Val-Tyr (BioDeep_00000615465)

Main id: BioDeep_00000026916

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-[2-amino-3-(4-hydroxyphenyl)propanamido]-3-methylbutanoic acid

化学式: C14H20N2O4 (280.14230000000003)
中文名称: L-缬氨酰基-L-酪氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)N
InChI: InChI=1S/C14H20N2O4/c1-8(2)12(15)13(18)16-11(14(19)20)7-9-3-5-10(17)6-4-9/h3-6,8,11-12,17H,7,15H2,1-2H3,(H,16,18)(H,19,20)/t11-,12-/m0/s1

描述信息

A dipeptide formed from L-valine and L-tyrosine residues.
H-Val-Tyr-OH is an endogenous metabolite.

同义名列表

10 个代谢物同义名

Val-Tyr; 2-[2-amino-3-(4-hydroxyphenyl)propanamido]-3-methylbutanoic acid; Valine-tyrosine dipeptide; Valine tyrosine dipeptide; L-Valyl-L-tyrosine; Valyl-tyrosine; Valyltyrosine; V-Y dipeptide; VY dipeptide; H-Val-Tyr-OH



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Juliana Dias, Fernanda M Ferrão, Flavia Axelband, Adriana K Carmona, Lucienne S Lara, Adalberto Vieyra. ANG-(3-4) inhibits renal Na+-ATPase in hypertensive rats through a mechanism that involves dissociation of ANG II receptors, heterodimers, and PKA. American journal of physiology. Renal physiology. 2014 Apr; 306(8):F855-63. doi: 10.1152/ajprenal.00488.2013. [PMID: 24523384]
  • Joseph Thomas Ryan, Reynolds Paul Ross, Declan Bolton, Gerald F Fitzgerald, Catherine Stanton. Bioactive peptides from muscle sources: meat and fish. Nutrients. 2011 09; 3(9):765-91. doi: 10.3390/nu3090765. [PMID: 22254123]
  • Nao Inoue, Koji Nagao, Kotaro Sakata, Naomi Yamano, Pathma Elgoda Ranawakage Gunawardena, Seo-Young Han, Toshiro Matsui, Toshihiro Nakamori, Hitoshi Furuta, Kiyoharu Takamatsu, Teruyoshi Yanagita. Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo. Lipids in health and disease. 2011 May; 10(?):85. doi: 10.1186/1476-511x-10-85. [PMID: 21600040]
  • Toshiro Matsui, Xiao Lin Zhu, Keisuke Watanabe, Keisuke Tanaka, Yoko Kusano, Kiyoshi Matsumoto. Combined administration of captopril with an antihypertensive Val-Tyr di-peptide to spontaneously hypertensive rats attenuates the blood pressure lowering effect. Life sciences. 2006 Nov; 79(26):2492-8. doi: 10.1016/j.lfs.2006.08.013. [PMID: 16959271]
  • Takao Ueno, Mitsuru Tanaka, Toshiro Matsui, Kiyoshi Matsumoto. Determination of antihypertensive small peptides, Val-Tyr and Ile-Val-Tyr, by fluorometric high-performance liquid chromatography combined with a double heart-cut column-switching technique. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2005 Aug; 21(8):997-1000. doi: 10.2116/analsci.21.997. [PMID: 16122175]
  • Matsui Toshiro, Takao Ueno, Mitsuru Tanaka, Hiromi Oka, Takahisa Miyamotq, Katsuhiro Osajima, Kiyoshi Matsumoto. Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells. Hypertension research : official journal of the Japanese Society of Hypertension. 2005 Jun; 28(6):545-52. doi: 10.1291/hypres.28.545. [PMID: 16231761]
  • Toshiro Matsui, Miho Imamura, Hiromi Oka, Katsuhiro Osajima, Ko-Ichi Kimoto, Terukazu Kawasaki, Kiyoshi Matsumoto. Tissue distribution of antihypertensive dipeptide, Val-Tyr, after its single oral administration to spontaneously hypertensive rats. Journal of peptide science : an official publication of the European Peptide Society. 2004 Sep; 10(9):535-45. doi: 10.1002/psc.568. [PMID: 15473262]
  • Toshiro Matsui, Atsumi Hayashi, Kei Tamaya, Kiyoshi Matsumoto, Terukazu Kawasaki, Kazuo Murakami, Ko-ichi Kimoto. Depressor effect induced by dipeptide, Val-Tyr, in hypertensive transgenic mice is due, in part, to the suppression of human circulating renin-angiotensin system. Clinical and experimental pharmacology & physiology. 2003 Apr; 30(4):262-5. doi: 10.1046/j.1440-1681.2003.03824.x. [PMID: 12680844]
  • Terukazu Kawasaki, Chen Jian Jun, Yoichi Fukushima, Kaori Kegai, Eiji Seki, Katsuhiro Osajima, Kazue Itoh, Toshiro Matsui, Kiyoshi Matsumoto. [Antihypertensive effect and safety evaluation of vegetable drink with peptides derived from sardine protein hydrolysates on mild hypertensive, high-normal and normal blood pressure subjects]. Fukuoka igaku zasshi = Hukuoka acta medica. 2002 Oct; 93(10):208-18. doi: NULL. [PMID: 12471719]
  • Toshiro Matsui, Kei Tamaya, Eiji Seki, Katsuhiro Osajima, Kiyoshi Matsumo, Terukazu Kawasaki. Absorption of Val-Tyr with in vitro angiotensin I-converting enzyme inhibitory activity into the circulating blood system of mild hypertensive subjects. Biological & pharmaceutical bulletin. 2002 Sep; 25(9):1228-30. doi: 10.1248/bpb.25.1228. [PMID: 12230125]
  • Toshiro Matsui, Kei Tamaya, Eiji Seki, Katsuhiro Osajima, Kiyoshi Matsumoto, Terukazu Kawasaki. Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system. Clinical and experimental pharmacology & physiology. 2002 Mar; 29(3):204-8. doi: 10.1046/j.1440-1681.2002.03628.x. [PMID: 11906484]
  • T Kawasaki, E Seki, K Osajima, M Yoshida, K Asada, T Matsui, Y Osajima. Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects. Journal of human hypertension. 2000 Aug; 14(8):519-23. doi: 10.1038/sj.jhh.1001065. [PMID: 10962520]