prazepam (BioDeep_00000405998)

Main id: BioDeep_00000002352

 


代谢物信息卡片


prazepam

化学式: C19H17ClN2O (324.1029)
中文名称: 普拉西
谱图信息: 最多检出来源 Homo sapiens(urine) 65%

分子结构信息

SMILES: C1CC1CN2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4
InChI: InChI=1S/C19H17ClN2O/c20-15-8-9-17-16(10-15)19(14-4-2-1-3-5-14)21-11-18(23)22(17)12-13-6-7-13/h1-5,8-10,13H,6-7,11-12H2

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

2 个代谢物同义名

prazepam; Prazepam



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. Journal of chromatography. A. 2012 Aug; 1249(?):147-54. doi: 10.1016/j.chroma.2012.06.023. [PMID: 22749457]
  • François-Ludovic Sauvage, Nicolas Picard, Franck Saint-Marcoux, Jean-Michel Gaulier, Gérard Lachâtre, Pierre Marquet. General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: applications and constraints. Journal of separation science. 2009 Sep; 32(18):3074-83. doi: 10.1002/jssc.200900092. [PMID: 19697309]
  • Mitsuhiro Nakamura, Tomofumi Ohmori, Yoshinori Itoh, Masato Terashita, Kazuyuki Hirano. Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds. Biomedical chromatography : BMC. 2009 Apr; 23(4):357-64. doi: 10.1002/bmc.1122. [PMID: 18937304]
  • Emmanuelle Giraud, Elisabeth Rey, Jean-Marc Tréluyer, Gérard Pons, Vincent Jullien. Quantification of tipranavir in human plasma by high-performance liquid chromatography with UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jan; 830(1):86-90. doi: 10.1016/j.jchromb.2005.10.024. [PMID: 16260190]
  • Luigi Stella, Ciro D'Ambra, Filomena Mazzeo, Annalisa Capuano, Francesco Del Franco, Amalia Avolio, Francesco Ambrosino. Naltrexone plus benzodiazepine aids abstinence in opioid-dependent patients. Life sciences. 2005 Oct; 77(21):2717-22. doi: 10.1016/j.lfs.2005.05.036. [PMID: 15979652]
  • Paraskevi Valavani, Julia Atta-Politou, Irene Panderi. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the quantitation of prazepam and its main metabolites in human plasma. Journal of mass spectrometry : JMS. 2005 Apr; 40(4):516-26. doi: 10.1002/jms.824. [PMID: 15712230]
  • Carsten Kratzsch, Oliver Tenberken, Frank T Peters, Armin A Weber, Thomas Kraemer, Hans H Maurer. Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. Journal of mass spectrometry : JMS. 2004 Aug; 39(8):856-72. doi: 10.1002/jms.599. [PMID: 15329838]
  • Alan Wayne Jones, Helena Larsson. Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit. Therapeutic drug monitoring. 2004 Aug; 26(4):380-5. doi: 10.1097/00007691-200408000-00007. [PMID: 15257067]
  • Marc Deveaux, Nicolas Hubert, Christophe Demarly. Colchicine poisoning: case report of two suicides. Forensic science international. 2004 Jul; 143(2-3):219-22. doi: 10.1016/j.forsciint.2004.02.040. [PMID: 15240048]
  • M R Shiran, A Gregory, A Rostami-Hodjegan, G T Tucker, M S Lennard. Determination of midazolam and 1'-hydroxymidazolam by liquid chromatography-mass spectrometry in plasma of patients undergoing methadone maintenance treatment. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 783(1):303-7. doi: 10.1016/s1570-0232(02)00673-6. [PMID: 12450551]
  • A Chiffoleau, H Huguenin, G Veyrac, V Argaiz, D Dupe, M Kayser, M Bourin, P Jolliet. [Interaction between melilot and acenocoumarol? (Melilotruscus aculeatus)]. Therapie. 2001 May; 56(3):321-2. doi: ". [PMID: 11475815]
  • T Soriano, C Jurado, M Menéndez, M Repetto. Improved solid-phase extraction method for systematic toxicological analysis in biological fluids. Journal of analytical toxicology. 2001 Mar; 25(2):137-43. doi: 10.1093/jat/25.2.137. [PMID: 11300506]
  • F Berthault, P Kintz, P Mangin. Simultaneous high-performance liquid chromatographic analysis of flunitrazepam and four metabolites in serum. Journal of chromatography. B, Biomedical applications. 1996 Oct; 685(2):383-7. doi: 10.1016/s0378-4347(96)00220-4. [PMID: 8953185]
  • H L Tai, R J Osiewicz, D P Bofinger. A salt-free isocratic high-pressure liquid chromatographic method for the quantitation of benzodiazepines in serum. Clinical biochemistry. 1993 Jun; 26(3):165-71. doi: 10.1016/0009-9120(93)90021-w. [PMID: 8101143]
  • K Ensing, J P Franke, A Temmink, X H Chen, R A de Zeeuw. Application of Empore C-8 extraction disks for screening urine in systematic toxicological analysis. Journal of forensic sciences. 1992 Mar; 37(2):460-6. doi: NULL. [PMID: 1354247]
  • C Girre, M Hirschhorn, L Bertaux, S Palombo, P E Fournier. Comparison of performance of healthy volunteers given prazepam alone or combined with ethanol. Relation to drug plasma concentrations. International clinical psychopharmacology. 1991; 6(4):227-38. doi: 10.1097/00004850-199100640-00004. [PMID: 1816280]
  • M C Dios-Vieitez, M J Renedo, D Fos. Pharmacokinetic profiles of prazepam and 14C-prazepam in rat. European journal of drug metabolism and pharmacokinetics. 1991; Spec No 3(?):3-8. doi: NULL. [PMID: 1820896]
  • C Girre, L Bertaux, E Dussaucy, D Bonnet, S Palombo, P E Fournier. Comparison of the effect of two prazepam formulations on psychomotor and cognitive function in healthy volunteers. International clinical psychopharmacology. 1990 Jan; 5(1):57-64. doi: 10.1097/00004850-199001000-00006. [PMID: 2332608]
  • D J Greenblatt, J S Harmatz, C Dorsey, R I Shader. Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo. Clinical pharmacology and therapeutics. 1988 Sep; 44(3):326-34. doi: 10.1038/clpt.1988.158. [PMID: 3138056]
  • P Jacqmin, M Ansseau. Comparison of sublingual and oral prazepam in normal subjects. II. Pharmacokinetic and pharmacodynamic data. Neuropsychobiology. 1988; 19(4):186-91. doi: 10.1159/000118458. [PMID: 2854609]
  • R I Shader, R J Pary, J S Harmatz, S Allison, A Locniskar, D J Greenblatt. Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam. The Journal of clinical psychiatry. 1984 Oct; 45(10):411-3. doi: . [PMID: 6148339]
  • H R Ochs, D J Greenblatt, B Verburg-Ochs, A Locniskar. Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam. Journal of clinical pharmacology. 1984 Oct; 24(10):446-51. doi: 10.1002/j.1552-4604.1984.tb01817.x. [PMID: 6150943]
  • M Ansseau, A Doumont, R von Frenckell, J Collard. Duration of benzodiazepine clinical activity: lack of direct relationship with plasma half-life. A comparison of single vs divided dosage schedules of prazepam. Psychopharmacology. 1984; 84(3):293-8. doi: 10.1007/bf00555201. [PMID: 6151206]
  • R Calaf, P Marie, C Ghiglione, M Bory, J Reynaud. [Determination of plasma diltiazem by gas chromatography]. Journal of chromatography. 1983 Feb; 272(2):385-91. doi: NULL. [PMID: 6833436]
  • M Saletu, B Saletu, J Grünberger, R Mader, M Karobath. Clinical symptomatology and computer analyzed EEG before, during and after anxiolytic therapy of alcohol withdrawal patients. Neuropsychobiology. 1983; 9(2-3):119-34. doi: 10.1159/000117949. [PMID: 6353268]
  • J Ikuta, Y Yamauchi, S Shimizu. [Effect of prazepam on experimental hypertensive models]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1982 Jun; 79(6):581-9. doi: 10.1254/fpj.79.581. [PMID: 7129244]
  • E U Kölle. [Pharmacokinetics of oral prazepam]. Fortschritte der Medizin. 1981 Jun; 99(22):874-9. doi: NULL. [PMID: 6790396]
  • R R Brodie, L F Chasseaud, T Taylor. Concentrations of N-descyclopropylmethylprazepam in whole-blood, plasma, and milk after administration of prazepam to humans. Biopharmaceutics & drug disposition. 1981 Jan; 2(1):59-68. doi: 10.1002/bdd.2510020107. [PMID: 6786389]
  • M D Allen, D J Greenblatt, J S Harmatz, R I Shader. Desmethyldiazepam kinetics in the elderly after oral prazepam. Clinical pharmacology and therapeutics. 1980 Aug; 28(2):196-202. doi: 10.1038/clpt.1980.150. [PMID: 6772370]
  • H Nau, C Liddiard, D Jesdinsky, W Wittfoht. Quantitative analysis of prazepam and its metabolites by electron capture gas chromatography and selected ion monitoring. Application to diaplacetal passage and fetal hepatic metabolism in early human pregnancy. Journal of chromatography. 1978 Sep; 146(2):227-39. doi: 10.1016/s0378-4347(00)81889-7. [PMID: 701422]
  • H Ishihama, H Kimata, M Yonemitsu, S Matsumoto, T Ota, T Koga, G Otani. [Studies on metabolism of prazepam. III. Metabolic fate of cyclopropylmethyl group of prazepam in rats (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1978 Jul; 98(7):937-43. doi: 10.1248/yakushi1947.98.7_937. [PMID: 712558]
  • H Kimata, H Ishihama. [Binding of prazepam, desalkylprazepam and diazepam to human serum albumin (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1978 Jun; 98(6):715-9. doi: 10.1248/yakushi1947.98.6_715. [PMID: 357700]
  • C B McAllister. Use of internal standards in the estimation of diazepam in plasma. Journal of chromatography. 1978 Apr; 151(1):62-6. doi: 10.1016/s0021-9673(01)91986-7. [PMID: 641125]
  • D M Hailey. Chromatography of the 1,4-benzodiazepines. Journal of chromatography. 1974 Oct; 98(3):527-68. doi: 10.1016/s0021-9673(00)84071-6. [PMID: 4153870]
  • J P Viau, J E Epps, J Di Carlo. Prazepam metabolism after chronic administration to humans. Xenobiotica; the fate of foreign compounds in biological systems. 1973 Sep; 3(9):581-7. doi: 10.3109/00498257309151546. [PMID: 4763144]
  • J P Viau, J E Epps, F J Di Carlo. Prazepam metabolism in the rat. Journal of pharmaceutical sciences. 1973 Apr; 62(4):641-5. doi: 10.1002/jps.2600620422. [PMID: 4698988]