Acrylonitrile (BioDeep_00000004817)

 

Secondary id: BioDeep_00001867715

human metabolite blood metabolite


代谢物信息卡片


Acrylonitrile; Propenenitrile; Vinyl cyanide

化学式: C3H3N (53.026547799999996)
中文名称: 丙烯腈
谱图信息: 最多检出来源 Homo sapiens(blood) 1.01%

分子结构信息

SMILES: C=CC#N
InChI: InChI=1S/C3H3N/c1-2-3-4/h2H,1H2

描述信息

D009676 - Noxae > D002273 - Carcinogens

同义名列表

11 个代谢物同义名

Acrylonitrile; Propenenitrile; Vinyl cyanide; Nitrile acrylique; prop-2-enenitrile; Cyanure de vinyle; Acrylsaeurenitril; 2-Propenenitrile; Propenenitrile; Cyanide, vinyl; Vinyl cyanide; Acrylonitrile; Acrylnitril



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

13 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(13)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhen Zhang, Jun Zhang, Lucian A Lucia, Noureddine Abidi. Bamboo fiber reinforced poly (acrylonitrile-styrene-acrylic)/chlorinated polyethylene via compabilization. International journal of biological macromolecules. 2024 May; 266(Pt 2):131287. doi: 10.1016/j.ijbiomac.2024.131287. [PMID: 38565367]
  • Gary M Marsh, Adam Kruchten. A reevaluation of selected mortality risks in the updated NCI/NIOSH acrylonitrile cohort study. Frontiers in public health. 2023; 11(?):1122346. doi: 10.3389/fpubh.2023.1122346. [PMID: 37089484]
  • Vahid Ahmadi-Moshiran, Ali Asghar Sajedian, Ahmad Soltanzadeh, Fatemeh Seifi, Rozhin Koobasi, Neda Nikbakht, Mohsen Sadeghi-Yarandi. Carcinogenic and health risk assessment of respiratory exposure to acrylonitrile, 1,3-butadiene and styrene in the petrochemical industry using the US Environmental Protection Agency method. International journal of occupational safety and ergonomics : JOSE. 2022 Dec; 28(4):i-ix. doi: 10.1080/10803548.2022.2059171. [PMID: 35363589]
  • Xiaoming Zhu, Lu Feng, Shixian Cao, Jianguo Wang, Guangle Niu. Donor-Acceptor-Acceptor-Conjugated Dual-State Emissive Acrylonitriles: Investigating the Effect of Acceptor Unit Order and Biological Imaging. Organic letters. 2022 11; 24(45):8305-8309. doi: 10.1021/acs.orglett.2c03274. [PMID: 36351250]
  • Sungshim L Park, Loic Le Marchand, Guang Cheng, Silvia Balbo, Menglan Chen, Steven G Carmella, Nicole M Thomson, Younghan Lee, Yesha M Patel, Daniel O Stram, Joni Jensen, Dorothy K Hatsukami, Sharon E Murphy, Stephen S Hecht. Quantitation of DNA Adducts Resulting from Acrolein Exposure and Lipid Peroxidation in Oral Cells of Cigarette Smokers from Three Racial/Ethnic Groups with Differing Risks for Lung Cancer. Chemical research in toxicology. 2022 10; 35(10):1914-1922. doi: 10.1021/acs.chemrestox.2c00171. [PMID: 35998368]
  • Ameer Ali Kubar, Nana Jin, Yi Cui, Xinjuan Hu, Jingya Qian, Xinyi Zan, Cunsheng Zhang, Feifei Zhu, Santosh Kumar, Shuhao Huo. Magnetic/electric field intervention on oil-rich filamentous algae production in the application of acrylonitrile butadiene styrene based wastewater treatment. Bioresource technology. 2022 Jul; 356(?):127272. doi: 10.1016/j.biortech.2022.127272. [PMID: 35526707]
  • Carlos J Bethencourt-Estrella, Samuel Delgado-Hernández, Atteneri López-Arencibia, Desirée San Nicolás-Hernández, David Tejedor, Fernando García-Tellado, Jacob Lorenzo-Morales, José E Piñero. In vitro activity and cell death mechanism induced by acrylonitrile derivatives against Leishmania amazonensis. Bioorganic chemistry. 2022 07; 124(?):105872. doi: 10.1016/j.bioorg.2022.105872. [PMID: 35597192]
  • Christine Njiru, Corinna Saalwaechter, Oliver Gutbrod, Sven Geibel, Nicky Wybouw, Thomas Van Leeuwen. A H258Y mutation in subunit B of the succinate dehydrogenase complex of the spider mite Tetranychus urticae confers resistance to cyenopyrafen and pyflubumide, but likely reinforces cyflumetofen binding and toxicity. Insect biochemistry and molecular biology. 2022 05; 144(?):103761. doi: 10.1016/j.ibmb.2022.103761. [PMID: 35341907]
  • Markus Rimann, Astrid Jüngel, Sara Mousavi, Nicole Moeschlin, Maurizio Calcagni, Karin Wuertz-Kozak, Florian Brunner, Stefan Dudli, Oliver Distler, Christian Adlhart. Acrylonitrile and Pullulan Based Nanofiber Mats as Easily Accessible Scaffolds for 3D Skin Cell Models Containing Primary Cells. Cells. 2022 01; 11(3):. doi: 10.3390/cells11030445. [PMID: 35159255]
  • Banrida Wahlang, Tyler C Gripshover, Hong Gao, Tatiana Krivokhizhina, Rachel J Keith, Israel D Sithu, Shesh N Rai, Aruni Bhatnagar, Craig J McClain, Sanjay Srivastava, Mathew C Cave. Associations Between Residential Exposure to Volatile Organic Compounds and Liver Injury Markers. Toxicological sciences : an official journal of the Society of Toxicology. 2021 12; 185(1):50-63. doi: 10.1093/toxsci/kfab119. [PMID: 34668566]
  • Shannon Kindilien, Elle Goldberg. Household tobacco smoke exposure and acrylonitrile metabolite levels in a US pediatric sample. Environmental toxicology and pharmacology. 2021 May; 84(?):103616. doi: 10.1016/j.etap.2021.103616. [PMID: 33609751]
  • Víctor R De Jesús, Luyu Zhang, Deepak Bhandari, Wanzhe Zhu, Joanne T Chang, Benjamin C Blount. Characterization of acrylonitrile exposure in the United States based on urinary n-acetyl-S-(2-cyanoethyl)-L-cysteine (2CYEMA): NHANES 2011-2016. Journal of exposure science & environmental epidemiology. 2021 03; 31(2):377-385. doi: 10.1038/s41370-020-00286-1. [PMID: 33424026]
  • Heike Sigloch, Frank S Bierkandt, Ajay V Singh, Ashish K Gadicherla, Peter Laux, Andreas Luch. 3D Printing - Evaluating Particle Emissions of a 3D Printing Pen. Journal of visualized experiments : JoVE. 2020 10; ?(164):. doi: 10.3791/61829. [PMID: 33104072]
  • Xianghua Luo, Steven G Carmella, Menglan Chen, Joni A Jensen, Lynne R Wilkens, Loic Le Marchand, Dorothy K Hatsukami, Sharon E Murphy, Stephen S Hecht. Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2020 10; 22(10):1744-1747. doi: 10.1093/ntr/ntaa080. [PMID: 32391548]
  • David L Ashley, Víctor R De Jesús, Osama A Abulseoud, Marilyn A Huestis, Daniel F Milan, Benjamin C Blount. Urinary Acrylonitrile Metabolite Concentrations Before and after Smoked, Vaporized, and Oral Cannabis in Frequent and Occasional Cannabis Users. International journal of environmental research and public health. 2020 09; 17(18):. doi: 10.3390/ijerph17186438. [PMID: 32899602]
  • Pramod P Kattimani, Shilpa M Somagond, Praveen K Bayannavar, Ravindra R Kamble, Subhas C Bijjaragi, Raveendra K Hunnur, Shrinivas D Joshi. Novel 5-(1-aryl-1H-pyrazol-3-yl)-1H-tetrazoles as glycogen phosphorylase inhibitors: An in vivo antihyperglycemic activity study. Drug development research. 2020 02; 81(1):70-84. doi: 10.1002/ddr.21606. [PMID: 31696542]
  • Longyi Zhu, Yang Li, Lei Zhang, Yunjie Wen, Huangxian Ju, Jianping Lei. Controlled assembly of AIEgens based on a super-quadruplex scaffold for detection of plasma membrane proteins. Analytica chimica acta. 2020 Jan; 1094(?):130-135. doi: 10.1016/j.aca.2019.10.010. [PMID: 31761039]
  • Ebrahim Moradi, Homeira Ebrahimzadeh, Zahra Mehrani. Electrospun acrylonitrile butadiene styrene nanofiber film as an efficient nanosorbent for head space thin film microextraction of polycyclic aromatic hydrocarbons from water and urine samples. Talanta. 2019 Dec; 205(?):120080. doi: 10.1016/j.talanta.2019.06.080. [PMID: 31450445]
  • Angel L M de Francisco, Manuel Macía, Fabiola Alonso, Patricia García, Eduardo Gutierrez, Luis Fernando Quintana, Borja Quiroga, Isidro Torregrosa. Onco-Nephrology: Cancer, chemotherapy and kidney. Nefrologia. 2019 Sep; 39(5):473-481. doi: 10.1016/j.nefro.2018.10.016. [PMID: 30929891]
  • Yingshuang Zhang, Shuaijun Chen, Hui Wang, Maozhi Luo. Separation of polyvinylchloride and acrylonitrile-butadiene-styrene combining advanced oxidation by S2O82-/Fe2+ system and flotation. Waste management (New York, N.Y.). 2019 May; 91(?):80-88. doi: 10.1016/j.wasman.2019.04.048. [PMID: 31203945]
  • Charles Pudrith, William N Dudley. Sensorineural hearing loss and volatile organic compound metabolites in urine. American journal of otolaryngology. 2019 May; 40(3):409-412. doi: 10.1016/j.amjoto.2019.03.001. [PMID: 30871731]
  • Jin-Cui Chen, Ya-Jun Gong, Pan Shi, Ze-Hua Wang, Li-Jun Cao, Peng Wang, Shu-Jun Wei. Field-evolved resistance and cross-resistance of the two-spotted spider mite, Tetranychus urticae, to bifenazate, cyenopyrafen and SYP-9625. Experimental & applied acarology. 2019 Apr; 77(4):545-554. doi: 10.1007/s10493-019-00359-3. [PMID: 30997606]
  • Cheng Shang See, Mayumi Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine Wong, Sang Hyun Lee, Brian W Dymock. Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer. Bioorganic & medicinal chemistry letters. 2019 01; 29(2):216-219. doi: 10.1016/j.bmcl.2018.11.053. [PMID: 30503634]
  • Menglan Chen, Steven G Carmella, Chistopher Sipe, Joni Jensen, Xianghua Luo, Chap T Le, Sharon E Murphy, Neal L Benowitz, F Joseph McClernon, Ryan Vandrey, Sharon S Allen, Rachel Denlinger-Apte, Paul M Cinciripini, Andrew A Strasser, Mustafa al'Absi, Jason D Robinson, Eric C Donny, Dorothy Hatsukami, Stephen S Hecht. Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein. PloS one. 2019; 14(1):e0210104. doi: 10.1371/journal.pone.0210104. [PMID: 30608961]
  • Mehtab Parveen, Afroz Aslam, Shahab A A Nami, Musheer Ahmad. Z-Acrylonitrile Derivatives: Improved Synthesis, X-ray Structure, and Interaction with Human Serum Albumin. Current organic synthesis. 2019; 16(8):1149-1160. doi: 10.2174/1570179416666191008085806. [PMID: 31984921]
  • Ebenezer Olatunde Farombi, Amos Olalekan Abolaji, Babatunde Oluwafemi Adetuyi, Olaide Awosanya, Mobolaji Fabusoro. Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats. Journal of basic and clinical physiology and pharmacology. 2018 Dec; 30(3):. doi: 10.1515/jbcpp-2018-0114. [PMID: 30864424]
  • Pengfei Lin, Jingjing Miao, Luqing Pan, Lei Zheng, Xiufen Wang, Yufei Lin, Jiangyue Wu. Acute and chronic toxicity effects of acrylonitrile to the juvenile marine flounder Paralichthys olivaceus. Environmental science and pollution research international. 2018 Dec; 25(35):35301-35311. doi: 10.1007/s11356-018-3430-z. [PMID: 30341758]
  • Lei Zheng, Luqing Pan, Jingjing Miao, Yufei Lin, Jiangyue Wu. Application of a series of biomarkers in Scallop Chlamys farreri to assess the toxic effects after exposure to a priority hazardous and noxious substance (HNS)-Acrylonitrile. Environmental toxicology and pharmacology. 2018 Dec; 64(?):122-130. doi: 10.1016/j.etap.2018.10.002. [PMID: 30342373]
  • Yuhui Dang, Zhilan Li, Qian Wei, Ruiping Zhang, Hongli Xue, Yingmei Zhang. Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats. Inflammation. 2018 Aug; 41(4):1448-1459. doi: 10.1007/s10753-018-0791-x. [PMID: 29687413]
  • Chien-Yu Lin, Hui-Ling Lee, Fung-Chang Sung, Ta-Chen Su. Investigating the association between urinary levels of acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine and the oxidative stress product 8-hydroxydeoxyguanosine in adolescents and young adults. Environmental pollution (Barking, Essex : 1987). 2018 Aug; 239(?):493-498. doi: 10.1016/j.envpol.2018.04.010. [PMID: 29684876]
  • Mayumi Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine Wong, See Cheng Shang, Noriaki Minami, Oltea Sampetrean, Hideyuki Saya, Dai Lingyun, Nayana Prabhu, Go Ka Diam, Radoslaw Sobota, Andreas Larsson, Pär Nordlund, Frank McCormick, Sujoy Ghosh, David M Epstein, Brian W Dymock, Sang Hyun Lee. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nature communications. 2017 12; 8(1):2200. doi: 10.1038/s41467-017-02287-5. [PMID: 29259156]
  • Kevin De Bruycker, Maarten Delahaye, Pieter Cools, Johan Winne, Filip E Du Prez. Covalent Fluorination Strategies for the Surface Modification of Polydienes. Macromolecular rapid communications. 2017 Jun; 38(11):. doi: 10.1002/marc.201700122. [PMID: 28394488]
  • Carlo Donadio, Danika Tognotti, Laura Caponi, Aldo Paolicchi. β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes. BMC nephrology. 2017 02; 18(1):68. doi: 10.1186/s12882-017-0489-6. [PMID: 28219328]
  • Masafumi Yamato, Yusuke Minematsu, Yuta Ikemiya, Junichi Shibata, Junya Fujii, Takumi Minato, Sachie Miyagawa, Kaori Takaori, Yoko Tomiyama, Ikue Nagayama, Akira Wada, Takahito Ito, Hirotsugu Iwatani. Continuous Hemodiafiltration with an AN69ST Hemofilter (AN69ST-CHDF) as FGF-23-Lowering Therapy. Clinical laboratory. 2016 Dec; 62(12):2349-2354. doi: 10.7754/clin.lab.2016.160423. [PMID: 28164555]
  • Amit Bhatt, Mansour A Parsi, Tyler Stevens, Scott Gabbard, Arthi Kumaravel, Sunguk Jang, David Grove, Rocio Lopez, Sudish Murthy, John J Vargo, Raed Dweik. Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: a pilot study. Gastrointestinal endoscopy. 2016 Oct; 84(4):597-603. doi: 10.1016/j.gie.2015.11.031. [PMID: 26646671]
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  • Chunhong Na, Ying Zhang, Minjie Deng, Xie Quan, Shuo Chen, Yaobin Zhang. Evaluation of the detoxication efficiencies for acrylonitrile wastewater treated by a combined anaerobic oxic-aerobic biological fluidized tank (A/O-ABFT) process: Acute toxicity and zebrafish embryo toxicity. Chemosphere. 2016 Jul; 154(?):1-7. doi: 10.1016/j.chemosphere.2016.03.037. [PMID: 27037768]
  • K Simons, T De Smedt, C Stove, P De Paepe, M Bader, B Nemery, C Vleminckx, K De Cremer, I Van Overmeire, S Fierens, B Mertens, T Göen, T Schettgen, H Van Oyen, J Van Loco, A Van Nieuwenhuyse. Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium. Environmental research. 2016 07; 148(?):256-263. doi: 10.1016/j.envres.2016.03.031. [PMID: 27085497]
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  • T S Ulanova, T Nurislamova, N A Popova, O A Maltseva. [Evaluation of contamination levels of serum and expired air of mechanical rubber production workers exposed to acrylonitrile at work]. Meditsina truda i promyshlennaia ekologiia. 2016 ; ?(8):37-42. doi: NULL. [PMID: 30351755]
  • Bai Yu, Yin Changsheng, Zhao Wenjun, Li Ben, Qian Hai, Ma Jing, Xing Guangwei, Wang Shuhua, Li Fang, Michael Aschner, Lu Rongzhu. Differential protection of pre- versus post-treatment with curcumin, Trolox, and N-acetylcysteine against acrylonitrile-induced cytotoxicity in primary rat astrocytes. Neurotoxicology. 2015 Dec; 51(?):58-66. doi: 10.1016/j.neuro.2015.09.011. [PMID: 26409646]
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  • T De Smedt, K De Cremer, C Vleminckx, S Fierens, B Mertens, I Van Overmeire, M Bader, P De Paepe, T Göen, B Nemery, T Schettgen, C Stove, H Van Oyen, J Van Loco, A Van Nieuwenhuyse. Acrylonitrile exposure in the general population following a major train accident in Belgium: a human biomonitoring study. Toxicology letters. 2014 Dec; 231(3):344-51. doi: 10.1016/j.toxlet.2014.09.009. [PMID: 25223249]
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