Adrenaline (BioDeep_00000408845)

描述信息

A catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen.

Adrenaline, also known as epinephrine, is a hormone and medication[7][8] which is involved in regulating visceral functions (e.g., respiration).[7][9] It appears as a white microcrystalline granule.[10] Adrenaline is normally produced by the adrenal glands and by a small number of neurons in the medulla oblongata.[11] It plays an essential role in the fight-or-flight response by increasing blood flow to muscles, heart output by acting on the SA node,[12] pupil dilation response, and blood sugar level.[13][14] It does this by binding to alpha and beta receptors.[14] It is found in many animals, including humans, and some single-celled organisms.[15][16] It has also been isolated from the plant Scoparia dulcis found in Northern Vietnam.[17]

As a medication, it is used to treat several conditions, including allergic reaction anaphylaxis, cardiac arrest, and superficial bleeding.[5] Inhaled adrenaline may be used to improve the symptoms of croup.[18] It may also be used for asthma when other treatments are not effective. It is given intravenously, by injection into a muscle, by inhalation, or by injection just under the skin.[5] Common side effects include shakiness, anxiety, and sweating. A fast heart rate and high blood pressure may occur. Occasionally it may result in an abnormal heart rhythm. While the safety of its use during pregnancy and breastfeeding is unclear, the benefits to the mother must be taken into account.[5]

A case has been made for the use of adrenaline infusion in place of the widely accepted treatment of inotropes for preterm infants with clinical cardiovascular compromise. Although sufficient data strongly recommends adrenaline infusions as a viable treatment, more trials are needed to conclusively determine that these infusions will successfully reduce morbidity and mortality rates among preterm, cardiovascularly compromised infants.[19]

Epinephrine can also be used to treat open-angle glaucoma, as it has been found to lower the outflow of aqueous humor in the eye. This lowers the intraocular pressure in the eye and thus aids in treatment.

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