Gallamine (BioDeep_00000600539)

   


代谢物信息卡片


Gallamine

化学式: C24H45N3O3 (423.34607400000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCOC1=C(C(=CC=C1)OCCN(CC)CC)OCCN(CC)CC
InChI: InChI=1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3

描述信息

D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
M - Musculo-skeletal system > M03 - Muscle relaxants > M03A - Muscle relaxants, peripherally acting agents
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent

同义名列表

1 个代谢物同义名

Gallamine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chibing Dai, Na Liu, Wenmei Chen, Wei Qian, Xiaohua Hou. Simo decoction promotes contraction of antral circular smooth muscle mainly via muscarinic M3 receptor. Journal of ethnopharmacology. 2012 Nov; 144(2):270-6. doi: 10.1016/j.jep.2012.09.008. [PMID: 23022322]
  • Bina P Butala, Veena R Shah, Guruprasad P Bhosale, Rajkiran B Shah. Medication error: Subarachnoid injection of tranexamic acid. Indian journal of anaesthesia. 2012 Mar; 56(2):168-70. doi: 10.4103/0019-5049.96335. [PMID: 22701210]
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  • Andrew J Mulherin, Amy H Oh, Helena Kim, Anthony Grieco, Lina M Lauffer, Patricia L Brubaker. Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell. Endocrinology. 2011 Dec; 152(12):4610-9. doi: 10.1210/en.2011-1485. [PMID: 21971158]
  • Liansheng Liu, Qian Li, Robert Sapolsky, Min Liao, Kshama Mehta, Aditi Bhargava, Pankaj J Pasricha. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. PloS one. 2011 May; 6(5):e19498. doi: 10.1371/journal.pone.0019498. [PMID: 21589865]
  • Eduardo N Barata, Peter C Hubbard, Olinda G Almeida, António Miranda, Adelino Vm Canário. Male urine signals social rank in the Mozambique tilapia (Oreochromis mossambicus). BMC biology. 2007 Dec; 5(?):54. doi: 10.1186/1741-7007-5-54. [PMID: 18076759]
  • Marcielli Silva Grangeiro, Ana Paula Calheiros-Lima, Manoel Francisco Martins, Luis Frederico Arruda, Lúcia Garcez-do-Carmo, Wilson C Santos. Pharmacological effects of Eugenia punicifolia (Myrtaceae) in cholinergic nicotinic neurotransmission. Journal of ethnopharmacology. 2006 Nov; 108(1):26-30. doi: 10.1016/j.jep.2006.04.021. [PMID: 16759829]
  • Camiel F de Jong, Rico J E Derks, Ben Bruyneel, Wilfried Niessen, Hubertus Irth. High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts. Journal of chromatography. A. 2006 Apr; 1112(1-2):303-10. doi: 10.1016/j.chroma.2006.01.059. [PMID: 16516896]
  • Yuko Fukudome, Takako Ohno-Shosaku, Minoru Matsui, Yuko Omori, Masahiro Fukaya, Hiroshi Tsubokawa, Makoto M Taketo, Masahiko Watanabe, Toshiya Manabe, Masanobu Kano. Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. The European journal of neuroscience. 2004 May; 19(10):2682-92. doi: 10.1111/j.0953-816x.2004.03384.x. [PMID: 15147302]
  • Reinoud Gosens, Mechteld M Grootte Bromhaar, Annet Tonkes, Dedmer Schaafsma, Johan Zaagsma, S Adriaan Nelemans, Herman Meurs. Muscarinic M(3) receptor-dependent regulation of airway smooth muscle contractile phenotype. British journal of pharmacology. 2004 Mar; 141(6):943-50. doi: 10.1038/sj.bjp.0705709. [PMID: 14993104]
  • J Y Datté, P A Yapo, G G Kouamé-Koffi, S Kati-Coulibaly, K E Amoikon, A M Offoumou. Leaf extract of Caesalpinia bonduc Roxb. (Caesalpiniaceae) induces an increase of contractile force in rat skeletal muscle in situ. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2004 Feb; 11(2-3):235-41. doi: 10.1078/0944-7113-00292. [PMID: 15070178]
  • Younes Anini, Patricia L Brubaker. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells. Endocrinology. 2003 Jul; 144(7):3244-50. doi: 10.1210/en.2003-0143. [PMID: 12810581]
  • Ibrahim Bilgen, Gülsen Oner, Mustafa Edremitlioğlu, Zeliha Alkan, Selma Cirrik. Involvement of cholinoceptors in cadmium-induced endothelial dysfunction. Journal of basic and clinical physiology and pharmacology. 2003; 14(1):55-76. doi: 10.1515/jbcpp.2003.14.1.55. [PMID: 12901446]
  • Younes Anini, Tanya Hansotia, Patricia L Brubaker. Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats. Endocrinology. 2002 Jun; 143(6):2420-6. doi: 10.1210/endo.143.6.8840. [PMID: 12021207]
  • Lucy Sasongko, Iqbal Ramzan, Kenneth M Williams, Andrew J McLachlan. Muscle distribution of the neuromuscular blocker gallamine using microdialysis. Journal of pharmaceutical sciences. 2002 Mar; 91(3):769-75. doi: 10.1002/jps.10082. [PMID: 11920762]
  • C H M Kerskes, K J Lusthof, P G M Zweipfenning, J P Franke. The detection and identification of quaternary nitrogen muscle relaxants in biological fluids and tissues by ion-trap LC-ESI-MS. Journal of analytical toxicology. 2002 Jan; 26(1):29-34. doi: 10.1093/jat/26.1.29. [PMID: 11890177]
  • K Finlayson, J McLuckie, J Hern, I Aramori, H J Olverman, J S Kelly. Characterisation of [(125)I]-apamin binding sites in rat brain membranes with HE293 cells transfected with SK channel subtypes. Neuropharmacology. 2001 Sep; 41(3):341-50. doi: 10.1016/s0028-3908(01)00067-3. [PMID: 11522325]
  • M C Theroux, J B Rose, S Iyengar, M S Katz. Succinylcholine pretreatment using gallamine or mivacurium during rapid sequence induction in children: a randomized, controlled study. Journal of clinical anesthesia. 2001 Jun; 13(4):287-92. doi: 10.1016/s0952-8180(01)00267-7. [PMID: 11435054]
  • L Sasongko, I Ramzan, K M Williams, A J McLachlan. Application of a high-performance liquid chromatographic assay for the neuromuscular blocker gallamine to analysis of rat plasma, muscle and microdialysate samples. Journal of chromatography. B, Biomedical sciences and applications. 2001 Apr; 754(2):467-75. doi: 10.1016/s0378-4347(01)00032-9. [PMID: 11339290]
  • D M Wynter-Adams, O R Simon, M D Gossell-Williams, M E West. Isolation of a muscarinic alkaloid with ocular hypotensive action from Trophis racemosa. Phytotherapy research : PTR. 1999 Dec; 13(8):670-4. doi: 10.1002/(sici)1099-1573(199912)13:8<670::aid-ptr514>3.0.co;2-8. [PMID: 10594936]
  • K Sato, K Windisch, I Matko, E S Vizi. Effects of non-depolarizing neuromuscular blocking agents on norepinephrine release from human atrial tissue obtained during cardiac surgery. British journal of anaesthesia. 1999 Jun; 82(6):904-9. doi: 10.1093/bja/82.6.904. [PMID: 10562787]
  • J D Wadsworth, S Torelli, K B Doorty, P N Strong. Structural diversity among subtypes of small-conductance Ca2+-activated potassium channels. Archives of biochemistry and biophysics. 1997 Oct; 346(1):151-60. doi: 10.1006/abbi.1997.0280. [PMID: 9328295]
  • Y Mishra, I Ramzan. Ranitidine reverses gallamine paralysis in rats. Anesthesia and analgesia. 1993 Mar; 76(3):627-30. doi: 10.1213/00000539-199303000-00032. [PMID: 8452279]
  • Y Mishra, I Ramzan. Influence of cimetidine on gallamine-induced neuromuscular paralysis in rats. Clinical and experimental pharmacology & physiology. 1992 Dec; 19(12):803-7. doi: 10.1111/j.1440-1681.1992.tb00418.x. [PMID: 1473295]
  • W Burke, I Ramzan. Myoclonus in the decerebrate cat produced by gallamine. Brain research. 1992 May; 580(1-2):189-96. doi: 10.1016/0006-8993(92)90944-5. [PMID: 1504799]
  • K Nomura, K Naruse, K Watanabe, M Sokabe. Aminoglycoside blockade of Ca2(+)-activated K+ channel from rat brain synaptosomal membranes incorporated into planar bilayers. The Journal of membrane biology. 1990 May; 115(3):241-51. doi: 10.1007/bf01868639. [PMID: 2374160]
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  • K J Burchiel. Carbamazepine inhibits spontaneous activity in experimental neuromas. Experimental neurology. 1988 Nov; 102(2):249-53. doi: 10.1016/0014-4886(88)90101-x. [PMID: 3181365]
  • P Blount, J P Merlie. Native folding of an acetylcholine receptor alpha subunit expressed in the absence of other receptor subunits. The Journal of biological chemistry. 1988 Jan; 263(2):1072-80. doi: NULL. [PMID: 2826454]
  • I M Ramzan. Determination of the neuromuscular blocking drug gallamine in rat serum using high-performance liquid chromatography. Journal of chromatography. 1987 Jul; 417(2):428-33. doi: 10.1016/0378-4347(87)80140-8. [PMID: 3654893]
  • M J Shao, K D Fallon, S N Khalil, E Abouleish. Quantitation of gallamine (Flaxedil) in human plasma using high-performance liquid chromatography. Journal of chromatography. 1985 Nov; 345(1):184-6. doi: 10.1016/0378-4347(85)80152-3. [PMID: 4086579]
  • D G Harle, B A Baldo, M M Fisher. Inhibition of histamine-N-methyltransferase activity by neuromuscular blocking drugs. Agents and actions. 1985 Oct; 17(1):27-31. doi: 10.1007/bf01966676. [PMID: 4083176]
  • A S Laurence. Biochemical changes following suxamethonium. Serum myoglobin, potassium and creatinine kinase changes before commencement of surgery. Anaesthesia. 1985 Sep; 40(9):854-9. doi: 10.1111/j.1365-2044.1985.tb11046.x. [PMID: 4051151]
  • C J Limas, C Limas. Carbachol induces desensitization of cardiac beta-adrenergic receptors through muscarinic M1 receptors. Biochemical and biophysical research communications. 1985 Apr; 128(2):699-704. doi: 10.1016/0006-291x(85)90103-2. [PMID: 2986622]
  • G Jagadeesh, P V Sulakhe. Gallamine binding to heart M2 cholinergic receptors does not antagonize cholinergic inhibition of adenylate cyclase in isolated plasma membrane. European journal of pharmacology. 1985 Feb; 109(2):311-3. doi: 10.1016/0014-2999(85)90439-x. [PMID: 3996474]
  • M F Cummings, W J Russell, D B Frewin, W A Miller. The effects of gallamine and a mixture of pancuronium and alcuronium on the pressor and plasma catecholamine responses to tracheal intubation. Anaesthesia and intensive care. 1984 Feb; 12(1):22-6. doi: 10.1177/0310057x8401200105. [PMID: 6703312]
  • O Erkola, A Salmenperä, R Kuoppamäki. Five non-depolarizing muscle relaxants in precurarization. Acta anaesthesiologica Scandinavica. 1983 Dec; 27(6):427-32. doi: 10.1111/j.1399-6576.1983.tb01981.x. [PMID: 6141695]
  • C A Shanks, I M Ramzan, J S Walker, K F Brown. Gallamine disposition in open-heart surgery involving cardiopulmonary bypass. Clinical pharmacology and therapeutics. 1983 Jun; 33(6):792-9. doi: 10.1038/clpt.1983.108. [PMID: 6851410]
  • I M Ramzan, C A Shanks, E J Triggs. Relationship between gallamine plasma concentration and neuromuscular paralysis in surgical patients. Journal of clinical pharmacology. 1983 May; 23(5-6):243-51. doi: 10.1002/j.1552-4604.1983.tb02731.x. [PMID: 6875023]
  • A S Foutz, C Dauthier, B Kerdelhué. beta-Endorphin plasma levels during neuromuscular blockade in unanesthetized cat. Brain research. 1983 Mar; 263(1):119-23. doi: 10.1016/0006-8993(83)91207-6. [PMID: 6301640]
  • C A Shanks, D I Funk, M J Avram, T K Henthorn. Gallamine administered by combined bolus and infusion. Anesthesia and analgesia. 1982 Oct; 61(10):847-52. doi: NULL. [PMID: 6289700]
  • T K Henthorn, M J Avram, M C Frederiksen, A J Atkinson. Heterogeneity of interstitial fluid space demonstrated by simultaneous kinetic analysis of the distribution and elimination of inulin and gallamine. The Journal of pharmacology and experimental therapeutics. 1982 Aug; 222(2):389-94. doi: NULL. [PMID: 7097559]
  • P M Ertama. Histamine liberation in surgical patients following administration of neuromuscular blocking drugs. Annals of clinical research. 1982 Feb; 14(1):15-26. doi: NULL. [PMID: 6182834]
  • B G Woodcock, E L Masinde, H Schnieden. Neuromuscular blocking activity in an extract from the East African wild sisal Sansevieria ehrenbergii. Toxicon : official journal of the International Society on Toxinology. 1982; 20(3):659-61. doi: 10.1016/0041-0101(82)90060-5. [PMID: 7101311]
  • V M Popović. [The effect of non-depolarizing muscle relaxants on plasma potassium]. Srpski arhiv za celokupno lekarstvo. 1981 Sep; 109(9):1159-64. doi: NULL. [PMID: 7345643]
  • M I Ramzan, C A Shanks, E J Triggs. Gallamine disposition in surgical patients with chronic renal failure. British journal of clinical pharmacology. 1981 Aug; 12(2):141-7. doi: 10.1111/j.1365-2125.1981.tb01192.x. [PMID: 7306428]
  • P Westra, G A Vermeer, A R de Lange, A H Scaf, D K Meijer, H Wesseling. Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis. British journal of anaesthesia. 1981 Apr; 53(4):331-8. doi: 10.1093/bja/53.4.331. [PMID: 7225266]
  • J E Kendrick, S J De Haan, J D Parke. Regulation of blood flow to respiratory muscles during hypoxia and hypercapnia. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1981 Feb; 166(2):157-61. doi: 10.3181/00379727-166-41039. [PMID: 7208476]
  • M I Ramzan, A A Somogyi, J S Walker, C A Shanks, E J Triggs. Clinical pharmacokinetics of the non-depolarising muscle relaxants. Clinical pharmacokinetics. 1981 Jan; 6(1):25-60. doi: 10.2165/00003088-198106010-00002. [PMID: 7018787]
  • P Westra, M C Houwertjes, A R de Lange, A H Scaf, F R Hindriks, S Agoston. Effect of experimental cholestasis on neuromuscular blocking drugs in cats. British journal of anaesthesia. 1980 Aug; 52(8):747-57. doi: 10.1093/bja/52.8.747. [PMID: 7426252]
  • M I Ramzan, E J Triggs, C A Shanks. Pharmacokinetic studies in man with gallamine triethiodide. I. Single and multiple clinical doses. European journal of clinical pharmacology. 1980 Feb; 17(2):135-43. doi: 10.1007/bf00562622. [PMID: 7371705]
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  • S N Glisson, M M Sanchez, A A El-Etr, R A Lim. Nitroglycerin and the neuromuscular blockade produced by gallamine, succinylcholine, d-tubocurarine, and pancuronium. Anesthesia and analgesia. 1980 Feb; 59(2):117-22. doi: NULL. [PMID: 6768318]
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  • D Cozanitis, E Haapanen. Studies on muscle relaxants during haemodialysis. Acta anaesthesiologica Scandinavica. 1979 Jun; 23(3):225-34. doi: 10.1111/j.1399-6576.1979.tb01444.x. [PMID: 484179]
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  • J Stovner, L Theodorsen, E Bjelke. Sensitivity to gallamine and pancuronium with special reference to serum proteins. British journal of anaesthesia. 1971 Oct; 43(10):953-8. doi: 10.1093/bja/43.10.953. [PMID: 4255962]
  • L F Walts, W K Thorpe, J B Dillon. Recurarization--fact or fiction. Anesthesia and analgesia. 1971 Sep; 50(5):879-85. doi: 10.1213/00000539-197150050-00033. [PMID: 4255898]
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  • M M Singer, R Dutton, W L Way. Untoward results of gallamine administration during bilateral nephrectomy: treatment with haemodialysis. Case reports. British journal of anaesthesia. 1971 Apr; 43(4):404-6. doi: 10.1093/bja/43.4.404. [PMID: 5575188]
  • E Lowenstein, C Goldfine, W E Flacke. Administration of gallamine in the presence of renal failure--reversal of neuromuscular blockade by peritoneal dialysis. Anesthesiology. 1970 Nov; 33(5):556-8. doi: 10.1097/00000542-197011000-00023. [PMID: 4249164]
  • D K Meijer, J G Weitering. Curare-like agents: relation between lipid solubility and transport into bile in perfused rat liver. European journal of pharmacology. 1970 May; 10(2):283-9. doi: 10.1016/0014-2999(70)90284-0. [PMID: 4245935]
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