Anidulafungin (BioDeep_00000614945)
Chemicals and Drugs
代谢物信息卡片
N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^{9,13}]heptacosan-18-yl]-4-{4-[4-(pentyloxy)phenyl]phenyl}benzamide
化学式: C58H73N7O17 (1139.5062688)
中文名称: 阿尼芬净
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O
InChI: InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1
描述信息
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents > D054714 - Echinocandins
C254 - Anti-Infective Agent > C514 - Antifungal Agent
An azamacrocyclic anti-fungal drug.
同义名列表
2 个代谢物同义名
Anidulafungin; N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^{9,13}]heptacosan-18-yl]-4-{4-[4-(pentyloxy)phenyl]phenyl}benzamide
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:55346
- PubChem: 166548
- Metlin: METLIN85369
- DrugBank: DB00362
- ChEMBL: CHEMBL264241
- MeSH: Anidulafungin
- CAS: 166663-25-8
- MetaboLights: MTBLC55346
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 1883 - Streptomyces: 10.1007/S13205-019-1946-7
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Letícia Kraft, Victoria Stadler Tasca Ribeiro, Geiziane Aparecida Gonçalves, Paula Hansen Suss, Felipe Francisco Tuon. Comparison of amphotericin B lipid complex, deoxycholate amphotericin B, fluconazole, and anidulafungin activity against Candida albicans biofilm isolated from breakthrough candidemia.
Enfermedades infecciosas y microbiologia clinica (English ed.).
2023 Jan; ?(?):. doi:
10.1016/j.eimce.2022.07.009. [PMID: 36707288] - Cid Manso de Mello Vianna, Gabriela Bittencourt Gonzalez Mosegui, Marcus Paulo da Silva Rodrigues. Cost-effectiveness analysis and budgetary impact of anidulafungin treatment for patients with candidemia and other forms of invasive candidiasis in Brazil.
Revista do Instituto de Medicina Tropical de Sao Paulo.
2023; 65(?):e9. doi:
10.1590/s1678-9946202365009. [PMID: 36722671] - Panagiota-Christina Georgiou, Maiken Cavling Arendrup, Joseph Meletiadis. Early phenotypic detection of fluconazole- and anidulafungin-resistant Candida glabrata isolates.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1655-1661. doi:
10.1093/jac/dkac075. [PMID: 35323941] - Javad Naderi, Hans J Griesser, Bryan R Coad. Assessment of nonreleasing antifungal surface coatings bearing covalently attached pharmaceuticals.
Biointerphases.
2021 11; 16(6):061001. doi:
10.1116/6.0001099. [PMID: 34794317] - João Nobrega de Almeida, Igor B Brandão, Elaine C Francisco, Silvio Luis R de Almeida, Patrícia de Oliveira Dias, Felicidade M Pereira, Fábio Santos Ferreira, Thaisse Souza de Andrade, Magda M de Miranda Costa, Regiane T de Souza Jordão, Jacques F Meis, Arnaldo L Colombo. Axillary Digital Thermometers uplifted a multidrug-susceptible Candida auris outbreak among COVID-19 patients in Brazil.
Mycoses.
2021 Sep; 64(9):1062-1072. doi:
10.1111/myc.13320. [PMID: 34009677] - Ahmed Gamal, Lisa Long, Janet Herrada, Jalal Aram, Thomas S McCormick, Mahmoud A Ghannoum. Efficacy of Voriconazole, Isavuconazole, Fluconazole, and Anidulafungin in the Treatment of Emerging Candida auris Using an Immunocompromised Murine Model of Disseminated Candidiasis.
Antimicrobial agents and chemotherapy.
2021 08; 65(9):e0054921. doi:
10.1128/aac.00549-21. [PMID: 34228541] - Melanie T Cushion, Parag Kumar, Ruying Lu, Alan Ashbaugh, Lilian W Adeojo, Raul Alfaro, Raphael Mannino, Edmund Tramont, Joseph A Kovacs. A Novel Encochleated Formulation Improves Atovaquone Activity in a Murine Model of Pneumocystis Pneumonia.
The Journal of infectious diseases.
2021 07; 224(2):326-331. doi:
10.1093/infdis/jiaa731. [PMID: 33245345] - Francesca Gioia, Alicia Gomez-Lopez, Maria Elena Alvarez, Elia Gomez-García de la Pedrosa, Pilar Martín-Davila, Manuel Cuenca-Estrella, Santiago Moreno, Jesús Fortun. Pharmacokinetics of echinocandins in suspected candida peritonitis: A potential risk for resistance.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Dec; 101(?):24-28. doi:
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Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00275-20. [PMID: 32340985] - Davide Lazzarotto, Gabriele Facchin, Anna Candoni, Renato Fanin. 18F-FDG Positron Emission Tomography (PET) Scan as a Useful Tool to Assess Response to Antimycotic Therapy in Disseminated Invasive Mycosis in Acute Myeloid Leukemia.
Mycopathologia.
2020 06; 185(3):597-598. doi:
10.1007/s11046-020-00441-0. [PMID: 32266558] - René Welte, Herbert Oberacher, Bernhard Schwärzler, Michael Joannidis, Romuald Bellmann. Quantification of anidulafungin and micafungin in human body fluids by high performance-liquid chromatography with UV-detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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10.1016/j.jchromb.2019.121937. [PMID: 31958565] - Dong-Gun Lee, Hye-Jung Lee, Jean Li Yan, Stephen Sheng-Fong Lin, Jalal A Aram. Efficacy and safety of combination antifungal therapy in Korean haematological patients with invasive aspergillosis.
Mycoses.
2019 Oct; 62(10):969-978. doi:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2019 Sep; 86(?):142-146. doi:
10.1016/j.ijid.2019.07.008. [PMID: 31330325] - Maiken Cavling Arendrup, Karin Meinike Jørgensen, Rasmus Krøger Hare, Manuel Cuenca-Estrella, Oscar Zaragoza. EUCAST Reference Testing of Rezafungin Susceptibility and Impact of Choice of Plastic Plates.
Antimicrobial agents and chemotherapy.
2019 09; 63(9):. doi:
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World journal of microbiology & biotechnology.
2019 Jul; 35(7):109. doi:
10.1007/s11274-019-2687-9. [PMID: 31280382] - Maiken Cavling Arendrup, Anuradha Chowdhary, Karen M T Astvad, Karin Meinike Jørgensen. APX001A In Vitro Activity against Contemporary Blood Isolates and Candida auris Determined by the EUCAST Reference Method.
Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.01225-18. [PMID: 30104264] - Ona Rogiers, Michelle Holtappels, Wafi Siala, Mohamed Lamkanfi, Françoise Van Bambeke, Katrien Lagrou, Patrick Van Dijck, Sona Kucharíková. Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies.
The Journal of antimicrobial chemotherapy.
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10.1093/jac/dky246. [PMID: 30010876] - R Welte, P Eller, I Lorenz, M Joannidis, R Bellmann. Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients.
Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
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Antimicrobial agents and chemotherapy.
2018 03; 62(3):. doi:
10.1128/aac.02319-17. [PMID: 29311065] - Peter Kolbinger, Michael Gruber, Gabriel Roth, Bernhard M Graf, Karl-Peter Ittner. Filter Adsorption of Anidulafungin to a Polysulfone-Based Hemofilter During CVVHD In Vitro.
Artificial organs.
2018 Feb; 42(2):200-207. doi:
10.1111/aor.12982. [PMID: 29027687] - G Hazirolan, A Aypak, N Aksu. An unusual case of urinary tract infection caused by Saprochaete capitata under anidulafungin treatment.
Journal de mycologie medicale.
2017 Sep; 27(3):387-390. doi:
10.1016/j.mycmed.2017.04.001. [PMID: 28478968] - Adela Martin-Vicente, Javier Capilla, Josep Guarro. Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis.
Medical mycology.
2017 Jun; 55(4):457-460. doi:
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Antimicrobial agents and chemotherapy.
2017 02; 61(2):. doi:
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2016 Dec; 65(12):1445-1451. doi:
10.1099/jmm.0.000383. [PMID: 27902377] - Maria Siopi, Nikolaos Siafakas, Sophia Vourli, Johan W Mouton, Loukia Zerva, Joseph Meletiadis. Dose optimization of voriconazole/anidulafungin combination against Aspergillus fumigatus using an in vitro pharmacokinetic/pharmacodynamic model and response surface analysis: clinical implications for azole-resistant aspergillosis.
The Journal of antimicrobial chemotherapy.
2016 11; 71(11):3135-3147. doi:
10.1093/jac/dkw276. [PMID: 27494912] - Voon Ong, Grayson Hough, Michael Schlosser, Ken Bartizal, James M Balkovec, Kenneth D James, B Radha Krishnan. Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin.
Antimicrobial agents and chemotherapy.
2016 11; 60(11):6872-6879. doi:
10.1128/aac.00701-16. [PMID: 27620474] - Michael A Pfaller, Shawn A Messer, Paul R Rhomberg, Ronald N Jones, Mariana Castanheira. Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates.
The Journal of antimicrobial chemotherapy.
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Antimicrobial agents and chemotherapy.
2016 10; 60(10):6100-7. doi:
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BMC infectious diseases.
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Antimicrobial agents and chemotherapy.
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Medical mycology.
2015 Aug; 53(6):630-5. doi:
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Revista iberoamericana de micologia.
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10.1016/j.riam.2014.10.003. [PMID: 25858598] - Eline W Muilwijk, Vincent J C Lempers, David M Burger, Adilia Warris, Peter Pickkers, Rob E Aarnoutse, Roger J M Brüggemann. Impact of special patient populations on the pharmacokinetics of echinocandins.
Expert review of anti-infective therapy.
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10.1586/14787210.2015.1028366. [PMID: 25947367] - Sandra Gil-Alonso, Nerea Jauregizar, Emilia Cantón, Elena Eraso, Guillermo Quindós. In vitro fungicidal activities of anidulafungin, caspofungin, and micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis evaluated by time-kill studies.
Antimicrobial agents and chemotherapy.
2015; 59(6):3615-8. doi:
10.1128/aac.04474-14. [PMID: 25801575] - Katihuska Paredes, Francisco Javier Pastor, Javier Capilla, Deanna A Sutton, Emilio Mayayo, Annette W Fothergill, Josep Guarro. Therapies against murine Candida guilliermondii infection, relationship between in vitro antifungal pharmacodynamics and outcome.
Revista iberoamericana de micologia.
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10.1016/j.riam.2013.10.008. [PMID: 24594291] - Tan N Doan, David C M Kong, Kashyap Patel, Patricia Walker, Andrew Spencer, Carl M J Kirkpatrick. Comparison of the probability of target attainment of anidulafungin against Candida spp. in patients with acute leukaemia.
International journal of antimicrobial agents.
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The Journal of antimicrobial chemotherapy.
2014 Jun; 69(6):1620-3. doi:
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Antimicrobial agents and chemotherapy.
2014 06; 58(6):3550-2. doi:
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Mycoses.
2014 Jun; 57(6):377-9. doi:
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Journal of chemotherapy (Florence, Italy).
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Antimicrobial agents and chemotherapy.
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2013 Apr; 57(4):1672-6. doi:
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The Journal of antimicrobial chemotherapy.
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2012 Nov; 56(11):5875-82. doi:
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