Hydroxytyrosol (BioDeep_00000017272)

 

Secondary id: BioDeep_00000402914, BioDeep_00000604274

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


InChI=1/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2

化学式: C8H10O3 (154.062991)
中文名称: 羟基酪醇, 3,4-二羟基苯乙醇
谱图信息: 最多检出来源 Homo sapiens(feces) 0.41%

分子结构信息

SMILES: C1=CC(=C(C=C1CCO)O)O
InChI: InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2

描述信息

Hydroxytyrosol is a member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities. It has a role as a metabolite, an antioxidant and an antineoplastic agent. It is a member of catechols and a primary alcohol. It is functionally related to a 2-(4-hydroxyphenyl)ethanol.
Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer.
Hydroxytyrosol is a natural product found in Teucrium polium, Syringa reticulata, and other organisms with data available.
Hydroxytyrosol is a phenolic phytochemical naturally occurring in extra virgin olive oil, with potential antioxidant, anti-inflammatory and cancer preventive activities. Although the mechanisms of action through which hydroxytyrosol exerts its effects have yet to be fully determined, this agent affects the expression of various components of the inflammatory response, possibly through the modulation of the nuclear factor-kappa B (NF-kB) pathway. The effects include the modulation of pro-inflammatory cytokines, such as the inhibition of interleukin-1alpha (IL-1a), IL-1beta, IL-6, IL-12, and tumor necrosis factor-alpha (TNF-a); increased secretion of the anti-inflammatory cytokine IL-10; inhibition of the production of certain chemokines, such as C-X-C motif chemokine ligand 10 (CXCL10/IP-10), C-C motif chemokine ligand 2 (CCL2/MCP-1), and macrophage inflammatory protein-1beta (CCL4/MIP-1b); and inhibition of the expression of the enzymes inducible nitric oxide synthase (iNOS/NOS2) and prostaglandin E2 synthase (PGES), which prevent the production of nitric oxide (NO) and prostaglandin E (PGE2), respectively. In addition, hydroxytyrosol is able to regulate the expression of other genes involved in the regulation of tumor cell proliferation, such as extracellular signal-regulated and cyclin-dependent kinases. Also, hydroxytyrosol scavenges free radicals and prevents oxidative DNA damage. This induces apoptosis and inhibits proliferation in susceptible cancer cells.
Hydroxytyrosol is a polyphenol extracted from virgin olive oil and a natural antioxidant. It has a protective effect in preventing protein damage induced by ultraviolet radiation (PMID: 15749387). Research results suggest that Hydroxytyrosol could exert its antioxidant effect by scavenging hydrogen peroxide but not superoxide anion released during the respiratory burst (PMID: 15476671). Hydroxytyrosol has been found to be a metabolite of Escherichia (PMID: 22948011).
A member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities.
Indicator of maturity in olives which increases as the fruit ripens [DFC]. Hydroxytyrosol is found in many foods, some of which are fruits, olive, cloves, and grape wine.
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D000890 - Anti-Infective Agents
Hydroxytyrosol (DOPET) is a phenolic compound with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].
Hydroxytyrosol (DOPET) is a phenolic compound with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].

同义名列表

31 个代谢物同义名

InChI=1/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2; 3,4-Dihydroxyphenethyl Alcohol;3,4-Dihydroxyphenyl ethanol; 3-Hydroxytyrosol, analytical standard; beta-3,4-dihydroxyphenylethyl alcohol; 1,2-Benzenediol, 4-(2-hydroxyethyl)-; 2-(3,4-Dihydroxyphenyl)ethyl Alcohol; 4-(2-Hydroxy-ethyl)-benzene-1,2-diol; 4-(2-hydroxyethyl)benzene-1,2-diol; 4-(2-hydroxyethyl)-1,2-Benzenediol; 2-(3,4-Di-hydroxyphenyl)-ethanol; 3-Hydroxytyrosol, >=98\\% (HPLC); 2-(3,4-dihydroxyphenyl)ethanol; 3,4-dihydroxy-1-benzeneethanol; 3,4-Dihydroxyphenethyl Alcohol; 3,4-Dihydroxyphenethylalcohol; 2-(3,4-Hydroxyphenyl)ethanol; JUUBCHWRXWPFFH-UHFFFAOYSA-N; 2-(3-hydroxyphenyl)ethanol; Homoprotocatechuyl alcohol; JUUBCHWRXWPFFH-UHFFFAOYSA-; 3,4-Dihydroxyphenylethanol; HYDROXYTYROSOL [WHO-DD]; Dihydroxyphenylethanol; HYDROXYTYROSOL [INCI]; HYDROXYTYROSOL [MI]; 3-Hydroxytyrosol; UNII-QEU0NE4O90; Hydroxytyrosol; QEU0NE4O90; Dopaol; dopet



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li Fan, Lijuan Zhao, Yangbo Zhu, Lin Li, Xueping Yang, Ping Ma, Jian Liu, Qingwei Zhao, Xiaobo Li. Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition. Food & function. 2024 May; 15(9):5103-5117. doi: 10.1039/d4fo01027b. [PMID: 38680105]
  • Qizhen Cui, Qingqing Liu, Yutong Fan, Chenhe Wang, Yufei Li, Shuyuan Li, Jianguo Zhang, Guodong Rao. Functional differentiation of olive PLP_deC genes: insights into metabolite biosynthesis and genetic improvement at the whole-genome level. Plant cell reports. 2024 Apr; 43(5):127. doi: 10.1007/s00299-024-03212-z. [PMID: 38652203]
  • Jiaojiao Yuan, Su Tuo, Xiuhong Shi, Junling Tu. A new combined technology: Macroporous adsorption resin and high speed counter current chromatography for hydroxytyrosol separation from olive leaf enzymatic hydrolysate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Mar; 1235(?):124058. doi: 10.1016/j.jchromb.2024.124058. [PMID: 38394917]
  • Mojtaba Baharsaadi, Maryam Hezavehei, Abdolhossein Shahverdi, Iman Halvaei. Evaluation of the effects of hydroxytyrosol on human sperm parameters during cryopreservation. Cryobiology. 2024 03; 114(?):104840. doi: 10.1016/j.cryobiol.2023.104840. [PMID: 38104853]
  • Regina Viana de Carvalho Faria, Matheus Silva Duarte, Jeane de Souza Nogueira, Bianca Martins Gregório, Bruna Romana-Souza. Nrf2 activation by hydroxytyrosol and dimethyl fumarate ameliorates skin tissue repair in high-fat diet-fed mice by promoting M2 macrophage polarization and normalizing inflammatory response and oxidative damage. Journal of biochemical and molecular toxicology. 2024 Feb; 38(2):e23652. doi: 10.1002/jbt.23652. [PMID: 38348708]
  • Anabel González-Acedo, Rebeca Illescas-Montes, Elvira de Luna-Bertos, Concepción Ruiz, Javier Ramos-Torrecillas, Olga García-Martínez, Lucía Melguizo-Rodríguez. Extra Virgin Olive Oil Phenolic Compounds Modulate the Gene Expression of Biomarkers Involved in Fibroblast Proliferation and Differentiation. Genes. 2024 Jan; 15(2):. doi: 10.3390/genes15020173. [PMID: 38397163]
  • Jose M Romero-Márquez, María D Navarro-Hortal, Tamara Y Forbes-Hernández, Alfonso Varela-López, Juan G Puentes, Cristina Sánchez-González, Sandra Sumalla-Cano, Maurizio Battino, Roberto García-Ruiz, Sebastián Sánchez, José L Quiles. Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity. Food chemistry. 2024 Jan; 444(?):138516. doi: 10.1016/j.foodchem.2024.138516. [PMID: 38306771]
  • Maria Kourti, Zoi Skaperda, Fotios Tekos, Panagiotis Stathopoulos, Christina Koutra, Alexios Leandros Skaltsounis, Demetrios Kouretas. The Bioactivity of a Hydroxytyrosol-Enriched Extract Originated after Direct Hydrolysis of Olive Leaves from Greek Cultivars. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020299. [PMID: 38257212]
  • Marta Ramos-Barbero, Eva E Rufino-Palomares, Sergio Serrano-Carmona, Manuel Hernández-Yera, Leticia García-Salguero, José Antonio Lupiáñez, Amalia Pérez-Jiménez. Effect of Nutraceutical Factors on Hepatic Intermediary Metabolism in Wistar Rats with Induced Tendinopathy. International journal of molecular sciences. 2024 Jan; 25(1):. doi: 10.3390/ijms25010629. [PMID: 38203800]
  • Huijing Wang, Lian Wang, Jianbin Chen, Minglong Hu, Fang Fang, Jingwen Zhou. Promoting FADH2 Regeneration of Hydroxylation for High-Level Production of Hydroxytyrosol from Glycerol in Escherichia coli. Journal of agricultural and food chemistry. 2023 Nov; 71(44):16681-16690. doi: 10.1021/acs.jafc.3c05477. [PMID: 37877749]
  • María-Carmen López de Las Hazas, Andrea Del Saz-Lara, Lídia Cedó, María Carmen Crespo, João Tomé-Carneiro, Luis A Chapado, Alba Macià, Francesco Visioli, Joan C Escola-Gil, Alberto Dávalos. Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model. Molecular nutrition & food research. 2023 Nov; ?(?):e2300508. doi: 10.1002/mnfr.202300508. [PMID: 37933702]
  • Panagiota Binou, Athena Stergiou, Ourania Kosta, Nikolaos Tentolouris, Vaios T Karathanos. Positive contribution of hydroxytyrosol-enriched wheat bread to HbA1c levels, lipid profile, markers of inflammation and body weight in subjects with overweight/obesity and type 2 diabetes mellitus. European journal of nutrition. 2023 Aug; 62(5):2165-2176. doi: 10.1007/s00394-023-03133-9. [PMID: 37017765]
  • Tomoya Hara, Daiju Fukuda, Byambasuren Ganbaatar, Phuong Tran Pham, Kunduziayi Aini, Arief Rahadian, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata. Olive mill wastewater and hydroxytyrosol inhibits atherogenesis in apolipoprotein E-deficient mice. Heart and vessels. 2023 Jul; ?(?):. doi: 10.1007/s00380-023-02290-5. [PMID: 37462755]
  • Ignatios Ikonomidis, Konstantinos Katogiannis, Christina Chania, Nikolaos Iakovis, Maria Tsoumani, Andriana Christodoulou, Evangelia Brinia, George Pavlidis, John Thymis, Damianos Tsilivarakis, Aikaterini Kountouri, Emmanouil Korakas, Vaia Lambadiari, Filippos Triposkiadis, Leandros Skaltsounis, Ioulia Tseti, Efstathios K Iliodromitis, Ioanna Andreadou. Association of hydroxytyrosol enriched olive oil with vascular function in chronic coronary disease. European journal of clinical investigation. 2023 Jul; 53(7):e13983. doi: 10.1111/eci.13983. [PMID: 36912212]
  • Sara Falsini, Marzia Cristiana Rosi, Elia Ravegnini, Silvia Schiff, Cristina Gonnelli, Alessio Papini, Alessandra Adessi, Silvia Urciuoli, Sandra Ristori. Nanoformulations with exopolysaccharides from cyanobacteria: enhancing the efficacy of bioactive molecules in the Mediterranean fruit fly control. Environmental science and pollution research international. 2023 Jul; 30(35):83760-83770. doi: 10.1007/s11356-023-28180-x. [PMID: 37347326]
  • Yu-Ping Fu, Karl Egil Malterud, Anne Grethe Hamre, Kari Tvete Inngjerdingen, Helle Wangensteen. Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots. Chemistry & biodiversity. 2023 Jun; ?(?):e202300161. doi: 10.1002/cbdv.202300161. [PMID: 37337851]
  • Asma Mahmoudi, Fatma Hadrich, Zouhaier Bouallagui, Ines Feki, Hela Ghorbel, Lobna Ayadi, Mohamed Chamkha, Sami Sayadi. Comparative study of the effect of oleuropein and hydroxytyrosol rich extracts on the reproductive toxicity induced by bisphenol A in male rats: biochemical, histopathological, and molecular analyses. Environmental science and pollution research international. 2023 Jun; ?(?):. doi: 10.1007/s11356-023-27836-y. [PMID: 37273043]
  • Yushiro Fuji, Kai Uchida, Tomoyoshi Akashi, Takashi Ohtsuki, Hiroshi Matsufuji, Masami Yokota Hirai. Molecular Identification of UDP-Sugar Dependent Glycosyltransferase and Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis Induced by Methyl Jasmonate in Sesamum indicum L. Plant & cell physiology. 2023 May; ?(?):. doi: 10.1093/pcp/pcad053. [PMID: 37233612]
  • Maite Garcia-Guasch, Eduard Escrich, Raquel Moral, Iola F Duarte. Metabolomics Insights into the Differential Response of Breast Cancer Cells to the Phenolic Compounds Hydroxytyrosol and Luteolin. Molecules (Basel, Switzerland). 2023 May; 28(9):. doi: 10.3390/molecules28093886. [PMID: 37175295]
  • Pengfei Gong, Jiali Tang, Jiaying Wang, Chengtao Wang, Wei Chen. A Novel Microbial Consortia Catalysis Strategy for the Production of Hydroxytyrosol from Tyrosine. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24086944. [PMID: 37108108]
  • Joana Madureira, Bianca Albuquerque, Maria Inês Dias, José Pinela, Ricardo C Calhelha, Celestino Santos-Buelga, Fernanda M A Margaça, Isabel C F R Ferreira, Sandra Cabo Verde, Lillian Barros. Ultrasound-assisted extraction of hydroxytyrosol and tyrosol from olive pomace treated by gamma radiation: process optimization and bioactivity assessment. Food & function. 2023 Apr; 14(7):3038-3050. doi: 10.1039/d2fo03607j. [PMID: 36896737]
  • Federica Flamminii, Riccardo De Flaviis, Giampiero Sacchetti, Francesco Caponio, Vito Michele Paradiso, Carla Daniela Di Mattia. Unravelling the role of sodium chloride and hydroxytyrosol on the colloidal properties and oxidative stability of olive oil-based o/w emulsions: A multivariate statistical approach. Food chemistry. 2023 Mar; 405(Pt A):134767. doi: 10.1016/j.foodchem.2022.134767. [PMID: 36368103]
  • Rodrigo Gonzalez-Ortega, Carla Daniela Di Mattia, Paola Pittia, Poklar Ulrih Natasa. Effect of heat treatment on phenolic composition and radical scavenging activity of olive leaf extract at different pH conditions: a spectroscopic and kinetic study. Journal of the science of food and agriculture. 2023 Mar; 103(4):2047-2056. doi: 10.1002/jsfa.12371. [PMID: 36461135]
  • Cecilia Bender, Ilaria Candi, Eva Rogel. Efficacy of Hydroxytyrosol-Rich Food Supplements on Reducing Lipid Oxidation in Humans. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065521. [PMID: 36982623]
  • Elisabeta-Irina Geana, Corina Teodora Ciucure, Irina Mirela Apetrei, Maria Lisa Clodoveo, Constantin Apetrei. Discrimination of Olive Oil and Extra-Virgin Olive Oil from Other Vegetable Oils by Targeted and Untargeted HRMS Profiling of Phenolic and Triterpenic Compounds Combined with Chemometrics. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065292. [PMID: 36982366]
  • QingXia Guan, XiaoYing Zhou, FangFang Yang, Xue Zhang, YanHong Wang, WeiNan Li, XiuYan Li. A novel strategy against hepatitis B virus: Glycyrrhetnic acid conjugated multi-component synergistic nano-drug delivery system for targeted therapy. Journal of biomaterials applications. 2023 03; 37(8):1393-1408. doi: 10.1177/08853282221139132. [PMID: 36373787]
  • Carlo Cervellati, Alessandro Trentini, Valentina Rosta, Giovanni Zuliani, Francesco Vieceli Dalla Sega, Francesca Fortini, Paola Rizzo, Paolo Cimaglia, Gianluca Campo. A Nutraceutical Compound Containing a Low Dose of Monacolin K, Polymethoxyflavones, Phenolic Acids, Flavonoids, and Hydroxytyrosol Improves HDL Functionality. Current vascular pharmacology. 2023 Feb; ?(?):. doi: 10.2174/1570161121666230221142131. [PMID: 36824007]
  • Ubashini Vijakumaran, Janushaa Shanmugam, Jun Wei Heng, Siti Sarah Azman, Muhammad Dain Yazid, Nur Atiqah Haizum Abdullah, Nadiah Sulaiman. Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041861. [PMID: 36838850]
  • Rosario Sánchez, Laura Arroyo, Pilar Luaces, Carlos Sanz, Ana G Pérez. Olive Polyphenol Oxidase Gene Family. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043233. [PMID: 36834644]
  • Monica Nardi, Steve Brocchini, Satyanarayana Somavarapu, Antonio Procopio. Hydroxytyrosol oleate: A promising neuroprotective nanocarrier delivery system of oleuropein and derivatives. International journal of pharmaceutics. 2023 Jan; 631(?):122498. doi: 10.1016/j.ijpharm.2022.122498. [PMID: 36535454]
  • Sara Franceschelli, Federica De Cecco, Mirko Pesce, Patrizio Ripari, Maria Teresa Guagnano, Arturo Bravo Nuevo, Alfredo Grilli, Silvia Sancilio, Lorenza Speranza. Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032057. [PMID: 36768382]
  • Cecilia Bender, Sarah Strassmann, Christian Golz. Oral Bioavailability and Metabolism of Hydroxytyrosol from Food Supplements. Nutrients. 2023 Jan; 15(2):. doi: 10.3390/nu15020325. [PMID: 36678196]
  • Andrea Del Saz-Lara, Hatim Boughanem, María-Carmen López de Las Hazas, Carmen Crespo, Alicia Saz-Lara, Francesco Visioli, Manuel Macias-González, Alberto Dávalos. Hydroxytyrosol decreases EDNRA expression through epigenetic modification in colorectal cancer cells. Pharmacological research. 2023 01; 187(?):106612. doi: 10.1016/j.phrs.2022.106612. [PMID: 36528246]
  • Manuela Leo, Livio Muccillo, Erica Pranzini, Giovannina Barisciano, Matteo Parri, Giulia Lopatriello, Marco Carlomagno, Alice Santi, Maria Letizia Taddei, Lina Sabatino. Transcriptomic Analysis of Colorectal Cancer Cells Treated with Oil Production Waste Products (OPWPs) Reveals Enrichment of Pathways of Mitochondrial Functionality. Cells. 2022 12; 11(24):. doi: 10.3390/cells11243992. [PMID: 36552757]
  • María Del Mar Contreras, Irene Gómez-Cruz, Anouar Feriani, Saleh Alwasel, Abdel Halim Harrath, Inmaculada Romero, Eulogio Castro, Nizar Tlili. Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods. Food & function. 2022 Nov; 13(22):11915-11928. doi: 10.1039/d2fo00888b. [PMID: 36321712]
  • Shuyan Han, Yongjin Wang, Zhongxiang Fang, Yiren Zhang, Wei Zeng, Emad Karrar, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang. Effect of olive polyphenols on lipid oxidation of high-fat beef during digestion. Food research international (Ottawa, Ont.). 2022 11; 161(?):111843. doi: 10.1016/j.foodres.2022.111843. [PMID: 36192973]
  • Yingjie Liu, Dong Song, Haitao Hu, Ruijin Yang, Xiaomei Lyu. De Novo Production of Hydroxytyrosol by Saccharomyces cerevisiae-Escherichia coli Coculture Engineering. ACS synthetic biology. 2022 09; 11(9):3067-3077. doi: 10.1021/acssynbio.2c00300. [PMID: 35952699]
  • Rebeca Quirós-Fernández, Bricia López-Plaza, Laura M Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gómez Candela. Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A Randomized, Double-Blind, Controlled and Crossover Trial. Nutrients. 2022 Apr; 14(9):. doi: 10.3390/nu14091879. [PMID: 35565844]
  • Christina Fytili, Theodora Nikou, Nikolaos Tentolouris, Ioulia K Tseti, Charilaos Dimosthenopoulos, Petros P Sfikakis, Dimitrios Simos, Alexandros Kokkinos, Alexios L Skaltsounis, Nikolaos Katsilambros, Maria Halabalaki. Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study. Nutrients. 2022 Apr; 14(7):. doi: 10.3390/nu14071525. [PMID: 35406139]
  • Alexandra V Chatzikonstantinou, Αrchontoula Giannakopoulou, Stamatia Spyrou, Yannis V Simos, Vassiliki G Kontogianni, Dimitrios Peschos, Petros Katapodis, Angeliki C Polydera, Haralambos Stamatis. Production of hydroxytyrosol rich extract from Olea europaea leaf with enhanced biological activity using immobilized enzyme reactors. Environmental science and pollution research international. 2022 Apr; 29(20):29624-29637. doi: 10.1007/s11356-021-17081-6. [PMID: 34676481]
  • Ahmed Al Saqr, Manjusha Annaji, Ishwor Poudel, Shivani Rangari, Sai H S Boddu, Amit K Tiwari, R Jayachandra Babu. Niosomal formulation of hydroxytyrosol, a polyphenolic antioxidant, for enhancing transdermal delivery across human cadaver skin. Pharmaceutical development and technology. 2022 Feb; 27(2):155-163. doi: 10.1080/10837450.2022.2025540. [PMID: 34978253]
  • Fatma Hadrich, Sven-Uwe Geißen, Mohamed Chamkha, Sami Sayadi. Optimizing the Extraction Conditions of Hydroxytyrosol from Olive Leaves Using a Modified Spherical Activated Carbon: A New Experimental Design. BioMed research international. 2022; 2022(?):6199627. doi: 10.1155/2022/6199627. [PMID: 35620226]
  • Chunlan Shan, Fujun Miao. Immunomodulatory and antioxidant effects of hydroxytyrosol in cyclophosphamide-induced immunosuppressed broilers. Poultry science. 2022 Jan; 101(1):101516. doi: 10.1016/j.psj.2021.101516. [PMID: 34784517]
  • Y Bhusan Tripathi, N Pandey, P Mishra, P Tripathi, M Coatto, K Anpilogov, K Dhuli, K Donato, S Michelini, S Cecchin, T Beccari, M R Ceccarini, S Paolacci, M Bertelli. Effect of a dietary supplement on the reduction of lymphedema-progression in mouse tail-cut model. European review for medical and pharmacological sciences. 2021 12; 25(1 Suppl):56-66. doi: 10.26355/eurrev_202112_27334. [PMID: 34890035]
  • S Paolacci, A K Kiani, P Shree, D Tripathi, Y B Tripathi, P Tripathi, G M Tartaglia, M Farronato, G Farronato, S T Connelly, M R Ceccarini, M Coatto, M C Ergoren, T Sanlidag, A Dautaj, M Bertelli. Scoping review on the role and interactions of hydroxytyrosol and alpha-cyclodextrin in lipid-raft-mediated endocytosis of SARS-CoV-2 and bioinformatic molecular docking studies. European review for medical and pharmacological sciences. 2021 12; 25(1 Suppl):90-100. doi: 10.26355/eurrev_202112_27338. [PMID: 34890039]
  • Z Naureen, A Dautaj, S Nodari, F Fioretti, K Dhuli, K Anpilogov, L Lorusso, S Paolacci, S Michelini, T Guda, M Kallazi, M Bertelli. Proposal of a food supplement for the management of post-COVID syndrome. European review for medical and pharmacological sciences. 2021 12; 25(1 Suppl):67-73. doi: 10.26355/eurrev_202112_27335. [PMID: 34890036]
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