noroxymorphone (BioDeep_00000464868)
代谢物信息卡片
Nor Oxymorphone
化学式: C16H17NO4 (287.11575220000003)
中文名称: 14-羟基二氢降吗啡酮盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2(C3CC4=C5C2(CCN3)C(C1=O)OC5=C(C=C4)O)O
InChI: InChI=1S/C16H17NO4/c18-9-2-1-8-7-11-16(20)4-3-10(19)14-15(16,5-6-17-11)12(8)13(9)21-14/h1-2,11,14,17-18,20H,3-7H2/t11-,14+,15+,16-/m1/s1
描述信息
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cornel N Stanciu, Samantha Gnanasegaram. Naltrexone and Its Noroxymorphone Minor Metabolite - A Case Report.
Journal of psychoactive drugs.
2020 Apr; 52(2):169-171. doi:
10.1080/02791072.2019.1649507. [PMID: 31366308] - John R Cashman, Mark Gohdes, Annelies de Kater, Grant Schoenhard. N-Oxygenation of Oxycodone and Retro-reduction of Oxycodone N-Oxide.
Drug metabolism and disposition: the biological fate of chemicals.
2020 02; 48(2):106-115. doi:
10.1124/dmd.119.089300. [PMID: 31727673] - Anne Leuppi-Taegtmeyer, Urs Duthaler, Felix Hammann, Yasmin Schmid, Michael Dickenmann, Patricia Amico, Andreas W Jehle, Stefan Kalbermatter, Christoph Lenherr, Henriette E Meyer Zu Schwabedissen, Manuel Haschke, Matthias E Liechti, Stephan Krähenbühl. Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2019 04; 34(4):692-702. doi:
10.1093/ndt/gfy285. [PMID: 30189012] - Boaz Gedaliahu Samolsky Dekel, Gabriele Donati, Alessio Vasarri, Anna Laura Croci Chiocchini, Alberto Gori, Giuseppe Cavallari, Gianfranco Di Nino, Laura Mercolini, Michele Protti, Roberto Mandrioli, Rita Maria Melotti, Gaetano La Manna. Dialyzability of Oxycodone and Its Metabolites in Chronic Noncancer Pain Patients with End-Stage Renal Disease.
Pain practice : the official journal of World Institute of Pain.
2017 06; 17(5):604-615. doi:
10.1111/papr.12483. [PMID: 27589376] - Merja Kokki, Marja Heikkinen, Pyry Välitalo, Heidi Hautajärvi, Juho Hokkanen, Hanna Pitkänen, Ulla Sankilampi, Veli-Pekka Ranta, Hannu Kokki. Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine.
British journal of clinical pharmacology.
2017 04; 83(4):791-800. doi:
10.1111/bcp.13164. [PMID: 27780305] - Anne Z DePriest, Rebecca Heltsley, David L Black, John M Mitchell, Charles LoDico, Ronald Flegel, Edward J Cone. Prescription Opioids. V. Metabolism and Excretion of Oxymorphone in Urine Following Controlled Single Dose Administration.
Journal of analytical toxicology.
2016 Oct; 40(8):566-574. doi:
10.1093/jat/bkw064. [PMID: 27405370] - Guang-Tao Hao, Hai-Yan Zhou, Hong-Zhi Gao, Heng-Yan Qu, Yu-Guang Liang, Yuan-Yuan Li, Rui-Hua Dong, Li-Juan Zhang, Xiao-Fang Wang, Ze-Yuan Liu. Pharmacokinetics of oxycodone hydrochloride and three of its metabolites after intravenous administration in Chinese patients with pain.
Pharmacological reports : PR.
2014 Feb; 66(1):153-8. doi:
10.1016/j.pharep.2013.08.012. [PMID: 24905321] - Edward J Cone, Rebecca Heltsley, David L Black, John M Mitchell, Charles P Lodico, Ronald R Flegel. Prescription opioids. I. Metabolism and excretion patterns of oxycodone in urine following controlled single dose administration.
Journal of analytical toxicology.
2013 Jun; 37(5):255-64. doi:
10.1093/jat/bkt031. [PMID: 23609023] - Ulrike M Stamer, Lan Zhang, Malte Book, Lutz E Lehmann, Frank Stuber, Frank Musshoff. CYP2D6 genotype dependent oxycodone metabolism in postoperative patients.
PloS one.
2013; 8(3):e60239. doi:
10.1371/journal.pone.0060239. [PMID: 23555934] - Trine Naalsund Andreassen, Ingrid Eftedal, Pål Klepstad, Andrew Davies, Kristin Bjordal, Staffan Lundström, Stein Kaasa, Ola Dale. Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study.
European journal of clinical pharmacology.
2012 Jan; 68(1):55-64. doi:
10.1007/s00228-011-1093-5. [PMID: 21735164] - Antti Liukas, Kristiina Kuusniemi, Riku Aantaa, Petri Virolainen, Mikko Neuvonen, Pertti J Neuvonen, Klaus T Olkkola. Elimination of intravenous oxycodone in the elderly: a pharmacokinetic study in postoperative orthopaedic patients of different age groups.
Drugs & aging.
2011 Jan; 28(1):41-50. doi:
10.2165/11586140-000000000-00000. [PMID: 21174486] - M Wagner, E Bourgogne, E Varesio, G Hopfgartner. Quantitation of polar analytes using column-switching: application to oxycodone and three metabolites in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Mar; 878(7-8):637-44. doi:
10.1016/j.jchromb.2010.01.014. [PMID: 20138595] - Wenfang B Fang, Yan Chang, Elinore F McCance-Katz, David E Moody. Determination of naloxone and nornaloxone (noroxymorphone) by high-performance liquid chromatography-electrospray ionization- tandem mass spectrometry.
Journal of analytical toxicology.
2009 Oct; 33(8):409-17. doi:
10.1093/jat/33.8.409. [PMID: 19874646] - Mikko Neuvonen, Pertti J Neuvonen. Determination of oxycodone, noroxycodone, oxymorphone, and noroxymorphone in human plasma by liquid chromatography-electrospray-tandem mass spectrometry.
Therapeutic drug monitoring.
2008 Jun; 30(3):333-40. doi:
10.1097/ftd.0b013e31816e2d4b. [PMID: 18520605]