5beta-dihydrodeoxycorticosterone (BioDeep_00000055169)

   

human metabolite


代谢物信息卡片


(1S,2S,7R,10R,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one

化学式: C21H32O3 (332.23513219999995)
中文名称:
谱图信息: 最多检出来源 Bos taurus(endogenous) 80%

分子结构信息

SMILES: CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4C(=O)CO)C
InChI: InChI=1S/C21H32O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13,15-18,22H,3-12H2,1-2H3/t13-,15+,16+,17+,18-,20+,21+/m1/s1

描述信息

5beta-dihydrodeoxycorticosterone, also known as Hydroxydione or 21-Hydroxy-5beta-pregnane-3,20-dione, is classified as a member of the 21-hydroxysteroids. 21-hydroxysteroids are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. 5beta-dihydrodeoxycorticosterone is considered to be practically insoluble (in water) and relatively neutral
D018377 - Neurotransmitter Agents > D000081227 - Neurosteroids

同义名列表

15 个代谢物同义名

(1S,2S,7R,10R,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one; 21-Hydroxy-5 alpha-pregnane-3,20-dione; 5 alpha-Dihydro-11-deoxycorticosterone; 21-Hydroxy-5beta-pregnane-3,20-dione; 21-Hydroxy-5b-pregnane-3,20-dione; 21-Hydroxy-5β-pregnane-3,20-dione; 5beta-dihydrodeoxycorticosterone; Hydroxydione, (5 alpha)-isomer; 5Β-dihydrodeoxycorticosterone; 5b-Dihydrodeoxycorticosterone; Hydroxydione sodium; hydroxydione; Viadryl; Viadril; Predion



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wei-Hsuan Huang, Chao-Hsiang Chang, Chi-Ping Huang, Hsi-Chin Wu, Po-Fan Hsieh I. The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy. International braz j urol : official journal of the Brazilian Society of Urology. 2017 Jan; 43(1):80-86. doi: 10.1590/s1677-5538.ibju.2015.0423. [PMID: 28124529]
  • Aaron T Wild, Xiaobu Ye, Susannah G Ellsworth, Jessica A Smith, Amol K Narang, Tanu Garg, Jian Campian, Daniel A Laheru, Lei Zheng, Christopher L Wolfgang, Phuoc T Tran, Stuart A Grossman, Joseph M Herman. The Association Between Chemoradiation-related Lymphopenia and Clinical Outcomes in Patients With Locally Advanced Pancreatic Adenocarcinoma. American journal of clinical oncology. 2015 Jun; 38(3):259-65. doi: 10.1097/coc.0b013e3182940ff9. [PMID: 23648440]
  • E Forestier, S Vinzio, R Sapin, J L Schlienger, B Goichot. Increased reverse triiodothyronine is associated with shorter survival in independently-living elderly: the Alsanut study. European journal of endocrinology. 2009 Feb; 160(2):207-14. doi: 10.1530/eje-08-0519. [PMID: 19001060]
  • Borislav D Dimitrov, Annalisa Perna, Piero Ruggenenti, Giuseppe Remuzzi. Predicting end-stage renal disease: Bayesian perspective of information transfer in the clinical decision-making process at the individual level. Kidney international. 2003 May; 63(5):1924-33. doi: 10.1046/j.1523-1755.2003.00923.x. [PMID: 12675873]
  • H Sekihara, Y Yazaki. 5 alpha-Dihydro-11-deoxycorticosterone as a mineralocorticoid agonist and antagonist: evidence for a weak mineralocorticoid as an antagonist of potent mineralocorticoids. The Journal of steroid biochemistry and molecular biology. 1993 Apr; 45(4):235-8. doi: 10.1016/0960-0760(93)90337-v. [PMID: 8499332]
  • J Carroll, P Komanicky, J C Melby. 5 alpha-Dihydro-11-deoxycorticosterone: effect on blood pressure in the rat. Steroids. 1981 Jan; 37(1):111-20. doi: 10.1016/0039-128x(81)90013-1. [PMID: 7222141]
  • G GRASSI, J RAIMONDI. [STEROID ANESTHESIA IN CESAREAN SECTION AND THE COLPOCYTOHORMONAL ASPECT OF THE NEWBORN]. Acta anaesthesiologica. 1963 Sep; 14(?):409-15. doi: NULL. [PMID: 14090311]
  • M PAPPALARDO, A RUGGERI. [Changes in various serum and tissue enzyme activities in relation to the administration of anesthetics. I. The G.O. and G.P. transminases after intravenous perfusion of Viadril]. Rivista di patologia e clinica. 1960 Dec; 15(?):918-24. doi: NULL. [PMID: 13732673]
  • M PAPPALARDO, A RUGGERI. [Changes in various serum and tissue enzyme activities in relation to the administration of anesthetics. II. Aldolase and lactic dehydrogenase after intravenous perfusion of Viadril]. Rivista di patologia e clinica. 1960 Dec; 15(?):969-75. doi: NULL. [PMID: 13732674]
  • F KUNZ, F REUBI. [The behavior of renal hemodynamics in hydroxydione anesthesia]. Der Anaesthesist. 1960 Jun; 9(?):197-201. doi: NULL. [PMID: 14412791]
  • R E PECK. Use of hydroxydione as a 'truth serum'. Journal of neuropsychiatry. 1960 Jan; 1(?):163-6. doi: NULL. [PMID: 14431291]
  • F GIARDINI, L D'ALESSANDRO. [Steroid narcosis and urinary excretion of aldosterone]. Archivio di medicina interna. 1959 Aug; 11(?):171-4. doi: NULL. [PMID: 13827870]
  • H LANGECKER, A RUPPRECHT. [The level of pregnane-21-ol-3,20-dione-hemisuccinate-sodium (hydroxydione) and its metabolites in maternal plasma and umbilical cord plasma in obstetrical hydroxydione anesthesia]. Arztliche Wochenschrift. 1959 Jul; 14(?):538-40. doi: NULL. [PMID: 14413909]
  • G F RUBINO, L PETTINATI, G MARTINA, G CERRATO. [The use of hydroxydione in therapy of several spastic syndromes of the soft musculature]. Minerva medica. 1959 Jan; 50(8):204-7. doi: NULL. [PMID: 13643831]
  • R CUOCOLO, R CONDURSO. [Kidney function in relation to viadril administration]. Minerva anestesiologica. 1958 Aug; 24(8):338-41. doi: NULL. [PMID: 13612826]
  • O YLINEN, S PESONEN. Studies on the excretion of urinary pregnanediol after steroid anesthesia (hydroxydione). Annales chirurgiae et gynaecologiae Fenniae. Supplementum. 1958; 47(81):287-96. doi: NULL. [PMID: 13606471]
  • W B JAKOBY, G TOMKINS. Enzymatic detoxification mechanism for viadril. Science (New York, N.Y.). 1956 May; 123(3204):940-1. doi: 10.1126/science.123.3204.940. [PMID: 13324120]