Methantheline (BioDeep_00000006617)

 

Secondary id: BioDeep_00000614994

human metabolite blood metabolite


代谢物信息卡片


diethyl(methyl)[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium

化学式: C21H26NO3+ (340.1912586000001)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC[N+](C)(CC)CCOC(=O)C1C2=CC=CC=C2OC2=CC=CC=C12
InChI: InChI=1S/C21H26NO3/c1-4-22(3,5-2)14-15-24-21(23)20-16-10-6-8-12-18(16)25-19-13-9-7-11-17(19)20/h6-13,20H,4-5,14-15H2,1-3H3/q+1

描述信息

Methantheline is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Methantheline is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children).
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AB - Synthetic anticholinergics, quaternary ammonium compounds
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists

同义名列表

12 个代谢物同义名

diethyl(methyl)[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium; Methanthelinium bromide; Methantheline Bromide; Methanthine bromide; Banthine bromide; Methanthelinium; Dixamon bromide; Methanthelinum; methantheline; Vagantin; Banthine; MTB 51



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Christian Müller, Jörn Lötsch, Thomas Giessmann, Gerd Franke, Regina Walter, Michael Zschiesche, Werner Siegmund. Relative bioavailability and pharmacodynamic effects of methantheline compared with atropine in healthy subjects. European journal of clinical pharmacology. 2012 Nov; 68(11):1473-81. doi: 10.1007/s00228-012-1286-6. [PMID: 22527350]
  • A Puigvert, D Ruano. [Etiopathogenesis of so-called congenital hydronephrosis]. Journal d'urologie et de nephrologie. 1979 Jan; 85(1-2):1-12. doi: NULL. [PMID: 439196]
  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]
  • F G SMITH, N LITMAN, H LATTA. LUPUS GLOMERULONEPHRITIS. THE EFFECT OF LARGE DOSES OF CORTICOSTEROIDS ON RENAL FUNCTION AND RENAL LESIONS IN TWO CHILDREN. American journal of diseases of children (1960). 1965 Sep; 110(?):302-8. doi: NULL. [PMID: 14332367]
  • C CRAIG, R E GRANT. THE USE OF THE VALSALVA MANOEUVRE IN THE VISUALIZATION OF THE LOWER URETERS DURING INTRAVENOUS PYELOGRAPHY. Journal of the College of Radiologists of Australasia. 1965 Feb; 9(?):83. doi: 10.1111/j.1440-1673.1965.tb00984.x. [PMID: 14292204]
  • M S GROSSMAN. PROLONGED HYPERAMYLASEMIA FOLLOWING ACUTE PANCREATITIS. The American journal of digestive diseases. 1964 Sep; 9(?):618-24. doi: 10.1007/bf02232120. [PMID: 14215811]
  • A R ISAAC. ACUTE PANCREATITIS. Journal of the Royal College of Surgeons of Edinburgh. 1964 Apr; 10(?):225-7. doi: NULL. [PMID: 14148025]
  • J T MCCARTHY, E OSSERMAN, P C LOMBARDO, K TAKATSUKI. AN ABNORMAL SERUM GLOBULIN IN LICHEN MYXEDEMATOSUS. Archives of dermatology. 1964 Mar; 89(?):446-50. doi: 10.1001/archderm.1964.01590270132030. [PMID: 14096371]
  • T MOORE. THE MANAGEMENT OF INCONTINENCE OF URINE IN THE ADULT. The Practitioner. 1964 Mar; 192(?):376-84. doi: NULL. [PMID: 14130834]
  • J L BREEN, R P HATCH, R S DAVIS. ACUTE PANCREATITIS AND PREGNANCY; A CASE REPORT. Western journal of surgery, obstetrics, and gynecology. 1963 Nov; 71(?):269-71. doi: NULL. [PMID: 14081381]
  • C CRAIG, R E GRANT, E GILFORD, D A HUTCHINSON. The use of probanthine in attempts to visualise the lower ureters during intravenous pyelography. Journal of the College of Radiologists of Australasia. 1961 Dec; 5(?):85-7. doi: 10.1111/j.1440-1673.1961.tb03378.x. [PMID: 13881953]
  • F MODICA. [Biological effects of vitamin B4; behavior of agglutinating antibodies and of tributyrinolytic plasma lipase]. Bollettino dell'Istituto sieroterapico milanese. 1959 May; 38(5-6):167-73. doi: NULL. [PMID: 13671124]
  • A L MEENA, J H CONN, H NAUMANN, J D HARDY. Pepsin in gastric physiology: effect of ulcer diathesis, ACTH, histamine, anesthesia-operation, banthine, pilocarpine, epinephrine, and sedation upon blood and urine pepsin levels and upon gastric acidity. Surgical forum. 1957; 7(?):366-70. doi: NULL. [PMID: 13433390]
  • P H FRIEDLANDER. Ambulatory treatment of duodenal ulcers; effects of fruit juice, olive oil, hexamethonium, and methantheline. Lancet (London, England). 1954 Feb; 266(6808):286-9. doi: . [PMID: 13131865]
  • K FISHER, T WINSOR. Control of vagal cardiovascular reflexes during surgery employing beta-diethylaminoethyl xanthene-9-carboxylate methobromide. Anesthesiology. 1953 Nov; 14(6):596-608. doi: 10.1097/00000542-195311000-00009. [PMID: 13105013]