SC-560 (BioDeep_00000605567)

   

natural product


代谢物信息卡片


5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

化学式: C17H12ClF3N2O (352.059)
中文名称: SC-560
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=C(C=C1)N2C(=CC(=N2)C(F)(F)F)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3

描述信息

D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

2 个代谢物同义名

5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole; SC-560



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Miroslav Sisa, Lukáš Konečný, Veronika Temml, Alejandro Carazo, Přemysl Mladěnka, Přemysl Landa. SC-560 and mofezolac isosteres as new potent COX-1 selective inhibitors with antiplatelet effect. Archiv der Pharmazie. 2023 Feb; ?(?):e2200549. doi: 10.1002/ardp.202200549. [PMID: 36772878]
  • Ahmed Ayyash, Alison C Holloway. Fluoxetine-induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15-deoxy-Δ12,14 PGJ2. Journal of applied toxicology : JAT. 2022 06; 42(6):1004-1015. doi: 10.1002/jat.4272. [PMID: 34897744]
  • Marcela Dvorakova, Lenka Langhansova, Veronika Temml, Antonio Pavicic, Tomas Vanek, Premysl Landa. Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core. ACS medicinal chemistry letters. 2021 Apr; 12(4):610-616. doi: 10.1021/acsmedchemlett.1c00004. [PMID: 33854702]
  • Renata Czekaj, Jolanta Majka, Katarzyna Magierowska, Zbigniew Sliwowski, Marcin Magierowski, Robert Pajdo, Agata Ptak-Belowska, Marcin Surmiak, Slawomir Kwiecien, Tomasz Brzozowski. Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions. Journal of gastroenterology. 2018 May; 53(5):618-630. doi: 10.1007/s00535-017-1385-3. [PMID: 28856444]
  • Yanmei Zhang, Yican Wang, Chuang He, Xiaorong Liu, Yongzhi Lu, Tingting Chen, Qiong Pan, Jingfang Xiong, Miaoqin She, Zhengchao Tu, Xiaochu Qin, Minke Li, Micky D Tortorella, John J Talley. Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation. Journal of medicinal chemistry. 2017 05; 60(10):4135-4146. doi: 10.1021/acs.jmedchem.6b01484. [PMID: 28475316]
  • Viswanathan Saraswathi, Curtis Perriotte-Olson, Murali Ganesan, Cyrus V Desouza, Yazen Alnouti, Michael J Duryee, Geoffrey M Thiele, Tara M Nordgren, Dahn L Clemens. A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice. The Journal of nutritional biochemistry. 2017 04; 42(?):149-159. doi: 10.1016/j.jnutbio.2017.01.011. [PMID: 28187366]
  • Paulrayer Antonisamy, Mariadhas Valan Arasu, Muniappan Dhanasekaran, Ki Choon Choi, Adithan Aravinthan, Nam Soo Kim, Chang-Won Kang, Jong-Hoon Kim. Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. Food & function. 2016 Jan; 7(1):398-408. doi: 10.1039/c5fo00403a. [PMID: 26499137]
  • Katharina Mederle, Manuel Meurer, Hayo Castrop, Klaus Höcherl. Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice. American journal of physiology. Renal physiology. 2015 Aug; 309(4):F332-40. doi: 10.1152/ajprenal.00567.2014. [PMID: 26017977]
  • Jaime H Gómez-Zamudio, Rebeca García-Macedo, Martha Lázaro-Suárez, Maximiliano Ibarra-Barajas, Jesús Kumate, Miguel Cruz. Vascular endothelial function is improved by oral glycine treatment in aged rats. Canadian journal of physiology and pharmacology. 2015 Jun; 93(6):465-73. doi: 10.1139/cjpp-2014-0393. [PMID: 25988540]
  • Jia Xiao, Emily C Liong, Hai Huang, Wing On Tse, Kam Shing Lau, Jingfei Pan, Amin A Nanji, Man Lung Fung, Feiyue Xing, George L Tipoe. Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):430-40. doi: 10.1093/toxsci/kfu244. [PMID: 25432964]
  • Suresh Ranga Rao, T M Balaji, P S G Prakash, Vamsi Lavu. Elevated levels of cyclooxygenase 1 and 2 in human cyclosporine induced gingival overgrowth. Prostaglandins & other lipid mediators. 2014 Oct; 113-115(?):69-74. doi: 10.1016/j.prostaglandins.2014.07.003. [PMID: 25124319]
  • Paulrayer Antonisamy, Muniyappan Dhanasekaran, Savarimuthu Ignacimuthu, Veeramuthu Duraipandiyan, Joseph Devadass Balthazar, Paul Agastian, Jong-Hoon Kim. Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Jun; 21(7):966-9. doi: 10.1016/j.phymed.2014.02.010. [PMID: 24680619]
  • Ariane Bischoff, Michael Bucher, Michael Gekle, Christoph Sauvant. Differential effect of COX1 and COX2 inhibitors on renal outcomes following ischemic acute kidney injury. American journal of nephrology. 2014; 40(1):1-11. doi: 10.1159/000363251. [PMID: 24943263]
  • Ninitha Asirvatham-Jeyaraj, Andrew J King, Carrie A Northcott, Shivanshu Madan, Gregory D Fink. Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat. American journal of physiology. Heart and circulatory physiology. 2013 Nov; 305(10):H1462-70. doi: 10.1152/ajpheart.00245.2013. [PMID: 24014677]
  • H Polat, S Mamuk, E S Akarsu. Hormonal synchronization of lipopolysaccharide-induced hypothermic response in rats. Journal of endocrinological investigation. 2013 Nov; 36(10):816-24. doi: 10.3275/8945. [PMID: 23612418]
  • Elodie Gautier-Veyret, Claire Arnaud, Magnus Bäck, Jean-Louis Pépin, Marcelo H Petri, Jean-Philippe Baguet, Renaud Tamisier, Patrick Lévy, Françoise Stanke-Labesque. Intermittent hypoxia-activated cyclooxygenase pathway: role in atherosclerosis. The European respiratory journal. 2013 Aug; 42(2):404-13. doi: 10.1183/09031936.00096512. [PMID: 23060635]
  • Stefanie Frölich, Anke Olliges, Niklas Kern, Yannik Schreiber, Shuh Narumiya, Rolf M Nüsing. Temporal expression of the PGE2 synthetic system in the kidney is associated with the time frame of renal developmental vulnerability to cyclooxygenase-2 inhibition. American journal of physiology. Renal physiology. 2012 Jul; 303(2):F209-19. doi: 10.1152/ajprenal.00418.2011. [PMID: 22573380]
  • Ana B Fernández-Martínez, María I Arenas Jiménez, Francisco J Lucio Cazaña. Retinoic acid increases hypoxia-inducible factor-1α through intracrine prostaglandin E(2) signaling in human renal proximal tubular cells HK-2. Biochimica et biophysica acta. 2012 Apr; 1821(4):672-83. doi: 10.1016/j.bbalip.2012.01.010. [PMID: 22306363]
  • S Kwiecien, P C Konturek, Z Sliwowski, M Mitis-Musiol, M W Pawlik, B Brzozowski, K Jasnos, M Magierowski, S J Konturek, T Brzozowski. Interaction between selective cyclooxygenase inhibitors and capsaicin-sensitive afferent sensory nerves in pathogenesis of stress-induced gastric lesions. Role of oxidative stress. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2012 Apr; 63(2):143-51. doi: . [PMID: 22653901]
  • Kohei Tanaka, Tomoyuki Furuyashiki, Shiho Kitaoka, Yuta Senzai, Yuki Imoto, Eri Segi-Nishida, Yuichi Deguchi, Richard M Breyer, Matthew D Breyer, Shuh Narumiya. Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Mar; 32(12):4319-29. doi: 10.1523/jneurosci.5952-11.2012. [PMID: 22442093]
  • Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry. 2012 Mar; 55(5):2287-300. doi: 10.1021/jm201528b. [PMID: 22263894]
  • Malgorzata Zwolinska-Wcislo, Tomasz Brzozowski, Agata Ptak-Belowska, Aneta Targosz, Katarzyna Urbanczyk, Slawomir Kwiecien, Zbigniew Sliwowski. Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis. World journal of gastroenterology. 2011 Sep; 17(36):4076-89. doi: 10.3748/wjg.v17.i36.4076. [PMID: 22039321]
  • M Pawlik, R Pajdo, S Kwiecien, A Ptak-Belowska, Z Sliwowski, M Mazurkiewicz-Janik, S J Konturek, W W Pawlik, T Brzozowski. Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2011 Feb; 62(1):75-86. doi: . [PMID: 21451212]
  • Hiroki Kubota, Shoichi Sasaki, Yasue Kubota, Yukihiro Umemoto, Yoshimasa Yanai, Keiichi Tozawa, Yutaro Hayashi, Kenjiro Kohri. Cyclooxygenase-2 protects germ cells against spermatogenesis disturbance in experimental cryptorchidism model mice. Journal of andrology. 2011 Jan; 32(1):77-85. doi: 10.2164/jandrol.109.008888. [PMID: 20671144]
  • Xi-Chun Zhang, Vanessa Kainz, Rami Burstein, Dan Levy. Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 Jan; 152(1):140-149. doi: 10.1016/j.pain.2010.10.002. [PMID: 21036476]
  • Kristopher Silver, Ludovic Leloup, Lisa C Freeman, Alan Wells, James D Lillich. Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease. The international journal of biochemistry & cell biology. 2010 Dec; 42(12):2030-6. doi: 10.1016/j.biocel.2010.09.007. [PMID: 20854926]
  • Torrance Green, Jorge Rodriguez, L Gabriel Navar. Augmented cyclooxygenase-2 effects on renal function during varying states of angiotensin II. American journal of physiology. Renal physiology. 2010 Nov; 299(5):F954-62. doi: 10.1152/ajprenal.00609.2009. [PMID: 20668099]
  • Carmen Mingorance, Maria Alvarez de Sotomayor, Elisa Marhuenda, Maria Dolores Herrera. Chronic treatment with the cannabinoid 1 antagonist rimonabant altered vasoactive cyclo-oxygenase-derived products on arteries from obese Zucker rats. Journal of cardiovascular pharmacology. 2010 Nov; 56(5):560-9. doi: 10.1097/fjc.0b013e3181f7141a. [PMID: 20729749]
  • Chen Qu, Susan W S Leung, Paul M Vanhoutte, Ricky Y K Man. Chronic inhibition of nitric-oxide synthase potentiates endothelium-dependent contractions in the rat aorta by augmenting the expression of cyclooxygenase-2. The Journal of pharmacology and experimental therapeutics. 2010 Aug; 334(2):373-80. doi: 10.1124/jpet.110.167098. [PMID: 20444882]
  • Qiang Fu, Ke Zan, Mingbo Zhao, Sixiang Zhou, Shepo Shi, Yong Jiang, Pengfei Tu. Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity. Journal of natural products. 2010 Jul; 73(7):1234-9. doi: 10.1021/np100057y. [PMID: 20540535]
  • Yukiko Enomoto, Seiji Adachi, Rie Matsushima-Nishiwaki, Tomoaki Doi, Masayuki Niwa, Shigeru Akamatsu, Haruhiko Tokuda, Shinji Ogura, Shinichi Yoshimura, Toru Iwama, Osamu Kozawa. Thromboxane A(2) promotes soluble CD40 ligand release from human platelets. Atherosclerosis. 2010 Apr; 209(2):415-21. doi: 10.1016/j.atherosclerosis.2009.10.024. [PMID: 19932480]
  • Louise Elander, Johan Ruud, Marina Korotkova, Per-Johan Jakobsson, Anders Blomqvist. Cyclooxygenase-1 mediates the immediate corticosterone response to peripheral immune challenge induced by lipopolysaccharide. Neuroscience letters. 2010 Feb; 470(1):10-2. doi: 10.1016/j.neulet.2009.12.036. [PMID: 20034541]
  • Shawna N Greene, José A Ramos-Vara, Bruce A Craig, Steven B Hooser, Cheryl Anderson, Lindsey M Fourez, Brenda M Johnson, Jane C Stewart, Deborah W Knapp. Effects of cyclooxygenase inhibitor treatment on the renal toxicity of cisplatin in rats. Cancer chemotherapy and pharmacology. 2010 Feb; 65(3):549-56. doi: 10.1007/s00280-009-1061-2. [PMID: 19629487]
  • Tao Feng, Yan Li, Xiang-Hai Cai, Xun Gong, Ya-Ping Liu, Rong-Ting Zhang, Xiang-Yun Zhang, Qin-Gang Tan, Xiao-Dong Luo. Monoterpenoid indole alkaloids from Alstonia yunnanensis. Journal of natural products. 2009 Oct; 72(10):1836-41. doi: 10.1021/np900374s. [PMID: 19775092]
  • Mika Okamoto, Masashi Sakai, Yukinori Goto, Mohammed T A Salim, Chiaki Baba, Kaku Goto, Koichi Watashi, Kunitada Shimotohno, Masanori Baba. Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560. Antiviral chemistry & chemotherapy. 2009 Sep; 20(1):47-54. doi: 10.3851/imp1372. [PMID: 19794231]
  • Alexandre A Steiner, John C Hunter, Sean M Phipps, Tatiane B Nucci, Daniela L Oliveira, Jennifer L Roberts, Adrienne C Scheck, Daniel L Simmons, Andrej A Romanovsky. Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Aug; 297(2):R485-94. doi: 10.1152/ajpregu.91026.2008. [PMID: 19515980]
  • Samantha P Tull, Clara M Yates, Benjamin H Maskrey, Valerie B O'Donnell, Jackie Madden, Robert F Grimble, Philip C Calder, Gerard B Nash, G Ed Rainger. Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS biology. 2009 Aug; 7(8):e1000177. doi: 10.1371/journal.pbio.1000177. [PMID: 19707265]
  • Magali Araujo, William J Welch. Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide. American journal of physiology. Renal physiology. 2009 Apr; 296(4):F790-4. doi: 10.1152/ajprenal.90446.2008. [PMID: 19144694]
  • Mitsuaki Okayama, Shusaku Hayashi, Yoko Aoi, Hikaru Nishio, Shinichi Kato, Koji Takeuchi. Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. Digestive diseases and sciences. 2007 Sep; 52(9):2095-103. doi: 10.1007/s10620-006-9597-z. [PMID: 17429720]
  • Yanmei Jin, Caiqiao Zhang, Weidong Zeng, Kazuyoshi Taya, Tu Quang Tan. Interactive actions of prostaglandin and epidermal growth factor to enhance proliferation of granulosa cells from chicken prehierarchical follicles. Prostaglandins & other lipid mediators. 2007 Jun; 83(4):285-94. doi: 10.1016/j.prostaglandins.2007.02.002. [PMID: 17499748]
  • Y Honma, I Arai, N Futaki, Y Hashimoto, M Sugimoto, T Sakurai, S Nakaike. Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice. The British journal of dermatology. 2007 Jun; 156(6):1178-87. doi: 10.1111/j.1365-2133.2007.07882.x. [PMID: 17459048]
  • Eyup S Akarsu, Soner Mamuk. Escherichia coli lipopolysaccharides produce serotype-specific hypothermic response in biotelemetered rats. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 May; 292(5):R1846-50. doi: 10.1152/ajpregu.00786.2006. [PMID: 17272660]
  • Tillmann Cyrus, Yuemang Yao, Tao Ding, Jean Michel Dogné, Domenico Praticò. Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice. Blood. 2007 Apr; 109(8):3291-6. doi: 10.1182/blood-2006-08-044990. [PMID: 17158227]
  • Jin Cheng Yao, Wei Gang Duan, Yu Yun, De Quan Liu, Ming Yan, Zhen Zhou Jiang, Lu Yong Zhang. Screening method for nonsteroidal antiinflammatory drugs based on the cyclooxygenase 2 pathway activated by serum-free stimulation in A549 cells. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2007 Mar; 127(3):527-32. doi: 10.1248/yakushi.127.527. [PMID: 17329938]
  • Edwin S L Chan, Hongwei Zhang, Patricia Fernandez, Sari D Edelman, Michael H Pillinger, Louis Ragolia, Thomas Palaia, Steven Carsons, Allison B Reiss. Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. Arthritis research & therapy. 2007; 9(1):R4. doi: 10.1186/ar2109. [PMID: 17244362]
  • Christian Doutremepuich, Omar Aguejouf, Francisco X Eizayaga, Vanessa Desplat. Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition?. Pathophysiology of haemostasis and thrombosis. 2007; 36(1):40-4. doi: 10.1159/000112638. [PMID: 18332613]
  • Alessandro Menozzi, Cristina Pozzoli, Elena Giovannini, Elvira Solenghi, Daniela Grandi, Silvia Bonardi, Simone Bertini, Valentina Vasina, Gabriella Coruzzi. Intestinal effects of nonselective and selective cyclooxygenase inhibitors in the rat. European journal of pharmacology. 2006 Dec; 552(1-3):143-50. doi: 10.1016/j.ejphar.2006.08.089. [PMID: 17069793]
  • Elena Piazuelo, Pilar Jiménez, Mark Strunk, Sonia Santander, Asunción García, Francisco Esteva, Angel Lanas. Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus. Prostaglandins & other lipid mediators. 2006 Dec; 81(3-4):150-61. doi: 10.1016/j.prostaglandins.2006.09.002. [PMID: 17085323]
  • Jinshan Cao, Takio Kitazawa, Kazushige Takehana, Tetsuro Taneike. Endogenous prostaglandins regulate spontaneous contractile activity of uterine strips isolated from non-pregnant pigs. Prostaglandins & other lipid mediators. 2006 Dec; 81(3-4):93-105. doi: 10.1016/j.prostaglandins.2006.08.003. [PMID: 17085318]
  • Gillian M Borthwick, A Sarah Johnson, Matthew Partington, John Burn, Robert Wilson, Helen M Arthur. Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Oct; 20(12):2009-16. doi: 10.1096/fj.06-5987com. [PMID: 17012253]
  • R John Aitken, Jordana K Wingate, Geoffry N De Iuliis, Adam J Koppers, Eileen A McLaughlin. Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa. The Journal of clinical endocrinology and metabolism. 2006 Oct; 91(10):4154-63. doi: 10.1210/jc.2006-1309. [PMID: 16895947]
  • Timothy D Warner, Ivana Vojnovic, David Bishop-Bailey, Jane A Mitchell. Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Mar; 20(3):542-4. doi: 10.1096/fj.05-4434fje. [PMID: 16403783]
  • Véronique Blais, Nicolas P Turrin, Serge Rivest. Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli. Journal of neurochemistry. 2005 Dec; 95(6):1563-74. doi: 10.1111/j.1471-4159.2005.03480.x. [PMID: 16277613]
  • Pierre-Olivier Hétu, Denis Riendeau. Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain. The Biochemical journal. 2005 Nov; 391(Pt 3):561-6. doi: 10.1042/bj20050451. [PMID: 16008526]
  • Olimpia Pepicelli, Ernesto Fedele, Maria Berardi, Maurizio Raiteri, Giulio Levi, Anita Greco, Maria Antonietta Ajmone-Cat, Luisa Minghetti. Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus. Journal of neurochemistry. 2005 Jun; 93(6):1561-7. doi: 10.1111/j.1471-4159.2005.03150.x. [PMID: 15935072]
  • S Soodvilai, V Chatsudthipong, K K Evans, S H Wright, W H Dantzler. Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. American journal of physiology. Renal physiology. 2004 Nov; 287(5):F1021-9. doi: 10.1152/ajprenal.00080.2004. [PMID: 15238352]
  • C Härtel, J von Puttkamer, F Gallner, T Strunk, C Schultz. Dose-dependent immunomodulatory effects of acetylsalicylic acid and indomethacin in human whole blood: potential role of cyclooxygenase-2 inhibition. Scandinavian journal of immunology. 2004 Oct; 60(4):412-20. doi: 10.1111/j.0300-9475.2004.01481.x. [PMID: 15379866]
  • Tomasz Brzozowski, Peter C Konturek, Stanislaw J Konturek, Robert Pajdo, Slawomir Kwiecien, Michal Pawlik, Danuta Drozdowicz, Zbigniew Sliwowski, Wieslaw W Pawlik. Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves. European journal of pharmacology. 2004 Sep; 499(1-2):201-13. doi: 10.1016/j.ejphar.2004.07.072. [PMID: 15363968]
  • Pierre-Yves von der Weid, Morley D Hollenberg, Stefano Fiorucci, John L Wallace. Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone. Circulation. 2004 Sep; 110(10):1320-5. doi: 10.1161/01.cir.0000140985.89766.cb. [PMID: 15326064]
  • Xiao Wei Teng, Neal M Davies. High-performance liquid chromatographic analysis of a selective cyclooxygenase-1 inhibitor SC-560 in rat serum: application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2004 Sep; 35(5):1143-7. doi: 10.1016/j.jpba.2004.03.013. [PMID: 15336360]
  • Pilar J Oviedo, Carlos Hermenegildo, Antonio Cano. Raloxifene increases the capacity of serum to promote prostacyclin release in human endothelial cells: implication of COX-1 and COX-2. Menopause (New York, N.Y.). 2004 Jul; 11(4):430-7. doi: 10.1097/01.gme.0000111544.61545.48. [PMID: 15243281]
  • Dan Wang, Tina Chabrashvili, Christopher S Wilcox. Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium. Circulation research. 2004 Jun; 94(11):1436-42. doi: 10.1161/01.res.0000129578.76799.75. [PMID: 15117817]
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