dopet (BioDeep_00000604274)

Main id: BioDeep_00000017272

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


beta-3,4-dihydroxyphenylethyl alcohol

化学式: C8H10O3 (154.062991)
中文名称: 羟基酪醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1CCO)O)O
InChI: InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D000890 - Anti-Infective Agents
Hydroxytyrosol (DOPET) is a phenolic compound with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].
Hydroxytyrosol (DOPET) is a phenolic compound with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].

同义名列表

16 个代谢物同义名

beta-3,4-dihydroxyphenylethyl alcohol; 1,2-Benzenediol, 4-(2-hydroxyethyl)-; 4-(2-hydroxyethyl)benzene-1,2-diol; 2-(3,4-dihydroxyphenyl)ethanol; 4-(2-hydroxyethyl)pyrocatechol; 3,4-Dihydroxyphenylethanol; Hydroxytyrosol; AIDS-470832; AIDS470832; 10597-60-1; ST5437419; dopet; 4-(2-hydroxyethyl)-1,2-Benzenediol; 3,4-Dihydroxyphenyl ethanol; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li Fan, Lijuan Zhao, Yangbo Zhu, Lin Li, Xueping Yang, Ping Ma, Jian Liu, Qingwei Zhao, Xiaobo Li. Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition. Food & function. 2024 May; 15(9):5103-5117. doi: 10.1039/d4fo01027b. [PMID: 38680105]
  • Qizhen Cui, Qingqing Liu, Yutong Fan, Chenhe Wang, Yufei Li, Shuyuan Li, Jianguo Zhang, Guodong Rao. Functional differentiation of olive PLP_deC genes: insights into metabolite biosynthesis and genetic improvement at the whole-genome level. Plant cell reports. 2024 Apr; 43(5):127. doi: 10.1007/s00299-024-03212-z. [PMID: 38652203]
  • Jiaojiao Yuan, Su Tuo, Xiuhong Shi, Junling Tu. A new combined technology: Macroporous adsorption resin and high speed counter current chromatography for hydroxytyrosol separation from olive leaf enzymatic hydrolysate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Mar; 1235(?):124058. doi: 10.1016/j.jchromb.2024.124058. [PMID: 38394917]
  • Mojtaba Baharsaadi, Maryam Hezavehei, Abdolhossein Shahverdi, Iman Halvaei. Evaluation of the effects of hydroxytyrosol on human sperm parameters during cryopreservation. Cryobiology. 2024 03; 114(?):104840. doi: 10.1016/j.cryobiol.2023.104840. [PMID: 38104853]
  • Regina Viana de Carvalho Faria, Matheus Silva Duarte, Jeane de Souza Nogueira, Bianca Martins Gregório, Bruna Romana-Souza. Nrf2 activation by hydroxytyrosol and dimethyl fumarate ameliorates skin tissue repair in high-fat diet-fed mice by promoting M2 macrophage polarization and normalizing inflammatory response and oxidative damage. Journal of biochemical and molecular toxicology. 2024 Feb; 38(2):e23652. doi: 10.1002/jbt.23652. [PMID: 38348708]
  • Anabel González-Acedo, Rebeca Illescas-Montes, Elvira de Luna-Bertos, Concepción Ruiz, Javier Ramos-Torrecillas, Olga García-Martínez, Lucía Melguizo-Rodríguez. Extra Virgin Olive Oil Phenolic Compounds Modulate the Gene Expression of Biomarkers Involved in Fibroblast Proliferation and Differentiation. Genes. 2024 Jan; 15(2):. doi: 10.3390/genes15020173. [PMID: 38397163]
  • Jose M Romero-Márquez, María D Navarro-Hortal, Tamara Y Forbes-Hernández, Alfonso Varela-López, Juan G Puentes, Cristina Sánchez-González, Sandra Sumalla-Cano, Maurizio Battino, Roberto García-Ruiz, Sebastián Sánchez, José L Quiles. Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity. Food chemistry. 2024 Jan; 444(?):138516. doi: 10.1016/j.foodchem.2024.138516. [PMID: 38306771]
  • Maria Kourti, Zoi Skaperda, Fotios Tekos, Panagiotis Stathopoulos, Christina Koutra, Alexios Leandros Skaltsounis, Demetrios Kouretas. The Bioactivity of a Hydroxytyrosol-Enriched Extract Originated after Direct Hydrolysis of Olive Leaves from Greek Cultivars. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020299. [PMID: 38257212]
  • Marta Ramos-Barbero, Eva E Rufino-Palomares, Sergio Serrano-Carmona, Manuel Hernández-Yera, Leticia García-Salguero, José Antonio Lupiáñez, Amalia Pérez-Jiménez. Effect of Nutraceutical Factors on Hepatic Intermediary Metabolism in Wistar Rats with Induced Tendinopathy. International journal of molecular sciences. 2024 Jan; 25(1):. doi: 10.3390/ijms25010629. [PMID: 38203800]
  • Huijing Wang, Lian Wang, Jianbin Chen, Minglong Hu, Fang Fang, Jingwen Zhou. Promoting FADH2 Regeneration of Hydroxylation for High-Level Production of Hydroxytyrosol from Glycerol in Escherichia coli. Journal of agricultural and food chemistry. 2023 Nov; 71(44):16681-16690. doi: 10.1021/acs.jafc.3c05477. [PMID: 37877749]
  • María-Carmen López de Las Hazas, Andrea Del Saz-Lara, Lídia Cedó, María Carmen Crespo, João Tomé-Carneiro, Luis A Chapado, Alba Macià, Francesco Visioli, Joan C Escola-Gil, Alberto Dávalos. Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model. Molecular nutrition & food research. 2023 Nov; ?(?):e2300508. doi: 10.1002/mnfr.202300508. [PMID: 37933702]
  • Panagiota Binou, Athena Stergiou, Ourania Kosta, Nikolaos Tentolouris, Vaios T Karathanos. Positive contribution of hydroxytyrosol-enriched wheat bread to HbA1c levels, lipid profile, markers of inflammation and body weight in subjects with overweight/obesity and type 2 diabetes mellitus. European journal of nutrition. 2023 Aug; 62(5):2165-2176. doi: 10.1007/s00394-023-03133-9. [PMID: 37017765]
  • Tomoya Hara, Daiju Fukuda, Byambasuren Ganbaatar, Phuong Tran Pham, Kunduziayi Aini, Arief Rahadian, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata. Olive mill wastewater and hydroxytyrosol inhibits atherogenesis in apolipoprotein E-deficient mice. Heart and vessels. 2023 Jul; ?(?):. doi: 10.1007/s00380-023-02290-5. [PMID: 37462755]
  • Ignatios Ikonomidis, Konstantinos Katogiannis, Christina Chania, Nikolaos Iakovis, Maria Tsoumani, Andriana Christodoulou, Evangelia Brinia, George Pavlidis, John Thymis, Damianos Tsilivarakis, Aikaterini Kountouri, Emmanouil Korakas, Vaia Lambadiari, Filippos Triposkiadis, Leandros Skaltsounis, Ioulia Tseti, Efstathios K Iliodromitis, Ioanna Andreadou. Association of hydroxytyrosol enriched olive oil with vascular function in chronic coronary disease. European journal of clinical investigation. 2023 Jul; 53(7):e13983. doi: 10.1111/eci.13983. [PMID: 36912212]
  • Sara Falsini, Marzia Cristiana Rosi, Elia Ravegnini, Silvia Schiff, Cristina Gonnelli, Alessio Papini, Alessandra Adessi, Silvia Urciuoli, Sandra Ristori. Nanoformulations with exopolysaccharides from cyanobacteria: enhancing the efficacy of bioactive molecules in the Mediterranean fruit fly control. Environmental science and pollution research international. 2023 Jul; 30(35):83760-83770. doi: 10.1007/s11356-023-28180-x. [PMID: 37347326]
  • Yu-Ping Fu, Karl Egil Malterud, Anne Grethe Hamre, Kari Tvete Inngjerdingen, Helle Wangensteen. Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots. Chemistry & biodiversity. 2023 Jun; ?(?):e202300161. doi: 10.1002/cbdv.202300161. [PMID: 37337851]
  • Asma Mahmoudi, Fatma Hadrich, Zouhaier Bouallagui, Ines Feki, Hela Ghorbel, Lobna Ayadi, Mohamed Chamkha, Sami Sayadi. Comparative study of the effect of oleuropein and hydroxytyrosol rich extracts on the reproductive toxicity induced by bisphenol A in male rats: biochemical, histopathological, and molecular analyses. Environmental science and pollution research international. 2023 Jun; ?(?):. doi: 10.1007/s11356-023-27836-y. [PMID: 37273043]
  • Yushiro Fuji, Kai Uchida, Tomoyoshi Akashi, Takashi Ohtsuki, Hiroshi Matsufuji, Masami Yokota Hirai. Molecular Identification of UDP-Sugar Dependent Glycosyltransferase and Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis Induced by Methyl Jasmonate in Sesamum indicum L. Plant & cell physiology. 2023 May; ?(?):. doi: 10.1093/pcp/pcad053. [PMID: 37233612]
  • Maite Garcia-Guasch, Eduard Escrich, Raquel Moral, Iola F Duarte. Metabolomics Insights into the Differential Response of Breast Cancer Cells to the Phenolic Compounds Hydroxytyrosol and Luteolin. Molecules (Basel, Switzerland). 2023 May; 28(9):. doi: 10.3390/molecules28093886. [PMID: 37175295]
  • Pengfei Gong, Jiali Tang, Jiaying Wang, Chengtao Wang, Wei Chen. A Novel Microbial Consortia Catalysis Strategy for the Production of Hydroxytyrosol from Tyrosine. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24086944. [PMID: 37108108]
  • Joana Madureira, Bianca Albuquerque, Maria Inês Dias, José Pinela, Ricardo C Calhelha, Celestino Santos-Buelga, Fernanda M A Margaça, Isabel C F R Ferreira, Sandra Cabo Verde, Lillian Barros. Ultrasound-assisted extraction of hydroxytyrosol and tyrosol from olive pomace treated by gamma radiation: process optimization and bioactivity assessment. Food & function. 2023 Apr; 14(7):3038-3050. doi: 10.1039/d2fo03607j. [PMID: 36896737]
  • Federica Flamminii, Riccardo De Flaviis, Giampiero Sacchetti, Francesco Caponio, Vito Michele Paradiso, Carla Daniela Di Mattia. Unravelling the role of sodium chloride and hydroxytyrosol on the colloidal properties and oxidative stability of olive oil-based o/w emulsions: A multivariate statistical approach. Food chemistry. 2023 Mar; 405(Pt A):134767. doi: 10.1016/j.foodchem.2022.134767. [PMID: 36368103]
  • Rodrigo Gonzalez-Ortega, Carla Daniela Di Mattia, Paola Pittia, Poklar Ulrih Natasa. Effect of heat treatment on phenolic composition and radical scavenging activity of olive leaf extract at different pH conditions: a spectroscopic and kinetic study. Journal of the science of food and agriculture. 2023 Mar; 103(4):2047-2056. doi: 10.1002/jsfa.12371. [PMID: 36461135]
  • Cecilia Bender, Ilaria Candi, Eva Rogel. Efficacy of Hydroxytyrosol-Rich Food Supplements on Reducing Lipid Oxidation in Humans. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065521. [PMID: 36982623]
  • Elisabeta-Irina Geana, Corina Teodora Ciucure, Irina Mirela Apetrei, Maria Lisa Clodoveo, Constantin Apetrei. Discrimination of Olive Oil and Extra-Virgin Olive Oil from Other Vegetable Oils by Targeted and Untargeted HRMS Profiling of Phenolic and Triterpenic Compounds Combined with Chemometrics. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065292. [PMID: 36982366]
  • QingXia Guan, XiaoYing Zhou, FangFang Yang, Xue Zhang, YanHong Wang, WeiNan Li, XiuYan Li. A novel strategy against hepatitis B virus: Glycyrrhetnic acid conjugated multi-component synergistic nano-drug delivery system for targeted therapy. Journal of biomaterials applications. 2023 03; 37(8):1393-1408. doi: 10.1177/08853282221139132. [PMID: 36373787]
  • Carlo Cervellati, Alessandro Trentini, Valentina Rosta, Giovanni Zuliani, Francesco Vieceli Dalla Sega, Francesca Fortini, Paola Rizzo, Paolo Cimaglia, Gianluca Campo. A Nutraceutical Compound Containing a Low Dose of Monacolin K, Polymethoxyflavones, Phenolic Acids, Flavonoids, and Hydroxytyrosol Improves HDL Functionality. Current vascular pharmacology. 2023 Feb; ?(?):. doi: 10.2174/1570161121666230221142131. [PMID: 36824007]
  • Ubashini Vijakumaran, Janushaa Shanmugam, Jun Wei Heng, Siti Sarah Azman, Muhammad Dain Yazid, Nur Atiqah Haizum Abdullah, Nadiah Sulaiman. Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041861. [PMID: 36838850]
  • Rosario Sánchez, Laura Arroyo, Pilar Luaces, Carlos Sanz, Ana G Pérez. Olive Polyphenol Oxidase Gene Family. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043233. [PMID: 36834644]
  • Monica Nardi, Steve Brocchini, Satyanarayana Somavarapu, Antonio Procopio. Hydroxytyrosol oleate: A promising neuroprotective nanocarrier delivery system of oleuropein and derivatives. International journal of pharmaceutics. 2023 Jan; 631(?):122498. doi: 10.1016/j.ijpharm.2022.122498. [PMID: 36535454]
  • Sara Franceschelli, Federica De Cecco, Mirko Pesce, Patrizio Ripari, Maria Teresa Guagnano, Arturo Bravo Nuevo, Alfredo Grilli, Silvia Sancilio, Lorenza Speranza. Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032057. [PMID: 36768382]
  • Cecilia Bender, Sarah Strassmann, Christian Golz. Oral Bioavailability and Metabolism of Hydroxytyrosol from Food Supplements. Nutrients. 2023 Jan; 15(2):. doi: 10.3390/nu15020325. [PMID: 36678196]
  • Andrea Del Saz-Lara, Hatim Boughanem, María-Carmen López de Las Hazas, Carmen Crespo, Alicia Saz-Lara, Francesco Visioli, Manuel Macias-González, Alberto Dávalos. Hydroxytyrosol decreases EDNRA expression through epigenetic modification in colorectal cancer cells. Pharmacological research. 2023 01; 187(?):106612. doi: 10.1016/j.phrs.2022.106612. [PMID: 36528246]
  • Manuela Leo, Livio Muccillo, Erica Pranzini, Giovannina Barisciano, Matteo Parri, Giulia Lopatriello, Marco Carlomagno, Alice Santi, Maria Letizia Taddei, Lina Sabatino. Transcriptomic Analysis of Colorectal Cancer Cells Treated with Oil Production Waste Products (OPWPs) Reveals Enrichment of Pathways of Mitochondrial Functionality. Cells. 2022 12; 11(24):. doi: 10.3390/cells11243992. [PMID: 36552757]
  • María Del Mar Contreras, Irene Gómez-Cruz, Anouar Feriani, Saleh Alwasel, Abdel Halim Harrath, Inmaculada Romero, Eulogio Castro, Nizar Tlili. Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods. Food & function. 2022 Nov; 13(22):11915-11928. doi: 10.1039/d2fo00888b. [PMID: 36321712]
  • Shuyan Han, Yongjin Wang, Zhongxiang Fang, Yiren Zhang, Wei Zeng, Emad Karrar, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang. Effect of olive polyphenols on lipid oxidation of high-fat beef during digestion. Food research international (Ottawa, Ont.). 2022 11; 161(?):111843. doi: 10.1016/j.foodres.2022.111843. [PMID: 36192973]
  • Yingjie Liu, Dong Song, Haitao Hu, Ruijin Yang, Xiaomei Lyu. De Novo Production of Hydroxytyrosol by Saccharomyces cerevisiae-Escherichia coli Coculture Engineering. ACS synthetic biology. 2022 09; 11(9):3067-3077. doi: 10.1021/acssynbio.2c00300. [PMID: 35952699]
  • Rebeca Quirós-Fernández, Bricia López-Plaza, Laura M Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gómez Candela. Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A Randomized, Double-Blind, Controlled and Crossover Trial. Nutrients. 2022 Apr; 14(9):. doi: 10.3390/nu14091879. [PMID: 35565844]
  • Christina Fytili, Theodora Nikou, Nikolaos Tentolouris, Ioulia K Tseti, Charilaos Dimosthenopoulos, Petros P Sfikakis, Dimitrios Simos, Alexandros Kokkinos, Alexios L Skaltsounis, Nikolaos Katsilambros, Maria Halabalaki. Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study. Nutrients. 2022 Apr; 14(7):. doi: 10.3390/nu14071525. [PMID: 35406139]
  • Alexandra V Chatzikonstantinou, Αrchontoula Giannakopoulou, Stamatia Spyrou, Yannis V Simos, Vassiliki G Kontogianni, Dimitrios Peschos, Petros Katapodis, Angeliki C Polydera, Haralambos Stamatis. Production of hydroxytyrosol rich extract from Olea europaea leaf with enhanced biological activity using immobilized enzyme reactors. Environmental science and pollution research international. 2022 Apr; 29(20):29624-29637. doi: 10.1007/s11356-021-17081-6. [PMID: 34676481]
  • Ahmed Al Saqr, Manjusha Annaji, Ishwor Poudel, Shivani Rangari, Sai H S Boddu, Amit K Tiwari, R Jayachandra Babu. Niosomal formulation of hydroxytyrosol, a polyphenolic antioxidant, for enhancing transdermal delivery across human cadaver skin. Pharmaceutical development and technology. 2022 Feb; 27(2):155-163. doi: 10.1080/10837450.2022.2025540. [PMID: 34978253]
  • Fatma Hadrich, Sven-Uwe Geißen, Mohamed Chamkha, Sami Sayadi. Optimizing the Extraction Conditions of Hydroxytyrosol from Olive Leaves Using a Modified Spherical Activated Carbon: A New Experimental Design. BioMed research international. 2022; 2022(?):6199627. doi: 10.1155/2022/6199627. [PMID: 35620226]
  • Chunlan Shan, Fujun Miao. Immunomodulatory and antioxidant effects of hydroxytyrosol in cyclophosphamide-induced immunosuppressed broilers. Poultry science. 2022 Jan; 101(1):101516. doi: 10.1016/j.psj.2021.101516. [PMID: 34784517]
  • Y Bhusan Tripathi, N Pandey, P Mishra, P Tripathi, M Coatto, K Anpilogov, K Dhuli, K Donato, S Michelini, S Cecchin, T Beccari, M R Ceccarini, S Paolacci, M Bertelli. Effect of a dietary supplement on the reduction of lymphedema-progression in mouse tail-cut model. European review for medical and pharmacological sciences. 2021 12; 25(1 Suppl):56-66. doi: 10.26355/eurrev_202112_27334. [PMID: 34890035]
  • S Paolacci, A K Kiani, P Shree, D Tripathi, Y B Tripathi, P Tripathi, G M Tartaglia, M Farronato, G Farronato, S T Connelly, M R Ceccarini, M Coatto, M C Ergoren, T Sanlidag, A Dautaj, M Bertelli. Scoping review on the role and interactions of hydroxytyrosol and alpha-cyclodextrin in lipid-raft-mediated endocytosis of SARS-CoV-2 and bioinformatic molecular docking studies. European review for medical and pharmacological sciences. 2021 12; 25(1 Suppl):90-100. doi: 10.26355/eurrev_202112_27338. [PMID: 34890039]
  • Z Naureen, A Dautaj, S Nodari, F Fioretti, K Dhuli, K Anpilogov, L Lorusso, S Paolacci, S Michelini, T Guda, M Kallazi, M Bertelli. Proposal of a food supplement for the management of post-COVID syndrome. European review for medical and pharmacological sciences. 2021 12; 25(1 Suppl):67-73. doi: 10.26355/eurrev_202112_27335. [PMID: 34890036]
  • S Paolacci, M C Ergoren, D De Forni, E Manara, B Poddesu, G Cugia, K Dhuli, G Camilleri, G Tuncel, H Kaya Suer, N Sultanoglu, M Sayan, M Dundar, T Beccari, M R Ceccarini, I S Gunsel, A Dautaj, T Sanlidag, S T Connelly, G M Tartaglia, M Bertelli. In vitro and clinical studies on the efficacy of α-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection. European review for medical and pharmacological sciences. 2021 12; 25(1 Suppl):81-89. doi: 10.26355/eurrev_202112_27337. [PMID: 34890038]
  • Thanh Truong Giang Ly, Jisoo Yun, Dong-Hyung Lee, Joo-Seop Chung, Sang-Mo Kwon. Protective Effects and Benefits of Olive Oil and Its Extracts on Women's Health. Nutrients. 2021 Nov; 13(12):. doi: 10.3390/nu13124279. [PMID: 34959830]
  • Gabriela Pérez-Barrón, Sergio Montes, Yoshajandith Aguirre-Vidal, Marti Santiago, Elena Gallardo, José Luis Espartero, Camilo Ríos, Antonio Monroy-Noyola. Antioxidant Effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Nitrohydroxytyrosol in a Rat MPP+ Model of Parkinson's Disease. Neurochemical research. 2021 Nov; 46(11):2923-2935. doi: 10.1007/s11064-021-03379-x. [PMID: 34260002]
  • Shu-Shong Hsu, Yung-Shang Lin, Wei-Zhe Liang. Inhibition of the pesticide rotenone-induced Ca2+ signaling, cytotoxicity and oxidative stress in HCN-2 neuronal cells by the phenolic compound hydroxytyrosol. Pesticide biochemistry and physiology. 2021 Nov; 179(?):104979. doi: 10.1016/j.pestbp.2021.104979. [PMID: 34802529]
  • Katia Todoerti, Maria Eugenia Gallo Cantafio, Manuela Oliverio, Giada Juli, Carmine Rocca, Rita Citraro, Pierfrancesco Tassone, Antonio Procopio, Giovambattista De Sarro, Antonino Neri, Giuseppe Viglietto, Nicola Amodio. Oleil Hydroxytyrosol (HTOL) Exerts Anti-Myeloma Activity by Antagonizing Key Survival Pathways in Malignant Plasma Cells. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111639. [PMID: 34769070]
  • Nikolaos Katsinas, Amalia Enríquez-de-Salamanca, Andreia Bento da Silva, Maria Rosário Bronze, Soraya Rodríguez-Rojo. Olive Pomace Phenolic Compounds Stability and Safety Evaluation: From Raw Material to Future Ophthalmic Applications. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26196002. [PMID: 34641545]
  • Hussein A Abd Elmaksoud, Muhammed H Motawea, Afaf A Desoky, Mohamed G Elharrif, Asmaa Ibrahimi. Hydroxytyrosol alleviate intestinal inflammation, oxidative stress and apoptosis resulted in ulcerative colitis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112073. doi: 10.1016/j.biopha.2021.112073. [PMID: 34463261]
  • Antonella Maria Aresta, Nicolella De Vietro, Maria Lisa Clodoveo, Riccardo Amirante, Filomena Corbo, Francesco Paolo Schena, Carlo Zambonin. Determination of hydroxytyrosol and tyrosol in human urine after intake of extra virgin olive oil produced with an ultrasounds-based technology. Journal of pharmaceutical and biomedical analysis. 2021 Sep; 203(?):114204. doi: 10.1016/j.jpba.2021.114204. [PMID: 34130008]
  • Antonella Mosca, Annalisa Crudele, Antonella Smeriglio, Maria Rita Braghini, Nadia Panera, Donatella Comparcola, Arianna Alterio, Maria Rita Sartorelli, Giulia Tozzi, Massimiliano Raponi, Domenico Trombetta, Anna Alisi. Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2021 Sep; 53(9):1154-1158. doi: 10.1016/j.dld.2020.09.021. [PMID: 33060043]
  • Rosario Pastor, Cristina Bouzas, Josep A Tur. Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: Systematic review and meta-analysis. Free radical biology & medicine. 2021 08; 172(?):372-385. doi: 10.1016/j.freeradbiomed.2021.06.017. [PMID: 34153478]
  • Elisa Pannucci, Rocco Caracciolo, Annalisa Romani, Francesco Cacciola, Paola Dugo, Roberta Bernini, Leonardo Varvaro, Luca Santi. An hydroxytyrosol enriched extract from olive mill wastewaters exerts antioxidant activity and antimicrobial activity on Pseudomonas savastanoi pv. savastanoi and Agrobacterium tumefaciens. Natural product research. 2021 Aug; 35(16):2677-2684. doi: 10.1080/14786419.2019.1662006. [PMID: 31496275]
  • Aurélia Malapert, Emmanuelle Reboul, Olivier Dangles, Alain Thiéry, N'nabinty Sylla, Valérie Tomao. One-Step Extraction of Olive Phenols from Aqueous Solution Using β-Cyclodextrin in the Solid State, a Simple Eco-Friendly Method Providing Photochemical Stability to the Extracts. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154463. [PMID: 34361616]
  • Chen Chen, Qidi Ai, Yuhui Wei. Hydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. International immunopharmacology. 2021 Jul; 96(?):107805. doi: 10.1016/j.intimp.2021.107805. [PMID: 34162164]
  • Jia Liu, Zengyuan Liu, Lili Wang, Hao He, Hailong Mu, Wenjing Sun, Yu Zhou, Yingqiu Liu, Wuren Ma, Weimin Zhang, Mingzhe Fu, Yunpeng Fan, Xiaoping Song. Bioactivity-guided isolation of immunomodulatory compounds from the fruits of Ligustrum lucidum. Journal of ethnopharmacology. 2021 Jun; 274(?):114079. doi: 10.1016/j.jep.2021.114079. [PMID: 33798661]
  • Camila G Dossi, Romina G Vargas, Rodrigo Valenzuela, Luis A Videla. Beneficial effects of natural compounds on experimental liver ischemia-reperfusion injury. Food & function. 2021 May; 12(9):3787-3798. doi: 10.1039/d1fo00289a. [PMID: 33977997]
  • Mingzhe Li, Baoan Ning, Tianhui Wang. The mechanism and prevention of mitochondrial injury after exercise. Journal of physiology and biochemistry. 2021 May; 77(2):215-225. doi: 10.1007/s13105-021-00802-3. [PMID: 33650090]
  • Emanuele Mauri, Manuele Gori, Sara Maria Giannitelli, Andrea Zancla, Pamela Mozetic, Franca Abbruzzese, Nicolò Merendino, Giuseppe Gigli, Filippo Rossi, Marcella Trombetta, Alberto Rainer. Nano-encapsulation of hydroxytyrosol into formulated nanogels improves therapeutic effects against hepatic steatosis: An in vitro study. Materials science & engineering. C, Materials for biological applications. 2021 May; 124(?):112080. doi: 10.1016/j.msec.2021.112080. [PMID: 33947572]
  • Alfredo García-Layana, Sergio Recalde, Maria Hernandez, Maximino J Abraldes, João Nascimento, Emiliano Hernández-Galilea, Begoña Olmedilla-Alonso, Jose Juan Escobar-Barranco, Miguel Angel Zapata, Rufino Silva, Mariana Caballero Arredondo, María Carmen Lopez-Sabater, Silvia Mendez-Martínez, Nieves Pardiñas-Barón, Pilar Calvo, Patricia Fernández-Robredo. A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration. Nutrients. 2021 Apr; 13(4):. doi: 10.3390/nu13041253. [PMID: 33920232]
  • Francesca Luzi, Elisa Pannucci, Mariangela Clemente, Edoardo Grande, Silvia Urciuoli, Annalisa Romani, Luigi Torre, Debora Puglia, Roberta Bernini, Luca Santi. Hydroxytyrosol and Oleuropein-Enriched Extracts Obtained from Olive Oil Wastes and By-Products as Active Antioxidant Ingredients for Poly (Vinyl Alcohol)-Based Films. Molecules (Basel, Switzerland). 2021 Apr; 26(7):. doi: 10.3390/molecules26072104. [PMID: 33917644]
  • Carolina Alemán-Jiménez, Raúl Domínguez-Perles, Sonia Medina, Iva Prgomet, Iván López-González, Agustín Simonelli-Muñoz, Maria Campillo-Cano, David Auñón, Federico Ferreres, Ángel Gil-Izquierdo. Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans. European journal of nutrition. 2021 Mar; 60(2):905-915. doi: 10.1007/s00394-020-02295-0. [PMID: 32524230]
  • Annalisa Noce, Giulia Marrone, Silvia Urciuoli, Francesca Di Daniele, Manuela Di Lauro, Anna Pietroboni Zaitseva, Nicola Di Daniele, Annalisa Romani. Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients. Nutrients. 2021 Feb; 13(2):. doi: 10.3390/nu13020581. [PMID: 33578682]
  • Yohei Takeda, Dulamjav Jamsransuren, Sachiko Matsuda, Roberto Crea, Haruko Ogawa. The SARS-CoV-2-Inactivating Activity of Hydroxytyrosol-Rich Aqueous Olive Pulp Extract (HIDROX®) and Its Use as a Virucidal Cream for Topical Application. Viruses. 2021 02; 13(2):. doi: 10.3390/v13020232. [PMID: 33540713]
  • Hui-Yuan Lu, Jian-Sheng Zhu, Jing Xie, Zhan Zhang, Jun Zhu, Shan Jiang, Wei-Jian Shen, Bin Wu, Tao Ding, Shou-Lin Wang. Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion via Induction of Autophagy in ER-Positive Breast Cancer Cell Lines (MCF7 and T47D). Nutrition and cancer. 2021; 73(2):350-360. doi: 10.1080/01635581.2020.1750661. [PMID: 32286090]
  • Manuele Gori, Sara Maria Giannitelli, Andrea Zancla, Pamela Mozetic, Marcella Trombetta, Nicolò Merendino, Alberto Rainer. Quercetin and hydroxytyrosol as modulators of hepatic steatosis: A NAFLD-on-a-chip study. Biotechnology and bioengineering. 2021 01; 118(1):142-152. doi: 10.1002/bit.27557. [PMID: 32889748]
  • Alessandra Ricelli, Fabio Gionfra, Zulema Percario, Martina De Angelis, Ludovica Primitivo, Veronica Bonfantini, Roberto Antonioletti, Simonetta Maria Bullitta, Luciano Saso, Sandra Incerpi, Jens Zacho Pedersen. Antioxidant and Biological Activities of Hydroxytyrosol and Homovanillic Alcohol Obtained from Olive Mill Wastewaters of Extra-Virgin Olive Oil Production. Journal of agricultural and food chemistry. 2020 Dec; 68(52):15428-15439. doi: 10.1021/acs.jafc.0c05230. [PMID: 33305574]
  • Q Fang, Y Zhang, D-S Jiang, Y Chen. Hydroxytyrosol inhibits apoptosis in ischemia/reperfusion-induced acute kidney injury via activating Sonic Hedgehog signaling pathway. European review for medical and pharmacological sciences. 2020 12; 24(23):12380-12388. doi: 10.26355/eurrev_202012_24032. [PMID: 33336758]
  • Stefano Paolacci, Maria Rachele Ceccarini, Michela Codini, Elena Manara, Silvia Tezzele, Marcella Percio, Natale Capodicasa, Dorela Kroni, Munis Dundar, Mahmut Cerkez Ergoren, Tamer Sanlidag, Tommaso Beccari, Marco Farronato, Giampietro Farronato, Gianluca Martino Tartaglia, Matteo Bertelli. Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis. Acta bio-medica : Atenei Parmensis. 2020 11; 91(13-S):e2020009. doi: 10.23750/abm.v91i13-s.10583. [PMID: 33170175]
  • Mahmut Cerkez Ergoren, Stefano Paolacci, Elena Manara, Astrit Dautaj, Kristjana Dhuli, Kyrylo Anpilogov, Giorgio Camilleri, Huseyin Kaya Suer, Murat Sayan, Gulten Tuncel, Nazife Sultanoglu, Marco Farronato, Gianluca Martino Tartaglia, Munis Dundar, Giampietro Farronato, Irfan Suat Gunsel, Matteo Bertelli, Tamer Sanlidag. A pilot study on the preventative potential of alpha-cyclodextrin and hydroxytyrosol against SARS-CoV-2 transmission. Acta bio-medica : Atenei Parmensis. 2020 11; 91(13-S):e2020022. doi: 10.23750/abm.v91i13-s.10817. [PMID: 33170176]
  • Aysha Karim Kiani, Giacinto Abele Donato Miggiano, Barbara Aquilanti, Valeria Velluti, Giuseppina Matera, Lucilla Gagliardi, Matteo Bertelli. Food supplements based on palmitoylethanolamide plus hydroxytyrosol from olive tree or Bacopa monnieri extracts for neurological diseases. Acta bio-medica : Atenei Parmensis. 2020 11; 91(13-S):e2020007. doi: 10.23750/abm.v91i13-s.10582. [PMID: 33170159]
  • Evangelia Kritikou, Natasa P Kalogiouri, Lydia Kolyvira, Nikolaos S Thomaidis. Target and Suspect HRMS Metabolomics for the Determination of Functional Ingredients in 13 Varieties of Olive Leaves and Drupes from Greece. Molecules (Basel, Switzerland). 2020 Oct; 25(21):. doi: 10.3390/molecules25214889. [PMID: 33105803]
  • Sara Fernandes, Catarina Ribeiro, Fátima Paiva-Martins, Cristina Catarino, Alice Santos-Silva. Protective effect of olive oil polyphenol phase II sulfate conjugates on erythrocyte oxidative-induced hemolysis. Food & function. 2020 Oct; 11(10):8670-8679. doi: 10.1039/d0fo01690j. [PMID: 32939526]
  • Annalisa Romani, Roberta Bernini, Annalisa Noce, Silvia Urciuoli, Manuela Di Lauro, Anna Pietroboni Zaitseva, Giulia Marrone, Nicola Di Daniele. Potential Beneficial Effects of Extra Virgin Olive Oils Characterized by High Content in Minor Polar Compounds in Nephropathic Patients: A Pilot Study. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204757. [PMID: 33081292]
  • Ian Breakspear, Claudia Guillaume. A Quantitative Phytochemical Comparison of Olive Leaf Extracts on the Australian Market. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184099. [PMID: 32911652]
  • Yan-Zou Dong, Lei Li, Marit Espe, Kang-Le Lu, Samad Rahimnejad. Hydroxytyrosol Attenuates Hepatic Fat Accumulation via Activating Mitochondrial Biogenesis and Autophagy through the AMPK Pathway. Journal of agricultural and food chemistry. 2020 Sep; 68(35):9377-9386. doi: 10.1021/acs.jafc.0c03310. [PMID: 32786840]
  • Chiara D'Angelo, Sara Franceschelli, José Luis Quiles, Lorenza Speranza. Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases. Cells. 2020 08; 9(9):. doi: 10.3390/cells9091932. [PMID: 32825589]
  • Jorge A Ramírez-Tejero, Esther Martínez-Lara, M Ángeles Peinado, María Luisa Del Moral, Eva Siles. Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia. Nutrients. 2020 Aug; 12(8):. doi: 10.3390/nu12082386. [PMID: 32784915]
  • Yun-Dong Xie, Ji-Ping Liu, Wei Wang, Yong-Heng Shi, Xiao-Ping Wang, Meng Sun, Xin-Ya Xu, Na Li. 3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant, hypoglycemic and hypolipidemic effects. Bioorganic & medicinal chemistry letters. 2020 08; 30(15):127277. doi: 10.1016/j.bmcl.2020.127277. [PMID: 32527456]
  • Francesco Pini, Chiara Aquilani, Luciana Giovannetti, Carlo Viti, Carolina Pugliese. Characterization of the microbial community composition in Italian Cinta Senese sausages dry-fermented with natural extracts as alternatives to sodium nitrite. Food microbiology. 2020 Aug; 89(?):103417. doi: 10.1016/j.fm.2020.103417. [PMID: 32138987]
  • Macarena Ortiz, Sandra A Soto-Alarcón, Paula Orellana, Alejandra Espinosa, Cristian Campos, Sandra López-Arana, Miguel A Rincón, Paola Illesca, Rodrigo Valenzuela, Luis A Videla. Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2020 08; 52(8):895-904. doi: 10.1016/j.dld.2020.04.019. [PMID: 32620521]
  • Manfredi Guglielmotti, Paolo Passaghe, Stefano Buiatti. Use of olive (Olea europaea L.) leaves as beer ingredient, and their influence on beer chemical composition and antioxidant activity. Journal of food science. 2020 Aug; 85(8):2278-2285. doi: 10.1111/1750-3841.15318. [PMID: 32652593]
  • Sonia Medina, Raúl Domínguez-Perles, David Auñón, Espérance Moine, Thierry Durand, Céline Crauste, Federico Ferreres, Ángel Gil-Izquierdo. Targeted Lipidomics Profiling Reveals the Generation of Hydroxytyrosol-Fatty Acids in Hydroxytyrosol-Fortified Oily Matrices: New Analytical Methodology and Cytotoxicity Evaluation. Journal of agricultural and food chemistry. 2020 Jul; 68(29):7789-7799. doi: 10.1021/acs.jafc.0c01938. [PMID: 32603105]
  • M A Zullo, M C Schiavi, A Di Pinto, G Prata, M Scudo, P Luffarelli, C Oliva. Efficacy and safety of oral administration of a product based on hydroxytyrosol as preventive therapy for recurrent vulvo-vaginal candidosis: a prospective observational pilot study. European review for medical and pharmacological sciences. 2020 07; 24(13):7427-7432. doi: 10.26355/eurrev_202007_21911. [PMID: 32706082]
  • Y-B Yu, H-Z Zhuang, X-J Ji, L Dong, M-L Duan. Hydroxytyrosol suppresses LPS-induced intrahepatic inflammatory responses via inhibition of ERK signaling pathway activation in acute liver injury. European review for medical and pharmacological sciences. 2020 06; 24(11):6455-6462. doi: 10.26355/eurrev_202006_21544. [PMID: 32572943]
  • Bruna Romana-Souza, Bianca Oliveira Saguie, Natália Pereira de Almeida Nogueira, Marcia Paes, Samuel Dos Santos Valença, Georgia Correa Atella, Andréa Monte-Alto-Costa. Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-κB and NRF2 pathways. Food research international (Ottawa, Ont.). 2020 05; 131(?):108984. doi: 10.1016/j.foodres.2020.108984. [PMID: 32247459]
  • María Roca, Antonio Pérez-Gálvez. Profile of Chlorophyll Catabolites in Senescent Leaves of Epipremnun aureum Includes a Catabolite Esterified with Hydroxytyrosol 1-O-Glucoside. Journal of natural products. 2020 04; 83(4):873-880. doi: 10.1021/acs.jnatprod.9b00546. [PMID: 32134654]
  • Amira E Alsemeh, Mai A Samak, Samaa Salah Abd El-Fatah. Therapeutic prospects of hydroxytyrosol on experimentally induced diabetic testicular damage: potential interplay with AMPK expression. Cell and tissue research. 2020 Apr; 380(1):173-189. doi: 10.1007/s00441-019-03143-2. [PMID: 31838605]
  • Jun Yao, Yang He, Nannan Su, Sakshibeedu R Bharath, Yong Tao, Jian-Ming Jin, Wei Chen, Haiwei Song, Shuang-Yan Tang. Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps. Nature communications. 2020 03; 11(1):1515. doi: 10.1038/s41467-020-14918-5. [PMID: 32251291]
  • Erika Terzuoli, Ginevra Nannelli, Antonio Giachetti, Lucia Morbidelli, Marina Ziche, Sandra Donnini. Targeting endothelial-to-mesenchymal transition: the protective role of hydroxytyrosol sulfate metabolite. European journal of nutrition. 2020 Mar; 59(2):517-527. doi: 10.1007/s00394-019-01920-x. [PMID: 30725211]
  • Matteo Bertelli, Aysha Karim Kiani, Stefano Paolacci, Elena Manara, Danjela Kurti, Kristjana Dhuli, Vilma Bushati, Jan Miertus, Domenico Pangallo, Mirko Baglivo, Tommaso Beccari, Sandro Michelini. Hydroxytyrosol: A natural compound with promising pharmacological activities. Journal of biotechnology. 2020 Feb; 309(?):29-33. doi: 10.1016/j.jbiotec.2019.12.016. [PMID: 31884046]
  • Yang Zhang, Mingchun Wen, Pan Zhou, Maolin Tian, Jie Zhou, Liang Zhang. Analysis of chemical composition in Chinese olive leaf tea by UHPLC-DAD-Q-TOF-MS/MS and GC-MS and its lipid-lowering effects on the obese mice induced by high-fat diet. Food research international (Ottawa, Ont.). 2020 02; 128(?):108785. doi: 10.1016/j.foodres.2019.108785. [PMID: 31955756]
  • Matteo Bertelli, Aysha Karim Kiani, Stefano Paolacci, Elena Manara, Astrit Dautaj, Tommaso Beccari, Sandro Michelini. Molecular pathways involved in lymphedema: Hydroxytyrosol as a candidate natural compound for treating the effects of lymph accumulation. Journal of biotechnology. 2020 Jan; 308(?):82-86. doi: 10.1016/j.jbiotec.2019.11.017. [PMID: 31794783]
  • Xinxin Zhang, Yating Qin, Xiaoning Wan, Hao Liu, Chao Iv, Weibin Ruan, Li Lu, Lin He, Xiaomei Guo. Hydroxytyrosol Plays Antiatherosclerotic Effects through Regulating Lipid Metabolism via Inhibiting the p38 Signal Pathway. BioMed research international. 2020; 2020(?):5036572. doi: 10.1155/2020/5036572. [PMID: 32685494]
  • Ines Fki, Sami Sayadi, Asma Mahmoudi, Ines Daoued, Rim Marrekchi, Hela Ghorbel. Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats. BioMed research international. 2020; 2020(?):1315202. doi: 10.1155/2020/1315202. [PMID: 31998777]