2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid (BioDeep_00000054216)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


2,8-Bis(trifluoromethyl)-4-quinolinecarboxylic acid

化学式: C12H5F6NO2 (309.0224462)
中文名称: 羧甲基氟喹
谱图信息: 最多检出来源 Homo sapiens(blood) 0.69%

分子结构信息

SMILES: C1=CC2=C(C(=C1)C(F)(F)F)N=C(C=C2C(=O)O)C(F)(F)F
InChI: InChI=1S/C12H5F6NO2/c13-11(14,15)7-3-1-2-5-6(10(20)21)4-8(12(16,17)18)19-9(5)7/h1-4H,(H,20,21)

描述信息

2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid is a metabolite of mefloquine. Mefloquine hydrochloride (also known as Lariam or Mefaquin) is an orally administered medication used in the prevention and treatment of malaria. Mefloquine was developed in the 1970s at the United States Department of Defenses Walter Reed Army Institute of Research as a synthetic analogue of quinine. The brand name drug, Lariam, is manufactured by the Swiss company Hoffmann–La Roche. In August 2009, Roche stopped marketing Lariam in the United States. (Wikipedia)

同义名列表

9 个代谢物同义名

2,8-Bis(trifluoromethyl)-4-quinolinecarboxylic acid; 2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid; 2,8-bis(trifluoromethyl)quinoline-4-carboxylic acid; 2,8-BIS(TRIFLUROMETHYL)-4-QUINOLINCARBOXYLIC ACID; 2,8-Bis(trifluoromethyl)quinoline-4-carboxylate; 2,8-Bis-trifluoromethyl-4-quinoline carboxylate; Mefloquine carboxylic acid; Carboxymefloquine; 2,8-MMQ



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • José Luiz Fernandes Vieira, Juan Gonzalo Bardalez Rivera, Luann Wendel Pereira de Sena, Michelle Valeria Dias Ferreira. Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria. Antimicrobial agents and chemotherapy. 2020 02; 64(3):. doi: 10.1128/aac.01731-19. [PMID: 31844010]
  • Michael Ramharter, Matthias Schwab, Ghyslain Mombo-Ngoma, Rella Zoleko Manego, Daisy Akerey-Diop, Arti Basra, Jean-Rodolphe Mackanga, Heike Würbel, Jan-Georg Wojtyniak, Raquel Gonzalez, Ute Hofmann, Mirjam Geditz, Pierre-Blaise Matsiegui, Peter G Kremsner, Clara Menendez, Reinhold Kerb, Thorsten Lehr. Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon. Antimicrobial agents and chemotherapy. 2019 02; 63(2):. doi: 10.1128/aac.01113-18. [PMID: 30455233]
  • Igor Rafael dos Santos Magalhães, Pierina Sueli Bonato. Two-step liquid-phase microextraction and high-performance liquid chromatography for the simultaneous analysis of the enantiomers of mefloquine and its main metabolite carboxymefloquine in plasma. Analytical and bioanalytical chemistry. 2009 Mar; 393(6-7):1805-13. doi: 10.1007/s00216-009-2620-4. [PMID: 19184594]
  • C A Crevoisier, I Joseph, M Fischer, H Graf. Influence of hemodialysis on plasma concentration-time profiles of mefloquine in two patients with end-stage renal disease: a prophylactic drug monitoring study. Antimicrobial agents and chemotherapy. 1995 Aug; 39(8):1892-5. doi: 10.1128/aac.39.8.1892. [PMID: 7486943]
  • U Hellgren, C M Kihamia, Y Bergqvist, L Rombo. Standard and reduced doses of mefloquine for treatment of Plasmodium falciparum in Tanzania: whole blood concentrations in relation to adverse reactions, in vivo response, and in vitro susceptibility. The American journal of tropical medicine and hygiene. 1991 Aug; 45(2):254-62. doi: 10.4269/ajtmh.1991.45.254. [PMID: 1877721]
  • Y Bergqvist, U Hellgren, F C Churchill. High-performance liquid chromatographic assay for the simultaneous monitoring of mefloquine and its acid metabolite in biological samples using protein precipitation and ion-pair extraction. Journal of chromatography. 1988 Nov; 432(?):253-63. doi: 10.1016/s0378-4347(00)80650-7. [PMID: 3265419]