5'-Phosphoribosyl-N-formylglycinamidine (BioDeep_00000005600)

 

Secondary id: BioDeep_00000019523

human metabolite Endogenous


代谢物信息卡片


[(2R,3S,4R,5R)-5-[(Z)-(1-amino-2-formamidoethylidene)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

化学式: C8H16N3O8P (313.0675)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 8.05%

分子结构信息

SMILES: C(/C(=N/[C@H]1[C@@H]([C@@H]([C@@H](COP(=O)(O)O)O1)O)O)/N)NC=O
InChI: InChI=1S/C8H16N3O8P/c9-5(1-10-3-12)11-8-7(14)6(13)4(19-8)2-18-20(15,16)17/h3-4,6-8,13-14H,1-2H2,(H2,9,11)(H,10,12)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1

描述信息

5-Phosphoribosyl-N-formylglycinamidine, also known as FGAM or phosphoribosylformylglycinamidine, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. FGAM is a very strong basic compound (based on its pKa). Within humans, FGAM participates in several enzymatic reactions. FGAM is an intermediate in purine metabolism and it can be biosynthesized (along with L-glutamic acid) from 5-phosphoribosyl-N-formylglycinamide (FGAR) and L-glutamine. This reaction is catalyzed by the enzyme phosphoribosylformylglycinamidine synthase (EC 6.3.5.3). Additionally, FGAM can be converted into aminoimidazole ribotide (AIR) through its interaction with the enzyme trifunctional purine biosynthetic protein adenosine-3 (EC 6.3.3.1). Outside of the human body, FGAM has been detected, but not quantified in, several different foods, such as Welsh onions, green beans, chicories, European cranberries, and Mexican oregano. This could make FGAM a potential biomarker for the consumption of these foods.
5-Phosphoribosyl-n-formylglycineamidine is a substrate for Glucosamine-6-phosphate isomerase. [HMDB]. Phosphoribosylformylglycineamidine is found in many foods, some of which are greenthread tea, cardamom, mulberry, and carrot.
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同义名列表

24 个代谢物同义名

[(2R,3S,4R,5R)-5-[(Z)-(1-amino-2-formamidoethylidene)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate; {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-formamidoethanimidamido)oxolan-2-yl]methoxy}phosphonic acid; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-formamidoethanimidamido)oxolan-2-yl]methoxyphosphonic acid; N-[2-Imino-2-[(5-O-phosphono-beta-D-ribofuranosyl)amino]ethyl]formamide; N-[2-Imino-2-[(5-O-phosphono-β-D-ribofuranosyl)amino]ethyl]formamide; 2-formamido-N(1)-(5-O-phosphonato-D-ribosyl)acetamidine; 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine; 2-(Formamido)-N1-(5’-phosphoribosyl)acetamidine; 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine; 5-Phosphoribosyl-alpha-N-formylglycineamidine; 1-(5’-Phosphoribosyl)-N-formylglycinamidine; 1-(5-Phosphoribosyl)-N-formylglycinamidine; 5’-Phosphoribosyl-α-N-formylglycineamidine; 5-Phosphoribosyl-α-N-formylglycineamidine; 5’-Phosphoribosyl-N-formyl glycineamidine; 5-Phosphoribosyl-N-formyl glycineamidine; 5’-Phosphoribosyl-N-formylglycinamidine; 5-Phosphoribosyl-N-formylglycinamidine; 5’-Phosphoribosylformylglycinamidine; 5-Phosphoribosylformylglycinamidine; Phosphoribosylformylglycineamidine; Formylglycinamidine ribonucleotide; Phosphoribosylformylglycinamidine; FGAM



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(0)

代谢反应

57 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(9)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(46)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 1 PFAS
cytosol 2 AKR1C2, PFAS
Cytoplasm, cytosol 1 AKR1C2
extracellular exosome 1 PFAS


文献列表