Milbemycin A4 (BioDeep_00000408786)
代谢物信息卡片
Milbemycin A4
化学式: C32H46O7 (542.3243365999999)
中文名称: 密灭汀A4
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C14O)([H])(O5)C(O)C(=CC1(C(OC(C2)([H])CC(CC=C(C)CC(C)C=CC=C4C5)(OC(O3)2CCC(C)C3CC)[H])=O)[H])C
InChI: InChI=1S/C32H46O7/c1-6-27-21(4)12-13-31(39-27)17-25-16-24(38-31)11-10-20(3)14-19(2)8-7-9-23-18-36-29-28(33)22(5)15-26(30(34)37-25)32(23,29)35/h7-10,15,19,21,24-29,33,35H,6,11-14,16-18H2,1-5H3/b8-7+,20-10+,23-9+/t19-,21-,24+,25-,26-,27+,28+,29+,31+,32+/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:39229
- PubChem: 9959038
- ChEMBL: CHEMBL2272397
- CAS: 51596-11-3
- MoNA: WA000156
- MoNA: WA000155
- MoNA: WA000154
- MoNA: WA000153
- MoNA: WA000152
- MetaboLights: MTBLC39229
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- L Laber, C Eichberg, A Zimmerbeutel, R-A Düring, T W Donath. Effects of macrocyclic lactone anthelmintics on seed germination of temperate grassland species.
Plant biology (Stuttgart, Germany).
2023 Dec; 25(7):1046-1057. doi:
10.1111/plb.13577. [PMID: 37703534] - Lars Laber, Anabell Jandowsky, Kai Frölich, Andre P Heinrich, Rolf-Alexander Düring, Tobias W Donath, Carsten Eichberg. Dose-dependent in vivo effects of formulated moxidectin on seedling emergence of temperate grassland species.
The Science of the total environment.
2023 Sep; 905(?):167152. doi:
10.1016/j.scitotenv.2023.167152. [PMID: 37730042] - Haiyan Wang, Yuqing Liu, Xu Cheng, Yanyan Zhang, Shanshan Li, Xiangjing Wang, Wensheng Xiang. Titer improvement of milbemycins via coordinating metabolic competition and transcriptional co-activation controlled by Streptomyces antibiotic regulatory protein family regulator in Streptomyces bingchenggensis.
Biotechnology and bioengineering.
2022 05; 119(5):1252-1263. doi:
10.1002/bit.28044. [PMID: 35084043] - Beesan Tan, Nicholas Opoku, Simon K Attah, Kwablah Awadzi, Annette C Kuesel, Janis Lazdins-Helds, Craig Rayner, Victoria Ryg-Cornejo, Mark Sullivan, Lawrence Fleckenstein. Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection.
PLoS neglected tropical diseases.
2022 03; 16(3):e0010005. doi:
10.1371/journal.pntd.0010005. [PMID: 35333880] - Nilima Dinesh Kumar, Bram M Ter Ellen, Ellen M Bouma, Berit Troost, Denise P I van de Pol, Heidi H van der Ende-Metselaar, Djoke van Gosliga, Leonie Apperloo, Orestes A Carpaij, Maarten van den Berge, Martijn C Nawijn, Ymkje Stienstra, Izabela A Rodenhuis-Zybert, Jolanda M Smit. Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0154321. doi:
10.1128/aac.01543-21. [PMID: 34633839] - Carsten Eichberg, Alwin M Hartman, Alexandra-Marie Kronenberger, Rolf-Alexander Düring, Tobias W Donath. Temperature moderates impact of formulated moxidectin on seed germination of three temperate grassland species.
PloS one.
2022; 17(11):e0277865. doi:
10.1371/journal.pone.0277865. [PMID: 36409735] - Dave M Leathwick, Paul C Mason, Karl Fraser, Chris M Miller, Peter Green. Route of administration affects the efficacy of moxidectin against Ostertagiinae nematodes in farmed red deer (Cervus elaphus).
Veterinary parasitology.
2021 Oct; 298(?):109525. doi:
10.1016/j.vetpar.2021.109525. [PMID: 34274762] - Thomas Geurden, Filip De Keersmaecker, Sofie De Keersmaecker, Edwin Claerebout, Dave M Leathwick, Martin K Nielsen, Christian W Sauermann. Three-year study to evaluate an anthelmintic treatment regimen with reduced treatment frequency in horses on two study sites in Belgium.
Veterinary parasitology.
2021 Oct; 298(?):109538. doi:
10.1016/j.vetpar.2021.109538. [PMID: 34364153] - Daniela Hofmann, Somphou Sayasone, Khanpaseuth Sengngam, Bounthunh Chongvilay, Jan Hattendorf, Jennifer Keiser. Efficacy and safety of ascending doses of moxidectin against Strongyloides stercoralis infections in adults: a randomised, parallel-group, single-blinded, placebo-controlled, dose-ranging, phase 2a trial.
The Lancet. Infectious diseases.
2021 08; 21(8):1151-1160. doi:
10.1016/s1473-3099(20)30691-5. [PMID: 33798487] - Qiu Jicheng, Xiao Hongzhi, Sun Pan, Cao Yuying, Wu Qinyao, Zhang Ximo, Zhang Lu, Gong Xiaohui, Cao Xingyuan, Sun Feifei. Tissue residues and withdrawal time of moxidectin treatment of swine by topical pour-on application.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2021 Apr; 38(4):602-608. doi:
10.1080/19440049.2021.1877833. [PMID: 33684319] - Benedetto Morandi, Maria Chiara Sabetti, Fabrizia Veronesi, Giulia Morganti, Marco Pietra, Giovanni Poglayen, Nikolina Linta, Gary Conboy, Roberta Galuppi. A case of a dog refractory to different treatments for pulmonary capillariasis.
Parasitology research.
2021 Mar; 120(3):1137-1141. doi:
10.1007/s00436-020-06940-9. [PMID: 33103217] - Yuqing Liu, Haiyan Wang, Shanshan Li, Yanyan Zhang, Xu Cheng, Wensheng Xiang, Xiangjing Wang. Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis.
Applied microbiology and biotechnology.
2021 Mar; 105(5):1875-1887. doi:
10.1007/s00253-021-11164-7. [PMID: 33564920] - Luiz Fellipe Monteiro Couto, Dina María Beltrán Zapa, Luciana Maffini Heller, Alliny Souza de Assis Cavalcante, João Eduardo Nicaretta, Leonardo Bueno Cruvinel, Marcos Henrique Alcantara Colli, Lorena Lopes Ferreira, Amanda Alencar, Rubens Dias de Melo-Junior, Vando Edesio Soares, Fernando de Almeida Borges, Welber Daniel Zanetti Lopes. Gastrointestinal nematode control programs in yearling Nellore heifers: Analysis of fecal egg counts, weight gain and reproductive indices.
Animal reproduction science.
2021 Mar; 226(?):106695. doi:
10.1016/j.anireprosci.2021.106695. [PMID: 33485086] - Daniela Hofmann, Somphou Sayasone, Jennifer Keiser. Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample, blood, and plasma: Application to a pharmacokinetic study of adults infected with Strongyloides stercoralis in Laos.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Mar; 1166(?):122556. doi:
10.1016/j.jchromb.2021.122556. [PMID: 33535101] - S Luque, M Lloberas, P Cardozo, G Virkel, C Farias, P Viviani, C Lanusse, L Alvarez, A Lifschitz. Combined moxidectin-levamisole treatment against multidrug-resistant gastrointestinal nematodes: A four-year efficacy monitoring in lambs.
Veterinary parasitology.
2021 Feb; 290(?):109362. doi:
10.1016/j.vetpar.2021.109362. [PMID: 33524780] - Shabnam Jawahar, Nancy Tricoche, Christina A Bulman, Judy Sakanari, Sara Lustigman. Drugs that target early stages of Onchocerca volvulus: A revisited means to facilitate the elimination goals for onchocerciasis.
PLoS neglected tropical diseases.
2021 02; 15(2):e0009064. doi:
10.1371/journal.pntd.0009064. [PMID: 33600426] - Beatrice Barda, Christian Schindler, Rahel Wampfler, Shaali Ame, Said M Ali, Jennifer Keiser. Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial.
BMC microbiology.
2020 10; 20(1):298. doi:
10.1186/s12866-020-01963-9. [PMID: 33008301] - Molly D Savadelis, Amanda E Coleman, Gregg S Rapoport, Ajay Sharma, Kaori Sakamoto, Deborah A Keys, Cameon M Ohmes, Joe A Hostetler, Michael T Dzimianski, Andrew R Moorhead. Clinical assessment of heartworm-infected Beagles treated with a combination of imidacloprid/moxidectin and doxycycline, or untreated.
Journal of veterinary internal medicine.
2020 Sep; 34(5):1734-1745. doi:
10.1111/jvim.15853. [PMID: 32691900] - Xiao-Qian Li, Chang-Wu Yue, Wen-Hui Xu, Yu-Hong Lü, Yan-Jie Huang, Peng Tian, Tie Liu. A milbemycin compound isolated from Streptomyces Sp. FJS31-2 with cytotoxicity and reversal of cisplatin resistance activity in A549/DDP cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Aug; 128(?):110322. doi:
10.1016/j.biopha.2020.110322. [PMID: 32505822] - Wenxin Xue, Simon Snoeck, Christine Njiru, Emre Inak, Wannes Dermauw, Thomas Van Leeuwen. Geographical distribution and molecular insights into abamectin and milbemectin cross-resistance in European field populations of Tetranychus urticae.
Pest management science.
2020 Aug; 76(8):2569-2581. doi:
10.1002/ps.5831. [PMID: 32237053] - Julie Swenson, Holly J Haefele, Robert H Poppenga. SUSPECTED MOXIDECTIN TOXICOSIS IN A ROAN ANTELOPE (HIPPOTRAGUS EQUINUS), A SABLE ANTELOPE (HIPPOTRAGUS NIGER), AND AN ARABIAN ORYX (ORYX LEUCORYX) AT A SEMI-FREE RANGE ZOOLOGICAL PARK.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2020 Jun; 51(2):416-425. doi:
10.1638/2019-0061. [PMID: 32549573] - Haiyan Wang, Xu Cheng, Yuqing Liu, Shanshan Li, Yanyan Zhang, Xiangjing Wang, Wensheng Xiang. Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis.
Applied microbiology and biotechnology.
2020 Apr; 104(7):2935-2946. doi:
10.1007/s00253-020-10410-8. [PMID: 32043186] - J A Scare, D M Leathwick, C W Sauermann, E T Lyons, A E Steuer, B A Jones, M Clark, M K Nielsen. Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins.
International journal for parasitology. Drugs and drug resistance.
2020 04; 12(?):28-34. doi:
10.1016/j.ijpddr.2019.12.002. [PMID: 31883485] - João Henrique Silva Vera, Daniele Floriano Fachiolli, Lívia Magosso Ramires, Isabela de Lima Saes, Paulo Henrique Yamada, Juliana Alencar Gonçalves, Kátia de Oliveira, Alessandro Francisco Talamini do Amarante, Ricardo Velludo Gomes de Soutello. Eficacy of ivermectin, moxidectin and febendazole in equine in Brazil.
Veterinary parasitology, regional studies and reports.
2020 04; 20(?):100374. doi:
10.1016/j.vprsr.2020.100374. [PMID: 32448518] - Laura G Cooper, Gabriel Caffe, Julieta Cerutti, Martin K Nielsen, Oscar S Anziani. Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina.
Veterinary parasitology, regional studies and reports.
2020 04; 20(?):100388. doi:
10.1016/j.vprsr.2020.100388. [PMID: 32448542] - Ladina Keller, Marta S Palmeirim, Shaali M Ame, Said M Ali, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser. Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris trichiura in Adolescents: A Randomized Controlled Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 03; 70(6):1193-1201. doi:
10.1093/cid/ciz326. [PMID: 31044235] - Fang Liu, Yue Xie, Anne M Zajac, Yan Hu, Raffi V Aroian, Joseph F Urban, Robert W Li. Gut microbial signatures associated with moxidectin treatment efficacy of Haemonchus contortus in infected goats.
Veterinary microbiology.
2020 Mar; 242(?):108607. doi:
10.1016/j.vetmic.2020.108607. [PMID: 32122611] - Kristina Kryda, Sean P Mahabir, Tammy Inskeep, Jady Rugg. Safety and efficacy of a novel oral chewable combination tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against natural flea infestations in client-owned dogs in the USA.
Parasites & vectors.
2020 Mar; 13(1):98. doi:
10.1186/s13071-020-3952-3. [PMID: 32113472] - Csilla Becskei, Kristina Kryda, Daphne Fias, Stacey L Follis, Magda Wozniakiewicz, Sean P Mahabir, Robert Farkas. Field efficacy and safety of a novel oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against naturally acquired gastrointestinal nematode infections in dogs presented as veterinary patients in Europe and the USA.
Parasites & vectors.
2020 Mar; 13(1):70. doi:
10.1186/s13071-020-3947-0. [PMID: 32113470] - Anastasia Diakou, Dimitris Dimzas, Christos Astaras, Ioannis Savvas, Angela Di Cesare, Simone Morelli, Κostantinos Neofitos, Despina Migli, Donato Traversa. Clinical investigations and treatment outcome in a European wildcat (Felis silvestris silvestris) infected by cardio-pulmonary nematodes.
Veterinary parasitology, regional studies and reports.
2020 01; 19(?):100357. doi:
10.1016/j.vprsr.2019.100357. [PMID: 32057385] - Charlotte L Kerr, David R Armstrong, Alison J Anderson. Short communication: A practical farm-based trial to compare ewe nematode control strategies in peri-parturient ewes.
PloS one.
2020; 15(8):e0236143. doi:
10.1371/journal.pone.0236143. [PMID: 32790679] - Anastasia Diakou, Simone Morelli, Dimitris Dimzas, Angela Di Cesare, Gioia Capelli, Chiara Parrinello, Matthias Pollmeier, Roland Schaper, Donato Traversa. Efficacy of a moxidectin/imidacloprid spot-on formulation (Advocate®) for the treatment of Troglostrongylus brevior in naturally infected cats in a field study in Greece.
Parasites & vectors.
2019 Nov; 12(1):519. doi:
10.1186/s13071-019-3760-9. [PMID: 31685011] - R A Torres-Fajardo, P G González-Pech, C A Sandoval-Castro, J Ventura-Cordero, J F J Torres-Acosta. Criollo goats limit their grass intake in the early morning suggesting a prophylactic self-medication behaviour in a heterogeneous vegetation.
Tropical animal health and production.
2019 Nov; 51(8):2473-2479. doi:
10.1007/s11250-019-01966-3. [PMID: 31197723] - Roger K Prichard, Timothy G Geary. Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance.
International journal for parasitology. Drugs and drug resistance.
2019 08; 10(?):69-83. doi:
10.1016/j.ijpddr.2019.06.002. [PMID: 31229910] - Luise Kultscher, Barbara Hinney, Ronald Schmäschke, Anja Joachim, Thomas Wittek. Current anthelmintic treatment is not always effective at controlling strongylid infections in German alpaca herds.
Parasites & vectors.
2019 Jul; 12(1):330. doi:
10.1186/s13071-019-3588-3. [PMID: 31266521] - L K Novelo-Chi, P G González-Pech, J Ventura-Cordero, J F J Torres-Acosta, C A Sandoval-Castro, R Cámara-Sarmiento. Gastrointestinal nematode infection and feeding behaviour of goats in a heterogeneous vegetation: No evidence of therapeutic self-medication.
Behavioural processes.
2019 May; 162(?):7-13. doi:
10.1016/j.beproc.2019.01.006. [PMID: 30685411] - L H Morris, S Colgan, D M Leathwick, M K Nielsen. Anthelmintic efficacy of single active and combination products against commonly occurring parasites in foals.
Veterinary parasitology.
2019 Apr; 268(?):46-52. doi:
10.1016/j.vetpar.2019.02.006. [PMID: 30981305] - Victor H Suarez, Juan F Micheloud, Virginia Araoz, Gabriela M Martínez, Diana E Rosa, Guillermo A Mattioli. Effect of gastrointestinal nematodes on serum copper and phosphorus of growing beef calves in northwestern Argentina.
Tropical animal health and production.
2019 Mar; 51(3):613-618. doi:
10.1007/s11250-018-1729-x. [PMID: 30353458] - Yashpal S Chhonker, Richard L Sleightholm, Daryl J Murry. Bioanalytical method development and validation of moxidectin in plasma by LC-MS/MS: Application to in vitro metabolism.
Biomedical chromatography : BMC.
2019 Feb; 33(2):e4389. doi:
10.1002/bmc.4389. [PMID: 30238696] - Luis Fazzio, Laura Moreno, Walter Galvan, Candela Canton, Luis Alvarez, Nicolás Streitenberger, Ricardo Sánchez, Carlos Lanusse, Rodrigo Sanabria. Pharmacokinetic profile and anthelmintic efficacy of moxidectin administered by different doses and routes to feedlot calves.
Veterinary parasitology.
2019 Feb; 266(?):73-79. doi:
10.1016/j.vetpar.2018.12.016. [PMID: 30736951] - Hongzhi Xiao, Haoyuan Peng, Ting Zhao, Jingyuan Kong, Jiao Xue, Jianzhong Wang, Yalong Lin, Suxia Zhang, Xingyuan Cao. The pharmacokinetics of moxidectin following intravenous and topical administration to swine.
Journal of veterinary pharmacology and therapeutics.
2019 Jan; 42(1):111-115. doi:
10.1111/jvp.12693. [PMID: 30393987] - Nadja Rohdich, Eva Zschiesche, Oliver Wolf, Wolfgang Loehlein, Zvezdelina Kirkova, Petar Iliev, Dhimitër Rapti, Rezart Postoli, Balázs Capári, Róbert Farkas, Rainer K A Roepke. A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus).
Parasites & vectors.
2018 Nov; 11(1):589. doi:
10.1186/s13071-018-3169-x. [PMID: 30449275] - Sally A Kinrade, Jay W Mason, Carlos R Sanabria, Craig R Rayner, Julie M Bullock, Stephanie H Stanworth, Mark T Sullivan. Evaluation of the Cardiac Safety of Long-Acting Endectocide Moxidectin in a Randomized Concentration-QT Study.
Clinical and translational science.
2018 11; 11(6):582-589. doi:
10.1111/cts.12583. [PMID: 30117300] - Hima Gopinath, Manju Aishwarya, Kaliaperumal Karthikeyan. Tackling scabies: novel agents for a neglected disease.
International journal of dermatology.
2018 Nov; 57(11):1293-1298. doi:
10.1111/ijd.13999. [PMID: 29663338] - Valentina M Merola, Paul A Eubig. Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats.
The Veterinary clinics of North America. Small animal practice.
2018 Nov; 48(6):991-1012. doi:
10.1016/j.cvsm.2018.07.002. [PMID: 30139545] - H W Ploeger, R R Everts. Alarming levels of anthelmintic resistance against gastrointestinal nematodes in sheep in the Netherlands.
Veterinary parasitology.
2018 Oct; 262(?):11-15. doi:
10.1016/j.vetpar.2018.09.007. [PMID: 30389005] - Keke Wei, Yuanjie Wu, Lei Li, Weihong Jiang, Jinfeng Hu, Yinhua Lu, Shaoxin Chen. MilR2, a novel TetR family regulator involved in 5-oxomilbemycin A3/A4 biosynthesis in Streptomyces hygroscopicus.
Applied microbiology and biotechnology.
2018 Oct; 102(20):8841-8853. doi:
10.1007/s00253-018-9280-2. [PMID: 30121749] - Melissa A Nashat, Rodolfo J Ricart Arbona, Michelle L Lepherd, Sara F Santagostino, Robert S Livingston, Elyn R Riedel, Neil S Lipman. Ivermectin-compounded Feed Compared with Topical Moxidectin-Imidacloprid for Eradication of Demodex musculi in Laboratory Mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2018 09; 57(5):483-497. doi:
10.30802/aalas-jaalas-18-000003. [PMID: 30185284] - Leticia M Mesa, J Hörler, I Lindt, M F Gutiérrez, L Negro, G Mayora, L Montalto, M Ballent, A Lifschitz. Effects of the Antiparasitic Drug Moxidectin in Cattle Dung on Zooplankton and Benthic Invertebrates and its Accumulation in a Water-Sediment System.
Archives of environmental contamination and toxicology.
2018 Aug; 75(2):316-326. doi:
10.1007/s00244-018-0539-5. [PMID: 29846763] - Maurice Mahieu, Rémy Arquet, Carine Marie-Magdeleine. Effectiveness of several anthelmintics to control a Strongyloides sp. outbreak in Creole-de-Guadeloupe male kids aged 7 months.
Veterinary parasitology, regional studies and reports.
2018 08; 13(?):224-227. doi:
10.1016/j.vprsr.2018.07.006. [PMID: 31014879] - Jessica M Abbate, Ettore Napoli, Francesca Arfuso, Gabriella Gaglio, Salvatore Giannetto, Lenaig Halos, Frederic Beugnet, Emanuele Brianti. Six-month field efficacy and safety of the combined treatment of dogs with Frontline Tri-Act® and NexGard Spectra®.
Parasites & vectors.
2018 Jul; 11(1):425. doi:
10.1186/s13071-018-2957-7. [PMID: 30012179] - Michelle Del Bianchi A Cruz, Maria Ângela M Fernandes, Alda Lúcia G Monteiro, Juliana A Teles, Arturo Anadón, Felix G R Reyes. Tissue residue depletion of moxidectin in lambs (Ovis aries) following subcutaneous administration.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2018 Jul; 35(7):1278-1285. doi:
10.1080/19440049.2018.1465207. [PMID: 29718774] - Scott W Korte, Craig L Franklin, Rebecca A Dorfmeyer, Aaron C Ericsson. Effects of Fenbendazole-impregnated Feed and Topical Moxidectin during Quarantine on the Gut Microbiota of C57BL/6 Mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2018 05; 57(3):229-235. doi:
NULL. [PMID: 29784074] - L E Peachey, R A Molena, T P Jenkins, A Di Cesare, D Traversa, J E Hodgkinson, C Cantacessi. The relationships between faecal egg counts and gut microbial composition in UK Thoroughbreds infected by cyathostomins.
International journal for parasitology.
2018 05; 48(6):403-412. doi:
10.1016/j.ijpara.2017.11.003. [PMID: 29432771] - V H Suarez, G M Martínez, J F Micheloud, A E Viñabal. Epidemiology and effect of gastrointestinal nematodes on beef cattle from tropical Argentina.
Tropical animal health and production.
2018 Apr; 50(4):801-806. doi:
10.1007/s11250-017-1498-y. [PMID: 29274052] - Melissa M George, Lorraine Lopez-Soberal, Bob E Storey, Sue B Howell, Ray M Kaplan. Motility in the L3 stage is a poor phenotype for detecting and measuring resistance to avermectin/milbemycin drugs in gastrointestinal nematodes of livestock.
International journal for parasitology. Drugs and drug resistance.
2018 04; 8(1):22-30. doi:
10.1016/j.ijpddr.2017.12.002. [PMID: 29274827] - Gilad Segev, Alicia Rojas, Eran Lavy, Marganit Yaffe, Itamar Aroch, Gad Baneth. Evaluation of a spot-on imidacloprid-moxidectin formulation (Advocate®) for the treatment of naturally occurring esophageal spirocercosis in dogs: a double-blinded, placebo-controlled study.
Parasites & vectors.
2018 03; 11(1):127. doi:
10.1186/s13071-018-2731-x. [PMID: 29506575] - Molly D Savadelis, Jennifer L Roveto, Cameon M Ohmes, Joe A Hostetler, Terry L Settje, Michael T Dzimianski, Andrew R Moorhead. Evaluation of heat-treating heartworm-positive canine serum samples during treatment with Advantage Multi® for Dogs and doxycycline.
Parasites & vectors.
2018 02; 11(1):98. doi:
10.1186/s13071-018-2685-z. [PMID: 29458396] - Michelle Del Bianchi A Cruz, Maria A M Fernandes, Patricia A de C Braga, Alda L G Monteiro, Daniela Daniel, Felix G R Reyes. Moxidectin residues in lamb tissues: Development and validation of analytical method by UHPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1072(?):390-396. doi:
10.1016/j.jchromb.2017.11.041. [PMID: 29241059] - Dwight D Bowman, Cameon M Ohmes, Joseph A Hostetler, Daniel J Keil, Terry L Settje, Samuel D Charles. Efficacy of 10\% imidacloprid + 2.5\% moxidectin topical solution (Advantage Multi® for Dogs) for the prevention of heartworm disease and infection all month long.
Parasites & vectors.
2017 Nov; 10(Suppl 2):478. doi:
10.1186/s13071-017-2432-x. [PMID: 29143660] - Maria Angela Machado Fernandes, Susana Gilaverte, Michele Dell Bianchi, Claudio José Araujo da Silva, Marcelo Beltrão Molento, Felix Guillermo Reyes Reyes, Alda Lucia Gomes Monteiro. Moxidectin residues in tissues of lambs submitted to three endoparasite control programs.
Research in veterinary science.
2017 Oct; 114(?):406-411. doi:
10.1016/j.rvsc.2017.07.010. [PMID: 28750211] - Gary West, Elizabeth E Hammond, Butch KuKanich. PILOT STUDY: PHARMACOKINETICS OF ORAL AND TOPICAL MOXIDECTIN IN THE RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2017 Jun; 48(2):536-539. doi:
10.1638/2016-0077r.1. [PMID: 28749301] - Thomas Geurden, David J Bartram, Hima Bindu Vanimisetti, Jane Fanke, Philippe Camuset, Jacques Devos, Andrew Sawyer, Georg von Samson-Himmelstjerna, Janina Demeler, Johannes Charlier. A multi-country study to assess the effect of a treatment with moxidectin pour-on during the dry period on milk production in dairy cows.
Veterinary parasitology.
2017 Apr; 237(?):104-109. doi:
10.1016/j.vetpar.2017.02.010. [PMID: 28259556] - Thomas Tzelos, Jessica S G Barbeito, Martin K Nielsen, Eric R Morgan, Jane E Hodgkinson, Jacqueline B Matthews. Strongyle egg reappearance period after moxidectin treatment and its relationship with management factors in UK equine populations.
Veterinary parasitology.
2017 Apr; 237(?):70-76. doi:
10.1016/j.vetpar.2017.02.018. [PMID: 28249767] - M Milhes, M Guillerm, M Robin, M Eichstadt, C Roy, C Grisez, F Prévot, E Liénard, E Bouhsira, M Franc, P Jacquiet. A real-time PCR approach to identify anthelmintic-resistant nematodes in sheep farms.
Parasitology research.
2017 Mar; 116(3):909-920. doi:
10.1007/s00436-016-5364-z. [PMID: 28101647] - Charlotte Bernigaud, Fang Fang, Katja Fischer, Anne Lespine, Ludwig Serge Aho, Dominique Dreau, Andrew Kelly, Jean-François Sutra, Francis Moreau, Thomas Lilin, Françoise Botterel, Jacques Guillot, Olivier Chosidow. Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model.
PLoS neglected tropical diseases.
2016 Oct; 10(10):e0005030. doi:
10.1371/journal.pntd.0005030. [PMID: 27732588] - Narelle Sales, Stephen Love. Resistance of Haemonchus sp. to monepantel and reduced efficacy of a derquantel / abamectin combination confirmed in sheep in NSW, Australia.
Veterinary parasitology.
2016 Sep; 228(?):193-196. doi:
10.1016/j.vetpar.2016.08.016. [PMID: 27692326] - Yanyan Zhang, Hairong He, Hui Liu, Haiyan Wang, Xiangjing Wang, Wensheng Xiang. Characterization of a pathway-specific activator of milbemycin biosynthesis and improved milbemycin production by its overexpression in Streptomyces bingchenggensis.
Microbial cell factories.
2016 Sep; 15(1):152. doi:
10.1186/s12934-016-0552-1. [PMID: 27604457] - Beatrice Barda, Jean T Coulibaly, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser. Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial.
PLoS neglected tropical diseases.
2016 09; 10(9):e0005008. doi:
10.1371/journal.pntd.0005008. [PMID: 27636542] - J Eppleston, B Watt, R van de Ven. Post-weaning growth of beef heifers drenched with long- or short-acting anthelmintics.
Australian veterinary journal.
2016 Sep; 94(9):341-6. doi:
10.1111/avj.12477. [PMID: 27569839] - C Paraud, T Marcotty, A Lespine, J F Sutra, I Pors, I Devos. Cross-resistance to moxidectin and ivermectin on a meat sheep farm in France.
Veterinary parasitology.
2016 Aug; 226(?):88-92. doi:
10.1016/j.vetpar.2016.06.033. [PMID: 27514891] - Sarah Preston, Junjie Luo, Yuezhou Zhang, Abdul Jabbar, Simon Crawford, Jonathan Baell, Andreas Hofmann, Min Hu, Hai-Bing Zhou, Robin B Gasser. Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus.
Parasites & vectors.
2016 06; 9(1):346. doi:
10.1186/s13071-016-1612-4. [PMID: 27306029] - T Tokiwa, H Sugiyama, K Taira, Y Yoshikawa, Y Une. Prevalence of Baylisascaris Roundworm in Captive Kinkajous in Japan.
The Journal of parasitology.
2016 04; 102(2):293-4. doi:
10.1645/15-816. [PMID: 26565681] - Ana Margarida Alho, Sofia Mouro, Hugo Pissarra, Ana Murta, Marta Lemos, Lídia Gomes, Clara Lima, Luís Madeira de Carvalho. First report of Eucoleus boehmi infection in a dog from Portugal.
Parasitology research.
2016 Apr; 115(4):1721-5. doi:
10.1007/s00436-016-4932-6. [PMID: 26857129] - Fernanda Ramos, Luiza Pires Portella, Fernando de Souza Rodrigues, Caroline Zamperete Reginato, Luciana Pötter, Alfredo Skrebsky Cezar, Luís Antônio Sangioni, Fernanda Silveira Flores Vogel. Anthelmintic resistance in gastrointestinal nematodes of beef cattle in the state of Rio Grande do Sul, Brazil.
International journal for parasitology. Drugs and drug resistance.
2016 Apr; 6(1):93-101. doi:
10.1016/j.ijpddr.2016.02.002. [PMID: 27054068] - Christine M Cocquyt, Sarel Van Amstel, Sherry Cox, Barton Rohrbach, Tomás Martín-Jiménez. Pharmacokinetics of moxidectin in alpacas following administration of an oral or subcutaneous formulation.
Research in veterinary science.
2016 Apr; 105(?):160-4. doi:
10.1016/j.rvsc.2015.12.011. [PMID: 27033926] - Jaroslav Vadlejch, Pavol Makovický, Zuzana Čadková, Iva Langrová. Efficacy and persistent activity of moxidectin against natural Muellerius capillaris infection in goats and pathological consequences of muelleriosis.
Veterinary parasitology.
2016 Mar; 218(?):98-101. doi:
10.1016/j.vetpar.2016.01.009. [PMID: 26872935] - Carsten Eichberg, Manuel Wohde, Kerstin Müller, Anja Rausch, Christina Scherrmann, Theresa Scheuren, Rolf-Alexander Düring, Tobias W Donath. The Anthelmintic Ingredient Moxidectin Negatively Affects Seed Germination of Three Temperate Grassland Species.
PloS one.
2016; 11(11):e0166366. doi:
10.1371/journal.pone.0166366. [PMID: 27846249] - M K Nielsen, A T Loynachan, S Jacobsen, J C Stewart, C R Reinemeyer, D W Horohov. Local and systemic inflammatory and immunologic reactions to cyathostomin larvicidal therapy in horses.
Veterinary immunology and immunopathology.
2015 Dec; 168(3-4):203-10. doi:
10.1016/j.vetimm.2015.09.009. [PMID: 26429413] - D M Leathwick, C M Miller, K Fraser. Selection for anthelmintic resistant Teladorsagia circumcincta in pre-weaned lambs by treating their dams with long-acting moxidectin injection.
International journal for parasitology. Drugs and drug resistance.
2015 12; 5(3):209-14. doi:
10.1016/j.ijpddr.2015.11.001. [PMID: 27120068] - Thomas Geurden, Christophe Chartier, Jane Fanke, Antonio Frangipane di Regalbono, Donato Traversa, Georg von Samson-Himmelstjerna, Janina Demeler, Hima Bindu Vanimisetti, David J Bartram, Matthew J Denwood. Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe.
International journal for parasitology. Drugs and drug resistance.
2015 Dec; 5(3):163-71. doi:
10.1016/j.ijpddr.2015.08.001. [PMID: 26448902] - Jeba Jesudoss Chelladurai, Chris Bader, Tymbrie Snobl, Drew Magstadt, Vickie Cooper, Matt T Brewer. Toxocara vitulorum infection in a cohort of beef calves in Iowa.
Veterinary parasitology.
2015 Nov; 214(1-2):96-9. doi:
10.1016/j.vetpar.2015.10.004. [PMID: 26518643] - James Patrick Crilly, Amy Jennings, Neil Sargison. Patterns of faecal nematode egg shedding after treatment of sheep with a long-acting formulation of moxidectin.
Veterinary parasitology.
2015 Sep; 212(3-4):275-80. doi:
10.1016/j.vetpar.2015.07.014. [PMID: 26276580] - Simon Cook, Simon L Priestnall, Damer Blake, Richard L Meeson. Angiostrongylus vasorum Causing Severe Granulomatous Hepatitis with Concurrent Multiple Acquired PSS.
Journal of the American Animal Hospital Association.
2015 Sep; 51(5):320-4. doi:
10.5326/jaaha-ms-6210. [PMID: 26355583] - Dwight D Bowman, Samuel D Charles, Robert G Arther, Terry Settje. Laboratory Evaluation of the Efficacy of 10 \% Imidacloprid + 2.5 \% Moxidectin Topical Solution (Advantage® Multi, Advocate®) for the Treatment of Dirofilaria immitis Circulating Microfilariae in Dogs.
Parasitology research.
2015 Aug; 114 Suppl 1(?):S165-74. doi:
10.1007/s00436-015-4522-z. [PMID: 26152417] - Robert W Li, Sitao Wu, Cong-Jun Li, Weizhong Li, Steven G Schroeder. Splice variants and regulatory networks associated with host resistance to the intestinal worm Cooperia oncophora in cattle.
Veterinary parasitology.
2015 Jul; 211(3-4):241-50. doi:
10.1016/j.vetpar.2015.05.010. [PMID: 26025321] - M Lloberas, L Alvarez, C Entrocasso, M Ballent, G Virkel, S Luque, C Lanusse, A Lifschitz. Comparative pharmacokinetic and pharmacodynamic response of single and double intraruminal doses of ivermectin and moxidectin in nematode-infected lambs.
New Zealand veterinary journal.
2015 Jul; 63(4):227-34. doi:
10.1080/00480169.2015.1015645. [PMID: 25689407] - Susan E Little, Joe A Hostetler, Jennifer E Thomas, Keith L Bailey, Anne W Barrett, Kaylynn Gruntmeir, Jeff Gruntmeir, Lindsay A Starkey, Chris Basel, Byron L Blagburn. Moxidectin steady state prior to inoculation protects cats from subsequent, repeated infection with Dirofilaria immitis.
Parasites & vectors.
2015 Feb; 8(?):107. doi:
10.1186/s13071-015-0710-z. [PMID: 25880531] - Leslie Gárate-Gallardo, Juan Felipe de Jesús Torres-Acosta, Armando Jacinto Aguilar-Caballero, Carlos Alfredo Sandoval-Castro, Ramón Cámara-Sarmiento, Hilda Lorena Canul-Ku. Comparing different maize supplementation strategies to improve resilience and resistance against gastrointestinal nematode infections in browsing goats.
Parasite (Paris, France).
2015; 22(?):19. doi:
10.1051/parasite/2015019. [PMID: 26071051] - D C K van Doorn, H W Ploeger, M Eysker, T Geurden, J A Wagenaar, F N J Kooyman. Cylicocyclus species predominate during shortened egg reappearance period in horses after treatment with ivermectin and moxidectin.
Veterinary parasitology.
2014 Dec; 206(3-4):246-52. doi:
10.1016/j.vetpar.2014.10.004. [PMID: 25458565] - José Henrique das Neves, Nadino Carvalho, Laura Rinaldi, Giuseppe Cringoli, Alessandro F T Amarante. Diagnosis of anthelmintic resistance in cattle in Brazil: a comparison of different methodologies.
Veterinary parasitology.
2014 Dec; 206(3-4):216-26. doi:
10.1016/j.vetpar.2014.10.015. [PMID: 25468021] - R Pérez, M J Núñez, C Palma, J Riquelme, M Arboix. Plasma disposition kinetics of moxidectin after subcutaneous administration to pregnant sheep.
Journal of veterinary pharmacology and therapeutics.
2014 Dec; 37(6):550-5. doi:
10.1111/jvp.12127. [PMID: 24731163] - John W McCall, Robert Arther, Wendell Davis, Terry Settje. Safety and efficacy of 10\% imidacloprid+2.5\% moxidectin for the treatment of Dirofilaria immitis circulating microfilariae in experimentally infected dogs.
Veterinary parasitology.
2014 Nov; 206(1-2):86-92. doi:
10.1016/j.vetpar.2014.09.011. [PMID: 25444277] - Eugene T Lyons, Sharon C Tolliver, Tetiana A Kuzmina, Igor I Dzeverin, Martin K Nielsen, Karen J McDowell. Profiles of strongyle EPG values for Thoroughbred mares on 14 farms in Kentucky (2012-2013).
Veterinary parasitology.
2014 Oct; 205(3-4):646-52. doi:
10.1016/j.vetpar.2014.08.001. [PMID: 25195192] - Maren E Mason, Nathan D Voris, Hunter A Ortis, Amy A Geeding, Ray M Kaplan. Comparison of a single dose of moxidectin and a five-day course of fenbendazole to reduce and suppress cyathostomin fecal egg counts in a herd of embryo transfer-recipient mares.
Journal of the American Veterinary Medical Association.
2014 Oct; 245(8):944-51. doi:
10.2460/javma.245.8.944. [PMID: 25285937] - Maurice Mahieu, Benjamin Ferré, Marylène Madassamy, Nathalie Mandonnet. Fifteen years later, anthelmintic resistances have dramatically spread over goat farms in Guadeloupe.
Veterinary parasitology.
2014 Sep; 205(1-2):379-84. doi:
10.1016/j.vetpar.2014.07.029. [PMID: 25149098] - Thomas Geurden, Deborah van Doorn, Edwin Claerebout, Frans Kooyman, Sofie De Keersmaecker, Jozef Vercruysse, Bruno Besognet, Bindu Vanimisetti, Antonio Frangipane di Regalbono, Paola Beraldo, Angela Di Cesare, Donato Traversa. Decreased strongyle egg re-appearance period after treatment with ivermectin and moxidectin in horses in Belgium, Italy and The Netherlands.
Veterinary parasitology.
2014 Aug; 204(3-4):291-6. doi:
10.1016/j.vetpar.2014.04.013. [PMID: 24880643] - Denis Wolf, Carlos Hermosilla, Anja Taubert. Oxyuris equi: lack of efficacy in treatment with macrocyclic lactones.
Veterinary parasitology.
2014 Mar; 201(1-2):163-8. doi:
10.1016/j.vetpar.2013.12.009. [PMID: 24472770] - Fabrizia Veronesi, Giulia Morganti, Angela Di Cesare, Roland Schaper, Donato Traversa. A pilot trial evaluating the efficacy of a 10\% imidacloprid/2.5\% moxidectin spot-on formulation in the treatment of natural nasal capillariosis in dogs.
Veterinary parasitology.
2014 Feb; 200(1-2):133-8. doi:
10.1016/j.vetpar.2013.11.026. [PMID: 24365240]