bisabolol (BioDeep_00000620310)

PANOMIX_OTCML-2023 Antitumor activity

代谢物信息卡片

alpha,4-Dimethyl-alpha-(4-methyl-3-penten-1-yl)-(alphaR,1R)-3-Cyclohexene-1-methanol

化学式: C15H26O (222.1983546)
中文名称: (±)-α-红没药醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C(C)=C\CC[C@@](O)([C@@H]1CCC(C)=CC1)C
InChI: InChI=1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m0/s1

描述信息

alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells[1][2].
alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells[1][2].

同义名列表

9 个代谢物同义名

alpha-Bisabolol; bisabolol; alpha,4-Dimethyl-alpha-(4-methyl-3-penten-1-yl)-(alphaR,1R)-3-Cyclohexene-1-methanol; (2R)-6-methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol; (+)-(1'R,2R)-alpha-Bisabolol; (+)-6R,7R-alpha-Bisabolol; (+)-alpha-Bisabolol; d-alpha-Bisabolol; (+)-a-Bisabolol

数据库引用编号

8 个数据库交叉引用编号

ChEBI: CHEBI:192031
PubChem: 1549992
Metlin: METLIN91346
ChEMBL: CHEMBL1171719
CAS: 25428-43-7
CAS: 23178-88-3
CAS: 515-69-5
medchemexpress: HY-121222

分类词条

萜类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

42 个相关的物种来源信息

97171 - Abies nephrolepis:
97169 - Abies sibirica: 10.1007/BF00579171
401875 - Artemisia adamsii: 10.1016/S0031-9422(00)83171-4
35608 - Artemisia annua: 10.1007/S11418-007-0175-2
72339 - Artemisia chamaemelifolia: 10.1016/0031-9422(86)80022-X
401898 - Artemisia gmelinii: 10.1016/0031-9422(86)80022-X
205376 - Artemisia santolinifolia: 10.1016/0031-9422(86)80022-X
401941 - Artemisia xanthochroa: 10.1016/0031-9422(90)85307-2
1573918 - Baccharis salicina: 10.1016/0031-9422(90)83041-X
82096 - Eleutherococcus senticosus: 10.1002/PTR.3346
434655 - Eremanthus erythropappus: 10.1016/S0031-9422(00)97763-X
1569399 - Eremanthus incanus: 10.1016/S0031-9422(00)83940-0
102769 - Eupatorium altissimum: 10.1016/S0031-9422(00)81232-7
662815 - Ferula hermonis: 10.1021/NP50068A033
586115 - Gaultheria mucronata: 10.1055/S-2007-969372
630321 - Helichrysum mimetes: 10.1016/S0031-9422(00)81569-1
466206 - Juniperus virginiana var. silicicola: 10.1016/J.PHYTOCHEM.2007.05.030
1745096 - Lasiolaena morii: 10.1016/0031-9422(82)80035-6
594549 - Lychnophora ericoides: 10.1016/J.PHYTOCHEM.2006.08.002
98504 - Matricaria chamomilla: 10.1055/S-2006-962089
13614 - Microbiota decussata:
524508 - Myrrha: -
268884 - Origanum majorana: 10.1055/S-2006-960024
23413 - Osyris lanceolata: 10.1016/J.PHYTOCHEM.2004.05.007
169279 - Osyris quadripartita: 10.1016/J.PHYTOCHEM.2004.05.007
210363 - Osyris wightiana: 10.1016/J.PHYTOCHEM.2004.05.007
40340 - Pellia epiphylla: 10.1016/S0031-9422(97)00414-7
98777 - Phlebia tremellosa: 10.1021/NP050520D
88728 - Pinus koraiensis:
71649 - Pinus pumila: 10.1007/BF00568368
62752 - Pinus sibirica:
425151 - Piper fimbriulatum: 10.1016/S0031-9422(97)00762-0
13216 - Piper nigrum: 10.3390/MOLECULES24234244
33090 - Plants: -
73824 - Populus balsamifera:
1616482 - Populus candicans:
120290 - Psidium guajava: 10.1016/J.PHYTOCHEM.2018.06.006
72971 - Pteronia incana: 10.1016/0031-9422(90)85434-H
453088 - Santalum spicatum: 10.3390/MOLECULES22060940
2502083 - Seseli transcaucasicum: 10.1007/BF00568028
2878271 - Thymus camphoratus: 10.1016/S0031-9422(97)00117-9
19953 - Valeriana officinalis: 10.1016/0031-9422(95)00492-P

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Homa Karami, Mohammad Reza Niavand, Rasool Haddadi, Alireza Noriyan, Seyed Yaser Vafaei. Development of a hydrogel containing bisabolol-loaded nanocapsules for the treatment of atopic dermatitis in a Balb/c mice model. International journal of pharmaceutics. 2024 May; 656(?):124029. doi: 10.1016/j.ijpharm.2024.124029. [PMID: 38527566]
Dhouha Alimi, Manel Hraoui, Azhar Hajri, Wael Taamalli, Slimen Selmi, Hichem Sebai. Bioactivity and molecular docking studies of selected plant compounds. Journal of the science of food and agriculture. 2024 May; 104(7):4391-4399. doi: 10.1002/jsfa.13327. [PMID: 38323805]
Marwa Mohamed Soliman, Yasmin Mohamed Elsaba, M S A Soliman, Eman Zakaria Ahmed. Composition and antimicrobial activity of Rosmarinus officinalis L. and Artemisia monosperma L. leaf essential oils and methanolic extracts from plants grown in normal and saline habitats in Egypt. Scientific reports. 2024 03; 14(1):7342. doi: 10.1038/s41598-024-57301-w. [PMID: 38538682]
Josyelem Tiburtino Leite Chaves, Geovane da Silva Dias, Marina Mariá Pereira, Ludmila da Silva Bastos, Maria Isabel Almeida Souza, Larissa Fonseca Andrade Vieira, Ana Cardoso Clemente Filha Ferreira de Paula, Cláudia Araújo Marco, Paulo Eduardo Ribeiro Marchiori, Elisa Monteze Bicalho. New Perspective on the Use of α-Bisabolol for Weed Control. Journal of agricultural and food chemistry. 2024 Mar; 72(12):6289-6301. doi: 10.1021/acs.jafc.3c08566. [PMID: 38502021]
Carlos Jonnathan Castro-Juárez, Silvia Luna-Suárez, Flor de Fátima Rosas-Cárdenas, Nemesio Villa-Ruano. Hernandulcin Production in Elicited Hairy Roots of Phyla scaberrima: Toward Sustainable Production of a Non-Caloric Sweetener with Nutraceutical Properties. Chemistry & biodiversity. 2024 Mar; 21(3):e202302095. doi: 10.1002/cbdv.202302095. [PMID: 38334300]
Sandra Regina Nunes de Andrade Medeiros, Iverson Conrado Bezerra, Artur José da Silva, Lucas Aleixo Leal Pedroza, Regildo Max Gomes Martins, Ana Maria Henrique Moniz, Ana Cristina Gonçalves Reis de Melo, Weslley Souza Paiva, Priscila Gubert, Antonio Alves de Melo Filho. In Vitro and In Silico Antioxidant Activity and Molecular Characterization of Bauhinia ungulata L. Essential Oil. Chemistry & biodiversity. 2023 Dec; ?(?):e202301536. doi: 10.1002/cbdv.202301536. [PMID: 38090811]
Mahalingam Jeyakumar, Devasahayam Jaya Balan, Chandramohan Kiruthiga, Sakthivel Jafni, Kasi Pandima Devi. α-bisabolol β-d-fucopyranoside (ABFP) ameliorates scopolamine-induced memory deficits through cholinesterase inhibition and attenuation of oxidative stress in zebrafish (Danio rerio). Journal of biochemical and molecular toxicology. 2023 Nov; ?(?):e23580. doi: 10.1002/jbt.23580. [PMID: 37961937]
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Chuansong Zhan, Long Lei, Hao Guo, Shen Zhou, Congping Xu, Zixin Liu, Zichen Wu, Yuan Deng, Yuanyuan Miao, Yu Han, Meng Zhang, Hua Li, Sishu Huang, Chenkun Yang, Feng Zhang, Yufei Li, Ling Liu, Xianqing Liu, Hafiz Muhammad Khalid Abbas, Alisdair R Fernie, Meng Yuan, Jie Luo. Disease resistance conferred by components of essential chrysanthemum oil and the epigenetic regulation of OsTPS1. Science China. Life sciences. 2023 05; 66(5):1108-1118. doi: 10.1007/s11427-022-2241-0. [PMID: 36462108]
Tong-Il Hyeon, Kyung-Sup Yoon. Ethosome Containing Ceramide as a Skin Carrier of Active Ingredients. Current drug delivery. 2023; 20(7):927-942. doi: 10.2174/1567201819666220720123737. [PMID: 35864796]
Vincenzo Ilardi, Giulia D'Agostino, Maurizio Bruno. The chemical composition of the aerial parts essential oil of Achillea cretica L. (Asteraceae) growing wild in Crete (Greece). Natural product research. 2022 Nov; ?(?):1-6. doi: 10.1080/14786419.2022.2148247. [PMID: 36408972]
Seenipandi Arunachalam, M F Nagoor Meeran, Sheikh Azimullah, Niraj Kumar Jha, Dhanya Saraswathiamma, Sandeep Subramanya, Alia Albawardi, Shreesh Ojha. α-Bisabolol Attenuates Doxorubicin Induced Renal Toxicity by Modulating NF-κB/MAPK Signaling and Caspase-Dependent Apoptosis in Rats. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810528. [PMID: 36142441]
Guangxia Li, Huayan Wu, Liqin Sun, Kang Cheng, Zhi Lv, Kaixian Chen, Fei Qian, Yiming Li. (-)-α-Bisabolol Alleviates Atopic Dermatitis by Inhibiting MAPK and NF-κB Signaling in Mast Cell. Molecules (Basel, Switzerland). 2022 Jun; 27(13):. doi: 10.3390/molecules27133985. [PMID: 35807237]
John Staton Laws Iii, Srijan Shrestha, Scott D Smid. Cannabis terpenes display variable protective and anti-aggregatory actions against neurotoxic β amyloid in vitro: highlighting the protective bioactivity of α-bisabolol in motorneuronal-like NSC-34 cells. Neurotoxicology. 2022 05; 90(?):81-87. doi: 10.1016/j.neuro.2022.03.001. [PMID: 35278524]
Lujain Bader Eddin, Niraj Kumar Jha, Sameer N Goyal, Yogeeta O Agrawal, Sandeep B Subramanya, Salim M A Bastaki, Shreesh Ojha. Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol. Nutrients. 2022 Mar; 14(7):. doi: 10.3390/nu14071370. [PMID: 35405982]
Emanuel Paula Magalhães, Brenna Pinheiro Silva, Natália Luna Aires, Lyanna Rodrigues Ribeiro, Arif Ali, Mariana Maciel Cavalcanti, João Victor Serra Nunes, Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Alice Maria Costa Martins. (-)-α-Bisabolol as a protective agent against epithelial renal cytotoxicity induced by amphotericin B. Life sciences. 2022 Feb; 291(?):120271. doi: 10.1016/j.lfs.2021.120271. [PMID: 34974077]
Mary A Egbuta, Shane McIntosh, Daniel L E Waters, Tony Vancov, Lei Liu. In Vitro Anti-Inflammatory Activity of Essential Oil and β-Bisabolol Derived from Cotton Gin Trash. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020526. [PMID: 35056836]
Paula Marchesini, Ari Sérgio de Oliveira Lemos, Ricardo de Oliveira Barbosa Bitencourt, Jéssica Fiorotti, Isabele da Costa Angelo, Rodrigo Luiz Fabri, Lívio Martins Costa-Júnior, Welber Daniel Zaneti Lopes, Vânia Rita Elias Pinheiro Bittencourt, Caio Monteiro. Assessment of lipid profile in fat body and eggs of Rhipicephalus microplus engorged females exposed to (E)-cinnamaldehyde and α-bisabolol, potential acaricide compounds. Veterinary parasitology. 2021 Dec; 300(?):109596. doi: 10.1016/j.vetpar.2021.109596. [PMID: 34695723]
Karoliny C R Almeida, Bruna B Silva, Cassia C F Alves, Tatiana M Vieira, Antônio E M Crotti, João M Souza, Carlos H G Martins, Arthur B Ribeiro, Iara S Squarisi, Denise C Tavares, Laura Dos S Bernabé, Lizandra G Magalhães, Mayker L D Miranda. Biological properties and chemical composition of essential oil from Nectandra megapotamica (Spreng.) Mez. leaves (Lauraceae). Natural product research. 2020 Nov; 34(21):3149-3153. doi: 10.1080/14786419.2019.1608539. [PMID: 31084218]
Hayate Javed, M F Nagoor Meeran, Sheikh Azimullah, Lujain Bader Eddin, Vivek Dhar Dwivedi, Niraj Kumar Jha, Shreesh Ojha. α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease. Biomolecules. 2020 10; 10(10):. doi: 10.3390/biom10101421. [PMID: 33049992]
Sethuraman Sathya, Balakrishnan Shanmuganathan, Kasi Pandima Devi. Deciphering the anti-apoptotic potential of α-bisabolol loaded solid lipid nanoparticles against Aβ induced neurotoxicity in Neuro-2a cells. Colloids and surfaces. B, Biointerfaces. 2020 Jun; 190(?):110948. doi: 10.1016/j.colsurfb.2020.110948. [PMID: 32160583]
Maqsood Ahmed, Qin Peiwen, Zumin Gu, Yuyang Liu, Aatika Sikandar, Dilbar Hussain, Ansar Javeed, Jamil Shafi, Mazher Farid Iqbal, Ran An, Hongxia Guo, Ying Du, Weijing Wang, Yumeng Zhang, Mingshan Ji. Insecticidal activity and biochemical composition of Citrullus colocynthis, Cannabis indica and Artemisia argyi extracts against cabbage aphid (Brevicoryne brassicae L.). Scientific reports. 2020 01; 10(1):522. doi: 10.1038/s41598-019-57092-5. [PMID: 31949220]
Antonella Rigo, Isacco Ferrarini, Erika Lorenzetto, Elena Darra, Irene Liparulo, Christian Bergamini, Cinzia Sissa, Elisabetta Cavalieri, Fabrizio Vinante. BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes. Cell death & disease. 2019 11; 10(12):889. doi: 10.1038/s41419-019-2126-8. [PMID: 31767857]
Alline L B Dias, Hellen R F Batista, Elisângela B B Estevam, Cassia C F Alves, Moacir R Forim, Heloiza D Nicolella, Ricardo A Furtado, Denise C Tavares, Thayna S Silva, Carlos H G Martins, Mayker L D Miranda. Chemical composition and in vitro antibacterial and antiproliferative activities of the essential oil from the leaves of Psidium myrtoides O. Berg (Myrtaceae). Natural product research. 2019 Sep; 33(17):2566-2570. doi: 10.1080/14786419.2018.1457664. [PMID: 29611435]
Paskorn Muangphrom, Momoka Misaki, Munenori Suzuki, Masaya Shimomura, Hideyuki Suzuki, Hikaru Seki, Toshiya Muranaka. Identification and characterization of (+)-α-bisabolol and 7-epi-silphiperfol-5-ene synthases from Artemisia abrotanum. Phytochemistry. 2019 Aug; 164(?):144-153. doi: 10.1016/j.phytochem.2019.05.010. [PMID: 31151061]
Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Dânya Bandeira Lima, Rose Anny Costa Silva, Isabella Evelyn Prado de Azevedo, Emanuel Paula Magalhães, Márcia Machado Marinho, Ricardo Pires Dos Santos, Alice Maria Costa Martins. Involvement of NADPH-oxidase enzyme in the nephroprotective effect of (-)-α-bisabolol on HK2 cells exposed to ischemia - Reoxygenation. European journal of pharmacology. 2019 Jul; 855(?):1-9. doi: 10.1016/j.ejphar.2019.04.044. [PMID: 31047876]
Katyuce Souza Farias, Natália Naomi Kato, Amanda Galdi Boaretto, Juliana Inês Weber, Flávia Roberta Brust, Flávio Macedo Alves, Tiana Tasca, Alexandre José Macedo, Denise Brentan Silva, Carlos Alexandre Carollo. Nectandra as a renewable source for (+)-α-bisabolol, an antibiofilm and anti-Trichomonas vaginalis compound. Fitoterapia. 2019 Jul; 136(?):104179. doi: 10.1016/j.fitote.2019.104179. [PMID: 31121252]
Airin Ghaderi, Ali Sonboli. Chemical composition and antimicrobial activity of the essential oil of Tanacetum walteri (Anthemideae-Asteraceae) from Iran. Natural product research. 2019 Jun; 33(12):1787-1790. doi: 10.1080/14786419.2018.1434640. [PMID: 29405745]
V F Carvalho, L Dos A Ramos, C A da Silva, L Nebo, D Moraes, F F A da Silva, N C A da Costa, R de O Rodrigues Junior, L F de Souza, R M Rodrigues. In vitro anthelmintic activity of Siparuna guianensis extract and essential oil against Strongyloides venezuelensis. Journal of helminthology. 2019 Apr; 94(?):e50. doi: 10.1017/s0022149x19000282. [PMID: 30973122]
Mohamed Fizur Nagoor Meeran, Farah Laham, Sheikh Azimullah, Saeed Tariq, Shreesh Ojha. α-Bisabolol abrogates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and intrinsic pathway of apoptosis in rats. Molecular and cellular biochemistry. 2019 Mar; 453(1-2):89-102. doi: 10.1007/s11010-018-3434-5. [PMID: 30159796]
Madona Khoury, Marc El Beyrouthy, Naïm Ouaini, Véronique Eparvier, Didier Stien. Hirtellina lobelii DC. essential oil, its constituents, its combination with antimicrobial drugs and its mode of action. Fitoterapia. 2019 Mar; 133(?):130-136. doi: 10.1016/j.fitote.2019.01.001. [PMID: 30654130]
Ah-Reum Lee, Moonhyuk Kwon, Min-Kyoung Kang, Jeonghan Kim, Soo-Un Kim, Dae-Kyun Ro. Increased sesqui- and triterpene production by co-expression of HMG-CoA reductase and biotin carboxyl carrier protein in tobacco (Nicotiana benthamiana). Metabolic engineering. 2019 03; 52(?):20-28. doi: 10.1016/j.ymben.2018.10.008. [PMID: 30389612]
Laura Hévila I Leite, Gerlânia O Leite, Bruno Anderson F da Silva, Sacha Aubrey A R Santos, Francisco Ernani A Magalhães, Paula P Menezes, Mairim R Serafini, Claudener S Teixeira, Renan G Brito, Priscila L Santos, José Galberto M da Costa, Adriano A S Araújo, Lucindo J Quintans-Júnior, Irwin R A de Menezes, Henrique Douglas M Coutinho, Adriana Rolim Campos. Molecular mechanism underlying orofacial antinociceptive activity of Vanillosmopsis arborea Baker (Asteraceae) essential oil complexed with β-cyclodextrin. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 55(?):293-301. doi: 10.1016/j.phymed.2018.09.173. [PMID: 30293859]
Nael Abutaha, Fahd A Nasr, Mohammed Al-Zharani, Ali S Alqahtani, Omar M Noman, Mohammed Mubarak, Semlali Abdelhabib, Muhammad A Wadaan. Effects of Hexane Root Extract of Ferula hermonis Boiss. on Human Breast and Colon Cancer Cells: An In Vitro and In Vivo Study. BioMed research international. 2019; 2019(?):3079895. doi: 10.1155/2019/3079895. [PMID: 31380416]
Thierry L Delatte, Giulia Scaiola, Jamil Molenaar, Katyuce de Sousa Farias, Leticia Alves Gomes Albertti, Jacqueline Busscher, Francel Verstappen, Carlos Carollo, Harro Bouwmeester, Jules Beekwilder. Engineering storage capacity for volatile sesquiterpenes in Nicotiana benthamiana leaves. Plant biotechnology journal. 2018 12; 16(12):1997-2006. doi: 10.1111/pbi.12933. [PMID: 29682901]
Jane M Budel, Mei Wang, Vijayasankar Raman, Jianping Zhao, Shabana I Khan, Junaid U Rehman, Natascha Techen, Babu Tekwani, Luciane M Monteiro, Gustavo Heiden, Inês J M Takeda, Paulo V Farago, Ikhlas A Khan. Essential Oils of Five Baccharis Species: Investigations on the Chemical Composition and Biological Activities. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102620. [PMID: 30322067]
Mohamed Fizur Nagoor Meeran, Farah Laham, Hasan Al-Taee, Sheikh Azimullah, Shreesh Ojha. Protective effects of α-bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol-induced myocardial infarction: In vivo and in vitro evidences. Journal of biochemical and molecular toxicology. 2018 Oct; 32(10):e22200. doi: 10.1002/jbt.22200. [PMID: 30088836]
Mehdi Sharifi-Rad, Jolanta Nazaruk, Letizia Polito, Maria Flaviana Bezerra Morais-Braga, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho, Bahare Salehi, Giulia Tabanelli, Chiara Montanari, María Del Mar Contreras, Zubaida Yousaf, William N Setzer, Deepa R Verma, Miquel Martorell, Antoni Sureda, Javad Sharifi-Rad. Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications. Microbiological research. 2018 Oct; 215(?):76-88. doi: 10.1016/j.micres.2018.06.010. [PMID: 30172312]
Soumaya Hajaji, Ines Sifaoui, Atteneri López-Arencibia, María Reyes-Batlle, Ignacio A Jiménez, Isabel L Bazzocchi, Basilio Valladares, Hafidh Akkari, Jacob Lorenzo-Morales, José E Piñero. Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil. Parasitology research. 2018 Sep; 117(9):2855-2867. doi: 10.1007/s00436-018-5975-7. [PMID: 29955971]
Mina Yarazavi, Ebrahim Noroozian. A novel sorbent based on carbon nanotube/amino-functionalized sol-gel for the headspace solid-phase microextraction of α-bisabolol from medicinal plant samples using experimental design. Journal of separation science. 2018 May; 41(10):2229-2236. doi: 10.1002/jssc.201700993. [PMID: 29436123]
Katyuce de S Farias, Thierry Delatte, Rosani do C de O Arruda, Flavio M Alves, Denise B Silva, Jules Beekwilder, Carlos A Carollo. In depth investigation of the metabolism of Nectandra megapotamica chemotypes. PloS one. 2018; 13(8):e0201996. doi: 10.1371/journal.pone.0201996. [PMID: 30080887]
Shirlley F M da Luz, Lydia F Yamaguchi, Massuo J Kato, Oriel F de Lemos, Luciana P Xavier, José Guilherme S Maia, Alessandra de R Ramos, William N Setzer, Joyce Kelly do R da Silva. Secondary Metabolic Profiles of Two Cultivars of Piper nigrum (Black Pepper) Resulting from Infection by Fusarium solani f. sp. piperis. International journal of molecular sciences. 2017 Dec; 18(12):. doi: 10.3390/ijms18122434. [PMID: 29215548]
Lars-Gernot Otto, Prodyut Mondal, Jonathan Brassac, Susanne Preiss, Jörg Degenhardt, Sang He, Jochen Christoph Reif, Timothy Francis Sharbel. Use of genotyping-by-sequencing to determine the genetic structure in the medicinal plant chamomile, and to identify flowering time and alpha-bisabolol associated SNP-loci by genome-wide association mapping. BMC genomics. 2017 08; 18(1):599. doi: 10.1186/s12864-017-3991-0. [PMID: 28797221]
Laura Scalvenzi, Alessandro Grandini, Antonella Spagnoletti, Massimo Tacchini, David Neill, José Luis Ballesteros, Gianni Sacchetti, Alessandra Guerrini. Myrcia splendens (Sw.) DC. (syn. M. fallax (Rich.) DC.) (Myrtaceae) Essential Oil from Amazonian Ecuador: A Chemical Characterization and Bioactivity Profile. Molecules (Basel, Switzerland). 2017 Jul; 22(7):. doi: 10.3390/molecules22071163. [PMID: 28704964]
Soumaya Hajaji, Ines Sifaoui, Atteneri López-Arencibia, María Reyes-Batlle, Basilio Valladares, José E Pinero, Jacob Lorenzo-Morales, Hafidh Akkari. Amoebicidal activity of α-bisabolol, the main sesquiterpene in chamomile (Matricaria recutita L.) essential oil against the trophozoite stage of Acanthamoeba castellani Neff. Acta parasitologica. 2017 Jun; 62(2):290-295. doi: 10.1515/ap-2017-0036. [PMID: 28426414]
Salvatore Chirumbolo, Geir Bjørklund. The sesquiterpene α-bisabolol in the adipocyte-cancer desmoplastic crosstalk: does it have an action on epithelial-mesenchymal transition mechanisms?. International journal of clinical oncology. 2017 Apr; 22(2):222-228. doi: 10.1007/s10147-016-1072-z. [PMID: 27942879]
Franciane Brackmann Mendes, Letícia Scussel Bergamin, Cristiane Dos Santos Stuepp, Elizandra Braganhol, Thatiana Terroso, Adriana Rafin Pohlmann, Sílvia Stanisçuaski Guterres, Ana Maria Oliveira Battastini. Alpha-bisabolol Promotes Glioma Cell Death by Modulating the Adenosinergic System. Anticancer research. 2017 04; 37(4):1819-1823. doi: 10.21873/anticanres.11516. [PMID: 28373446]
Mashael Marzouq AlShebly, Fatma Saeed AlQahtani, Marimuthu Govindarajan, Kasi Gopinath, Periasamy Vijayan, Giovanni Benelli. Toxicity of ar-curcumene and epi-β-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors. Ecotoxicology and environmental safety. 2017 Mar; 137(?):149-157. doi: 10.1016/j.ecoenv.2016.11.028. [PMID: 27918946]
Tiago J T de Souza, Sérgio A L Bordignon, Miriam A Apel. A Chemometrics Approach to the Investigation of the Intraspecific Variability of the Volatile Oil of Eupatorium tremulum from Southern Brazil. Journal of natural products. 2017 01; 80(1):45-52. doi: 10.1021/acs.jnatprod.6b00313. [PMID: 28098995]
Ana Paula L D'Almeida, Maria T Pacheco de Oliveira, Éverton T de Souza, Diego de Sá Coutinho, Bianca T Ciambarella, Cristiano R Gomes, Thatiana Terroso, Sílvia S Guterres, Adriana R Pohlmann, Patrícia Mr Silva, Marco A Martins, Andressa Bernardi. α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International journal of nanomedicine. 2017; 12(?):4479-4491. doi: 10.2147/ijn.s130798. [PMID: 28684908]
Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Marcus Felipe Bezerra da Costa, Gdayllon Cavalcante Meneses, Mauren Cristina Villalta Arrieta, Adriano José Maia Chaves Filho, Glayciane Bezerra de Morais, Alexandre Braga Libório, Renata Sousa Alves, Janaína Serra Azul Monteiro Evangelista, Alice Maria Costa Martins. Nephroprotective effects of (-)-α-bisabolol against ischemic-reperfusion acute kidney injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Dec; 23(14):1843-1852. doi: 10.1016/j.phymed.2016.11.008. [PMID: 27912887]
Matheus D Baldissera, Thirssa H Grando, Carine F de Souza, Luciana F Cossetin, Ana P T da Silva, Janince L Giongo, Silvia G Monteiro. A nanotechnology based new approach for Trypanosoma evansi chemotherapy: In vitro and vivo trypanocidal effect of (-)-α-bisabolol. Experimental parasitology. 2016 Nov; 170(?):156-160. doi: 10.1016/j.exppara.2016.09.018. [PMID: 27693361]
Raquel Rodríguez-Solana, Laura Vázquez-Araújo, José Manuel Salgado, José Manuel Domínguez, Sandra Cortés-Diéguez. Optimization of the process of aromatic and medicinal plant maceration in grape marc distillates to obtain herbal liqueurs and spirits. Journal of the science of food and agriculture. 2016 Nov; 96(14):4760-4771. doi: 10.1002/jsfa.7822. [PMID: 27235102]
V Corpas-López, G Merino-Espinosa, V Díaz-Sáez, F Morillas-Márquez, M C Navarro-Moll, J Martín-Sánchez. The sesquiterpene (-)-α-bisabolol is active against the causative agents of Old World cutaneous leishmaniasis through the induction of mitochondrial-dependent apoptosis. Apoptosis : an international journal on programmed cell death. 2016 10; 21(10):1071-81. doi: 10.1007/s10495-016-1282-x. [PMID: 27539477]
Rosana S S Barreto, Jullyana S S Quintans, Ruthy K L Amarante, Tainá S Nascimento, Rosana S Amarante, André S Barreto, Erik W M Pereira, Marcelo C Duarte, Henrique D M Coutinho, Irwin R A Menezes, Gokhan Zengin, Abdurrahman Aktumsek, Lucindo J Quintans-Júnior. Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice. Journal of ethnopharmacology. 2016 Sep; 191(?):9-18. doi: 10.1016/j.jep.2016.06.022. [PMID: 27292196]
Omar J Mohammed, Roseanna McAlpine, Phasawee Chiewhatpong, Muhammad Liaque Latif, Margaret K Pratten. Assessment of developmental cardiotoxic effects of some commonly used phytochemicals in mouse embryonic D3 stem cell differentiation and chick embryonic cardiomyocyte micromass culture models. Reproductive toxicology (Elmsford, N.Y.). 2016 09; 64(?):86-97. doi: 10.1016/j.reprotox.2016.04.011. [PMID: 27105832]
Paskorn Muangphrom, Hikaru Seki, Munenori Suzuki, Aya Komori, Mika Nishiwaki, Ryota Mikawa, Ery Odette Fukushima, Toshiya Muranaka. Functional Analysis of Amorpha-4,11-Diene Synthase (ADS) Homologs from Non-Artemisinin-Producing Artemisia Species: The Discovery of Novel Koidzumiol and (+)-α-Bisabolol Synthases. Plant & cell physiology. 2016 Aug; 57(8):1678-88. doi: 10.1093/pcp/pcw094. [PMID: 27273626]
Antonella Rigo, Fabrizio Vinante. The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes. Apoptosis : an international journal on programmed cell death. 2016 08; 21(8):917-27. doi: 10.1007/s10495-016-1257-y. [PMID: 27278818]
Syn Kok Yeo, Ahmed Y Ali, Olivia A Hayward, Daniel Turnham, Troy Jackson, Ifor D Bowen, Richard Clarkson. β-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytotherapy research : PTR. 2016 Mar; 30(3):418-25. doi: 10.1002/ptr.5543. [PMID: 26666387]
Rajesh K Joshi. Leucas aspera (Willd.) Link Essential Oil from India: β-Caryophyllene and 1-Octen-3-ol Chemotypes. Journal of chromatographic science. 2016 Mar; 54(3):295-8. doi: 10.1093/chromsci/bmv173. [PMID: 26620424]
Masanori Uno, Toshio Kokuryo, Yukihiro Yokoyama, Takeshi Senga, Masato Nagino. α-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation. Anticancer research. 2016 Feb; 36(2):583-9. doi: . [PMID: 26851012]
Mitsuo Miyazawa, Seiji Yoshinaga, Yusei Kashima, Hiroshi Nakahashi, Nobuyuki Hara, Hiroki Nakagawa, Atsushi Usami. Chemical Composition and Characteristic Odor Compounds in Essential Oil from Alismatis Rhizoma (Tubers of Alisma orientale). Journal of oleo science. 2016; 65(1):91-7. doi: 10.5650/jos.ess15176. [PMID: 26666273]
Sebastiano Pantò, Danilo Sciarrone, Mariarosa Maimone, Carla Ragonese, Salvatore Giofrè, Paola Donato, Sara Farnetti, Luigi Mondello. Performance evaluation of a versatile multidimensional chromatographic preparative system based on three-dimensional gas chromatography and liquid chromatography-two-dimensional gas chromatography for the collection of volatile constituents. Journal of chromatography. A. 2015 Oct; 1417(?):96-103. doi: 10.1016/j.chroma.2015.09.039. [PMID: 26410184]
S Nurulain, T Prytkova, A M Sultan, O Ievglevskyi, D Lorke, K-H S Yang, G Petroianu, F C Howarth, N Kabbani, M Oz. Inhibitory actions of bisabolol on α7-nicotinic acetylcholine receptors. Neuroscience. 2015 Oct; 306(?):91-9. doi: 10.1016/j.neuroscience.2015.08.019. [PMID: 26283025]
Laura Gheucă Solovăstru, Alina Stîncanu, Alessia De Ascentii, Guido Capparé, Paolo Mattana, Dan Vâţă. Randomized, controlled study of innovative spray formulation containing ozonated oil and α-bisabolol in the topical treatment of chronic venous leg ulcers. Advances in skin & wound care. 2015 Sep; 28(9):406-9. doi: 10.1097/01.asw.0000470155.29821.ed. [PMID: 26280699]
Jessie Moniodis, Christopher G Jones, E Liz Barbour, Julie A Plummer, Emilio L Ghisalberti, Joerg Bohlmann. The transcriptome of sesquiterpenoid biosynthesis in heartwood xylem of Western Australian sandalwood (Santalum spicatum). Phytochemistry. 2015 May; 113(?):79-86. doi: 10.1016/j.phytochem.2014.12.009. [PMID: 25624157]
Mariana Margatto Rottini, Ana Claudia Fernandes Amaral, Jose Luiz Pinto Ferreira, Jefferson Rocha de Andrade Silva, Noemi Nosomi Taniwaki, Celeste da Silva Freitas de Souza, Luiz Ney d'Escoffier, Fernando Almeida-Souza, Daiana de Jesus Hardoim, Sylvio Celso Gonçalves da Costa, Kátia da Silva Calabrese. In vitro evaluation of (-)α-bisabolol as a promising agent against Leishmania amazonensis. Experimental parasitology. 2015 Jan; 148(?):66-72. doi: 10.1016/j.exppara.2014.10.001. [PMID: 25448354]
Akbar Karami, Nematollah Dehghan-Mashtani. Composition of the essential oil of Stachys benthamiana Boiss. from the south of Iran. Natural product research. 2015; 29(15):1473-6. doi: 10.1080/14786419.2014.1003185. [PMID: 25605295]
Elwira Sieniawska, Marta Swatko-Ossor, Rafał Sawicki, Grażyna Ginalska. Morphological Changes in the Overall Mycobacterium tuberculosis H37Ra Cell Shape and Cytoplasm Homogeneity due to Mutellina purpurea L. Essential Oil and Its Main Constituents. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2015; 24(6):527-32. doi: 10.1159/000439351. [PMID: 26381133]
Young-Jin Son, Moonhyuk Kwon, Dae-Kyun Ro, Soo-Un Kim. Enantioselective microbial synthesis of the indigenous natural product (-)-α-bisabolol by a sesquiterpene synthase from chamomile (Matricaria recutita). The Biochemical journal. 2014 Oct; 463(2):239-48. doi: 10.1042/bj20140306. [PMID: 25048207]
Maja Tomić, Višnja Popović, Silvana Petrović, Radica Stepanović-Petrović, Ana Micov, Milica Pavlović-Drobac, Maria Couladis. Antihyperalgesic and antiedematous activities of bisabolol-oxides-rich matricaria oil in a rat model of inflammation. Phytotherapy research : PTR. 2014 May; 28(5):759-66. doi: 10.1002/ptr.5057. [PMID: 23983133]
Anil K Maurya, Monika Singh, Vijaya Dubey, Suchita Srivastava, Suaib Luqman, Dnyaneshwar U Bawankule. α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. Current pharmaceutical biotechnology. 2014; 15(2):173-81. doi: 10.2174/1389201015666140528152946. [PMID: 24894548]
Djamila Merghache, Zahia Boucherit-Otmani, Salima Merghache, Ilyas Chikhi, Chaouki Selles, Kebir Boucherit. Chemical composition, antibacterial, antifungal and antioxidant activities of Algerian Eryngium tricuspidatum L. essential oil. Natural product research. 2014; 28(11):795-807. doi: 10.1080/14786419.2014.883392. [PMID: 24559136]
Sandeep B Rajput, S Mohan Karuppayil. Small molecules inhibit growth, viability and ergosterol biosynthesis in Candida albicans. SpringerPlus. 2013 Dec; 2(1):26. doi: 10.1186/2193-1801-2-26. [PMID: 23449869]
Mohamed Attia, Soo-Un Kim, Dae-Kyun Ro. Molecular cloning and characterization of (+)-epi-α-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis. Archives of biochemistry and biophysics. 2012 Nov; 527(1):37-44. doi: 10.1016/j.abb.2012.07.010. [PMID: 22867794]
Christine Tschiggerl, Franz Bucar. Guaianolides and volatile compounds in chamomile tea. Plant foods for human nutrition (Dordrecht, Netherlands). 2012 Jun; 67(2):129-35. doi: 10.1007/s11130-012-0277-1. [PMID: 22410959]
Magaly L Mota, Lis Tavares Coelho Lobo, José M Galberto da Costa, Leandro S Costa, Hugo A O Rocha, Luiz F Rocha e Silva, Adrian M Pohlit, Valter F de Andrade Neto. In vitro and in vivo antimalarial activity of essential oils and chemical components from three medicinal plants found in northeastern Brazil. Planta medica. 2012 May; 78(7):658-64. doi: 10.1055/s-0031-1298333. [PMID: 22441836]
Maria del Carmen Romero, Adela Valero, Joaquina Martín-Sánchez, María Concepción Navarro-Moll. Activity of Matricaria chamomilla essential oil against anisakiasis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Apr; 19(6):520-3. doi: 10.1016/j.phymed.2012.02.005. [PMID: 22397992]
Ozgür Devrim Can, Umide Demir Özkay, Hülya Tuba Kıyan, Betül Demirci. Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Feb; 19(3-4):306-10. doi: 10.1016/j.phymed.2011.10.001. [PMID: 22070986]
Seyed Mehdi Razavi. Chemical and allelopathic analyses of essential oils of Prangos pabularia Lindl. from Iran. Natural product research. 2012; 26(22):2148-51. doi: 10.1080/14786419.2011.633079. [PMID: 22117109]
Maryam Yousefi, Somayyeh Gandomkar, Zohreh Habibi. Essential oil from aerial parts of of Betonica grandiflora Willd. from Iran. Natural product research. 2012; 26(2):146-51. doi: 10.1080/14786419.2010.534992. [PMID: 21809955]
Massimiliano Bonifacio, Antonella Rigo, Emanuele Guardalben, Christian Bergamini, Elisabetta Cavalieri, Romana Fato, Giovanni Pizzolo, Hisanori Suzuki, Fabrizio Vinante. α-bisabolol is an effective proapoptotic agent against BCR-ABL(+) cells in synergism with Imatinib and Nilotinib. PloS one. 2012; 7(10):e46674. doi: 10.1371/journal.pone.0046674. [PMID: 23056396]
Takashi Seki, Toshio Kokuryo, Yukihiro Yokoyama, Hisanori Suzuki, Keita Itatsu, Akifumi Nakagawa, Tetsushi Mizutani, Takashi Miyake, Masanori Uno, Kohei Yamauchi, Masato Nagino. Antitumor effects of α-bisabolol against pancreatic cancer. Cancer science. 2011 Dec; 102(12):2199-205. doi: 10.1111/j.1349-7006.2011.02082.x. [PMID: 21883695]
Nayrton Flávio Moura Rocha, Gersilene Valente de Oliveira, Fernanda Yvelize Ramos de Araújo, Emiliano Ricardo Vasconcelos Rios, Alyne Mara Rodrigues Carvalho, Leonardo Freire Vasconcelos, Danielle Silveira Macêdo, Pedro Marcos Gomes Soares, Damião Pergentino De Sousa, Francisca Cléa Florenço de Sousa. (-)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2011 Nov; 44(4):455-61. doi: 10.1016/j.ejps.2011.08.020. [PMID: 21924353]
Abdel-Hadi Al-Ja'fari, Roser Vila, Blanca Freixa, Felix Tomi, Joseph Casanova, Joan Costa, Salvador Cañigueral. Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis. Phytochemistry. 2011 Aug; 72(11-12):1406-13. doi: 10.1016/j.phytochem.2011.04.013. [PMID: 21609848]
Elisabetta Cavalieri, Antonella Rigo, Massimiliano Bonifacio, Alessandra Carcereri de Prati, Emanuele Guardalben, Christian Bergamini, Romana Fato, Giovanni Pizzolo, Hisanori Suzuki, Fabrizio Vinante. Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells. Journal of translational medicine. 2011 Apr; 9(?):45. doi: 10.1186/1479-5876-9-45. [PMID: 21510902]
Seyed Mehdi Razavi, Hossein Nazemiyeh, Abbas Delazar, Solmaz Asnaashari, Rogaieh Hajiboland, Satyajit D Sarker, Yadollah Omidi. Chemical variation of the essential oil of Prangos uloptera DC. at different stages of growth. Natural product research. 2011 Apr; 25(7):663-8. doi: 10.1080/14786410802270811. [PMID: 19606386]
Gerlânia de O Leite, Laura H I Leite, Renata de S Sampaio, Mariana Késsia A Araruna, Irwin Rose A de Menezes, José Galberto M da Costa, Adriana R Campos. (-)-α-Bisabolol attenuates visceral nociception and inflammation in mice. Fitoterapia. 2011 Mar; 82(2):208-11. doi: 10.1016/j.fitote.2010.09.012. [PMID: 20875845]
Jaouad Anter, Magdalena Romero-Jiménez, Zahira Fernández-Bedmar, Myriam Villatoro-Pulido, Mohamed Analla, Angeles Alonso-Moraga, Andrés Muñoz-Serrano. Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid. Journal of medicinal food. 2011 Mar; 14(3):276-83. doi: 10.1089/jmf.2010.0139. [PMID: 21182433]
Marziyeh Tolouee, Soheil Alinezhad, Reza Saberi, Ali Eslamifar, Seyed Javad Zad, Kamkar Jaimand, Jaleh Taeb, Mohammad-Bagher Rezaee, Masanobu Kawachi, Masoomeh Shams-Ghahfarokhi, Mehdi Razzaghi-Abyaneh. Effect of Matricaria chamomilla L. flower essential oil on the growth and ultrastructure of Aspergillus niger van Tieghem. International journal of food microbiology. 2010 May; 139(3):127-33. doi: 10.1016/j.ijfoodmicro.2010.03.032. [PMID: 20385420]
Lucia Magnelli, Riccardo Caldini, Nicola Schiavone, Hisanori Suzuki, Marta Chevanne. Differentiating and apoptotic dose-dependent effects in (-)-alpha-bisabolol-treated human endothelial cells. Journal of natural products. 2010 Apr; 73(4):523-6. doi: 10.1021/np9003933. [PMID: 20364847]
Roser Vila, Ana Isabel Santana, Renato Pérez-Rosés, Anayansi Valderrama, M Victoria Castelli, Sergio Mendonca, Susana Zacchino, Mahabir P Gupta, Salvador Cañigueral. Composition and biological activity of the essential oil from leaves of Plinia cerrocampanensis, a new source of alpha-bisabolol. Bioresource technology. 2010 Apr; 101(7):2510-4. doi: 10.1016/j.biortech.2009.11.021. [PMID: 20015638]
Carmen Formisano, Daniela Rigano, Felice Senatore, Gian Carlo Tenore, Maurizio Bruno, Franco Piozzi. Volatile compounds of flowers and leaves of Sideritis italica (Miller) Greuter et Burdet (Lamiaceae), a plant used as mountain tea. Natural product research. 2010 Apr; 24(7):640-6. doi: 10.1080/14786410902951203. [PMID: 20401796]
Aron de Miranda H Alves, Juan Carlos R Gonçalves, Jader Santos Cruz, Demetrius Antônio M Araújo. Evaluation of the sesquiterpene (-)-alpha-bisabolol as a novel peripheral nervous blocker. Neuroscience letters. 2010 Mar; 472(1):11-5. doi: 10.1016/j.neulet.2010.01.042. [PMID: 20105451]
M Morales-Yuste, F Morillas-Márquez, J Martín-Sánchez, A Valero-López, M C Navarro-Moll. Activity of (-)alpha-bisabolol against Leishmania infantum promastigotes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Mar; 17(3-4):279-81. doi: 10.1016/j.phymed.2009.05.019. [PMID: 19577452]
Visnja Popović, Silvana Petrović, Milica Pavlović, Marina Milenković, Maria Couladis, Olga Tzakou, Semija Duraki, Marjan Niketić. Essential oil from the underground parts of Laserpitium zernyi: potential source of alpha-bisabolol and its antimicrobial activity. Natural product communications. 2010 Feb; 5(2):307-10. doi: ". [PMID: 20334149]
Kathryn Russell, Sharon E Jacob. Bisabolol. Dermatitis : contact, atopic, occupational, drug. 2010 Jan; 21(1):57-8. doi: . [PMID: 20137740]
Sharon E Jacob, Jessica W Hsu. Reactions to Aquaphor: is bisabolol the culprit?. Pediatric dermatology. 2010 Jan; 27(1):103-4. doi: 10.1111/j.1525-1470.2009.01064.x. [PMID: 20199429]
S B Bezerra, L K A M Leal, N A P Nogueira, N A N Pinto, A R Campos. Bisabolol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide, and KATP+ channels. Journal of medicinal food. 2009 Dec; 12(6):1403-6. doi: 10.1089/jmf.2008.0290. [PMID: 20041801]