Dihydrolipoamide (BioDeep_00000004451)

 

Secondary id: BioDeep_00000630722

human metabolite Endogenous


代谢物信息卡片


Dihydrolipoamide, (+-)-isomer

化学式: C8H17NOS2 (207.0751512)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 0.28%

分子结构信息

SMILES: C(CCC(=O)N)CC(CCS)S
InChI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10)

描述信息

Dihydrolipoamide is an intermediate in glycolysis/gluconeogenesis, citrate cycle (TCA cycle), alanine, aspartate and pyruvate metabolism, and valine, leucine and isoleucine degradation (KEGG ID C00579). It is converted to lipoamide via the enzyme dihydrolipoamide dehydrogenase [EC:1.8.1.4]. Dihydrolipoamide is also a substrate of enzyme Acyltransferases [EC 2.3.1.-]. (KEGG) [HMDB]. Dihydrolipoamide is found in many foods, some of which are enokitake, mugwort, welsh onion, and tea.
Dihydrolipoamide is an intermediate in glycolysis/gluconeogenesis, citrate cycle (TCA cycle), alanine, aspartate and pyruvate metabolism, and valine, leucine and isoleucine degradation (KEGG ID C00579). It is converted to lipoamide via the enzyme dihydrolipoamide dehydrogenase [EC:1.8.1.4]. Dihydrolipoamide is also a substrate of enzyme Acyltransferases [EC 2.3.1.-]. (KEGG).

同义名列表

7 个代谢物同义名

Dihydrolipoamide, (+-)-isomer; 6,8-Bis-sulfanyloctanamide; 6,8-Dimercapto-octanamide; 6,8-Dimercaptooctanamide; 6,8-Disulfanyloctanamide; Dihydrothioctamide; dihydrolipoamide



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

79 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(5)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(74)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fagen Li, Ke Cao, Maoyun Wang, Yi Liu, Yin Zhang. Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway. Bioengineered. 2022 04; 13(4):10111-10122. doi: 10.1080/21655979.2022.2063664. [PMID: 35435117]
  • Teresia Hallström, Matthias Mörgelin, Diana Barthel, Marina Raguse, Anja Kunert, Ralf Hoffmann, Christine Skerka, Peter F Zipfel. Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen. Journal of immunology (Baltimore, Md. : 1950). 2012 Nov; 189(10):4939-50. doi: 10.4049/jimmunol.1200386. [PMID: 23071278]
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  • Shamima Akhtar Sharmin, Iftekhar Alam, Kyung-Hee Kim, Yong-Goo Kim, Pil Joo Kim, Jeong Dong Bahk, Byung-Hyun Lee. Chromium-induced physiological and proteomic alterations in roots of Miscanthus sinensis. Plant science : an international journal of experimental plant biology. 2012 May; 187(?):113-26. doi: 10.1016/j.plantsci.2012.02.002. [PMID: 22404839]
  • Myung Hee Nam, Sun Mi Huh, Kyung Mi Kim, Woong June Park, Jong Bok Seo, Kun Cho, Dool Yi Kim, Beom Gi Kim, In Sun Yoon. Comparative proteomic analysis of early salt stress-responsive proteins in roots of SnRK2 transgenic rice. Proteome science. 2012 Mar; 10(?):25. doi: 10.1186/1477-5956-10-25. [PMID: 22462395]
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  • Alessandra Folda, Anna Citta, Guido Scutari, Alberto Bindoli, Maria Pia Rigobello. Contrasting effects of selenite and tellurite on lipoamide dehydrogenase activity suggest a different biological behaviour of the two chalcogens. Archives of biochemistry and biophysics. 2012 Jan; 517(1):30-6. doi: 10.1016/j.abb.2011.11.009. [PMID: 22100759]
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  • Marcelo L Laia, Leandro M Moreira, Juliana Dezajacomo, Joice B Brigati, Cristiano B Ferreira, Maria I T Ferro, Ana C R Silva, Jesus A Ferro, Julio C F Oliveira. New genes of Xanthomonas citri subsp. citri involved in pathogenesis and adaptation revealed by a transposon-based mutant library. BMC microbiology. 2009 Jan; 9(?):12. doi: 10.1186/1471-2180-9-12. [PMID: 19149882]
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