Leu-phe (BioDeep_00000615282)
Main id: BioDeep_00000019170
PANOMIX_OTCML-2023
代谢物信息卡片
2-(2-amino-3-phenylpropanamido)-4-methylpentanoic acid
化学式: C15H22N2O3 (278.163)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)N
InChI: InChI=1S/C15H22N2O3/c1-10(2)8-12(16)14(18)17-13(15(19)20)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)/t12-,13-/m0/s1
描述信息
A dipeptide formed from L-leucine and L-phenylalanine residues.
Leucyl-phenylalanine belongs to the class of organic compounds known as dipeptides.
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:73585
- PubChem: 6992310
- Metlin: METLIN85839
- ChEMBL: CHEMBL54936
- CAS: 3063-05-6
- MetaboLights: MTBLC73585
- RefMet: Leu-Phe
- medchemexpress: HY-113278
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hsiang-Ruei Liao, Jih-Jung Chen, Yin-Huan Chien, Shinn-Zhi Lin, Shunchih Lin, Ching-Ping Tseng. 5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils.
Biochemical pharmacology.
2012 Jul; 84(2):182-91. doi:
10.1016/j.bcp.2012.03.015. [PMID: 22484311] - Rudolf Lampé. [Superoxide-anion production by neutrophil granulocytes in healthy and preeclamptic pregnant women].
Orvosi hetilap.
2012 Mar; 153(11):425-34. doi:
10.1556/oh.2012.29322. [PMID: 22390867] - Shihu Wei, Guang Chen, Wenfei He, Haidong Chi, Hideki Abe, Koichi Yamashita, Masanori Yokoyama, Hiroyuki Kodama. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils.
Phytotherapy research : PTR.
2012 Feb; 26(2):168-73. doi:
10.1002/ptr.3496. [PMID: 21584870] - Pia Chedid, Margarita Hurtado-Nedelec, Benoit Marion-Gaber, Odile Bournier, Gilles Hayem, Marie-Anne Gougerot-Pocidalo, Jan Frystyk, Alan Flyvbjerg, Jamel El Benna, Jean-Claude Marie. Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes.
The American journal of pathology.
2012 Feb; 180(2):682-92. doi:
10.1016/j.ajpath.2011.10.013. [PMID: 22119038] - Inger Gjertsson, Ing-Marie Jonsson, Andreas Peschel, Andrej Tarkowski, Catharina Lindholm. Formylated peptides are important virulence factors in Staphylococcus aureus arthritis in mice.
The Journal of infectious diseases.
2012 Jan; 205(2):305-11. doi:
10.1093/infdis/jir713. [PMID: 22102735] - Alessandro Corti, Maria Franzini, Silvana Cianchetti, Gabriella Bergamini, Evelina Lorenzini, Paola Melotti, Aldo Paolicchi, Pierluigi Paggiaro, Alfonso Pompella. Contribution by polymorphonucleate granulocytes to elevated gamma-glutamyltransferase in cystic fibrosis sputum.
PloS one.
2012; 7(4):e34772. doi:
10.1371/journal.pone.0034772. [PMID: 22496859] - Herbert H Lipowsky, Lujia Gao, Ann Lescanic. Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation.
American journal of physiology. Heart and circulatory physiology.
2011 Dec; 301(6):H2235-45. doi:
10.1152/ajpheart.00803.2011. [PMID: 21926341] - Cheng Wang, Rennan Feng, Dianjun Sun, Ying Li, Xinxin Bi, Changhao Sun. Metabolic profiling of urine in young obese men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC/Q-TOF MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Oct; 879(27):2871-6. doi:
10.1016/j.jchromb.2011.08.014. [PMID: 21890434] - Shou-Fang Wu, Tsong-Long Hwang, Shu-Li Chen, Chin-Chung Wu, Emika Ohkoshi, Kuo-Hsiung Lee, Fang-Rong Chang, Yang-Chang Wu. Bioactive components from the heartwood of Pterocarpus santalinus.
Bioorganic & medicinal chemistry letters.
2011 Sep; 21(18):5630-2. doi:
10.1016/j.bmcl.2011.06.036. [PMID: 21784631] - Ji-Liang Gao, Erich H Schneider, Eugene L Dimitrov, Forrest Haun, Therese M Pham, Abdul H Mohammed, Ted B Usdin, Philip M Murphy. Reduced fear memory and anxiety-like behavior in mice lacking formylpeptide receptor 1.
Behavior genetics.
2011 Sep; 41(5):724-33. doi:
10.1007/s10519-011-9467-0. [PMID: 21484271] - Ines Kaufmann, Matthias Feuerecker, Alex Salam, Gustav Schelling, Manfred Thiel, Alexander Choukèr. Adenosine A2(A) receptor modulates the oxidative stress response of primed polymorphonuclear leukocytes after parabolic flight.
Human immunology.
2011 Jul; 72(7):547-52. doi:
10.1016/j.humimm.2011.03.021. [PMID: 21513753] - Amit Prasad, Yonghui Jia, Anutosh Chakraborty, Yitang Li, Supriya K Jain, Jia Zhong, Saurabh Ghosh Roy, Fabien Loison, Subhanjan Mondal, Jiro Sakai, Catlyn Blanchard, Solomon H Snyder, Hongbo R Luo. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.
Nature immunology.
2011 Jun; 12(8):752-60. doi:
10.1038/ni.2052. [PMID: 21685907] - Edna Sayuri Suyenaga, Eduardo Luis Konrath, Roger Remy Dresch, Miriam Anders Apel, José Angelo Zuanazzi, Célia Gervásio Chaves, Amélia Teresinha Henriques. Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils.
Planta medica.
2011 May; 77(7):698-704. doi:
10.1055/s-0030-1250516. [PMID: 21058242] - Rudolf Lampé, Sándor Szucs, Róza Adány, Robert Póka. Granulocyte superoxide anion production and regulation by plasma factors in normal and preeclamptic pregnancy.
Journal of reproductive immunology.
2011 May; 89(2):199-206. doi:
10.1016/j.jri.2011.01.019. [PMID: 21529965] - Hsiu-Hui Chan, Tsong-Long Hwang, Mopur Vijaya Bhaskar Reddy, Ding-Tzai Li, Keduo Qian, Kenneth F Bastow, Kuo-Hsiung Lee, Tian-Shung Wu. Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.
Journal of natural products.
2011 Apr; 74(4):796-802. doi:
10.1021/np100851s. [PMID: 21417387] - Bi-Jiuan Liou, Hsun-Shuo Chang, Guei-Jane Wang, Michael Y Chiang, Chang-Hui Liao, Chu-Hung Lin, Ih-Sheng Chen. Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them.
Phytochemistry.
2011 Apr; 72(4-5):415-22. doi:
10.1016/j.phytochem.2011.01.006. [PMID: 21295319] - Mehmet Sahin, A Cihangir Uğuz, Halil Demirkan, Mustafa Nazıroğlu. Colchicine modulates oxidative stress in serum and leucocytes from remission patients with Family Mediterranean Fever through regulation of Ca²+ release and the antioxidant system.
The Journal of membrane biology.
2011 Mar; 240(1):55-62. doi:
10.1007/s00232-011-9342-1. [PMID: 21249347] - Robert G Sitrin, Timothy M Sassanella, Howard R Petty. An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils.
American journal of respiratory cell and molecular biology.
2011 Feb; 44(2):205-12. doi:
10.1165/rcmb.2010-0019oc. [PMID: 20378749] - Laurent Camous, Lubka Roumenina, Sylvain Bigot, Soumeya Brachemi, Véronique Frémeaux-Bacchi, Philippe Lesavre, Lise Halbwachs-Mecarelli. Complement alternative pathway acts as a positive feedback amplification of neutrophil activation.
Blood.
2011 Jan; 117(4):1340-9. doi:
10.1182/blood-2010-05-283564. [PMID: 21063021] - Irundika H K Dias, John B Matthews, Iain L C Chapple, Helen J Wright, Christopher R Dunston, Helen R Griffiths. Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines.
Journal of clinical periodontology.
2011 Jan; 38(1):1-7. doi:
10.1111/j.1600-051x.2010.01628.x. [PMID: 20964702] - Tamara A M Chessa, Karen E Anderson, Yanhua Hu, Qingbo Xu, Oliver Rausch, Len R Stephens, Phillip T Hawkins. Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.
Blood.
2010 Dec; 116(26):6027-36. doi:
10.1182/blood-2010-08-300889. [PMID: 20861461] - Pier Carlo Braga, Monica Dal Sasso, Maria Culici, Alessandra Spallino, Laura Marabini, Tiziana Bianchi, Giuseppe Nappi. Effects of sulphurous water on human neutrophil elastase release.
Therapeutic advances in respiratory disease.
2010 Dec; 4(6):333-40. doi:
10.1177/1753465810376783. [PMID: 20650977] - Alexander Ludwig, Grant P Otto, Kirsi Riento, Emily Hams, Padraic G Fallon, Ben J Nichols. Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment.
The Journal of cell biology.
2010 Nov; 191(4):771-81. doi:
10.1083/jcb.201005140. [PMID: 21059848] - Xing Jun Li, Christophe C Marchal, Natalie D Stull, Robert V Stahelin, Mary C Dinauer. p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.
The Journal of biological chemistry.
2010 Nov; 285(45):35169-79. doi:
10.1074/jbc.m110.164475. [PMID: 20817944] - Satyananda Patel, Bahia Djerdjouri, Yannick Raoul-Des-Essarts, Pham My-Chan Dang, Jamel El-Benna, Axel Périanin. Protein kinase B (AKT) mediates phospholipase D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells.
The Journal of biological chemistry.
2010 Oct; 285(42):32055-63. doi:
10.1074/jbc.m110.171058. [PMID: 20693286] - Chan Hun Jung, Ji Yun Lee, Jin Hyung Park, Bong Jae Cho, Sang Soo Sim, Chang Jong Kim. Flavonols attenuate the immediate and late-phase asthmatic responses to aerosolized-ovalbumin exposure in the conscious guinea pig.
Fitoterapia.
2010 Oct; 81(7):803-12. doi:
10.1016/j.fitote.2010.04.011. [PMID: 20460144] - Robert G Sitrin, Timothy M Sassanella, Jeffrey J Landers, Howard R Petty. Migrating human neutrophils exhibit dynamic spatiotemporal variation in membrane lipid organization.
American journal of respiratory cell and molecular biology.
2010 Oct; 43(4):498-506. doi:
10.1165/rcmb.2009-0286oc. [PMID: 19933376] - Josefin M Paulsson, Stefan H Jacobson, Joachim Lundahl. Neutrophil activation during transmigration in vivo and in vitro A translational study using the skin chamber model.
Journal of immunological methods.
2010 Sep; 361(1-2):82-8. doi:
10.1016/j.jim.2010.07.015. [PMID: 20691696] - Carl J Hauser, Tolga Sursal, Edward K Rodriguez, Paul T Appleton, Qin Zhang, Kiyoshi Itagaki. Mitochondrial damage associated molecular patterns from femoral reamings activate neutrophils through formyl peptide receptors and P44/42 MAP kinase.
Journal of orthopaedic trauma.
2010 Sep; 24(9):534-8. doi:
10.1097/bot.0b013e3181ec4991. [PMID: 20736789] - Christopher D Hapner, Patricia Deuster, Yifan Chen. Inhibition of oxidative hemolysis by quercetin, but not other antioxidants.
Chemico-biological interactions.
2010 Aug; 186(3):275-9. doi:
10.1016/j.cbi.2010.05.010. [PMID: 20510893] - Eva Schepers, Griet Glorieux, Vera Jankowski, Annemieke Dhondt, Joachim Jankowski, Raymond Vanholder. Dinucleoside polyphosphates: newly detected uraemic compounds with an impact on leucocyte oxidative burst.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Aug; 25(8):2636-44. doi:
10.1093/ndt/gfq080. [PMID: 20190246] - Jörg U Bleyl, Axel R Heller, Antonia Fehrenbach, Manuel Heintz, Heinz Fehrenbach, Gesa Klenz, Marcelo Gama de Abreu, Matthias Hübler, Peter M Spieth, Thea Koch. Pretreatment with perfluorohexane vapor attenuates fMLP-induced lung injury in isolated perfused rabbit lungs.
Experimental lung research.
2010 Aug; 36(6):342-51. doi:
10.3109/01902141003653320. [PMID: 20653469] - Hanna Kälvegren, Jonna Fridfeldt, Torbjörn Bengtsson. The role of plasma adenosine deaminase in chemoattractant-stimulated oxygen radical production in neutrophils.
European journal of cell biology.
2010 Jun; 89(6):462-7. doi:
10.1016/j.ejcb.2009.12.004. [PMID: 20207043] - Valérie Capra, Maria Rosa Accomazzo, Fabrizio Gardoni, Silvia Barbieri, G Enrico Rovati. A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes.
Journal of lipid research.
2010 May; 51(5):1075-84. doi:
10.1194/jlr.m003236. [PMID: 19965602] - Qin Zhang, Mustafa Raoof, Yu Chen, Yuka Sumi, Tolga Sursal, Wolfgang Junger, Karim Brohi, Kiyoshi Itagaki, Carl J Hauser. Circulating mitochondrial DAMPs cause inflammatory responses to injury.
Nature.
2010 Mar; 464(7285):104-7. doi:
10.1038/nature08780. [PMID: 20203610] - Marco Cosentino, Franca Marino, Ramòna Consuélo Maio, Marco Gioacchino Delle Canne, Marcello Luzzani, Silvano Paracchini, Sergio Lecchini. Immunomodulatory activity of the lignan 7-hydroxymatairesinol potassium acetate (HMR/lignan) extracted from the heartwood of Norway spruce (Picea abies).
International immunopharmacology.
2010 Mar; 10(3):339-43. doi:
10.1016/j.intimp.2009.12.005. [PMID: 20005303] - Jean Sainte-Laudy, Catherine Ouk. Use of lipid rafting for the analysis of human basophil activation by flow cytometry.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2010 Mar; 59 Suppl 2(?):S193-5. doi:
10.1007/s00011-009-0126-3. [PMID: 20013029] - Neil Dufton, Robert Hannon, Vincenzo Brancaleone, Jesmond Dalli, Hetal B Patel, Mohini Gray, Fulvio D'Acquisto, Julia C Buckingham, Mauro Perretti, Roderick J Flower. Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
Journal of immunology (Baltimore, Md. : 1950).
2010 Mar; 184(5):2611-2619. doi:
10.4049/jimmunol.0903526. [PMID: 20107188] - Hamama Bouriche, Juegen Arnhold. Effect of Cleome arabica leaf extract treated by naringinase on human neutrophil chemotaxis.
Natural product communications.
2010 Mar; 5(3):415-8. doi:
". [PMID: 20420319] - Makoto Nakata, Kouji Otsubo, Tomoko Kikuchi, Takuya Itou, Takeo Sakai. Chemotactic properties and absence of the formyl peptide receptor in ferret (Mustela putorius furo) neutrophils.
Research in veterinary science.
2010 Feb; 88(1):56-60. doi:
10.1016/j.rvsc.2009.05.019. [PMID: 19539964] - Vibeke Videm, Guro Dalheim Olsen. No relationship between neutrophil granulocyte activation and the myeloperoxidase gene - 129 G>A and - 463 G>A promoter polymorphisms: implications for investigations of cardiovascular disease.
Coronary artery disease.
2009 Nov; 20(7):446-52. doi:
10.1097/mca.0b013e3283313678. [PMID: 19877306] - Edgar Pastene, Hernán Speisky, Miriam Troncoso, Julio Alarcón, Guillermo Figueroa. In vitro inhibitory effect of apple peel extract on the growth of Helicobacter pylori and respiratory burst induced on human neutrophils.
Journal of agricultural and food chemistry.
2009 Sep; 57(17):7743-9. doi:
10.1021/jf9006592. [PMID: 19691323] - Tomoyuki Iwata, Alpdogan Kantarci, Motohiko Yagi, Tina Jackson, Hatice Hasturk, Hidemi Kurihara, Thomas E Van Dyke. Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis.
Journal of periodontology.
2009 Aug; 80(8):1300-6. doi:
10.1902/jop.2009.090092. [PMID: 19656030] - Peter N Pushparaj, Hwee Kee Tay, Cheng-Chun Wang, Wanjin Hong, Alirio J Melendez. VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation.
Journal of immunology (Baltimore, Md. : 1950).
2009 Jul; 183(2):1413-8. doi:
10.4049/jimmunol.0804061. [PMID: 19564343] - Tsong-Long Hwang, Yi-Chia Su, Han-Lin Chang, Yann-Lii Leu, Pei-Jen Chung, Liang-Mou Kuo, Yi-Ju Chang. Suppression of superoxide anion and elastase release by C18 unsaturated fatty acids in human neutrophils.
Journal of lipid research.
2009 Jul; 50(7):1395-408. doi:
10.1194/jlr.m800574-jlr200. [PMID: 19295184] - Antonio Di Gennaro, Ellinor Kenne, Min Wan, Oliver Soehnlein, Lennart Lindbom, Jesper Z Haeggström. Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2009 Jun; 23(6):1750-7. doi:
10.1096/fj.08-121277. [PMID: 19151333] - Eva Schepers, Griet Glorieux, Annemieke Dhondt, Luc Leybaert, Raymond Vanholder. Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 May; 24(5):1429-35. doi:
10.1093/ndt/gfn670. [PMID: 19059932] - Jennie Karlsson, Anna-Lena Stenfeldt, Marie-Josèphe Rabiet, Johan Bylund, Huamei Fu Forsman, Claes Dahlgren. The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels.
Cell calcium.
2009 May; 45(5):431-8. doi:
10.1016/j.ceca.2009.02.002. [PMID: 19282028] - Mei-Feng Hsu, Ling-Chu Chang, Li-Jiau Huang, Sheng-Chu Kuo, Hsiao-Yun Lee, Min-Chi Lu, Jih-Pyang Wang. The influence of acetylshikonin, a natural naphthoquinone, on the production of leukotriene B4 and thromboxane A2 in rat neutrophils.
European journal of pharmacology.
2009 Apr; 607(1-3):234-43. doi:
10.1016/j.ejphar.2009.02.005. [PMID: 19232341] - Silvia M Uriarte, Neelakshi R Jog, Gregory C Luerman, Samrath Bhimani, Richard A Ward, Kenneth R McLeish. Counterregulation of clathrin-mediated endocytosis by the actin and microtubular cytoskeleton in human neutrophils.
American journal of physiology. Cell physiology.
2009 Apr; 296(4):C857-67. doi:
10.1152/ajpcell.00454.2008. [PMID: 19176760] - Brett V Citarella, Veronika Miskolci, Ivana Vancurova, Dennis Davidson. Interleukin-10 versus dexamethasone: effects on polymorphonuclear leukocyte functions of the newborn.
Pediatric research.
2009 Apr; 65(4):425-9. doi:
10.1203/pdr.0b013e318199384d. [PMID: 19127214] - Christina Rappel, Dirk Schaumlöffel. Absolute peptide quantification by lutetium labeling and nanoHPLC-ICPMS with isotope dilution analysis.
Analytical chemistry.
2009 Jan; 81(1):385-93. doi:
10.1021/ac801814a. [PMID: 19117464] - Izabela Grabska-Kobylecka, Andrzej Kobylecki, Piotr Bialasiewicz, Maciej Krol, Golsa Ehteshamirad, Marek Kasielski, Dariusz Nowak. No evidence of enhanced oxidant production in blood obtained from patients with obstructive sleep apnea.
Journal of negative results in biomedicine.
2008 Nov; 7(?):10. doi:
10.1186/1477-5751-7-10. [PMID: 19032755] - Tsung-Hsien Chou, Ih-Sheng Chen, Tsong-Long Hwang, Tai-Chi Wang, Tzong-Huei Lee, Lin-Yang Cheng, Ya-Chih Chang, Jui-Ying Cho, Jih-Jung Chen. Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.
Journal of natural products.
2008 Oct; 71(10):1692-5. doi:
10.1021/np8004503. [PMID: 18817445] - Rudolf Lampé, Sándor Szucs, Márk Ormos, Róza Adány, Robert Póka. Effect of normal and preeclamptic plasma on superoxide-anion production of neutrophils from healthy non-pregnant women.
Journal of reproductive immunology.
2008 Oct; 79(1):63-9. doi:
10.1016/j.jri.2008.04.001. [PMID: 18538415] - Gerald Cohen, Jana Raupachova, Thomas Wimmer, Robert Deicher, Walter H Hörl. The uraemic retention solute para-hydroxy-hippuric acid attenuates apoptosis of polymorphonuclear leukocytes from healthy subjects but not from haemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Aug; 23(8):2512-9. doi:
10.1093/ndt/gfn098. [PMID: 18319358] - Y-H Wang, Y-C Shen, J-F Liao, C-H Lee, C-H Li, C-Y Chou, K-T Liou, Y-C Chou. Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice.
British journal of pharmacology.
2008 Jul; 154(6):1327-38. doi:
10.1038/bjp.2008.202. [PMID: 18500357] - Ernesto Dalli, Javier Milara, Julio Cortijo, Esteban J Morcillo, Juan Cosín-Sales, José Francisco Sotillo. Hawthorn extract inhibits human isolated neutrophil functions.
Pharmacological research.
2008 Jun; 57(6):445-50. doi:
10.1016/j.phrs.2008.05.001. [PMID: 18547815] - Tara M Randis, Kamal D Puri, Hairu Zhou, Thomas G Diacovo. Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils.
European journal of immunology.
2008 May; 38(5):1215-24. doi:
10.1002/eji.200838266. [PMID: 18412166] - Janeen R Jordan, Ernest E Moore, Eric L Sarin, Sagar S Damle, Sara B Kashuk, Christopher C Silliman, Anirban Banerjee. Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4.
Journal of applied physiology (Bethesda, Md. : 1985).
2008 Apr; 104(4):1161-6. doi:
10.1152/japplphysiol.00022.2007. [PMID: 18276905] - Payong Wanikiat, Ampai Panthong, Pacharawan Sujayanon, Chalobon Yoosook, Adriano G Rossi, Vichai Reutrakul. The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts.
Journal of ethnopharmacology.
2008 Mar; 116(2):234-44. doi:
10.1016/j.jep.2007.11.035. [PMID: 18207341] - Jih-Jung Chen, Tzu-Ying Wang, Tsong-Long Hwang. Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae.
Journal of natural products.
2008 Feb; 71(2):212-7. doi:
10.1021/np070594k. [PMID: 18211005] - S M Dyke, B S Carey, E R Kaminski. Effect of stress on basophil function in chronic idiopathic urticaria.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2008 Jan; 38(1):86-92. doi:
10.1111/j.1365-2222.2007.02864.x. [PMID: 17976217] - Susanna Genedani, Monica Filaferro, Chiara Carone, Rita Ostan, Laura Bucci, Elisa Cevenini, Claudio Franceschi, Daniela Monti. Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians.
Neuroimmunomodulation.
2008; 15(4-6):285-9. doi:
10.1159/000156472. [PMID: 19047806] - Tzai-Li Li, Pei-Yun Cheng. Alterations of immunoendocrine responses during the recovery period after acute prolonged cycling.
European journal of applied physiology.
2007 Nov; 101(5):539-46. doi:
10.1007/s00421-007-0529-1. [PMID: 17668230] - Marcia Riesselman, Heini M Miettinen, Jeannie M Gripentrog, Connie I Lord, Brendan Mumey, Edward A Dratz, Jamal Stie, Ross M Taylor, Algirdas J Jesaitis. C-terminal tail phosphorylation of N-formyl peptide receptor: differential recognition of two neutrophil chemoattractant receptors by monoclonal antibodies NFPR1 and NFPR2.
Journal of immunology (Baltimore, Md. : 1950).
2007 Aug; 179(4):2520-31. doi:
10.4049/jimmunol.179.4.2520. [PMID: 17675514] - So Youn Kim, Li-Yuan Chen, Wai Han Yiu, David A Weinstein, Janice Y Chou. Neutrophilia and elevated serum cytokines are implicated in glycogen storage disease type Ia.
FEBS letters.
2007 Aug; 581(20):3833-8. doi:
10.1016/j.febslet.2007.07.013. [PMID: 17659284] - Soumeya Brachemi, Agnès Mambole, Fadi Fakhouri, Luc Mouthon, Loïc Guillevin, Philippe Lesavre, Lise Halbwachs-Mecarelli. Increased membrane expression of proteinase 3 during neutrophil adhesion in the presence of anti proteinase 3 antibodies.
Journal of the American Society of Nephrology : JASN.
2007 Aug; 18(8):2330-9. doi:
10.1681/asn.2006121309. [PMID: 17634439] - Kirill Essin, Birgit Salanova, Ralph Kettritz, Matthias Sausbier, Friedrich C Luft, Dirk Kraus, Erwin Bohn, Ingo B Autenrieth, Andreas Peschel, Peter Ruth, Maik Gollasch. Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity.
American journal of physiology. Cell physiology.
2007 Jul; 293(1):C45-54. doi:
10.1152/ajpcell.00450.2006. [PMID: 17329399] - Jamal Stie, Andrew V Jesaitis, Connie I Lord, Jeannie M Gripentrog, Ross M Taylor, James B Burritt, Algirdas J Jesaitis. Localization of hCAP-18 on the surface of chemoattractant-stimulated human granulocytes: analysis using two novel hCAP-18-specific monoclonal antibodies.
Journal of leukocyte biology.
2007 Jul; 82(1):161-72. doi:
10.1189/jlb.0906586. [PMID: 17400609] - Neelakshi R Jog, Madhavi J Rane, George Lominadze, Gregory C Luerman, Richard A Ward, Kenneth R McLeish. The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets.
American journal of physiology. Cell physiology.
2007 May; 292(5):C1690-700. doi:
10.1152/ajpcell.00384.2006. [PMID: 17202227] - Masahiro Nagasawa, Yuko Nakagawa, Shigeyasu Tanaka, Itaru Kojima. Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages.
Journal of cellular physiology.
2007 Mar; 210(3):692-702. doi:
10.1002/jcp.20883. [PMID: 17154364] - J Olsson, E Dadfar, J Paulsson, J Lundahl, A Moshfegh, S H Jacobson. Preserved leukocyte CD11b expression at the site of interstitial inflammation in patients with high-flux hemodiafiltration.
Kidney international.
2007 Mar; 71(6):582-8. doi:
10.1038/sj.ki.5002090. [PMID: 17228360] - Hervé Guillou, Charlotte Lécureuil, Karen E Anderson, Sabine Suire, G John Ferguson, Chris D Ellson, Alexander Gray, Nullin Divecha, Phillip T Hawkins, Len R Stephens. Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach.
Journal of lipid research.
2007 Mar; 48(3):726-32. doi:
10.1194/jlr.d600038-jlr200. [PMID: 17130283] - Elaine Hatanaka, Patrícia Teófilo Monteagudo, Mauro Sérgio Martins Marrocos, Ana Campa. Interaction between serum amyloid A and leukocytes - a possible role in the progression of vascular complications in diabetes.
Immunology letters.
2007 Feb; 108(2):160-6. doi:
10.1016/j.imlet.2006.12.005. [PMID: 17267050] - Y-L Lai, J-C Lin, S-F Yang, T-Y Liu, S-L Hung. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes.
Journal of periodontal research.
2007 Feb; 42(1):69-76. doi:
10.1111/j.1600-0765.2006.00917.x. [PMID: 17214642] - Gwenny M Fuhler, Nel R Blom, Paul J Coffer, A Lyndsay Drayer, Edo Vellenga. The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formation.
Journal of leukocyte biology.
2007 Feb; 81(2):449-57. doi:
10.1189/jlb.0506311. [PMID: 17079651] - Naoyuki Hashiguchi, Linda Lum, Elizabeth Romeril, Yu Chen, Linda Yip, David B Hoyt, Wolfgang G Junger. Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients.
The Journal of trauma.
2007 Feb; 62(2):299-306. doi:
10.1097/01.ta.0000222956.88760.33. [PMID: 17297316] - Han-Chieh Ko, Yea-Hwey Wang, Kuo-Tong Liou, Chi-Ming Chen, Chih-Hsiang Chen, Wen-Yen Wang, Shiou Chang, Yu-Chang Hou, Kuo-Tung Chen, Chieh-Fu Chen, Yuh-Chiang Shen. Anti-inflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells.
European journal of pharmacology.
2007 Jan; 555(2-3):211-7. doi:
10.1016/j.ejphar.2006.10.002. [PMID: 17109845] - Masakatsu Nanamori, Jia Chen, Xiaoping Du, Richard D Ye. Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells.
Journal of immunology (Baltimore, Md. : 1950).
2007 Jan; 178(1):416-27. doi:
10.4049/jimmunol.178.1.416. [PMID: 17182580] - Robert G Sitrin, Sarah L Emery, Timothy M Sassanella, R Alexander Blackwood, Howard R Petty. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils.
Journal of immunology (Baltimore, Md. : 1950).
2006 Dec; 177(11):8177-84. doi:
10.4049/jimmunol.177.11.8177. [PMID: 17114494] - Tsong-Long Hwang, Yann-Lii Leu, Shu-Hui Kao, Ming-Chi Tang, Han-Lin Chang. Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway.
Free radical biology & medicine.
2006 Nov; 41(9):1433-41. doi:
10.1016/j.freeradbiomed.2006.08.001. [PMID: 17023270] - Bryan Heit, Gareth Jones, Derrice Knight, Joseph M Antony, M John Gill, Christopher Brown, Christopher Power, Paul Kubes. HIV and other lentiviral infections cause defects in neutrophil chemotaxis, recruitment, and cell structure: immunorestorative effects of granulocyte-macrophage colony-stimulating factor.
Journal of immunology (Baltimore, Md. : 1950).
2006 Nov; 177(9):6405-14. doi:
10.4049/jimmunol.177.9.6405. [PMID: 17056572] - Sabine Suire, Alison M Condliffe, G John Ferguson, Chris D Ellson, Hervé Guillou, Keith Davidson, Heidi Welch, John Coadwell, Martin Turner, Edwin R Chilvers, Phillip T Hawkins, Len Stephens. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.
Nature cell biology.
2006 Nov; 8(11):1303-9. doi:
10.1038/ncb1494. [PMID: 17041586] - Jacek Rysz, Elzbieta Potargowicz, Maciej Banach, Maria Luczyńska, Robert Stolarek, Piotr Białasiewicz, Marek Kasielski, Aleksandra Ciałkowska-Rysz, Dariusz Nowak. Increased whole blood chemiluminescence in patients with chronic renal failure independent of hemodialysis treatment.
Archivum immunologiae et therapiae experimentalis.
2006 Sep; 54(5):347-55. doi:
10.1007/s00005-006-0040-0. [PMID: 17031465] - Rimantas Stakauskas, Dieter Steinhagen, Giedrius Guzys, Lilija Mironova, Wolfgang Leibold, Hans-Joachim Schuberth. Quantitative and qualitative assessment of serum- and inflammatory mediator-induced migration of carp (Cyprinus carpio) head kidney neutrophils in vitro.
Fish & shellfish immunology.
2006 Aug; 21(2):187-98. doi:
10.1016/j.fsi.2005.11.007. [PMID: 16469507] - Chiara Dianzani, Roberta Cavalli, Gian Paolo Zara, Margherita Gallicchio, Grazia Lombardi, Maria Rosa Gasco, Patrizia Panzanelli, Roberto Fantozzi. Cholesteryl butyrate solid lipid nanoparticles inhibit adhesion of human neutrophils to endothelial cells.
British journal of pharmacology.
2006 Jul; 148(5):648-56. doi:
10.1038/sj.bjp.0706761. [PMID: 16702992] - Fabrizio Montecucco, Giordano Bianchi, Paola Gnerre, Maria Bertolotto, Franco Dallegri, Luciano Ottonello. Induction of neutrophil chemotaxis by leptin: crucial role for p38 and Src kinases.
Annals of the New York Academy of Sciences.
2006 Jun; 1069(?):463-71. doi:
10.1196/annals.1351.045. [PMID: 16855174] - Tsong-Long Hwang, Shang-Hsin Yeh, Yann-Lii Leu, Ching-Yuh Chern, Hui-Chi Hsu. Inhibition of superoxide anion and elastase release in human neutrophils by 3'-isopropoxychalcone via a cAMP-dependent pathway.
British journal of pharmacology.
2006 May; 148(1):78-87. doi:
10.1038/sj.bjp.0706712. [PMID: 16501579] - Maria Angélica O Mendonça, Fernando Q Cunha, Eddie Fernando C Murta, Beatriz M Tavares-Murta. Failure of neutrophil chemotactic function in breast cancer patients treated with chemotherapy.
Cancer chemotherapy and pharmacology.
2006 May; 57(5):663-70. doi:
10.1007/s00280-005-0086-4. [PMID: 16133528] - Christoph J Konrad, Guido K Schuepfer, Michael Neuburger, Marcus Schley, Martin Schmelz, Joachim Schmeck. Reduction of pulmonary edema by short-acting local anesthetics.
Regional anesthesia and pain medicine.
2006 May; 31(3):254-9. doi:
10.1016/j.rapm.2006.01.003. [PMID: 16701192] - Petra Jerström Skarman, Afsar Rahbar, Xun Xie, Cecilia Söderberg-Nauclér. Induction of polymorphonuclear leukocyte response by human cytomegalovirus.
Microbes and infection.
2006 May; 8(6):1592-601. doi:
10.1016/j.micinf.2006.01.017. [PMID: 16702012] - K Hochegger, J Gruber, K Lhotta. Acute inflammatory syndrome induced by mycophenolate mofetil in a patient following kidney transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2006 Apr; 6(4):852-4. doi:
10.1111/j.1600-6143.2006.01251.x. [PMID: 16539644] - Sunil K Manna, Yashin Sreenivasan, Abira Sarkar. Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity.
Journal of cellular physiology.
2006 Apr; 207(1):195-207. doi:
10.1002/jcp.20555. [PMID: 16331685] - Mei-Feng Hsu, Yu-San Chen, Li-Jiau Huang, Lo-Ti Tsao, Sheng-Chu Kuo, Jih-Pyang Wang. GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation.
European journal of pharmacology.
2006 Mar; 535(1-3):43-52. doi:
10.1016/j.ejphar.2006.02.013. [PMID: 16540105] - Sachiko N Yagi-Chaves, Gang Liu, Koichi Yamashita, Masanobu Manabe, Shao-Jiang Song, Hiroyuki Kodama. Effect of five triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of p47(phox), p67(phox), and rac to cell membrane in human neutrophils.
Archives of biochemistry and biophysics.
2006 Feb; 446(1):84-90. doi:
10.1016/j.abb.2005.11.006. [PMID: 16405902] - Pier Carlo Braga, Monica Dal Sasso, Maria Culici, Tiziana Bianchi, Luca Bordoni, Laura Marabini. Anti-inflammatory activity of thymol: inhibitory effect on the release of human neutrophil elastase.
Pharmacology.
2006; 77(3):130-6. doi:
10.1159/000093790. [PMID: 16763380] - Chaekyun Kim, Mary C Dinauer. Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid.
Journal of leukocyte biology.
2006 Jan; 79(1):223-34. doi:
10.1189/jlb.0705371. [PMID: 16275890] - Kendra D Martyn, Moon-Ju Kim, Mark T Quinn, Mary C Dinauer, Ulla G Knaus. p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils.
Blood.
2005 Dec; 106(12):3962-9. doi:
10.1182/blood-2005-03-0859. [PMID: 16099876]
