Ionomycin (BioDeep_00000624838)

   

natural product


代谢物信息卡片


Ionomycin

化学式: C41H72O9 (708.5176062)
中文名称: 离子霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC(=O)O)CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)O
InChI: InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1

描述信息

A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2,5-dimethyloctahydro-2,2-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
D007476 - Ionophores > D061207 - Calcium Ionophores
C254 - Anti-Infective Agent > C258 - Antibiotic
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

Ionomycin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Marion Pardons, Basiel Cole, Laurens Lambrechts, Willem van Snippenberg, Sofie Rutsaert, Ytse Noppe, Nele De Langhe, Annemieke Dhondt, Jerel Vega, Filmon Eyassu, Erik Nijs, Ellen Van Gulck, Daniel Boden, Linos Vandekerckhove. Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir. Nature communications. 2023 Dec; 14(1):8397. doi: 10.1038/s41467-023-44020-5. [PMID: 38110433]
  • Pakize Neslihan Taşlı. Usage of celery root exosome as an immune suppressant; Lipidomic characterization of apium graveolens originated exosomes and its suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. Journal of food biochemistry. 2022 12; 46(12):e14393. doi: 10.1111/jfbc.14393. [PMID: 36181394]
  • Larissa Smulders, Rachel Altman, Carolina Briseno, Alireza Saatchi, Leslie Wallace, Maha AlSebaye, Robert V Stahelin, Nikolas Nikolaidis. Phosphatidylinositol Monophosphates Regulate the Membrane Localization of HSPA1A, a Stress-Inducible 70-kDa Heat Shock Protein. Biomolecules. 2022 06; 12(6):. doi: 10.3390/biom12060856. [PMID: 35740982]
  • Huixian Hong, Fatima Alduraibi, David Ponder, Wayne L Duck, Casey D Morrow, Jeremy B Foote, Trenton R Schoeb, Huma Fatima, Charles O Elson, Hui-Chen Hsu, John D Mountz. Host Genetics But Not Commensal Microbiota Determines the Initial Development of Systemic Autoimmune Disease in BXD2 Mice. Arthritis & rheumatology (Hoboken, N.J.). 2022 04; 74(4):634-640. doi: 10.1002/art.42008. [PMID: 34725967]
  • Daria V Grigorieva, Irina V Gorudko, Natalia A Grudinina, Oleg M Panasenko, Igor V Semak, Alexey V Sokolov, Alexander V Timoshenko. Lactoferrin modified by hypohalous acids: Partial loss in activation of human neutrophils. International journal of biological macromolecules. 2022 Jan; 195(?):30-40. doi: 10.1016/j.ijbiomac.2021.11.165. [PMID: 34863835]
  • Stéphanie Lebreton, Simona Paladino, Dandan Liu, Maria Nitti, Julia von Blume, Paolo Pinton, Chiara Zurzolo. Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 2021 08; 118(33):. doi: 10.1073/pnas.2014709118. [PMID: 34389665]
  • Basiel Cole, Laurens Lambrechts, Pierre Gantner, Ytse Noppe, Noah Bonine, Wojciech Witkowski, Lennie Chen, Sarah Palmer, James I Mullins, Nicolas Chomont, Marion Pardons, Linos Vandekerckhove. In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia. Nature communications. 2021 06; 12(1):3727. doi: 10.1038/s41467-021-24080-1. [PMID: 34140517]
  • Yuka Nagata, Hirokazu Ando, Yohei Sasaki, Ryo Suzuki. Ephedra Herb, Mao, Inhibits Antigen-Induced Mast Cell Degranulation by Induction of the Affinity Receptor for IgE Internalization. Pharmaceutical research. 2021 Apr; 38(4):569-581. doi: 10.1007/s11095-021-03020-0. [PMID: 33754256]
  • Hamza Saidi, Babar Murtaza, Amira Sayed Khan, Elhadj Ahmed Koceir, Aziz Hichami, Naim Akhtar Khan. DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels. Biochimie. 2021 Feb; 181(?):169-175. doi: 10.1016/j.biochi.2020.12.005. [PMID: 33333171]
  • Muhammad N A Sahid, Shuang Liu, Takeshi Kiyoi, Kazutaka Maeyama, Masaki Mogi. Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction. Biological & pharmaceutical bulletin. 2021; 44(12):1902-1906. doi: 10.1248/bpb.b21-00717. [PMID: 34853276]
  • Yufei Mo, Kelvin Kai-Wang To, Runhong Zhou, Li Liu, Tianyu Cao, Haode Huang, Zhenglong Du, Chun Yu Hubert Lim, Lok-Yan Yim, Tsz-Yat Luk, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Owen Tak-Yin Tsang, Anthony Raymond Tam, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Zhiwei Chen. Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients. Frontiers in immunology. 2021; 12(?):799896. doi: 10.3389/fimmu.2021.799896. [PMID: 35095881]
  • Ayako Taima, Atsushi Fukui, Ayano Yamaya, Megumi Yokota, Rie Fukuhara, Yoshihito Yokoyama. A semen-based stimulation method to analyze cytokine production by uterine CD56bright natural killer cells in women with recurrent pregnancy loss. Journal of reproductive immunology. 2020 11; 142(?):103206. doi: 10.1016/j.jri.2020.103206. [PMID: 32957051]
  • Eduard Sarró, Mónica Durán, Ana Rico, Diana Bou-Teen, Vanesa Fernández-Majada, Anthony J Croatt, Karl A Nath, Maria Teresa Salcedo, Justin H Gundelach, Daniel Batlle, Richard J Bram, Anna Meseguer. Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype. Journal of molecular cell biology. 2020 07; 12(7):499-514. doi: 10.1093/jmcb/mjaa005. [PMID: 32162654]
  • Rainer Schreiber, Jiraporn Ousingsawat, Karl Kunzelmann. Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling. International journal of molecular sciences. 2020 Jun; 21(11):. doi: 10.3390/ijms21114065. [PMID: 32517157]
  • Kyle J Horning, Piyush Joshi, Rachana Nitin, Rekha C Balachandran, Frank M Yanko, Kwangho Kim, Plamen Christov, Michael Aschner, Gary A Sulikowski, C David Weaver, Aaron B Bowman. Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese. The Journal of biological chemistry. 2020 03; 295(12):3875-3890. doi: 10.1074/jbc.ra119.009781. [PMID: 32047113]
  • Astrid Fabri, Khalil Kandara, Rémy Coudereau, Morgane Gossez, Paul Abraham, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret, Fabienne Venet. Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study. Frontiers in immunology. 2020; 11(?):615009. doi: 10.3389/fimmu.2020.615009. [PMID: 33613540]
  • Ying Luo, Yalong Xie, Weijie Zhang, Qun Lin, Guoxing Tang, Shiji Wu, Min Huang, Botao Yin, Jin Huang, Wei Wei, Jing Yu, Hongyan Hou, Liyan Mao, Weiyong Liu, Feng Wang, Ziyong Sun. Combination of lymphocyte number and function in evaluating host immunity. Aging. 2019 12; 11(24):12685-12707. doi: 10.18632/aging.102595. [PMID: 31857499]
  • Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned. International journal of molecular sciences. 2019 Oct; 20(21):. doi: 10.3390/ijms20215395. [PMID: 31671916]
  • Natiele Carla da Silva Ferreira, Rômulo José Soares-Bezerra, Rebeca Ferreira Couto da Silveira, Clayton Menezes da Silva, Carla Santos de Oliveira, Andrea Surrage Calheiros, Tânia Maria Alves, Carlos Leomar Zani, Luiz Anastacio Alves. New Insights in Purinergic Therapy: Novel Antagonists for Uridine 5'-Triphosphate-Activated P2Y Receptors from Brazilian Flora. Journal of medicinal food. 2019 Feb; 22(2):211-224. doi: 10.1089/jmf.2018.0087. [PMID: 30526214]
  • Shun Zhang, Shu Xiang, Jinji Yang, Jinyue Shi, Xiaomei Guan, Jianrong Jiang, Yingming Wei, Chan Luo, Deshun Shi, Fenghua Lu. Optimization of parthenogenetic activation of rabbit oocytes and development of rabbit embryo by somatic cell nuclear transfer. Reproduction in domestic animals = Zuchthygiene. 2019 Feb; 54(2):258-269. doi: 10.1111/rda.13344. [PMID: 30220080]
  • Matjaž Stenovec, Eva Lasič, Pia Pužar Dominkuš, Saša Trkov Bobnar, Robert Zorec, Metka Lenassi, Marko Kreft. Slow Release of HIV-1 Protein Nef from Vesicle-like Structures Is Inhibited by Cytosolic Calcium Elevation in Single Human Microglia. Molecular neurobiology. 2019 Jan; 56(1):102-118. doi: 10.1007/s12035-018-1072-2. [PMID: 29679260]
  • Martin Veit, Katharina Isabelle Koyro, Björn Ahrens, Florian Bleibaum, Martin Munz, Hagen Rövekamp, Jörg Andrä, Rainer Schreiber, Karl Kunzelmann, Anselm Sommer, Sucharit Bhakdi, Karina Reiss. Anoctamin-6 regulates ADAM sheddase function. Biochimica et biophysica acta. Molecular cell research. 2018 11; 1865(11 Pt A):1598-1610. doi: 10.1016/j.bbamcr.2018.08.011. [PMID: 30327201]
  • Kyrylo A Pyrshev, Andrey S Klymchenko, Gábor Csúcs, Alexander P Demchenko. Apoptosis and eryptosis: Striking differences on biomembrane level. Biochimica et biophysica acta. Biomembranes. 2018 Jun; 1860(6):1362-1371. doi: 10.1016/j.bbamem.2018.03.019. [PMID: 29573990]
  • Zahir Hussain, Toru Uyama, Katsuhisa Kawai, Smriti Sultana Binte Mustafiz, Kazuhito Tsuboi, Nobukazu Araki, Natsuo Ueda. Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 May; 1863(5):493-502. doi: 10.1016/j.bbalip.2018.02.002. [PMID: 29447909]
  • Anthony R Cillo, Francis Hong, Angela Tsai, Alivelu Irrinki, Jasmine Kaur, Derek D Sloan, Mattie Follen, Romas Geleziunas, Tomas Cihlar, Sandra S Win, Jeffrey P Murry, John W Mellors. Blood biomarkers of expressed and inducible HIV-1. AIDS (London, England). 2018 03; 32(6):699-708. doi: 10.1097/qad.0000000000001748. [PMID: 29334544]
  • Alessandro Zerbini, Francesco Muratore, Luigi Boiardi, Francesco Ciccia, Martina Bonacini, Lucia Belloni, Alberto Cavazza, Luca Cimino, Antonio Moramarco, Riccardo Alessandro, Aroldo Rizzo, Maria Parmeggiani, Carlo Salvarani, Stefania Croci. Increased expression of interleukin-22 in patients with giant cell arteritis. Rheumatology (Oxford, England). 2018 01; 57(1):64-72. doi: 10.1093/rheumatology/kex334. [PMID: 28968695]
  • Chunqiu Liu, Peipei Jiang, Yuanhong Xu, Meijuan Zheng, Jinpin Qiao, Xueyong Zhou, Dake Huang, Maohong Bian. Inhibition of Suicidal Erythrocyte Death by Indirubin-3'-Monoxime. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 45(3):1108-1120. doi: 10.1159/000487352. [PMID: 29439254]
  • Hongyan Hou, Yu Zhou, Jing Yu, Lie Mao, Munyemana Jean Bosco, Juan Wang, Yanfang Lu, Liyan Mao, Xiaohui Wu, Feng Wang, Ziyong Sun. Establishment of the Reference Intervals of Lymphocyte Function in Healthy Adults Based on IFN-γ Secretion Assay upon Phorbol-12-Myristate-13-Acetate/Ionomycin Stimulation. Frontiers in immunology. 2018; 9(?):172. doi: 10.3389/fimmu.2018.00172. [PMID: 29467761]
  • Shigeru Hishinuma, Hiroshi Komazaki, Hayato Tsukamoto, Hirokazu Hatahara, Hiroyuki Fukui, Masaru Shoji. Ca2+ -dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells. Journal of neurochemistry. 2018 01; 144(1):68-80. doi: 10.1111/jnc.14245. [PMID: 29063596]
  • Jung Up Park, Bok Yun Kang, Young Ran Kim. Ethyl Acetate Fraction from Dendropanax morbifera Leaves Increases T Cell Growth by Upregulating NF-AT-Mediated IL-2 Secretion. The American journal of Chinese medicine. 2018; 46(2):453-467. doi: 10.1142/s0192415x18500234. [PMID: 29433394]
  • Heather Freer, Julia M Hillegas, Christine Wimer, Cynthia Baldwin, Joanna LaBresh, Bettina Wagner. A monoclonal antibody for detection of intracellular and secreted interleukin-2 in horses. Veterinary immunology and immunopathology. 2017 Sep; 191(?):30-35. doi: 10.1016/j.vetimm.2017.07.011. [PMID: 28895863]
  • Karina D Hamilton, Peter R Brooks, Steven M Ogbourne, Fraser D Russell. Natural products isolated from Tetragonula carbonaria cerumen modulate free radical-scavenging and 5-lipoxygenase activities in vitro. BMC complementary and alternative medicine. 2017 Apr; 17(1):232. doi: 10.1186/s12906-017-1748-6. [PMID: 28446157]
  • Jia Deng, Dao-Xin Wang, Ai-Ling Liang, Jing Tang, Da-Kai Xiang. Effects of baicalin on alveolar fluid clearance and α-ENaC expression in rats with LPS-induced acute lung injury. Canadian journal of physiology and pharmacology. 2017 Feb; 95(2):122-128. doi: 10.1139/cjpp-2016-0212. [PMID: 27992235]
  • Glaucy Rodrigues de Araújo, Ana Carolina Silveira Rabelo, Janaína Serenato Meira, Joamyr Victor Rossoni-Júnior, William de Castro-Borges, Renata Guerra-Sá, Maurício Azevedo Batista, Denise da Silveira-Lemos, Gustavo Henrique Bianco de Souza, Geraldo Célio Brandão, Míriam Martins Chaves, Daniela Caldeira Costa. Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47 phox phosphorylation of NADPH oxidase in SK Hep-1 cells. Experimental biology and medicine (Maywood, N.J.). 2017 02; 242(3):333-343. doi: 10.1177/1535370216672749. [PMID: 28103717]
  • Ming-Ming Wu, Yu-Jia Zhai, Yu-Xia Li, Qing-Qing Hu, Zhi-Rui Wang, Shi-Peng Wei, Li Zou, Abdel A Alli, Tiffany L Thai, Zhi-Ren Zhang, He-Ping Ma. Hydrogen peroxide suppresses TRPM4 trafficking to the apical membrane in mouse cortical collecting duct principal cells. American journal of physiology. Renal physiology. 2016 12; 311(6):F1360-F1368. doi: 10.1152/ajprenal.00439.2016. [PMID: 27956381]
  • Merril Curry, Sarah J Roberts-Thomson, Gregory R Monteith. PMCA2 silencing potentiates MDA-MB-231 breast cancer cell death initiated with the Bcl-2 inhibitor ABT-263. Biochemical and biophysical research communications. 2016 09; 478(4):1792-7. doi: 10.1016/j.bbrc.2016.09.030. [PMID: 27613092]
  • Jahahreeh Finley. Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1. Medical hypotheses. 2016 Aug; 93(?):34-47. doi: 10.1016/j.mehy.2016.05.012. [PMID: 27372854]
  • Irazú Contreras, Vladimir Paredes-Cervantes, Luis A García-Miranda, Francisco Bernardo Pliego-Rivero, José A Estrada. Leukocyte production of IFN-γ and TNF-α in 8- to 12-y-old children with low serum iron levels. Nutrition (Burbank, Los Angeles County, Calif.). 2016 May; 32(5):546-52. doi: 10.1016/j.nut.2015.11.005. [PMID: 26777439]
  • Jeffrey D Covington, Charmaine S Tam, Sudip Bajpeyi, Jose E Galgani, Robert C Noland, Steven R Smith, Leanne M Redman, Eric Ravussin. Myokine Expression in Muscle and Myotubes in Response to Exercise Stimulation. Medicine and science in sports and exercise. 2016 Mar; 48(3):384-90. doi: 10.1249/mss.0000000000000787. [PMID: 26460627]
  • Robin S B Williams, Clive Bate. An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling. Neuropharmacology. 2016 Feb; 101(?):566-75. doi: 10.1016/j.neuropharm.2015.06.013. [PMID: 26116815]
  • Saki Nakamura, Ayumi Nakanishi, Minami Takazawa, Shunsuke Okihiro, Shiro Urano, Koji Fukui. Ionomycin-induced calcium influx induces neurite degeneration in mouse neuroblastoma cells: analysis of a time-lapse live cell imaging system. Free radical research. 2016; 50(11):1214-1225. doi: 10.1080/10715762.2016.1227074. [PMID: 27573976]
  • Santiago Garcia-Vallvé, Laura Guasch, Sarah Tomas-Hernández, Josep Maria del Bas, Vincent Ollendorff, Lluís Arola, Gerard Pujadas, Miquel Mulero. Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage. Journal of medicinal chemistry. 2015 Jul; 58(14):5381-94. doi: 10.1021/jm501155f. [PMID: 25734377]
  • Tatiana Adasme, Andrea Paula-Lima, Cecilia Hidalgo. Inhibitory ryanodine prevents ryanodine receptor-mediated Ca²⁺ release without affecting endoplasmic reticulum Ca²⁺ content in primary hippocampal neurons. Biochemical and biophysical research communications. 2015 Feb; 458(1):57-62. doi: 10.1016/j.bbrc.2015.01.065. [PMID: 25623539]
  • Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler. Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor. PloS one. 2015; 10(9):e0139212. doi: 10.1371/journal.pone.0139212. [PMID: 26406890]
  • Michisato Okudera, Takahiro Gojoubori, Ichiro Tsujino, Masatake Asano. Effect of ionomycin on interaction of calnexin with vesicular stomatitis virus glycoprotein is cell type-specific. Journal of oral science. 2015; 57(4):305-12. doi: 10.2334/josnusd.57.305. [PMID: 26666853]
  • Guilai Liu, Guoxing Liu, Hong Chen, Kousi Alzoubi, Anja T Umbach, Meinrad Gawaz, Christos Stournaras, Florian Lang. Rapid Upregulation of Orai1 Abundance in the Plasma Membrane of Platelets Following Activation with Thrombin and Collagen Related Peptide. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2015; 37(5):1759-66. doi: 10.1159/000438539. [PMID: 26584277]
  • Jamie H Rosenblum Lichtenstein, Yi-Hsiang Hsu, Igor M Gavin, Thomas C Donaghey, Ramon M Molina, Khristy J Thompson, Chih-Lin Chi, Bruce S Gillis, Joseph D Brain. Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses. PloS one. 2015; 10(5):e0126926. doi: 10.1371/journal.pone.0126926. [PMID: 26010737]
  • Kazunari Okada, Shintaro Sato, Ayuko Sato, Ofer Mandelboim, Tatsuya Yamasoba, Hiroshi Kiyono. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PloS one. 2015; 10(11):e0142920. doi: 10.1371/journal.pone.0142920. [PMID: 26575399]
  • Alan D Marmorstein, Tyson R Kinnick, J Brett Stanton, Adiv A Johnson, Ronald M Lynch, Lihua Y Marmorstein. Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium. Molecular vision. 2015; 21(?):347-59. doi: . [PMID: 25878489]
  • Andrea Ladinig, Joan K Lunney, Carlos J H Souza, Carolyn Ashley, Graham Plastow, John C S Harding. Cytokine profiles in pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome. Veterinary research. 2014 Dec; 45(?):113. doi: 10.1186/s13567-014-0113-8. [PMID: 25479904]
  • Wing-Kee Lee, Thomas Dittmar. Cytosolic calcium measurements in renal epithelial cells by flow cytometry. Journal of visualized experiments : JoVE. 2014 Oct; ?(92):e51857. doi: 10.3791/51857. [PMID: 25407650]
  • Chang-Hoon Cho, Eunju Kim, Young-Sun Lee, Oleg Yarishkin, Jae Cheal Yoo, Jae-Yong Park, Seong-Geun Hong, Eun Mi Hwang. Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death. Molecular brain. 2014 Jul; 7(?):52. doi: 10.1186/s13041-014-0052-3. [PMID: 25047048]
  • Christian Herzog, Randy S Haun, Andreas Ludwig, Sudhir V Shah, Gur P Kaushal. ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A. The Journal of biological chemistry. 2014 May; 289(19):13308-22. doi: 10.1074/jbc.m114.559088. [PMID: 24662289]
  • Hidetaka Kaya, Ryo Nakajima, Megumi Iwano, Masahiro M Kanaoka, Sachie Kimura, Seiji Takeda, Tomoko Kawarazaki, Eriko Senzaki, Yuki Hamamura, Tetsuya Higashiyama, Seiji Takayama, Mitsutomo Abe, Kazuyuki Kuchitsu. Ca2+-activated reactive oxygen species production by Arabidopsis RbohH and RbohJ is essential for proper pollen tube tip growth. The Plant cell. 2014 Mar; 26(3):1069-80. doi: 10.1105/tpc.113.120642. [PMID: 24610725]
  • Peiying Yu, Weixing Han, Van Anthony M Villar, Yu Yang, Quansheng Lu, Hewang Lee, Fengmin Li, Mark T Quinn, John J Gildea, Robin A Felder, Pedro A Jose. Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells. Redox biology. 2014; 2(?):570-9. doi: 10.1016/j.redox.2014.01.020. [PMID: 24688893]
  • Lauryl E Campbell, Jennifer Nelson, Elizabeth Gibbons, Allan M Judd, John D Bell. Membrane properties involved in calcium-stimulated microparticle release from the plasma membranes of S49 lymphoma cells. TheScientificWorldJournal. 2014; 2014(?):537192. doi: 10.1155/2014/537192. [PMID: 24578641]
  • Zhao Zhang, Yun Zhang, Zheng Mou, Shifeng Chu, Xiaoyu Chen, Wenbin He, Xiaofeng Guo, Yuhe Yuan, Masami Takahashi, Naihong Chen. Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. PloS one. 2014; 9(4):e94574. doi: 10.1371/journal.pone.0094574. [PMID: 24718602]
  • Orla Maguire, Kathleen M Tornatore, Kieran L O'Loughlin, Rocco C Venuto, Hans Minderman. Nuclear translocation of nuclear factor of activated T cells (NFAT) as a quantitative pharmacodynamic parameter for tacrolimus. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2013 Dec; 83(12):1096-104. doi: 10.1002/cyto.a.22401. [PMID: 24136923]
  • Micah B Schott, Bryon Grove. Receptor-mediated Ca2+ and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin. Cellular signalling. 2013 Nov; 25(11):2125-35. doi: 10.1016/j.cellsig.2013.07.004. [PMID: 23838009]
  • Wenchao Ai, Haishan Li, Naining Song, Lei Li, Huiming Chen. Optimal method to stimulate cytokine production and its use in immunotoxicity assessment. International journal of environmental research and public health. 2013 Aug; 10(9):3834-42. doi: 10.3390/ijerph10093834. [PMID: 23985769]
  • A Kmit, R van Kruchten, J Ousingsawat, N J A Mattheij, B Senden-Gijsbers, J W M Heemskerk, R Schreiber, E M Bevers, K Kunzelmann. Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents. Cell death & disease. 2013 Apr; 4(?):e611. doi: 10.1038/cddis.2013.135. [PMID: 23618909]
  • R P Kerr, T M Krunkosky, D J Hurley, B S Cummings, S D Holladay, R M Gogal. Lead at 2.5 and 5.0 μM induced aberrant MH-II surface expression through increased MII exocytosis and increased autophagosome formation in Raw 267.4 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2013 Apr; 27(3):1018-24. doi: 10.1016/j.tiv.2013.01.018. [PMID: 23376802]
  • Hanan Elimam, Joan Papillon, Tomoko Takano, Andrey V Cybulsky. Complement-mediated activation of calcium-independent phospholipase A2γ: role of protein kinases and phosphorylation. The Journal of biological chemistry. 2013 Feb; 288(6):3871-85. doi: 10.1074/jbc.m112.396614. [PMID: 23258543]
  • Majed Abed, Siraskar Balasaheb, Syeda Tasneem Towhid, Christoph Daniel, Kerstin Amann, Florian Lang. Adhesion of annexin 7 deficient erythrocytes to endothelial cells. PloS one. 2013; 8(2):e56650. doi: 10.1371/journal.pone.0056650. [PMID: 23437197]
  • Takanobu Sato, Tsunaki Hongu, Megumi Sakamoto, Yuji Funakoshi, Yasunori Kanaho. Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable. Molecular and cellular biology. 2013 Jan; 33(1):136-45. doi: 10.1128/mcb.00869-12. [PMID: 23109426]
  • Jose Raul Gonzalez-Garcia, Zoltan Machaty, F Anthony Lai, Karl Swann. The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs. Journal of cellular physiology. 2013 Jan; 228(1):110-9. doi: 10.1002/jcp.24110. [PMID: 22566126]
  • Marcos Gonzaga dos Santos, Sandra Marcia Muxel, Ricardo Andrade Zampieri, Thomas Günther Pomorski, Lucile Maria Floeter-Winter. Transbilayer dynamics of phospholipids in the plasma membrane of the Leishmania genus. PloS one. 2013; 8(1):e55604. doi: 10.1371/journal.pone.0055604. [PMID: 23383240]
  • Yuemin Tian, Rainer Schreiber, Podchanart Wanitchakool, Patthara Kongsuphol, Marisa Sousa, Inna Uliyakina, Marta Palma, Diana Faria, Alexis E Traynor-Kaplan, José I Fragata, Margarida D Amaral, Karl Kunzelmann. Control of TMEM16A by INO-4995 and other inositolphosphates. British journal of pharmacology. 2013 Jan; 168(1):253-65. doi: 10.1111/j.1476-5381.2012.02193.x. [PMID: 22946960]
  • Anna Majowicz, Sander van der Marel, Anje A te Velde, Sybren L Meijer, Harald Petry, Sander J van Deventer, Valerie Ferreira. Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo. BMC gastroenterology. 2012 Dec; 12(?):172. doi: 10.1186/1471-230x-12-172. [PMID: 23198878]
  • Yuemin Tian, Rainer Schreiber, Karl Kunzelmann. Anoctamins are a family of Ca2+-activated Cl- channels. Journal of cell science. 2012 Nov; 125(Pt 21):4991-8. doi: 10.1242/jcs.109553. [PMID: 22946059]
  • Joshua J Park, Maria V Rubio, Zhihong Zhang, Tae Um, Yuhuan Xie, Stewart M Knoepp, Ashley J Snider, Terra C Gibbs, Kathryn E Meier. Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells. The Prostate. 2012 Nov; 72(15):1595-610. doi: 10.1002/pros.22513. [PMID: 22473839]
  • Marie-Claire Kleinegris, Ger H Koek, Kelly Mast, Eveline H C Mestrom, Jef L N Wolfs, Edouard M Bevers. Ribavirin-induced externalization of phosphatidylserine in erythrocytes is predominantly caused by inhibition of aminophospholipid translocase activity. European journal of pharmacology. 2012 Oct; 693(1-3):1-6. doi: 10.1016/j.ejphar.2012.07.041. [PMID: 22959357]
  • Abdel A Alli, Hui-Fang Bao, Alia A Alli, Yasir Aldrugh, John Z Song, He-Ping Ma, Ling Yu, Otor Al-Khalili, Douglas C Eaton. Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein. American journal of physiology. Renal physiology. 2012 Sep; 303(6):F800-11. doi: 10.1152/ajprenal.00703.2011. [PMID: 22791334]
  • Merril C Curry, Nicole A Luk, Paraic A Kenny, Sarah J Roberts-Thomson, Gregory R Monteith. Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells. The Journal of biological chemistry. 2012 Aug; 287(34):28598-608. doi: 10.1074/jbc.m112.364737. [PMID: 22733819]
  • Laurindo Ferreira da Rocha, Ângela Luzia Branco Pinto Duarte, Andréa Tavares Dantas, Henrique Ataíde Mariz, Ivan da Rocha Pitta, Suely Lins Galdino, Maira Galdino da Rocha Pitta. Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity. The Journal of rheumatology. 2012 Jul; 39(7):1320-5. doi: 10.3899/jrheum.111027. [PMID: 22589261]
  • Alfredo Amoroso, Fabio D'Amico, Maria Consolo, Evangelia Skarmoutsou, Sergio Neri, Umberto Dianzani, Demetrios A Spandidos, Maria Clorinda Mazzarino. Evaluation of circulating CD4+CD25+ and liver-infiltrating Foxp3+ cells in HCV-associated liver disease. International journal of molecular medicine. 2012 Jun; 29(6):983-8. doi: 10.3892/ijmm.2012.947. [PMID: 22446965]
  • Sachie Kimura, Hidetaka Kaya, Tomoko Kawarazaki, Goro Hiraoka, Eriko Senzaki, Masataka Michikawa, Kazuyuki Kuchitsu. Protein phosphorylation is a prerequisite for the Ca2+-dependent activation of Arabidopsis NADPH oxidases and may function as a trigger for the positive feedback regulation of Ca2+ and reactive oxygen species. Biochimica et biophysica acta. 2012 Feb; 1823(2):398-405. doi: 10.1016/j.bbamcr.2011.09.011. [PMID: 22001402]
  • Ganesh V Sangle, Lina M Lauffer, Anthony Grieco, Shivangi Trivedi, Roman Iakoubov, Patricia L Brubaker. Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue. Endocrinology. 2012 Feb; 153(2):564-73. doi: 10.1210/en.2011-1732. [PMID: 22186413]
  • L De Petrocellis, P Orlando, A Schiano Moriello, G Aviello, C Stott, A A Izzo, V Di Marzo. Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta physiologica (Oxford, England). 2012 Feb; 204(2):255-66. doi: 10.1111/j.1748-1716.2011.02338.x. [PMID: 21726418]
  • Alessandro Corti, Maria Franzini, Silvana Cianchetti, Gabriella Bergamini, Evelina Lorenzini, Paola Melotti, Aldo Paolicchi, Pierluigi Paggiaro, Alfonso Pompella. Contribution by polymorphonucleate granulocytes to elevated gamma-glutamyltransferase in cystic fibrosis sputum. PloS one. 2012; 7(4):e34772. doi: 10.1371/journal.pone.0034772. [PMID: 22496859]
  • Angela Vázquez-Calvo, Francisco Sobrino, Miguel A Martín-Acebes. Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus. PloS one. 2012; 7(9):e45172. doi: 10.1371/journal.pone.0045172. [PMID: 23028825]
  • Julien Gibon, Pierre Richaud, Alexandre Bouron. Hyperforin changes the zinc-storage capacities of brain cells. Neuropharmacology. 2011 Dec; 61(8):1321-6. doi: 10.1016/j.neuropharm.2011.08.002. [PMID: 21854792]
  • Adrien Weingärtner, Marcos Gonzaga dos Santos, Björn Drobot, Thomas Günther Pomorski. Ca2+-activated transbilayer movement of plasma membrane phospholipids in Leishmania donovani during ionomycin or thapsigargin stimulation. Molecular and biochemical parasitology. 2011 Oct; 179(2):59-68. doi: 10.1016/j.molbiopara.2011.05.006. [PMID: 21684309]
  • Thang Q Hoang, Christine Rampon, Jean-Marie Freyssinet, Sophie Vriz, Danièle Kerbiriou-Nabias. A method to assess the migration properties of cell-derived microparticles within a living tissue. Biochimica et biophysica acta. 2011 Sep; 1810(9):863-6. doi: 10.1016/j.bbagen.2011.05.003. [PMID: 21609754]
  • Yoshito Ihara, Yoko Inai, Midori Ikezaki. Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin. Journal of cellular biochemistry. 2011 Sep; 112(9):2518-28. doi: 10.1002/jcb.23176. [PMID: 21557298]
  • Melanie S Flint, Raluca A Budiu, Pang-ning Teng, Mai Sun, Donna B Stolz, Megan Lang, Brian L Hood, Anda M Vlad, Thomas P Conrads. Restraint stress and stress hormones significantly impact T lymphocyte migration and function through specific alterations of the actin cytoskeleton. Brain, behavior, and immunity. 2011 Aug; 25(6):1187-96. doi: 10.1016/j.bbi.2011.03.009. [PMID: 21426930]
  • Frederic Cailotto, Pascal Reboul, Sylvie Sebillaud, Patrick Netter, Jean-Yves Jouzeau, Arnaud Bianchi. Calcium input potentiates the transforming growth factor (TGF)-beta1-dependent signaling to promote the export of inorganic pyrophosphate by articular chondrocyte. The Journal of biological chemistry. 2011 Jun; 286(22):19215-28. doi: 10.1074/jbc.m110.175448. [PMID: 21471198]
  • W D Stamer, E A Hoffman, J M Luther, D L Hachey, K L Schey. Protein profile of exosomes from trabecular meshwork cells. Journal of proteomics. 2011 May; 74(6):796-804. doi: 10.1016/j.jprot.2011.02.024. [PMID: 21362503]
  • S F Burn, A Webb, R L Berry, J A Davies, A Ferrer-Vaquer, A K Hadjantonakis, N D Hastie, P Hohenstein. Calcium/NFAT signalling promotes early nephrogenesis. Developmental biology. 2011 Apr; 352(2):288-98. doi: 10.1016/j.ydbio.2011.01.033. [PMID: 21295565]
  • Shunsuke Tanigawa, Honghe Wang, Yili Yang, Nirmala Sharma, Nadya Tarasova, Rieko Ajima, Terry P Yamaguchi, Luis G Rodriguez, Alan O Perantoni. Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism. Developmental biology. 2011 Apr; 352(1):58-69. doi: 10.1016/j.ydbio.2011.01.012. [PMID: 21256838]
  • S O Sage, N Pugh, M J Mason, A G S Harper. Monitoring the intracellular store Ca2+ concentration in agonist-stimulated, intact human platelets by using Fluo-5N. Journal of thrombosis and haemostasis : JTH. 2011 Mar; 9(3):540-51. doi: 10.1111/j.1538-7836.2010.04159.x. [PMID: 21143372]
  • Jangja Hong, Suzue Aoyama, Noriyasu Hirasawa, Okpyo Zee, Kenji Ishihara, Chika Hashida, Michio Kimura, Toshio Seyama, Kazuo Ohuchi. Suppression of intracellular calcium levels and inhibition of degranulation in RBL-2H3 mast cells by the sesquiterpene lactone parthenolide. Planta medica. 2011 Feb; 77(3):252-6. doi: 10.1055/s-0030-1250221. [PMID: 20814853]
  • Yun Rose Li, Hiroaki Matsunami. Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. Science signaling. 2011 Jan; 4(155):ra1. doi: 10.1126/scisignal.2001230. [PMID: 21224444]
  • Lauren M Sparks, Cedric Moro, Barbara Ukropcova, Sudip Bajpeyi, Anthony E Civitarese, Matthew W Hulver, G Hege Thoresen, Arild C Rustan, Steven R Smith. Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes. PloS one. 2011; 6(7):e21068. doi: 10.1371/journal.pone.0021068. [PMID: 21760887]
  • Thomas Bollinger, Anton Leutz, Alexei Leliavski, Ludmila Skrum, Judit Kovac, Luigi Bonacina, Christian Benedict, Tanja Lange, Jürgen Westermann, Henrik Oster, Werner Solbach. Circadian clocks in mouse and human CD4+ T cells. PloS one. 2011; 6(12):e29801. doi: 10.1371/journal.pone.0029801. [PMID: 22216357]
  • Hong He, Pramod N Nehete, Bharti Nehete, Eric Wieder, Guojun Yang, Stephanie Buchl, K Jagannadha Sastry. Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques. PloS one. 2011; 6(5):e19607. doi: 10.1371/journal.pone.0019607. [PMID: 21602924]
  • Neil J Holden, Caroline O S Savage, Stephen P Young, Michael J Wakelam, Lorraine Harper, Julie M Williams. A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis. Molecular medicine (Cambridge, Mass.). 2011; 17(11-12):1242-52. doi: 10.2119/molmed.2011.00028. [PMID: 21833457]
  • Asma Ahmed, Sambuddho Mukherjee, Mukta Deobagkar, Tanushree Naik, Dipankar Nandi. Rapid burst of H2O2 by plant growth regulators increases intracellular Ca2+ amounts and modulates CD4+ T cell activation. International immunopharmacology. 2010 Nov; 10(11):1397-405. doi: 10.1016/j.intimp.2010.08.005. [PMID: 20728597]
  • Masao Sasai, Satoshi Tadokoro, Naohide Hirashima. Artificial exocytotic system that secretes intravesicular contents upon Ca2+ influx. Langmuir : the ACS journal of surfaces and colloids. 2010 Sep; 26(18):14788-92. doi: 10.1021/la102737e. [PMID: 20722459]