CP 55,940 (BioDeep_00000605501)
代谢物信息卡片
5-(1,1-dimethylheptyl)-2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-phenol
化学式: C24H40O3 (376.2977)
中文名称: 5-(1,1-二甲基庚基)-2-[5-羟基-2-(3-羟基丙基)环己基]苯酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCC(C)(C)C1=CC(=C(C=C1)C2CC(CCC2CCCO)O)O
InChI: InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91490
- PubChem: 4412255
- Metlin: METLIN62954
- ChEMBL: CHEMBL77520
- CAS: 83002-04-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Deepkamal Karelia, Zachary Corey, Haifeng Wang, Wesley M Raup-Konsavage, Kent E Vrana, Junxuan Lü, Cheng Jiang. Library Screening and Preliminary Characterization of Synthetic Cannabinoids Against Prostate and Pancreatic Cancer Cell Lines.
Cannabis and cannabinoid research.
2023 Mar; ?(?):. doi:
10.1089/can.2022.0270. [PMID: 36880938] - Laura L Erwin, Mark R Nilges, Ian B Denys, Jane C Sutphen, Ashton J Friend, Daniel R Kapusta, Peter J Winsauer. Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids.
Pharmacology, biochemistry, and behavior.
2021 08; 207(?):173218. doi:
10.1016/j.pbb.2021.173218. [PMID: 34118232] - Joseph K Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K Dempsey, Ningjun Li, Pin-Lan Li, Vijay Lyall. Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na+-K+-ATPase in Mouse Kidney Thick Ascending Limb Tubules.
The Journal of pharmacology and experimental therapeutics.
2021 01; 376(1):1-11. doi:
10.1124/jpet.120.000163. [PMID: 33087396] - Zhenhua Shao, Wei Yan, Karen Chapman, Karthik Ramesh, Aaron J Ferrell, Jie Yin, Xuehui Wang, Qingping Xu, Daniel M Rosenbaum. Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
Nature chemical biology.
2019 12; 15(12):1199-1205. doi:
10.1038/s41589-019-0387-2. [PMID: 31659318] - James R Foster, Shohta Ueno, Mao Xiang Chen, Jenni Harvey, Simon J Dowell, Andrew J Irving, Andrew J Brown. N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132.
Pharmacology research & perspectives.
2019 12; 7(6):e00542. doi:
10.1002/prp2.542. [PMID: 31768260] - Óscar Díaz, James A R Dalton, Jesús Giraldo. Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation.
Journal of medicinal chemistry.
2019 06; 62(11):5638-5654. doi:
10.1021/acs.jmedchem.9b00612. [PMID: 31095906] - Caitlin A D Jagla, Caitlin E Scott, Yaliang Tang, Changjiang Qiao, Gabriel E Mateo-Semidey, Guillermo A Yudowski, Dai Lu, Debra A Kendall. Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin-Dependent Responses.
Molecular pharmacology.
2019 01; 95(1):1-10. doi:
10.1124/mol.118.112854. [PMID: 30322873] - Benjamin M Ford, Lirit N Franks, Sherrica Tai, William E Fantegrossi, Edward L Stahl, Michael D Berquist, Christian V Cabanlong, Catheryn D Wilson, Narsimha R Penthala, Peter A Crooks, Paul L Prather. Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development.
Pharmacological research.
2017 Nov; 125(Pt B):161-177. doi:
10.1016/j.phrs.2017.08.008. [PMID: 28838808] - Maria Scherma, Valentina Satta, Roberto Collu, Maria Francesca Boi, Paolo Usai, Walter Fratta, Paola Fadda. Cannabinoid CB1 /CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia.
British journal of pharmacology.
2017 Aug; 174(16):2682-2695. doi:
10.1111/bph.13892. [PMID: 28561272] - Vanessa Minervini, Sujata Dahal, Charles P France. Behavioral Characterization of κ Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats.
The Journal of pharmacology and experimental therapeutics.
2017 Feb; 360(2):280-287. doi:
10.1124/jpet.116.235630. [PMID: 27903642] - Lawrence C Blume, Sandra Leone-Kabler, Deborah J Luessen, Glen S Marrs, Erica Lyons, Caroline E Bass, Rong Chen, Dana E Selley, Allyn C Howlett. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
Journal of neurochemistry.
2016 11; 139(3):396-407. doi:
10.1111/jnc.13767. [PMID: 27513693] - Evangelia Bakali, Yvonne Mbaki, David G Lambert, Ruth A Elliott, Robert Mason, Douglas G Tincello. Effects of cannabinoid receptor activation by CP55,940 on normal bladder function and irritation-induced bladder overactivity in non-awake anaesthetised rats.
International urogynecology journal.
2016 Sep; 27(9):1393-400. doi:
10.1007/s00192-016-2984-x. [PMID: 26942594] - E Rangel-López, A L Colín-González, A L Paz-Loyola, E Pinzón, I Torres, I N Serratos, P Castellanos, M Wajner, D O Souza, A Santamaría. Cannabinoid receptor agonists reduce the short-term mitochondrial dysfunction and oxidative stress linked to excitotoxicity in the rat brain.
Neuroscience.
2015 Jan; 285(?):97-106. doi:
10.1016/j.neuroscience.2014.11.016. [PMID: 25446347] - Jenny L Wiley, Julie A Marusich, Timothy W Lefever, Megan Grabenauer, Katherine N Moore, Brian F Thomas. Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.
Neuropharmacology.
2013 Dec; 75(?):145-54. doi:
10.1016/j.neuropharm.2013.07.022. [PMID: 23916483] - Eman Ilayan, Monika Feliszek, Barbara Malinowska, Eberhard Schlicker. Do cannabinoids exhibit a tyramine-like effect?.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Dec; 386(12):1041-6. doi:
10.1007/s00210-013-0903-y. [PMID: 23900610] - Muhammad T Akhtar, Shaukat Ali, Hassan Rashidi, Frank van der Kooy, Robert Verpoorte, Michael K Richardson. Developmental effects of cannabinoids on zebrafish larvae.
Zebrafish.
2013 Sep; 10(3):283-93. doi:
10.1089/zeb.2012.0785. [PMID: 23789728] - Jeffrey M Witkin, Susan Leucke, Linda K Thompson, Renee A Lynch, Chunjin Ding, Beverly Heinz, John T Catlow, Scott D Gleason, Xia Li. Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin.
CNS & neurological disorders drug targets.
2013 Jun; 12(4):498-505. doi:
10.2174/1871527311312040008. [PMID: 23574162] - Mark Bauer, Andrea Chicca, Marco Tamborrini, David Eisen, Raissa Lerner, Beat Lutz, Oliver Poetz, Gerd Pluschke, Jürg Gertsch. Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.
The Journal of biological chemistry.
2012 Oct; 287(44):36944-67. doi:
10.1074/jbc.m112.382481. [PMID: 22952224] - Irena Kasacka, Ewa Arciszewska, Maria Małgorzata Winnicka, Alicja Lewandowska. Effects of CP 55,940--agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas.
Folia histochemica et cytobiologica.
2012 Apr; 50(1):111-7. doi:
10.2478/18705. [PMID: 22532145] - Alejandro Higuera-Matas, Miguel Miguéns, Santiago M Coria, María Amparo Assis, Erika Borcel, Nuria del Olmo, Emilio Ambrosio. Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure.
Neuropharmacology.
2012 Apr; 62(5-6):1975-84. doi:
10.1016/j.neuropharm.2011.12.028. [PMID: 22245681] - Rebecca M Craft, Alexa A Wakley, Kimberly T Tsutsui, Jillian D Laggart. Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.
The Journal of pharmacology and experimental therapeutics.
2012 Mar; 340(3):787-800. doi:
10.1124/jpet.111.188540. [PMID: 22182934] - Tomohiro Kimura, Alexei A Yeliseev, Krishna Vukoti, Steven D Rhodes, Kejun Cheng, Kenner C Rice, Klaus Gawrisch. Recombinant cannabinoid type 2 receptor in liposome model activates g protein in response to anionic lipid constituents.
The Journal of biological chemistry.
2012 Feb; 287(6):4076-87. doi:
10.1074/jbc.m111.268425. [PMID: 22134924] - Alvaro Llorente-Berzal, Sílvia Fuentes, Humberto Gagliano, Meritxell López-Gallardo, Antonio Armario, María-Paz Viveros, Roser Nadal. Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour.
Addiction biology.
2011 Oct; 16(4):624-37. doi:
10.1111/j.1369-1600.2011.00318.x. [PMID: 21521421] - Joong-Youn Shim, Alexander C Bertalovitz, Debra A Kendall. Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation.
The Journal of biological chemistry.
2011 Sep; 286(38):33422-35. doi:
10.1074/jbc.m111.261651. [PMID: 21795705] - Xiaoyu Tian, Spiro Pavlopoulos, De-Ping Yang, Alexandros Makriyannis. The interaction of cannabinoid receptor agonists, CP55940 and WIN55212-2 with membranes using solid state 2H NMR.
Biochimica et biophysica acta.
2011 Sep; 1808(9):2095-101. doi:
10.1016/j.bbamem.2010.11.026. [PMID: 21129361] - Kathryn A B Simão da Silva, Ana F Paszcuk, Giselle F Passos, Eduardo S Silva, Allisson Freire Bento, Flavia C Meotti, João B Calixto. Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice.
Pain.
2011 Aug; 152(8):1872-1887. doi:
10.1016/j.pain.2011.04.005. [PMID: 21620566] - Andrew J Brown, Dion A Daniels, Mumta Kassim, Sue Brown, Carl P Haslam, Victoria R Terrell, Jason Brown, Paula L Nichols, Penny C Staton, Alan Wise, Simon J Dowell. Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist.
The Journal of pharmacology and experimental therapeutics.
2011 Apr; 337(1):236-46. doi:
10.1124/jpet.110.172650. [PMID: 21233197] - Anastasia Bologov, Mikhal Gafni, Ora Keren, Yosef Sarne. Dual neuroprotective and neurotoxic effects of cannabinoid drugs in vitro.
Cellular and molecular neurobiology.
2011 Mar; 31(2):195-202. doi:
10.1007/s10571-010-9604-y. [PMID: 21052827] - Shuxian Jiang, Meritxell Alberich-Jorda, Radoslaw Zagozdzon, Kalindi Parmar, Yigong Fu, Peter Mauch, Naheed Banu, Alexandros Makriyannis, Daniel G Tenen, Shalom Avraham, Jerome E Groopman, Hava Karsenty Avraham. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.
Blood.
2011 Jan; 117(3):827-38. doi:
10.1182/blood-2010-01-265082. [PMID: 21063029] - Alejandro Higuera-Matas, Fanny Botreau, Nuria Del Olmo, Miguel Miguéns, Oscar Olías, Gonzalo L Montoya, Carmen García-Lecumberri, Emilio Ambrosio. Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2010 Dec; 20(12):895-906. doi:
10.1016/j.euroneuro.2010.06.017. [PMID: 20655181] - Shuxian Jiang, Radoslaw Zagozdzon, Meritxell Alberich Jorda, Kalindi Parmar, Yigong Fu, John S Williams, Jodi Anne T Wood, Alexandros Makriyannis, Naheed Banu, Shalom Avraham, Jerome E Groopman, Hava Karsenty Avraham. Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment.
The Journal of biological chemistry.
2010 Nov; 285(46):35471-8. doi:
10.1074/jbc.m110.144758. [PMID: 20826813] - M V Catani, V Gasperi, G Catanzaro, S Baldassarri, A Bertoni, F Sinigaglia, L Avigliano, M Maccarrone. Human platelets express authentic CB₁ and CB₂ receptors.
Current neurovascular research.
2010 Nov; 7(4):311-8. doi:
10.2174/156720210793180774. [PMID: 20854251] - Sarah A Eisenstein, Jason R Clapper, Philip V Holmes, Daniele Piomelli, Andrea G Hohmann. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Pharmacological research.
2010 May; 61(5):419-29. doi:
10.1016/j.phrs.2009.12.013. [PMID: 20044005] - Anna Secher, Henriette Husum, Birgitte Holst, Kristoffer Lihme Egerod, Erling Mellerup. Risperidone treatment increases CB1 receptor binding in rat brain.
Neuroendocrinology.
2010; 91(2):155-68. doi:
10.1159/000245220. [PMID: 19815998] - Lamont Booker, Pattipati S Naidu, Raj K Razdan, Anu Mahadevan, Aron H Lichtman. Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Drug and alcohol dependence.
2009 Nov; 105(1-2):42-7. doi:
10.1016/j.drugalcdep.2009.06.009. [PMID: 19679411] - Ankur Kapur, Pingwei Zhao, Haleli Sharir, Yushi Bai, Marc G Caron, Larry S Barak, Mary E Abood. Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
The Journal of biological chemistry.
2009 Oct; 284(43):29817-27. doi:
10.1074/jbc.m109.050187. [PMID: 19723626] - A Higuera-Matas, F Botreau, M Miguéns, N Del Olmo, E Borcel, L Pérez-Alvarez, C García-Lecumberri, E Ambrosio. Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory.
Pharmacology, biochemistry, and behavior.
2009 Oct; 93(4):482-90. doi:
10.1016/j.pbb.2009.06.013. [PMID: 19576923] - Cm Kurz, U Baranowska, S Lupiński, M Göthert, B Malinowska, E Schlicker. Urethane, but not pentobarbitone, attenuates presynaptic receptor function in rats: a contribution to the choice of anaesthetic.
British journal of pharmacology.
2009 Aug; 157(8):1474-82. doi:
10.1111/j.1476-5381.2009.00315.x. [PMID: 19681871] - Tomohiro Kimura, Kejun Cheng, Kenner C Rice, Klaus Gawrisch. Location, structure, and dynamics of the synthetic cannabinoid ligand CP-55,940 in lipid bilayers.
Biophysical journal.
2009 Jun; 96(12):4916-24. doi:
10.1016/j.bpj.2009.03.033. [PMID: 19527650] - Hernán A Navarro, James L Howard, Gerald T Pollard, F Ivy Carroll. Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.
British journal of pharmacology.
2009 Apr; 156(7):1178-84. doi:
10.1111/j.1476-5381.2009.00124.x. [PMID: 19226282] - Tomás R Guilarte, Neal C Burton, Jennifer L McGlothan, Tatyana Verina, Yun Zhou, Mohab Alexander, Luu Pham, Michael Griswold, Dean F Wong, Tore Syversen, Jay S Schneider. Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism.
Journal of neurochemistry.
2008 Dec; 107(5):1236-47. doi:
10.1111/j.1471-4159.2008.05695.x. [PMID: 18808452] - Minoru Hojo, Yuka Sudo, Yuko Ando, Koichiro Minami, Masafumi Takada, Takehiro Matsubara, Masato Kanaide, Kohtaro Taniyama, Koji Sumikawa, Yasuhito Uezono. mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis.
Journal of pharmacological sciences.
2008 Nov; 108(3):308-19. doi:
10.1254/jphs.08244fp. [PMID: 19008645] - T South, X-F Huang. Temporal and site-specific brain alterations in CB1 receptor binding in high fat diet-induced obesity in C57Bl/6 mice.
Journal of neuroendocrinology.
2008 Nov; 20(11):1288-94. doi:
10.1111/j.1365-2826.2008.01785.x. [PMID: 18752650] - Yin Duan, Chengyong Liao, Saurabh Jain, Russell A Nicholson. The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [(3)H]batrachotoxinin A 20 alpha-benzoate binding to sodium channels and inhibit sodium channel function.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2008 Sep; 148(3):244-9. doi:
10.1016/j.cbpc.2008.06.002. [PMID: 18599378] - Ankur Kapur, Patrick Samaniego, Ganesh A Thakur, Alexandros Makriyannis, Mary E Abood. Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.
The Journal of pharmacology and experimental therapeutics.
2008 Apr; 325(1):341-8. doi:
10.1124/jpet.107.133256. [PMID: 18174385] - Teodora Georgieva, Savitha Devanathan, Dagmar Stropova, Chad K Park, Zdzislaw Salamon, Gordon Tollin, Victor J Hruby, William R Roeske, Henry I Yamamura, Eva Varga. Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
European journal of pharmacology.
2008 Feb; 581(1-2):19-29. doi:
10.1016/j.ejphar.2007.11.053. [PMID: 18162180] - Sharon Anavi-Goffer, Daniel Fleischer, Dow P Hurst, Diane L Lynch, Judy Barnett-Norris, Shanping Shi, Deborah L Lewis, Somnath Mukhopadhyay, Allyn C Howlett, Patricia H Reggio, Mary E Abood. Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.
The Journal of biological chemistry.
2007 Aug; 282(34):25100-13. doi:
10.1074/jbc.m703388200. [PMID: 17595161] - Tung M Fong, Xiao-Ming Guan, Donald J Marsh, Chun-Pyn Shen, D Sloan Stribling, Kim M Rosko, Julie Lao, Hong Yu, Yue Feng, Jing C Xiao, Lex H T Van der Ploeg, Mark T Goulet, Williams K Hagmann, Linus S Lin, Thomas J Lanza, James P Jewell, Ping Liu, Shrenik K Shah, Hongbo Qi, Xinchun Tong, Junying Wang, Suoyu S Xu, Barbara Francis, Alison M Strack, D Euan MacIntyre, Lauren P Shearman. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
The Journal of pharmacology and experimental therapeutics.
2007 Jun; 321(3):1013-22. doi:
10.1124/jpet.106.118737. [PMID: 17327489] - Ankur Kapur, Dow P Hurst, Daniel Fleischer, Rob Whitnell, Ganesh A Thakur, Alexandros Makriyannis, Patricia H Reggio, Mary E Abood. Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.
Molecular pharmacology.
2007 Jun; 71(6):1512-24. doi:
10.1124/mol.107.034645. [PMID: 17384224] - Stefan Raduner, William Bisson, Ruben Abagyan, Karl-Heinz Altmann, Jürg Gertsch. Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides.
Journal of natural products.
2007 Jun; 70(6):1010-5. doi:
10.1021/np060598+. [PMID: 17497806] - R G Pertwee, A Thomas, L A Stevenson, R A Ross, S A Varvel, A H Lichtman, B R Martin, R K Razdan. The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.
British journal of pharmacology.
2007 Mar; 150(5):586-94. doi:
10.1038/sj.bjp.0707124. [PMID: 17245367] - A Thomas, G L Baillie, A M Phillips, R K Razdan, R A Ross, R G Pertwee. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
British journal of pharmacology.
2007 Mar; 150(5):613-23. doi:
10.1038/sj.bjp.0707133. [PMID: 17245363] - Jane E Lauckner, Bertil Hille, Ken Mackie. The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Proceedings of the National Academy of Sciences of the United States of America.
2005 Dec; 102(52):19144-9. doi:
10.1073/pnas.0509588102. [PMID: 16365309] - Birgit Kraft, Hans G Kress. Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids.
The Journal of pharmacology and experimental therapeutics.
2005 Nov; 315(2):641-7. doi:
10.1124/jpet.105.084269. [PMID: 16055676] - Alex Dyson, Marcus Peacock, Alice Chen, Jean-Philippe Courade, Mohammed Yaqoob, Alex Groarke, Christopher Brain, Yvonne Loong, Alyson Fox. Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat.
Pain.
2005 Jul; 116(1-2):129-37. doi:
10.1016/j.pain.2005.03.037. [PMID: 15936883] - Kenneth J Valenzano, Laykea Tafesse, Gary Lee, James E Harrison, Jamie M Boulet, Susan L Gottshall, Lilly Mark, Michelle S Pearson, Wendy Miller, Shen Shan, Leyana Rabadi, Yakov Rotshteyn, Suzanne M Chaffer, Paul I Turchin, David A Elsemore, Mathew Toth, Lee Koetzner, Garth T Whiteside. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Neuropharmacology.
2005 Apr; 48(5):658-72. doi:
10.1016/j.neuropharm.2004.12.008. [PMID: 15814101] - Satyanarayana Valiveti, Paul K Kiptoo, Dana C Hammell, Audra L Stinchcomb. Transdermal permeation of WIN 55,212-2 and CP 55,940 in human skin in vitro.
International journal of pharmaceutics.
2004 Jun; 278(1):173-80. doi:
10.1016/j.ijpharm.2004.03.009. [PMID: 15158959] - Maria M Winnicka, Robert Ł Zbucki R, Jacek Dadan, Bogusław Sawicki, Anna Hryniewicz, Piotr Kosiorek, Izabela Bialuk, Zbigniew Puchalski. An immunohistochemical study of the thyroid parafollicular (C) cells in rats treated with cannabinoids - preliminary investigations.
Folia morphologica.
2003 Nov; 62(4):419-21. doi:
NULL. [PMID: 14655131] - Olov Nilsson, Stig O P Jacobsson, Christopher J Fowler. Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2003 Nov; 136(3):245-51. doi:
10.1016/s1532-0456(03)00228-x. [PMID: 14659458] - Miguel Biscaia, Susana Marín, Beatriz Fernández, Eva M Marco, Marina Rubio, Carmen Guaza, Emilio Ambrosio, Maria Paz Viveros. Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood.
Psychopharmacology.
2003 Nov; 170(3):301-308. doi:
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2003 Oct; 368(4):301-8. doi:
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Molecular pharmacology.
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Naunyn-Schmiedeberg's archives of pharmacology.
2003 May; 367(5):434-43. doi:
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Journal of neurochemistry.
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European journal of pharmacology.
2003 Feb; 461(1):27-34. doi:
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Pharmacology, biochemistry, and behavior.
2003 Feb; 74(3):649-56. doi:
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European journal of pharmacology.
2002 Dec; 456(1-3):99-106. doi:
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The Chinese journal of physiology.
2002 Sep; 45(3):95-100. doi:
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Brain research. Developmental brain research.
2002 Jun; 136(2):85-92. doi:
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The Chinese journal of physiology.
2002 Mar; 45(1):33-9. doi:
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British journal of pharmacology.
2001 Nov; 134(6):1319-27. doi:
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Life sciences.
2001 Aug; 69(13):1541-8. doi:
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2001 May; 64(4):429-36. doi:
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The Journal of pharmacology and experimental therapeutics.
2000 Aug; 294(2):707-13. doi:
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Visual neuroscience.
2000 May; 17(3):391-401. doi:
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The Journal of pharmacology and experimental therapeutics.
2000 Mar; 292(3):886-94. doi:
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Neuropharmacology.
1999 Apr; 38(4):533-41. doi:
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Pharmacology, biochemistry, and behavior.
1999 Mar; 62(3):473-80. doi:
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Molecular pharmacology.
1999 Mar; 55(3):605-13. doi:
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Brain research.
1999 Jan; 815(1):89-97. doi:
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British journal of pharmacology.
1999 Jan; 126(2):457-66. doi:
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Brain research.
1998 May; 793(1-2):212-8. doi:
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FEBS letters.
1998 Apr; 425(3):419-25. doi:
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Molecular and cellular biochemistry.
1998 Apr; 181(1-2):21-7. doi:
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Life sciences.
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Neurochemical research.
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Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1997 Jan; 214(1):69-75. doi:
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1996 May; 39(10):1967-74. doi:
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Molecular pharmacology.
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
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