N-Desmethyl Olanzapine (BioDeep_00000054393)
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C16H18N4S (298.12521080000005)
中文名称: 2-甲基-4-(1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯并二氮杂卓, 去甲奥氮平
谱图信息:
最多检出来源 Homo sapiens(urine) 6.22%
Last reviewed on 2024-09-14.
Cite this Page
N-Desmethyl Olanzapine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/n-desmethyl_olanzapine (retrieved
2024-11-25) (BioDeep RN: BioDeep_00000054393). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CC1=CC2=C(NC3=CC=CC=C3N=C2N2CCNCC2)S1
InChI: InChI=1S/C16H18N4S/c1-11-10-12-15(20-8-6-17-7-9-20)18-13-4-2-3-5-14(13)19-16(12)21-11/h2-5,10,17,19H,6-9H2,1H3
描述信息
4-N-desmethylolanzapine is a metabolite of olanzapine. Olanzapine (trade name Zyprexa or in combination with fluoxetine Symbyax) is an atypical antipsychotic, approved by the FDA for the treatment of schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine, but is classified as a thienobenzodiazepine. The olanzapine formulations are manufactured and marketed by the pharmaceutical company Eli Lilly and Company; the drug went generic in 2011. Sales of Zyprexa in 2008 were $2.2B in the US alone, and $4.7B in total. (Wikipedia)
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:168745
- PubChem: 135446209
- HMDB: HMDB0060959
- ChEMBL: CHEMBL1125
- CAS: 161696-76-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Huimei An, Hongzhen Fan, Song Chen, Siyuan Qi, Botao Ma, Jing Shi, Zhiren Wang, Fude Yang. Effects of Dose, Age, Sex, Body Weight, and Smoking on Plasma Concentrations of Olanzapine and N-desmethyl Olanzapine in Inpatients With Schizophrenia.
Journal of clinical psychopharmacology.
2021 May; 41(3):255-259. doi:
10.1097/jcp.0000000000001390. [PMID: 33814547] - Mong-Liang Lu, Chun-Hsin Chen, Pei-Ting Kuo, Chia-Hui Lin, Tzu-Hua Wu. Application of plasma levels of olanzapine and N-desmethyl-olanzapine to monitor metabolic parameters in patients with schizophrenia.
Schizophrenia research.
2018 03; 193(?):139-145. doi:
10.1016/j.schres.2017.07.022. [PMID: 28720417] - Mong-Liang Lu, Yi-Xiu Wu, Chun-Hsin Chen, Pei-Ting Kuo, Yi-Hua Chen, Chia-Hui Lin, Tzu-Hua Wu. Application of Plasma Levels of Olanzapine and N-Desmethyl-Olanzapine to Monitor Clinical Efficacy in Patients with Schizophrenia.
PloS one.
2016; 11(2):e0148539. doi:
10.1371/journal.pone.0148539. [PMID: 26849777] - Hong-gang Lou, Zou-rong Ruan, Bo Jiang, Jin-liang Chen. Simultaneous quantification of olanzapine and its metabolite N-desmethylolanzapine in human plasma by liquid chromatography tandem mass spectrometry for therapeutic drug monitoring.
Biomedical chromatography : BMC.
2015 May; 29(5):671-8. doi:
10.1002/bmc.3329. [PMID: 25297964] - Mong-Liang Lu, Chia-Hui Lin, Yi-Chuan Chen, Huai-Chih Yang, Tzu-Hua Wu. Determination of olanzapine and N-desmethyl-olanzapine in plasma using a reversed-phase HPLC coupled with coulochemical detection: correlation of olanzapine or N-desmethyl-olanzapine concentration with metabolic parameters.
PloS one.
2013; 8(5):e65719. doi:
10.1371/journal.pone.0065719. [PMID: 23741510] - Tore Haslemo, Helge Refsum, Espen Molden. The effect of ethinylestradiol-containing contraceptives on the serum concentration of olanzapine and N-desmethyl olanzapine.
British journal of clinical pharmacology.
2011 Apr; 71(4):611-5. doi:
10.1111/j.1365-2125.2010.03880.x. [PMID: 21395655] - Martin Josefsson, Markus Roman, Elisabeth Skogh, Marja-Liisa Dahl. Liquid chromatography/tandem mass spectrometry method for determination of olanzapine and N-desmethylolanzapine in human serum and cerebrospinal fluid.
Journal of pharmaceutical and biomedical analysis.
2010 Nov; 53(3):576-82. doi:
10.1016/j.jpba.2010.03.040. [PMID: 20452161] - Frank M Theisen, Michael Haberhausen, Eberhard Schulz, Christian Fleischhaker, Hans-Willi Clement, Monika Heinzel-Gutenbrunner, Helmut Remschmidt. Serum levels of olanzapine and its N-desmethyl and 2-hydroxymethyl metabolites in child and adolescent psychiatric disorders: effects of dose, diagnosis, age, sex, smoking, and comedication.
Therapeutic drug monitoring.
2006 Dec; 28(6):750-9. doi:
10.1097/01.ftd.0000249950.75462.7f. [PMID: 17164690] - C Chin, Z P Zhang, H T Karnes. A study of matrix effects on an LC/MS/MS assay for olanzapine and desmethyl olanzapine.
Journal of pharmaceutical and biomedical analysis.
2004 Sep; 35(5):1149-67. doi:
10.1016/j.jpba.2004.01.005. [PMID: 15336361] - P Chandrani Gunaratna, Peter T Kissinger, Candice B Kissinger, James F Gitzen. An automated blood sampler for simultaneous sampling of systemic blood and brain microdialysates for drug absorption, distribution, metabolism, and elimination studies.
Journal of pharmacological and toxicological methods.
2004 Jan; 49(1):57-64. doi:
10.1016/s1056-8719(03)00058-3. [PMID: 14670694] - M A Raggi, G Casamenti, R Mandrioli, V Volterra. A sensitive high-performance liquid chromatographic method using electrochemical detection for the analysis of olanzapine and desmethylolanzapine in plasma of schizophrenic patients using a new solid-phase extraction procedure.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Jan; 750(1):137-46. doi:
10.1016/s0378-4347(00)00438-2. [PMID: 11204214]