Pomolic acid (BioDeep_00000619510)

Main id: BioDeep_00000396786

 

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

化学式: C30H48O4 (472.3552408)
中文名称: 坡模酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1(C)O)C)C(=O)O
InChI: InChI=1S/C30H48O4/c1-18-10-15-30(24(32)33)17-16-27(5)19(23(30)29(18,7)34)8-9-21-26(4)13-12-22(31)25(2,3)20(26)11-14-28(21,27)6/h8,18,20-23,31,34H,9-17H2,1-7H3,(H,32,33)/t18-,20+,21-,22+,23-,26+,27-,28-,29-,30+/m1/s1

描述信息

Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from?Euscaphis japonica?(Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from?Euscaphis japonica?(Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].

同义名列表

12 个代谢物同义名

(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3.beta.)-; NCI60_024874; Pomolic acid; AIDS-070281; AIDS070281; 13849-91-7; NSC670661; 3beta,19-Dihydroxy-5alpha-urs-12-en-28-oic acid; 1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; Randialic acid A; Benthamic acid



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huiqiang Wei, Jianghong Guo, Xiao Sun, Wenfeng Gou, Hongxin Ning, Haihua Shang, Qiang Liu, Wenbin Hou, Yiliang Li. Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study. Journal of natural products. 2022 05; 85(5):1248-1255. doi: 10.1021/acs.jnatprod.1c01166. [PMID: 35500202]
  • Feilong Chen, Dong-Li Liu, Wei Wang, Xiao-Man Lv, Weixi Li, Li-Dong Shao, Wen-Jing Wang. Bioactive triterpenoids from Sambucus javanica Blume. Natural product research. 2020 Oct; 34(19):2816-2821. doi: 10.1080/14786419.2019.1596092. [PMID: 30968700]
  • Yan-Gang Cao, Yan-Li Zhang, Meng-Nan Zeng, Man Qi, Ying-Jie Ren, Yan-Ling Liu, Xuan Zhao, Xiao-Ke Zheng, Wei-Sheng Feng. Renoprotective Mono- and Triterpenoids from the Fruit of Gardenia jasminoides. Journal of natural products. 2020 04; 83(4):1118-1130. doi: 10.1021/acs.jnatprod.9b01119. [PMID: 32141747]
  • Ji-Hyun Park, Kyung Mi Jang, Hyun Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Byoungduck Park, Kwan-Kyu Park. Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways. Molecules (Basel, Switzerland). 2018 Sep; 23(9):. doi: 10.3390/molecules23092236. [PMID: 30177595]
  • Tian-Hang Li, Hong-Xia Yan. Antitumor‑ and apoptosis‑inducing effects of pomolic acid against SK‑MEL‑2 human malignant melanoma cells are mediated via inhibition of cell migration and sub‑G1 cell cycle arrest. Molecular medicine reports. 2018 Jan; 17(1):1035-1040. doi: 10.3892/mmr.2017.7977. [PMID: 29115486]
  • Vijay P Sonar, Angela Corona, Simona Distinto, Elias Maccioni, Rita Meleddu, Benedetta Fois, Costantino Floris, Nilesh V Malpure, Stefano Alcaro, Enzo Tramontano, Filippo Cottiglia. Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase. European journal of medicinal chemistry. 2017 Apr; 130(?):248-260. doi: 10.1016/j.ejmech.2017.02.054. [PMID: 28254698]
  • Maria Ferhat, Zahia Kabouchea, Yoshinori Fujimoto, Hiroshi Araya. Two New Triterpenes and Other Compounds from Mentha aquatica (Lamiaceae). Natural product communications. 2017 Apr; 12(4):483-486. doi: ". [PMID: 30520576]
  • Juan Carlos Romero-Benavides, Ana Lucía Ruano, Ronal Silva-Rivas, Paola Castillo-Veintimilla, Sara Vivanco-Jaramillo, Natalia Bailon-Moscoso. Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies. European journal of medicinal chemistry. 2017 Mar; 129(?):209-217. doi: 10.1016/j.ejmech.2017.02.005. [PMID: 28231520]
  • Quan Wen, Yan Lu, Zhi Chao, Dao-Feng Chen. Anticomplement triterpenoids from the roots of Ilex asprella. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):880-886. doi: 10.1016/j.bmcl.2017.01.007. [PMID: 28094185]
  • Ji-Hyun Park, Jaewoo Yoon, Byoungduck Park. Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Dec; 23(14):1716-1726. doi: 10.1016/j.phymed.2016.10.010. [PMID: 27912873]
  • Onat Kadioglu, Thomas Efferth. Pharmacogenomic Characterization of Cytotoxic Compounds from Salvia officinalis in Cancer Cells. Journal of natural products. 2015 Apr; 78(4):762-75. doi: 10.1021/np501007n. [PMID: 25713926]
  • Victor Kuete, Louis P Sandjo, Jackson A Seukep, Maen Zeino, Armelle T Mbaveng, Bonaventure Ngadjui, Thomas Efferth. Cytotoxic compounds from the fruits of Uapaca togoensis towards multifactorial drug-resistant cancer cells. Planta medica. 2015 Jan; 81(1):32-8. doi: 10.1055/s-0034-1383362. [PMID: 25473921]
  • Xiao-lu Chen, Quan-xi Mei, Hong-bo Zhou, Zhi-jian Fang, Ying-xin Zhu. [Chemical constituents from roots of Rubus parvifolius]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Jun; 37(6):995-7. doi: . [PMID: 25470966]
  • Masateru Ono, Shin Yasuda, Haruki Komatsu, Yukio Fujiwara, Motohiro Takeya, Toshihiro Nohara. Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage. Natural product research. 2014; 28(24):2347-50. doi: 10.1080/14786419.2014.939087. [PMID: 25033392]
  • Xi-Xi Zhou, Qiong-Ming Xu, Ying Zhou, Xiao-Ran Li, Shi-Lin Yang. [Chemical constituents from the root of Ilex cornuta]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Feb; 36(2):233-6. doi: . [PMID: 23901650]
  • Miao Ye, Jing-Jing Su, Shu-Ting Liu, Lei Cao, Juan Xiong, Yun Zhao, Hui Fan, Guo-Xun Yang, Gang Xia, Jin-Feng Hu. (24S)-ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells. Natural product research. 2013; 27(12):1136-40. doi: 10.1080/14786419.2012.715290. [PMID: 22889249]
  • Maria Paula Garofo Peixoto, Samuel Kaiser, Simone Gasparin Verza, Pedro Ernesto de Resende, Janine Treter, Cabral Pavei, Gustavo Luís Borré, George González Ortega. LC-UV assay method and UPLC/Q-TOF-MS characterisation of saponins from Ilex paraguariensis A. St. Hil. (mate) unripe fruits. Phytochemical analysis : PCA. 2012 Jul; 23(4):415-20. doi: 10.1002/pca.1374. [PMID: 22105927]
  • Claudia Alvarado-Castillo, Omar Estrada, Edilmo Carvajal. Pomolic acid, triterpenoid isolated from Licania pittieri, as competitive antagonist of ADP-induced aggregation of human platelets. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Apr; 19(6):484-7. doi: 10.1016/j.phymed.2011.12.011. [PMID: 22402243]
  • Chi-Ren Liao, Yuan-Shiun Chang, Wen-Huang Peng, Shang-Chih Lai, Yu-Ling Ho. Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice. The American journal of Chinese medicine. 2012; 40(3):581-97. doi: 10.1142/s0192415x12500449. [PMID: 22745072]
  • Chen-Chen Zhu, Li Gao, Zhong-Xiang Zhao, Chao-Zhan Lin. Triterpenes from Callicarpa integerrima Champ. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Jan; 47(1):77-83. doi: ". [PMID: 22493809]
  • Seog Hyeon Youn, Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Je Ryong Kim, Eil Sung Chang. Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells. Biological & pharmaceutical bulletin. 2012; 35(1):105-10. doi: 10.1248/bpb.35.105. [PMID: 22223345]
  • Omar Estrada, Juan Manuel González-Guzmán, Margarita Salazar-Bookaman, Ana Z Fernández, Alfonso Cardozo, Claudia Alvarado-Castillo. Pomolic acid of Licania pittieri elicits endothelium-dependent relaxation in rat aortic rings. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Apr; 18(6):464-9. doi: 10.1016/j.phymed.2010.10.008. [PMID: 21112754]
  • Chao-Zhan Lin, Chen-Chen Zhu, Gui-Hua Deng, Ling Chai, Yao-Bing Li, Yong-Kai Cao, Cui-Xian Zhang, Zhong-Xiang Zhao. [Studies on the chemical constituents of Callicarpa kochiana]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Jun; 33(6):897-900. doi: ". [PMID: 21049609]
  • Myung Sun Lee, Phuong Thien Thuong. Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Phytotherapy research : PTR. 2010 Jan; 24(1):49-53. doi: 10.1002/ptr.2865. [PMID: 19548274]
  • Mi Kyeong Lee, Ki Yong Lee, Hee Young Jeon, Sang Hyun Sung, Young Choong Kim. Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells. Journal of enzyme inhibition and medicinal chemistry. 2009 Dec; 24(6):1276-9. doi: 10.3109/14756360902829709. [PMID: 19807218]
  • Jing Li, Yuanqing Ding, Xing-Cong Li, Daneel Ferreira, Shabana Khan, Troy Smillie, Ikhlas A Khan. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. Journal of natural products. 2009 Jun; 72(6):983-7. doi: 10.1021/np900068t. [PMID: 19555121]
  • Phuong Thien Thuong, Chul Ho Lee, Trong Tuan Dao, Phi Hung Nguyen, Wan Gi Kim, Sang Jun Lee, Won Keun Oh. Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. Journal of natural products. 2008 Oct; 71(10):1775-8. doi: 10.1021/np800298w. [PMID: 18798681]
  • Jong Min Kim, Dae Sik Jang, Yun Mi Lee, Jeong Lim Yoo, Young Sook Kim, Joo-Hwan Kim, Jin Sook Kim. Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha. Chemistry & biodiversity. 2008 Feb; 5(2):352-6. doi: 10.1002/cbdv.200890034. [PMID: 18293434]
  • Guillermo Schinella, Silvia Aquila, Martín Dade, Rosa Giner, María del Carmen Recio, Etile Spegazzini, Perla de Buschiazzo, Horacio Tournier, José Luis Ríos. Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya. Planta medica. 2008 Feb; 74(3):215-20. doi: 10.1055/s-2008-1034301. [PMID: 18260049]
  • Guang-Bo Xie, Si-Xiang Zhou, Lian-Di Lei, Peng-Fei Tu. [Studies on triterpenoid constituents in leaf of Ilex pernyi]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Sep; 32(18):1890-2. doi: ". [PMID: 18051898]
  • Yong-hong Zhang, Jian-gang Zhang, Jie-ming Xie, Ge-lin Chen, Dong-liang Cheng. [Triterpenes from root of Rhaponticum uniflorum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 Dec; 30(23):1833-6. doi: ". [PMID: 16499021]
  • C L Cantrell, S G Franzblau, N H Fischer. Antimycobacterial plant terpenoids. Planta medica. 2001 Nov; 67(8):685-94. doi: 10.1055/s-2001-18365. [PMID: 11731906]
  • F Z Chen, S L Peng, L S Ding, Y H He, M K Wang. [Chemical constituents from the fruit of Rosa bella Rehd. et Wils]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2001 Aug; 26(8):549-51. doi: . [PMID: 12776369]
  • C C Neto, A J Vaisberg, B N Zhou, D G Kingston, G B Hammond. Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa. Planta medica. 2000 Jun; 66(5):483-4. doi: 10.1055/s-2000-8583. [PMID: 10909276]
  • Y Kashiwada, H K Wang, T Nagao, S Kitanaka, I Yasuda, T Fujioka, T Yamagishi, L M Cosentino, M Kozuka, H Okabe, Y Ikeshiro, C Q Hu, E Yeh, K H Lee. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. Journal of natural products. 1998 Sep; 61(9):1090-5. doi: 10.1021/np9800710. [PMID: 9748372]