FA 5:0;O (BioDeep_00000629016)

 

Secondary id: BioDeep_00000017754, BioDeep_00000405265

PANOMIX_OTCML-2023


代谢物信息卡片


3-Hydroxy-2-methyl-[S-(R,R)]-butanoic acid

化学式: C5H10O3 (118.06299100000001)
中文名称: 2-羟基-3-甲基丁酸, 3-羟基-2-甲基丁酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.18%

分子结构信息

SMILES: C(=O)(O)C(C)C(O)C
InChI: InChI=1S/C5H10O3/c6-4-2-1-3-5(7)8/h6H,1-4H2,(H,7,8)

描述信息

2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB, which is a naturally occurring neurotransmitter and a psychoactive agent.

同义名列表

31 个代谢物同义名

3-Hydroxy-2-methyl-[S-(R,R)]-butanoic acid; (2R,3R)-3-hydroxy-2-methylbutanoic acid; FA 5:0;O; 3-hydroxy-2-methyl-[R-(R,S)]-butanoic acid; (2S,3R)-3-hydroxy-2-methylbutanoic acid; 2-hydroxy-3-methylbutanoic acid; 2-Hydroxy-3-methylbutyric acid; 3-methyl-4-hydroxy-butanoic acid; 4-hydroxy-isovaleric acid; 3-hydroxy-3-methyl-butanoic acid; 3-hydroxy-isovaleric acid; 3S-hydroxy-2S-methyl-butanoic acid; 3R-hydroxy-2S-methyl-butanoic acid; 2-methyl-3-hydroxy-2-butanoic acid; 2-Methyl-3-hydroxybutyric acid; 2S-hydroxy-3-methyl-butanoic acid; 2-hydroxy-3-methyl-butyric acid; 2-hydroxy-2-methyl-butanoic acid; 2-hydroxy-2-methyl-butyric acid; 2-ethyl-3-hydroxy-propionic acid; 2-ethyl-hydracrylic acid; delta-hydrox yvaleric acid; 5-hydroxy-pentanoic acid; 5-hydroxy valeric acid; 4-hydroxy-pentanoic acid; 4-hydroxy-valeric acid; 3-ethyl hydroxy acrylic acid; 3-hydroxy-pentanoic acid; 3-hydroxy valeric acid; DL-2-hydroxy valeric acid; 2-hydroxy-pentanoic acid



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Chunfeng Lu, Yimei Wang, Zhiguo Sheng, Gang Liu, Ze Fu, Jing Zhao, Jun Zhao, Xianzhong Yan, Benzhan Zhu, Shuangqing Peng. NMR-based metabonomic analysis of the hepatotoxicity induced by combined exposure to PCBs and TCDD in rats. Toxicology and applied pharmacology. 2010 Nov; 248(3):178-84. doi: 10.1016/j.taap.2010.07.020. [PMID: 20691717]
  • Guilhian Leipnitz, Bianca Seminotti, Alexandre U Amaral, Carolina G Fernandes, Carlos S Dutra-Filho, Moacir Wajner. Evidence that 2-methylacetoacetate induces oxidative stress in rat brain. Metabolic brain disease. 2010 Sep; 25(3):261-7. doi: 10.1007/s11011-010-9204-z. [PMID: 20838866]
  • Alexandre Umpierrez Amaral, Guilhian Leipnitz, Carolina Gonçalves Fernandes, Bianca Seminotti, Patrícia Fernanda Schuck, Moacir Wajner. Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain. Brain research. 2010 Apr; 1324(?):75-84. doi: 10.1016/j.brainres.2010.02.018. [PMID: 20153737]
  • V A Khripach, V N Zhabinskiĭ, K V Parkhimovich, O V Gyliakevich. [Synthesis of brassinolide and its biosynthetic precursors using methyl-3-hydroxy-2-methylpropionate]. Bioorganicheskaia khimiia. 2009 Mar; 35(2):260-9. doi: 10.1134/s1068162009020137. [PMID: 19537178]
  • Judit García-Villoria, Aleix Navarro-Sastre, Carme Fons, Celia Pérez-Cerdá, Antonio Baldellou, Miguel Angel Fuentes-Castelló, Inmaculada González, Arturo Hernández-Gonzalez, Cristina Fernández, Jaume Campistol, Carina Delpiccolo, Nuria Cortés, Angel Messeguer, Paz Briones, Antonia Ribes. Study of patients and carriers with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: difficulties in the diagnosis. Clinical biochemistry. 2009 Jan; 42(1-2):27-33. doi: 10.1016/j.clinbiochem.2008.10.006. [PMID: 18996107]
  • Chang Shi, Chun-Qi Wu, An-Min Cao, He-Zhang Sheng, Xian-Zhong Yan, Ming-Yang Liao. NMR-spectroscopy-based metabonomic approach to the analysis of Bay41-4109, a novel anti-HBV compound, induced hepatotoxicity in rats. Toxicology letters. 2007 Sep; 173(3):161-7. doi: 10.1016/j.toxlet.2007.07.010. [PMID: 17826925]
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  • Till Beuerle, Claudine Theuring, Nico Klewer, Stefan Schulz, Thomas Hartmann. Absolute configuration of the creatonotines and callimorphines, two classes of arctiid-specific pyrrolizidine alkaloids. Insect biochemistry and molecular biology. 2007 Jan; 37(1):80-9. doi: 10.1016/j.ibmb.2006.10.005. [PMID: 17175448]
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  • Vilson de Castro Vasques, Fabrício Brinco, Moacir Wajner. Intrahippocampal administration of the branched-chain alpha-hydroxy acids accumulating in maple syrup urine disease compromises rat performance in aversive and non-aversive behavioral tasks. Journal of the neurological sciences. 2005 May; 232(1-2):11-21. doi: 10.1016/j.jns.2004.12.015. [PMID: 15850577]
  • Jörn Oliver Sass, Rosemarie Forstner, Wolfgang Sperl. 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency: impaired catabolism of isoleucine presenting as neurodegenerative disease. Brain & development. 2004 Jan; 26(1):12-4. doi: 10.1016/s0387-7604(03)00071-8. [PMID: 14729408]
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