beta-naphthoflavone (BioDeep_00000176640)

 

Secondary id: BioDeep_00000412768

human metabolite blood metabolite


代谢物信息卡片


3-Phenyl-1H-naphtho(2,1-b)pyran-1-one

化学式: C19H12O2 (272.0837252)
中文名称: β-萘黄酮
谱图信息: 最多检出来源 Homo sapiens(blood) 98.36%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC4=CC=CC=C43
InChI: InChI=1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H

描述信息

C1892 - Chemopreventive Agent > C54629 - Phase I Enzymes Inhibitor
C1892 - Chemopreventive Agent > C54630 - Phase II Enzymes Inducer
D004791 - Enzyme Inhibitors > D001571 - Benzoflavones

同义名列表

12 个代谢物同义名

3-Phenyl-1H-naphtho(2,1-b)pyran-1-one; 3-phenyl-1H-benzo[f]chromen-1-one; beta-naphthoflavone; beta Naphthoflavone; 5,6 Benzoflavone; 5,6-Benzoflavone; b-Naphthoflavone; β-Naphthoflavone; Benzo[F]flavone; beta-NF; b-NF; Β-NF



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Carolin Riegraf, Georg Reifferscheid, Liat Moscovici, Dror Shakibai, Henner Hollert, Shimshon Belkin, Sebastian Buchinger. Coupling high-performance thin-layer chromatography with a battery of cell-based assays reveals bioactive components in wastewater and landfill leachates. Ecotoxicology and environmental safety. 2021 May; 214(?):112092. doi: 10.1016/j.ecoenv.2021.112092. [PMID: 33690008]
  • Man Zhang, Heng Fan, Songwei Tan, Qing Tang, Xingxing Liu, Dongmei Zuo, Yi Liao, Zhen Nan, Chen Tan. The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation. Journal of ethnopharmacology. 2020 Apr; 251(?):112549. doi: 10.1016/j.jep.2020.112549. [PMID: 31918016]
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  • Carolin Riegraf, Georg Reifferscheid, Shimshon Belkin, Liat Moscovici, Dror Shakibai, Henner Hollert, Sebastian Buchinger. Combination of yeast-based in vitro screens with high-performance thin-layer chromatography as a novel tool for the detection of hormonal and dioxin-like compounds. Analytica chimica acta. 2019 Nov; 1081(?):218-230. doi: 10.1016/j.aca.2019.07.018. [PMID: 31446961]
  • Anne Mahringer, Alexandra Bernd, David S Miller, Gert Fricker. Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules. Biological chemistry. 2019 09; 400(10):1335-1345. doi: 10.1515/hsz-2018-0425. [PMID: 30913027]
  • Gulsum E Muku, Nicholas Blazanin, Fangcong Dong, Philip B Smith, Diane Thiboutot, Krishne Gowda, Shantu Amin, Iain A Murray, Gary H Perdew. Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Jun; ?(?):. doi: 10.1093/toxsci/kfz140. [PMID: 31225620]
  • Shalini Behl, Abdu Adem, Arif Hussain, Jaipaul Singh. Effects of rilpivirine, 17β-estradiol and β-naphthoflavone on the inflammatory status of release of adipocytokines in 3T3-L1 adipocytes in vitro. Molecular biology reports. 2019 Jun; 46(3):2643-2655. doi: 10.1007/s11033-019-04671-4. [PMID: 30927158]
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  • Rami El Dairi, Pasi Huuskonen, Markku Pasanen, Jaana Rysä. Peroxisome proliferator activated receptor gamma (PPAR-γ) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reproductive toxicology (Elmsford, N.Y.). 2018 10; 81(?):99-107. doi: 10.1016/j.reprotox.2018.07.077. [PMID: 30031879]
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  • Zhen Zhang, Beikang Ge, Limin Zhou, Tai-Ning Lam, Zhong Zuo. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. Journal of ethnopharmacology. 2014 Jul; 154(3):672-86. doi: 10.1016/j.jep.2014.04.047. [PMID: 24832110]
  • Nattharat Jearapong, Waranya Chatuphonprasert, Kanokwan Jarukamjorn. Miroestrol, a phytoestrogen from Pueraria mirifica, improves the antioxidation state in the livers and uteri of β-naphthoflavone-treated mice. Journal of natural medicines. 2014 Jan; 68(1):173-80. doi: 10.1007/s11418-013-0788-6. [PMID: 23812874]
  • Raquel Urtasun, Francisco Javier Cubero, Natalia Nieto. Oxidative stress modulates KLF6Full and its splice variants. Alcoholism, clinical and experimental research. 2012 Nov; 36(11):1851-62. doi: 10.1111/j.1530-0277.2012.01798.x. [PMID: 22486562]
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  • Hitomi Hayashi, Eriko Taniai, Reiko Morita, Atsunori Yafune, Kazuhiko Suzuki, Makoto Shibutani, Kunitoshi Mitsumori. Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats. The Journal of toxicological sciences. 2012; 37(3):517-26. doi: 10.2131/jts.37.517. [PMID: 22687991]
  • Roger Stacke Ferreira, José Maria Monserrat, Josencler Luís Ribas Ferreira, Ana Cristina Kalb, John Stegeman, Afonso Celso Dias Bainy, Juliano Zanette. Biomarkers of organic contamination in the South American fish Poecilia vivipara and Jenynsia multidentata. Journal of toxicology and environmental health. Part A. 2012; 75(16-17):1023-34. doi: 10.1080/15287394.2012.697813. [PMID: 22852852]
  • Waranya Chatuphonprasert, Tawun Remsungnen, Nobuo Nemoto, Kanokwan Jarukamjorn. Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2011 Dec; 25(8):1757-63. doi: 10.1016/j.tiv.2011.09.004. [PMID: 21963808]
  • Xanthi I Couroucli, Yan-hong Wei Liang, Weiwu Jiang, Lihua Wang, Roberto Barrios, Peiying Yang, Bhagavatula Moorthy. Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicology and applied pharmacology. 2011 Oct; 256(2):83-94. doi: 10.1016/j.taap.2011.06.018. [PMID: 21745492]
  • Ronald A Lubet, Brandy M Heckman, Silvio L De Flora, Vernon E Steele, James A Crowell, M Margaret Juliana, Clinton J Grubbs. Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?. Oncology reports. 2011 Sep; 26(3):731-6. doi: 10.3892/or.2011.1316. [PMID: 21617870]
  • Waranya Chatuphonprasert, Thewtas Sangkawat, Nobuo Nemoto, Kanokwan Jarukamjorn. Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine. Fitoterapia. 2011 Sep; 82(6):889-95. doi: 10.1016/j.fitote.2011.05.002. [PMID: 21624442]
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  • Ling Zhi Yu, Xian Le Yang, Xiang Ling Wang, Wen Juan Yu, Kun Hu. Effects of fish CYP inducers on difloxacin N-demethylation in kidney cell of Chinese idle (Ctenopharyngodon idellus). Fish physiology and biochemistry. 2010 Sep; 36(3):677-686. doi: 10.1007/s10695-009-9342-6. [PMID: 19685219]
  • Ioana Ferecatu, Marie-Caroline Borot, Camille Bossard, Melanie Leroux, Nicole Boggetto, Francelyne Marano, Armelle Baeza-Squiban, Karine Andreau. Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor. Particle and fibre toxicology. 2010 Jul; 7(?):18. doi: 10.1186/1743-8977-7-18. [PMID: 20663163]
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