Gly-GLN (BioDeep_00000615204)

   


代谢物信息卡片


2-(2-amino-4-carbamoylbutanamido)acetic acid

化学式: C7H13N3O4 (203.0906018)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)N)C(C(=O)[O-])NC(=O)C[NH3+]
InChI: InChI=1S/C7H13N3O4/c8-3-6(12)10-4(7(13)14)1-2-5(9)11/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14)/t4-/m0/s1

描述信息

A dipeptide formed from glycine and L-glutamine residues.

同义名列表

9 个代谢物同义名

Gly-GLN; 2-(2-amino-4-carbamoylbutanamido)acetic acid; Glycine-glutamine dipeptide; Glycine glutamine dipeptide; L-Glycyl-L-glutamine; Glycyl-Glutamine; Glycylglutamine; g-Q Dipeptide; GQ Dipeptide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yong Zhang, Hong Yan, Shang-Gun Lv, Lin Wang, Guang-Ping Liang, Qian-Xue Wan, Xi Peng. Effects of glycyl-glutamine dipeptide supplementation on myocardial damage and cardiac function in rats after severe burn injury. International journal of clinical and experimental pathology. 2013; 6(5):821-30. doi: NULL. [PMID: 23638213]
  • Jian-Wen Jiang, Zhi-Gang Ren, Lu-Yan Chen, Li Jiang, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng. Enteral supplementation with glycyl-glutamine improves intestinal barrier function after liver transplantation in rats. Hepatobiliary & pancreatic diseases international : HBPD INT. 2011 Aug; 10(4):380-5. doi: 10.1016/s1499-3872(11)60064-7. [PMID: 21813386]
  • Ruth Exner, Dietmar Tamandl, Peter Goetzinger, Martina Mittlboeck, Reinhold Fuegger, Thomas Sautner, Andreas Spittler, Erich Roth. Perioperative GLY-GLN infusion diminishes the surgery-induced period of immunosuppression: accelerated restoration of the lipopolysaccharide-stimulated tumor necrosis factor-alpha response. Annals of surgery. 2003 Jan; 237(1):110-5. doi: 10.1097/00000658-200301000-00015. [PMID: 12496537]
  • A Spittler, T Sautner, A Gornikiewicz, N Manhart, R Oehler, M Bergmann, R Függer, E Roth. Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes. Clinical nutrition (Edinburgh, Scotland). 2001 Feb; 20(1):37-42. doi: 10.1054/clnu.2000.0153. [PMID: 11161542]
  • X Zhou, M Thamotharan, A Gangopadhyay, C Serdikoff, S A Adibi. Characterization of an oligopeptide transporter in renal lysosomes. Biochimica et biophysica acta. 2000 Jun; 1466(1-2):372-8. doi: 10.1016/s0005-2736(00)00201-7. [PMID: 10825457]
  • J Jiang, J Li, Y Li, X Wang, Z Wang, F Liu. [Nutritional impact of glycyl-glutamine dipeptide on the autotransplanted small intestine in pig]. Zhonghua wai ke za zhi [Chinese journal of surgery]. 1999 Nov; 37(11):677-9. doi: NULL. [PMID: 11829925]
  • Y S Li, J S Li, J W Jiang, F N Liu, N Li, W S Qin, H Zhu. Glycyl-glutamine-enriched long-term total parenteral nutrition attenuates bacterial translocation following small bowel transplantation in the pig. The Journal of surgical research. 1999 Mar; 82(1):106-11. doi: 10.1006/jsre.1998.5525. [PMID: 10068533]
  • S A Brown, A Goringe, C Fegan, S V Davies, J Giddings, J A Whittaker, A K Burnett, C H Poynton. Parenteral glutamine protects hepatic function during bone marrow transplantation. Bone marrow transplantation. 1998 Aug; 22(3):281-4. doi: 10.1038/sj.bmt.1701321. [PMID: 9720743]
  • D Cardona Pera. [Administration of glutamine and its dipeptides in parenteral nutrition. Which patients are candidates?]. Nutricion hospitalaria. 1998 Jan; 13(1):8-20. doi: NULL. [PMID: 9578682]
  • G Weingartmann, P Fridrich, W Mauritz, P Götzinger, M Mittlböck, P Germann, J Karner, E Roth. Safety and efficacy of increasing dosages of glycyl-glutamine for total parenteral nutrition in polytrauma patients. Wiener klinische Wochenschrift. 1996; 108(21):683-8. doi: NULL. [PMID: 8956477]
  • W Hübl, W Druml, E Roth, H Lochs. Importance of liver and kidney for the utilization of glutamine-containing dipeptides in man. Metabolism: clinical and experimental. 1994 Sep; 43(9):1104-7. doi: 10.1016/0026-0495(94)90051-5. [PMID: 8084285]
  • R Babst, H Hörig, P Stehle, O Brand, L Filgueira, W Marti, M Fischer, M Oberholzer, F Gudat, P Fürst. Glutamine peptide-supplemented long-term total parenteral nutrition: effects on intracellular and extracellular amino acid patterns, nitrogen economy, and tissue morphology in growing rats. JPEN. Journal of parenteral and enteral nutrition. 1993 Nov; 17(6):566-74. doi: 10.1177/0148607193017006566. [PMID: 8003104]
  • H Daniel, S A Adibi. Transport of beta-lactam antibiotics in kidney brush border membrane. Determinants of their affinity for the oligopeptide/H+ symporter. The Journal of clinical investigation. 1993 Nov; 92(5):2215-23. doi: 10.1172/jci116824. [PMID: 8227336]
  • S A Adibi, H Lochs, N N Abumrad, H Daniel, J A Vazquez. Removal of glycylglutamine from plasma by individual tissues: mechanism and impact on amino acid fluxes in postabsorption and starvation. The Journal of nutrition. 1993 02; 123(2 Suppl):325-31. doi: 10.1093/jn/123.suppl_2.325. [PMID: 8429382]
  • R E Goldstein. Glycylglutamine: metabolism and effects on organ balances of amino acids in postabsorptive and starved subjects. JPEN. Journal of parenteral and enteral nutrition. 1992 Sep; 16(5):489-90. doi: 10.1177/0148607192016005489. [PMID: 1433787]
  • J A Vazquez, M Raghunath, S A Adibi. Uptake and hydrolysis of glycylglutamine at the blood-brain barrier. Metabolism: clinical and experimental. 1992 Feb; 41(2):121-4. doi: 10.1016/0026-0495(92)90137-y. [PMID: 1736032]
  • H Lochs, W Hübl, S Gasic, E Roth, E L Morse, S A Adibi. Glycylglutamine: metabolism and effects on organ balances of amino acids in postabsorptive and starved subjects. The American journal of physiology. 1992 Feb; 262(2 Pt 1):E155-60. doi: 10.1152/ajpendo.1992.262.2.e155. [PMID: 1539641]
  • L Haynes. Beta-endorphin C-terminal peptide evokes arachidonic acid release from cortical neurones. European journal of pharmacology. 1991 Jan; 192(3):397-401. doi: 10.1016/0014-2999(91)90231-e. [PMID: 1905234]
  • J Karner, E Roth, G Ollenschläger, P Fürst, A Simmel, J Karner. Glutamine-containing dipeptides as infusion substrates in the septic state. Surgery. 1989 Nov; 106(5):893-900. doi: NULL. [PMID: 2510334]
  • W Hübl, W Druml, K Langer, H Lochs. Influence of molecular structure and plasma hydrolysis on the metabolism of glutamine-containing dipeptides in humans. Metabolism: clinical and experimental. 1989 Aug; 38(8 Suppl 1):59-62. doi: 10.1016/0026-0495(89)90143-1. [PMID: 2761422]
  • N N Abumrad, E L Morse, H Lochs, P E Williams, S A Adibi. Possible sources of glutamine for parenteral nutrition: impact on glutamine metabolism. The American journal of physiology. 1989 Aug; 257(2 Pt 1):E228-34. doi: 10.1152/ajpendo.1989.257.2.e228. [PMID: 2504051]
  • G B Koelle, K A Skau, N S Thampi, D M Hymel, M S Han. Maintenance by glycyl-L-glutamine in vivo of molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Proceedings of the National Academy of Sciences of the United States of America. 1988 Aug; 85(16):6215-7. doi: 10.1073/pnas.85.16.6215. [PMID: 3413090]