Homoproline (BioDeep_00000615672)

   


代谢物信息卡片


2-(Pyrrolidin-2-yl)acetic acid

化学式: C6H11NO2 (129.0789746)
中文名称: 2-吡咯烷乙酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(NC1)CC(=O)O
InChI: InChI=1S/C6H11NO2/c8-6(9)4-5-2-1-3-7-5/h5,7H,1-4H2,(H,8,9)

描述信息

同义名列表

8 个代谢物同义名

2-(Pyrrolidin-2-yl)acetic acid; Pyrrolidine-2-acetic acid; 2-Pyrrolidineacetic acid; (+/-)-homoproline; beta-Homoproline; Pipecolic acid; b-Homoproline?; Homoproline



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobias Steffan, Thejavathi Renukappa-Gutke, Georg Höfner, Klaus T Wanner. Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids. Bioorganic & medicinal chemistry. 2015 Mar; 23(6):1284-306. doi: 10.1016/j.bmc.2015.01.035. [PMID: 25698617]
  • Xueqing Zhao, Cornelia E Hoesl, Georg C Hoefner, Klaus T Wanner. Synthesis and biological evaluation of new GABA-uptake inhibitors derived from proline and from pyrrolidine-2-acetic acid. European journal of medicinal chemistry. 2005 Mar; 40(3):231-47. doi: 10.1016/j.ejmech.2004.11.004. [PMID: 15725493]
  • A Köfalvi, B Sperlágh, T Zelles, E S Vizi. Long-lasting facilitation of 4-amino-n-[2,3-(3)H]butyric acid ([(3)H]GABA) release from rat hippocampal slices by nicotinic receptor activation. The Journal of pharmacology and experimental therapeutics. 2000 Nov; 295(2):453-62. doi: NULL. [PMID: 11046076]
  • L J Knutsen, K E Andersen, J Lau, B F Lundt, R F Henry, H E Morton, L Naerum, H Petersen, H Stephensen, P D Suzdak, M D Swedberg, C Thomsen, P O Sørensen. Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents. Journal of medicinal chemistry. 1999 Sep; 42(18):3447-62. doi: 10.1021/jm981027k. [PMID: 10479278]
  • V R Durgam, M Vitela, S W Mifflin. Enhanced gamma-aminobutyric acid-B receptor agonist responses and mRNA within the nucleus of the solitary tract in hypertension. Hypertension (Dallas, Tex. : 1979). 1999 Jan; 33(1 Pt 2):530-6. doi: 10.1161/01.hyp.33.1.530. [PMID: 9931160]
  • M D Simpson, P Slater, J F Deakin, C G Gottfries, I Karlsson, B Grenfeldt, T J Crow. Absence of basal ganglia amino acid neuron deficits in schizophrenia in three collections of brains. Schizophrenia research. 1998 May; 31(2-3):167-75. doi: 10.1016/s0920-9964(98)00020-6. [PMID: 9689721]
  • J M Yee, S Agulian, J D Kocsis. Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve. Epilepsy research. 1998 Feb; 29(3):195-200. doi: 10.1016/s0920-1211(97)00086-7. [PMID: 9551781]
  • J Verweij, M Kamermans, K Negishi, H Spekreijse. GABA sensitivity of spectrally classified horizontal cells in goldfish retina. Visual neuroscience. 1998 Jan; 15(1):77-86. doi: 10.1017/s0952523898151039. [PMID: 9456507]
  • A Del Arco, T R Castañeda, F Mora. Amphetamine releases GABA in striatum of the freely moving rat: involvement of calcium and high affinity transporter mechanisms. Neuropharmacology. 1998; 37(2):199-205. doi: 10.1016/s0028-3908(98)00013-6. [PMID: 9680244]
  • P Krogsgaard-Larsen, B F Frølund, E Falch. Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents. Methods in enzymology. 1998; 296(?):165-75. doi: 10.1016/s0076-6879(98)96013-x. [PMID: 9779447]
  • G D Zeevalk, W J Nicklas. Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina. Vision research. 1997 Dec; 37(24):3463-70. doi: 10.1016/s0042-6989(97)00184-3. [PMID: 9425523]
  • C Thomsen, P O Sørensen, J Egebjerg. 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. British journal of pharmacology. 1997 Mar; 120(6):983-5. doi: 10.1038/sj.bjp.0700957. [PMID: 9134205]
  • S C King, S R Fleming, C Brechtel. Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP. Journal of bacteriology. 1995 Sep; 177(18):5381-2. doi: 10.1128/jb.177.18.5381-5382.1995. [PMID: 7665533]
  • D Mbungu, L S Ross, S S Gill. Cloning, functional expression, and pharmacology of a GABA transporter from Manduca sexta. Archives of biochemistry and biophysics. 1995 Apr; 318(2):489-97. doi: 10.1006/abbi.1995.1258. [PMID: 7733681]
  • K Takahashi, S Miyoshi, A Kaneko, D R Copenhagen. Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. The Japanese journal of physiology. 1995; 45(3):457-73. doi: 10.2170/jjphysiol.45.457. [PMID: 7474528]
  • T G Dhar, L A Borden, S Tyagarajan, K E Smith, T A Branchek, R L Weinshank, C Gluchowski. Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. Journal of medicinal chemistry. 1994 Jul; 37(15):2334-42. doi: 10.1021/jm00041a012. [PMID: 8057281]
  • I Osawa, N Saito, T Koga, C Tanaka. Phorbol ester-induced inhibition of GABA uptake by synaptosomes and by Xenopus oocytes expressing GABA transporter (GAT1). Neuroscience research. 1994 May; 19(3):287-93. doi: 10.1016/0168-0102(94)90041-8. [PMID: 8058205]
  • Q R Liu, B López-Corcuera, S Mandiyan, H Nelson, N Nelson. Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected]. The Journal of biological chemistry. 1993 Jan; 268(3):2106-12. doi: . [PMID: 8420981]
  • G Bonanno, A Ruelle, G C Andrioli, M Raiteri. Cholinergic nerve terminals of human cerebral cortex possess a GABA transporter whose activation induces release of acetylcholine. Brain research. 1991 Jan; 539(2):191-5. doi: 10.1016/0006-8993(91)91620-g. [PMID: 2054596]
  • V Gallo, M Patrizio, G Levi. GABA release triggered by the activation of neuron-like non-NMDA receptors in cultured type 2 astrocytes is carrier-mediated. Glia. 1991; 4(3):245-55. doi: 10.1002/glia.440040302. [PMID: 1680100]
  • J Taylor, P R Gordon-Weeks. Calcium-independent gamma-aminobutyric acid release from growth cones: role of gamma-aminobutyric acid transport. Journal of neurochemistry. 1991 Jan; 56(1):273-80. doi: 10.1111/j.1471-4159.1991.tb02592.x. [PMID: 1987321]
  • T Segura, E M Hasser, R E Shade, J R Haywood. Evidence of an endogenous forebrain GABAergic system capable of inhibiting baroreceptor-mediated vasopressin release. Brain research. 1989 Oct; 499(1):53-62. doi: 10.1016/0006-8993(89)91134-7. [PMID: 2804669]
  • J M Catelli, W J Giakas, A F Sved. GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release. Brain research. 1987 Feb; 403(2):279-89. doi: 10.1016/0006-8993(87)90065-5. [PMID: 3828822]
  • J R Haywood, T J Brennan, C Hinojosa. Neurohumoral mechanisms of sodium-dependent hypertension. Federation proceedings. 1985 May; 44(8):2393-9. doi: NULL. [PMID: 2859221]
  • B I Kanner, A Bendahan, R Radian. Efflux and exchange of gamma-aminobutyric acid and nipecotic acid catalysed by synaptic plasma membrane vesicles isolated from immature rat brain. Biochimica et biophysica acta. 1983 May; 731(1):54-62. doi: 10.1016/0005-2736(83)90397-8. [PMID: 6849911]