β-Naphthoflavone (BioDeep_00000412768)

Main id: BioDeep_00000176640

 

natural product


代谢物信息卡片


beta-naphthoflavone

化学式: C19H12O2 (272.0837252)
中文名称: β-萘黄酮
谱图信息: 最多检出来源 Helianthus annuus(natural_products) 50%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC4=CC=CC=C43
InChI: InChI=1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H

描述信息

C1892 - Chemopreventive Agent > C54629 - Phase I Enzymes Inhibitor
C1892 - Chemopreventive Agent > C54630 - Phase II Enzymes Inducer
D004791 - Enzyme Inhibitors > D001571 - Benzoflavones
CONFIDENCE standard compound; INTERNAL_ID 1179; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10249; ORIGINAL_PRECURSOR_SCAN_NO 10247
CONFIDENCE standard compound; INTERNAL_ID 1179; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10266; ORIGINAL_PRECURSOR_SCAN_NO 10265
CONFIDENCE standard compound; INTERNAL_ID 1179; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10292; ORIGINAL_PRECURSOR_SCAN_NO 10291
CONFIDENCE standard compound; INTERNAL_ID 1179; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10225; ORIGINAL_PRECURSOR_SCAN_NO 10224
CONFIDENCE standard compound; INTERNAL_ID 1179; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10335; ORIGINAL_PRECURSOR_SCAN_NO 10334
CONFIDENCE standard compound; INTERNAL_ID 1179; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10310; ORIGINAL_PRECURSOR_SCAN_NO 10308

同义名列表

3 个代谢物同义名

beta-naphthoflavone; β-Naphthoflavone; 5,6-Benzoflavone



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Carolin Riegraf, Georg Reifferscheid, Liat Moscovici, Dror Shakibai, Henner Hollert, Shimshon Belkin, Sebastian Buchinger. Coupling high-performance thin-layer chromatography with a battery of cell-based assays reveals bioactive components in wastewater and landfill leachates. Ecotoxicology and environmental safety. 2021 May; 214(?):112092. doi: 10.1016/j.ecoenv.2021.112092. [PMID: 33690008]
  • Man Zhang, Heng Fan, Songwei Tan, Qing Tang, Xingxing Liu, Dongmei Zuo, Yi Liao, Zhen Nan, Chen Tan. The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation. Journal of ethnopharmacology. 2020 Apr; 251(?):112549. doi: 10.1016/j.jep.2020.112549. [PMID: 31918016]
  • Christopher R Manzella, Max Ackerman, Megha Singhal, Alexander L Ticho, Justin Ceh, Waddah A Alrefai, Seema Saksena, Pradeep K Dudeja, Ravinder K Gill. Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2020 Feb; 54(1):126-141. doi: 10.33594/000000209. [PMID: 32017483]
  • Carolin Riegraf, Georg Reifferscheid, Shimshon Belkin, Liat Moscovici, Dror Shakibai, Henner Hollert, Sebastian Buchinger. Combination of yeast-based in vitro screens with high-performance thin-layer chromatography as a novel tool for the detection of hormonal and dioxin-like compounds. Analytica chimica acta. 2019 Nov; 1081(?):218-230. doi: 10.1016/j.aca.2019.07.018. [PMID: 31446961]
  • Anne Mahringer, Alexandra Bernd, David S Miller, Gert Fricker. Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules. Biological chemistry. 2019 09; 400(10):1335-1345. doi: 10.1515/hsz-2018-0425. [PMID: 30913027]
  • Gulsum E Muku, Nicholas Blazanin, Fangcong Dong, Philip B Smith, Diane Thiboutot, Krishne Gowda, Shantu Amin, Iain A Murray, Gary H Perdew. Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Jun; ?(?):. doi: 10.1093/toxsci/kfz140. [PMID: 31225620]
  • Shalini Behl, Abdu Adem, Arif Hussain, Jaipaul Singh. Effects of rilpivirine, 17β-estradiol and β-naphthoflavone on the inflammatory status of release of adipocytokines in 3T3-L1 adipocytes in vitro. Molecular biology reports. 2019 Jun; 46(3):2643-2655. doi: 10.1007/s11033-019-04671-4. [PMID: 30927158]
  • Takumi Ishida, Shinji Takechi. β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. The Journal of toxicological sciences. 2019; 44(10):711-720. doi: 10.2131/jts.44.711. [PMID: 31588062]
  • Rami El Dairi, Pasi Huuskonen, Markku Pasanen, Jaana Rysä. Peroxisome proliferator activated receptor gamma (PPAR-γ) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reproductive toxicology (Elmsford, N.Y.). 2018 10; 81(?):99-107. doi: 10.1016/j.reprotox.2018.07.077. [PMID: 30031879]
  • Kerry R Belton, Yuan Tian, Limin Zhang, Mallappa Anitha, Philip B Smith, Gary H Perdew, Andrew D Patterson. Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice. Journal of proteome research. 2018 04; 17(4):1375-1382. doi: 10.1021/acs.jproteome.7b00709. [PMID: 29521512]
  • Roger Stacke Ferreira, Cíntia da Cruz Chivittz, Guilherme Senna Dos Santos, Juliano Zanette. Cytochrome P450 1A mRNA in the guppy Phalloceros caudimaculatus and response to beta-naphthoflavone and environmental samples. Aquatic toxicology (Amsterdam, Netherlands). 2016 Dec; 181(?):86-93. doi: 10.1016/j.aquatox.2016.10.023. [PMID: 27821351]
  • Kuo-Liang Wei, Fei-Yun Chen, Chih-Yi Lin, Guan-Lun Gao, Wen-Ya Kao, Chi-Hui Yeh, Chang-Rong Chen, Hao-Chun Huang, Wei-Ren Tsai, Koa-Jen Jong, Wan-Jung Li, Jyan-Gwo Joseph Su. Activation of aryl hydrocarbon receptor reduces carbendazim-induced cell death. Toxicology and applied pharmacology. 2016 09; 306(?):86-97. doi: 10.1016/j.taap.2016.06.004. [PMID: 27286660]
  • Elisabeth Holen, Pål A Olsvik. β-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B4 secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammation. Fish & shellfish immunology. 2016 Jul; 54(?):128-34. doi: 10.1016/j.fsi.2016.03.043. [PMID: 27041667]
  • Yinsong Zhu, Jiong Hu, Wenjuan He, Xiujuan Gao, Ping Ren, Hui Chen. DDPH, a novel antihypertensive agent, is a potential dual inhibitor of hepatic CYP2D and CYP3A. Chemico-biological interactions. 2016 Mar; 247(?):55-63. doi: 10.1016/j.cbi.2016.01.019. [PMID: 26827781]
  • Latiporn Udomsuk, Waranya Chatuphonprasert, Kanokwan Jarukamjorn, Paiboon Sithithaworn. Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and Lipid Peroxidation in Hamsters with Acute Opisthorchiasis. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2016 Jan; 99 Suppl 1(?):S22-7. doi: . [PMID: 26817235]
  • Tobias Lammel, Paul Boisseaux, José M Navas. Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1. Environmental toxicology. 2015 Sep; 30(10):1192-204. doi: 10.1002/tox.21991. [PMID: 24706484]
  • Ke Wang, Chenchen Feng, Chenggang Li, Jun Yao, Xiaofeng Xie, Likun Gong, Yang Luan, Guozhen Xing, Xue Zhu, Xinming Qi, Jin Ren. Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor. International journal of molecular sciences. 2015 Jul; 16(7):16454-68. doi: 10.3390/ijms160716454. [PMID: 26204831]
  • Félix Genoveva García-Montes de Oca, Ma de Lourdes López-González, Derly Constanza Escobar-Wilches, Roberto Chavira-Ramírez, Adolfo Sierra-Santoyo. Vinclozolin modulates hepatic cytochrome P450 isoforms during pregnancy. Reproductive toxicology (Elmsford, N.Y.). 2015 Jun; 53(?):119-26. doi: 10.1016/j.reprotox.2015.04.010. [PMID: 25929820]
  • Zhen Zhang, Beikang Ge, Limin Zhou, Tai-Ning Lam, Zhong Zuo. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. Journal of ethnopharmacology. 2014 Jul; 154(3):672-86. doi: 10.1016/j.jep.2014.04.047. [PMID: 24832110]
  • Nattharat Jearapong, Waranya Chatuphonprasert, Kanokwan Jarukamjorn. Miroestrol, a phytoestrogen from Pueraria mirifica, improves the antioxidation state in the livers and uteri of β-naphthoflavone-treated mice. Journal of natural medicines. 2014 Jan; 68(1):173-80. doi: 10.1007/s11418-013-0788-6. [PMID: 23812874]
  • Raquel Urtasun, Francisco Javier Cubero, Natalia Nieto. Oxidative stress modulates KLF6Full and its splice variants. Alcoholism, clinical and experimental research. 2012 Nov; 36(11):1851-62. doi: 10.1111/j.1530-0277.2012.01798.x. [PMID: 22486562]
  • Hitomi Hayashi, Eriko Taniai, Reiko Morita, Masahiro Hayashi, Daichi Nakamura, Atsushi Wakita, Kazuhiko Suzuki, Makoto Shibutani, Kunitoshi Mitsumori. Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone. The Journal of toxicological sciences. 2012; 37(5):969-85. doi: 10.2131/jts.37.969. [PMID: 23038005]
  • Sara C Novais, Wim De Coen, Mónica J B Amorim. Gene expression responses linked to reproduction effect concentrations (EC 10,20,50,90) of dimethoate, atrazine and carbendazim, in Enchytraeus albidus. PloS one. 2012; 7(4):e36068. doi: 10.1371/journal.pone.0036068. [PMID: 22558331]
  • Hitomi Hayashi, Eriko Taniai, Reiko Morita, Atsunori Yafune, Kazuhiko Suzuki, Makoto Shibutani, Kunitoshi Mitsumori. Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats. The Journal of toxicological sciences. 2012; 37(3):517-26. doi: 10.2131/jts.37.517. [PMID: 22687991]
  • Roger Stacke Ferreira, José Maria Monserrat, Josencler Luís Ribas Ferreira, Ana Cristina Kalb, John Stegeman, Afonso Celso Dias Bainy, Juliano Zanette. Biomarkers of organic contamination in the South American fish Poecilia vivipara and Jenynsia multidentata. Journal of toxicology and environmental health. Part A. 2012; 75(16-17):1023-34. doi: 10.1080/15287394.2012.697813. [PMID: 22852852]
  • Waranya Chatuphonprasert, Tawun Remsungnen, Nobuo Nemoto, Kanokwan Jarukamjorn. Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2011 Dec; 25(8):1757-63. doi: 10.1016/j.tiv.2011.09.004. [PMID: 21963808]
  • Xanthi I Couroucli, Yan-hong Wei Liang, Weiwu Jiang, Lihua Wang, Roberto Barrios, Peiying Yang, Bhagavatula Moorthy. Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicology and applied pharmacology. 2011 Oct; 256(2):83-94. doi: 10.1016/j.taap.2011.06.018. [PMID: 21745492]
  • Ronald A Lubet, Brandy M Heckman, Silvio L De Flora, Vernon E Steele, James A Crowell, M Margaret Juliana, Clinton J Grubbs. Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?. Oncology reports. 2011 Sep; 26(3):731-6. doi: 10.3892/or.2011.1316. [PMID: 21617870]
  • Waranya Chatuphonprasert, Thewtas Sangkawat, Nobuo Nemoto, Kanokwan Jarukamjorn. Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine. Fitoterapia. 2011 Sep; 82(6):889-95. doi: 10.1016/j.fitote.2011.05.002. [PMID: 21624442]
  • Robert L Brent, Mildred S Christian, Robert M Diener. Evaluation of the reproductive and developmental risks of caffeine. Birth defects research. Part B, Developmental and reproductive toxicology. 2011 Apr; 92(2):152-87. doi: 10.1002/bdrb.20288. [PMID: 21370398]
  • Whitney M Ellefson, Ashley M Lakner, Alicia Hamilton, Iain H McKillop, Herbert L Bonkovsky, Nury M Steuerwald, Yvette M Huet, Laura W Schrum. Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen. PloS one. 2011; 6(12):e29463. doi: 10.1371/journal.pone.0029463. [PMID: 22206017]
  • Emile P Chen, Liangfu Chen, Yan Ji, Guoying Tai, Yuan H Wen, Harma Ellens. A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. Drug metabolism and disposition: the biological fate of chemicals. 2010 Dec; 38(12):2278-85. doi: 10.1124/dmd.110.034421. [PMID: 20843940]
  • Ling Zhi Yu, Xian Le Yang, Xiang Ling Wang, Wen Juan Yu, Kun Hu. Effects of fish CYP inducers on difloxacin N-demethylation in kidney cell of Chinese idle (Ctenopharyngodon idellus). Fish physiology and biochemistry. 2010 Sep; 36(3):677-686. doi: 10.1007/s10695-009-9342-6. [PMID: 19685219]
  • Ioana Ferecatu, Marie-Caroline Borot, Camille Bossard, Melanie Leroux, Nicole Boggetto, Francelyne Marano, Armelle Baeza-Squiban, Karine Andreau. Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor. Particle and fibre toxicology. 2010 Jul; 7(?):18. doi: 10.1186/1743-8977-7-18. [PMID: 20663163]
  • Cheng Fang, Qing-Yu Zhang. The role of small-intestinal P450 enzymes in protection against systemic exposure of orally administered benzo[a]pyrene. The Journal of pharmacology and experimental therapeutics. 2010 Jul; 334(1):156-63. doi: 10.1124/jpet.110.167742. [PMID: 20400470]
  • Marwa E Elsherbiny, Ayman O S El-Kadi, Dion R Brocks. The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes. Toxicology letters. 2010 Jun; 195(2-3):147-54. doi: 10.1016/j.toxlet.2010.03.019. [PMID: 20362646]
  • E Albertsson, D G J Larsson, L Förlin. Induction of hepatic carbonyl reductase/20beta-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works--possible roles of aryl hydrocarbon receptor agonists and oxidative stress. Aquatic toxicology (Amsterdam, Netherlands). 2010 May; 97(3):243-9. doi: 10.1016/j.aquatox.2009.11.007. [PMID: 20004983]
  • Kristina Beijer, Alexandra Abrahamson, Björn Brunström, Ingvar Brandt. CYP1A inhibition in fish gill filaments: a novel assay applied on pharmaceuticals and other chemicals. Aquatic toxicology (Amsterdam, Netherlands). 2010 Jan; 96(2):145-50. doi: 10.1016/j.aquatox.2009.10.018. [PMID: 19913926]
  • Marwa E Elsherbiny, Dion R Brocks. The effect of CYP1A induction on amiodarone disposition in the rat. Journal of pharmaceutical sciences. 2010 Jan; 99(1):539-48. doi: 10.1002/jps.21841. [PMID: 19718765]
  • Nelly Aranibar, Vasanthi Bhaskaran, Karl-Heinz Ott, Jeff Vassallo, David Nelson, Lloyd Lecureux, Lei Gong, Steve Stryker, Lois Lehman-McKeeman. Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling. Magnetic resonance in chemistry : MRC. 2009 Dec; 47 Suppl 1(?):S12-9. doi: 10.1002/mrc.2503. [PMID: 19768707]
  • Ying Xiao, Xiang Xue, Yuan-feng Wu, Guo-zheng Xin, Yong Qian, Tian-pei Xie, Li-kun Gong, Jin Ren. beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta pharmacologica Sinica. 2009 Nov; 30(11):1559-65. doi: 10.1038/aps.2009.156. [PMID: 19890363]
  • Fong-Fu Hsu, Vijaya M Lakshmi, Terry V Zenser. Characterization of new metabolites from in vivo biotransformation of 2-amino-3-methylimidazo[4,5-f]quinoline in mouse by mass spectrometry. Journal of mass spectrometry : JMS. 2009 Sep; 44(9):1359-68. doi: 10.1002/jms.1620. [PMID: 19629964]
  • Vijaya M Lakshmi, Fong-Fu Hsu, Terry V Zenser. Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice. Drug metabolism and disposition: the biological fate of chemicals. 2009 Aug; 37(8):1690-7. doi: 10.1124/dmd.109.027342. [PMID: 19451400]
  • Dumrongsak Pekthong, Nadège Blanchard, Catherine Abadie, Alexandre Bonet, Bruno Heyd, Georges Mantion, Alain Berthelot, Lysiane Richert, Hélène Martin. Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures. Chemico-biological interactions. 2009 May; 179(2-3):247-55. doi: 10.1016/j.cbi.2008.10.054. [PMID: 19041297]
  • Susumu Kodama, Kumiko Okada, Keiko Akimoto, Hideyuki Inui, Hideo Ohkawa. Recombinant aryl hydrocarbon receptors for bioassay of aryl hydrocarbon receptor ligands in transgenic tobacco plants. Plant biotechnology journal. 2009 Feb; 7(2):119-28. doi: 10.1111/j.1467-7652.2008.00378.x. [PMID: 19055610]
  • Christopher J Kennedy, Keith B Tierney. Energy intake affects the biotransformation rate, scope for induction, and metabolite profile of benzo[a]pyrene in rainbow trout. Aquatic toxicology (Amsterdam, Netherlands). 2008 Nov; 90(3):172-81. doi: 10.1016/j.aquatox.2008.08.016. [PMID: 18922589]
  • I Ahmad, V L Maria, M Oliveira, M Pacheco, M A Santos. Modulatory role of copper on β-naphthoflavone-induced DNA damage in European eel (Anguilla anguilla L.). Ecotoxicology and environmental safety. 2008 Nov; 71(3):806-12. doi: 10.1016/j.ecoenv.2008.01.004. [PMID: 18304634]
  • Miroslav Dostalek, Klarissa D Hardy, Ginger L Milne, Jason D Morrow, Chi Chen, Frank J Gonzalez, Jun Gu, Xinxin Ding, Delinda A Johnson, Jeffrey A Johnson, Martha V Martin, F Peter Guengerich. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. The Journal of biological chemistry. 2008 Jun; 283(25):17147-57. doi: 10.1074/jbc.m802447200. [PMID: 18442974]
  • Jin-Hyoung Kim, Dae-Sik Hwang, Kyu-Hee Son, Sheikh Raisuddin, Jang-Seu Ki, Jae-Seong Lee, Kyung-Nam Han. cDNA cloning and expression of a xenobiotic metabolizing cytochrome P4501A (CYP1A) from the yellow catfish, Pelteobagrus fulvidraco (Siluriformes). Environmental toxicology. 2008 Jun; 23(3):346-53. doi: 10.1002/tox.20333. [PMID: 18214900]
  • Neelakanteswar Aluru, Mathilakath M Vijayan. Brain transcriptomics in response to beta-naphthoflavone treatment in rainbow trout: the role of aryl hydrocarbon receptor signaling. Aquatic toxicology (Amsterdam, Netherlands). 2008 Apr; 87(1):1-12. doi: 10.1016/j.aquatox.2007.12.012. [PMID: 18282621]
  • Qi-Biao Su, Fan He, Xue-Ding Wang, Su Guan, Zhi-Yong Xie, Lai-You Wang, Yu-Jing Lu, Lian-Quan Gu, Zhi-Shu Huang, Xiao Chen, Min Huang, Shu-Feng Zhou. Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Investigational new drugs. 2008 Apr; 26(2):119-37. doi: 10.1007/s10637-007-9089-9. [PMID: 17922078]
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  • Esther G van de Kerkhof, Inge A M de Graaf, Anna-Lena B Ungell, Geny M M Groothuis. Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug metabolism and disposition: the biological fate of chemicals. 2008 Mar; 36(3):604-13. doi: 10.1124/dmd.107.018820. [PMID: 18094037]
  • Yasuaki Dewa, Jihei Nishimura, Masako Muguruma, Meilan Jin, Yukie Saegusa, Toshiya Okamura, Masako Tasaki, Takashi Umemura, Kunitoshi Mitsumori. beta-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats. Toxicology. 2008 Feb; 244(2-3):179-89. doi: 10.1016/j.tox.2007.11.010. [PMID: 18164116]
  • Manuel Gesto, José L Soengas, Jesús M Míguez. Acute and prolonged stress responses of brain monoaminergic activity and plasma cortisol levels in rainbow trout are modified by PAHs (naphthalene, beta-naphthoflavone and benzo(a)pyrene) treatment. Aquatic toxicology (Amsterdam, Netherlands). 2008 Feb; 86(3):341-51. doi: 10.1016/j.aquatox.2007.11.014. [PMID: 18180048]
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