 May; 7 Suppl 1(?):25-31. doi:
NULL. [PMID: 8618110] - C Edlund, C Stark, C E Nord. The relationship between an increase in beta-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances.
The Journal of antimicrobial chemotherapy.
1994 Jul; 34(1):127-38. doi:
10.1093/jac/34.1.127. [PMID: 7961199] - K H Donn, N C James, J R Powell. Bioavailability of cefuroxime axetil formulations.
Journal of pharmaceutical sciences.
1994 Jun; 83(6):842-4. doi:
10.1002/jps.2600830617. [PMID: 9120818] - A E Kornberg, K Sherin, P Veiga, P K Mydlow, J J Collins, L G Feld. Two-day therapy with cefuroxime axetil is effective for urinary tract infections in children.
American journal of nephrology.
1994; 14(3):169-72. doi:
10.1159/000168709. [PMID: 7977475] - H S Brink, R M Huisman, W Geerlings, P E de Jong. Phosphate binders do not reduce bioavailability of oral cefuroxime-axetil in patients on peritoneal dialysis treatment.
Advances in peritoneal dialysis. Conference on Peritoneal Dialysis.
1994; 10(?):179-82. doi:
NULL. [PMID: 7999822] - J Renneberg, O M Christensen, N O Thomsen, C Tørholm. Cefuroxime concentrations in serum, joint fluid and bone in elderly patients undergoing arthroplasty after administration of cefuroxime axetil.
The Journal of antimicrobial chemotherapy.
1993 Nov; 32(5):751-5. doi:
10.1093/jac/32.5.751. [PMID: 8125839] - K Konishi, H Suzuki, M Hayashi, T Saruta. Pharmacokinetics of cefuroxime axetil in patients with normal and impaired renal function.
The Journal of antimicrobial chemotherapy.
1993 Mar; 31(3):413-20. doi:
10.1093/jac/31.3.413. [PMID: 8486575] - R R Chen, T Y Lee, W C Hsieh. Effect of food on pharmacokinetics of cefuroxime axetil in Chinese subjects.
Journal of the Formosan Medical Association = Taiwan yi zhi.
1992 Dec; 91(12):1177-81. doi:
. [PMID: 1363640] - D R Baldwin, J M Andrews, R Wise, D Honeybourne. Bronchoalveolar distribution of cefuroxime axetil and in-vitro efficacy of observed concentrations against respiratory pathogens.
The Journal of antimicrobial chemotherapy.
1992 Sep; 30(3):377-85. doi:
10.1093/jac/30.3.377. [PMID: 1452503] - R M Sudderick, V J Lund, J P Thomson, A McCombe, I S Mackay. An evaluation of the penetration of cefuroxime axetil into human paranasal sinus tissue.
Rhinology.
1992 Mar; 30(1):11-6. doi:
NULL. [PMID: 1579807] - R C Slack. Definition of urinary tract infection and assessment of efficacy in drug trials--a laboratory perspective.
Infection.
1992; 20 Suppl 3(?):S155-6. doi:
10.1007/bf01704359. [PMID: 1490741] - E Bingen, N Lambert-Zechovsky, C Doit, P Duvignaud, D Georges, P Mariani-Kurkdjian. Killing kinetics of cefuroxime axetil against Haemophilus influenzae in an in-vitro model simulating serum concentration profiles after oral administration.
The Journal of antimicrobial chemotherapy.
1991 Oct; 28(4):533-6. doi:
10.1093/jac/28.4.533. [PMID: 1761448] - D A Powell, N C James, M J Ossi, M C Nahata, K H Donn. Pharmacokinetics of cefuroxime axetil suspension in infants and children.
Antimicrobial agents and chemotherapy.
1991 Oct; 35(10):2042-5. doi:
10.1128/aac.35.10.2042. [PMID: 1759825] - N C James, K H Donn, J J Collins, I M Davis, T L Lloyd, R W Hart, J R Powell. Pharmacokinetics of cefuroxime axetil and cefaclor: relationship of concentrations in serum to MICs for common respiratory pathogens.
Antimicrobial agents and chemotherapy.
1991 Sep; 35(9):1860-3. doi:
10.1128/aac.35.9.1860. [PMID: 1952858] - F Kees, U Lukassek, K G Naber, H Grobecker. Comparative investigations on the bioavailability of cefuroxime axetil.
Arzneimittel-Forschung.
1991 Aug; 41(8):843-6. doi:
NULL. [PMID: 1781808] - E Ridgway, K Stewart, G Rai, M C Kelsey, C Bielawska. The pharmacokinetics of cefuroxime axetil in the sick elderly patient.
The Journal of antimicrobial chemotherapy.
1991 May; 27(5):663-8. doi:
10.1093/jac/27.5.663. [PMID: 1885424] - J Haddad, G Isaacson, D S Respler, R W Hart, H M Yilmaz, J J Collins, C D Bluestone. Concentration of cefuroxime in serum and middle ear effusion after single dose treatment with cefuroxime axetil.
The Pediatric infectious disease journal.
1991 Apr; 10(4):294-8. doi:
10.1097/00006454-199104000-00006. [PMID: 2062625] - O Jetlund, E Thurmann-Nielsen, R A Walstad. Comparison of the serum and tissue concentrations of cefuroxime from cefuroxime axetil and phenoxymethylpenicillin in patients undergoing tonsillectomy.
International journal of clinical pharmacology research.
1991; 11(1):1-6. doi:
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Wiener klinische Wochenschrift.
1991; 103(10):306-12. doi:
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Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti.
1990 Oct; 69(10):668-73. doi:
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The Journal of antimicrobial chemotherapy.
1990 Aug; 26(2):261-8. doi:
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The Journal of antimicrobial chemotherapy.
1990 Apr; 25(4):645-50. doi:
10.1093/jac/25.4.645. [PMID: 2351625] - T Morihana, K Inoshita. [Distribution of an antimicrobial agent in oral tissues of rabbit. Cefuroxime axetil].
The Japanese journal of antibiotics.
1990 Apr; 43(4):670-6. doi:
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The Japanese journal of antibiotics.
1990 Feb; 43(2):337-44. doi:
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The Journal of antimicrobial chemotherapy.
1990 Jan; 25(1):83-90. doi:
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The Journal of antimicrobial chemotherapy.
1989 Feb; 23(2):267-73. doi:
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Biopharmaceutics & drug disposition.
1987 Nov; 8(6):519-26. doi:
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Infection.
1987 Jul; 15(4):253-6. doi:
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The Journal of antimicrobial chemotherapy.
1987 Jan; 19(1):109-12. doi:
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The Journal of toxicological sciences.
1986 Nov; 11(4):237-77. doi:
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Antimicrobial agents and chemotherapy.
1985 Oct; 28(4):504-7. doi:
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The Journal of antimicrobial chemotherapy.
1985 Sep; 16(3):359-66. doi:
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British journal of clinical pharmacology.
1984 Oct; 18(4):535-9. doi:
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Antimicrobial agents and chemotherapy.
1984 Mar; 25(3):344-7. doi:
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Antimicrobial agents and chemotherapy.
1984 Jan; 25(1):78-82. doi:
10.1128/aac.25.1.78. [PMID: 6703686]