Milrinone (BioDeep_00000405907)

Main id: BioDeep_00000000281

 

Volatile Flavor Compounds


代谢物信息卡片


Milrinone

化学式: C12H9N3O (211.07455839999997)
中文名称: 米利酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1
InChI: InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 869; ORIGINAL_PRECURSOR_SCAN_NO 865
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CE - Phosphodiesterase inhibitors
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058987 - Phosphodiesterase 3 Inhibitors
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
D020011 - Protective Agents > D002316 - Cardiotonic Agents
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 859; ORIGINAL_PRECURSOR_SCAN_NO 857
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 857; ORIGINAL_PRECURSOR_SCAN_NO 854
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 861; ORIGINAL_PRECURSOR_SCAN_NO 858
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 861; ORIGINAL_PRECURSOR_SCAN_NO 859
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 863; ORIGINAL_PRECURSOR_SCAN_NO 859
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1584; ORIGINAL_PRECURSOR_SCAN_NO 1582
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1580; ORIGINAL_PRECURSOR_SCAN_NO 1578
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1589; ORIGINAL_PRECURSOR_SCAN_NO 1588
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1605; ORIGINAL_PRECURSOR_SCAN_NO 1603
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1600; ORIGINAL_PRECURSOR_SCAN_NO 1599
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1581; ORIGINAL_PRECURSOR_SCAN_NO 1580

同义名列表

3 个代谢物同义名

Milrinone; Milrinone; Milrinone



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xueyan Cui, Zhongsu Wang, Xue Dong, Zijie Cheng, Le Zhang, Yan Mu, Xin Huang, Yan Li, Yinglong Hong, Yi Han. Comparative Effectiveness and Safety of Milrinone and Levosimendan as Initial Inotrope Therapy in Patients With Acute Heart Failure With Renal Dysfunction. Journal of cardiovascular pharmacology. 2022 06; 79(6):781-790. doi: 10.1097/fjc.0000000000001255. [PMID: 35507915]
  • Sarah Jane Commander, Daniel Gonzalez, Karan R Kumar, Tracy Spears, Michael Cohen-Wolkowiez, Kanecia O Zimmerman, Stephen J Balevic, Christoph P Hornik. The relationship between simulated milrinone exposure and hypotension in children. Cardiology in the young. 2022 May; 32(5):782-788. doi: 10.1017/s1047951121003103. [PMID: 34350821]
  • Dominik J Vogel, Aimee Brame, Fraser Hanks, Chris Remmington, Natali Chung, Luigi Camporota. Improved oxygenation with inhaled milrinone in mechanically ventilated patients with severe COVID-19. British journal of anaesthesia. 2021 09; 127(3):e111-e113. doi: 10.1016/j.bja.2021.06.002. [PMID: 34218906]
  • Elin M Thorlacius, Maria Vistnes, Tiina Ojala, Juho Keski-Nisula, Mattias Molin, Birgitta S Romlin, Mats Synnergren, Sven-Erik Ricksten, Håkan Wåhlander, Albert Castellheim. Levosimendan Versus Milrinone and Release of Myocardial Biomarkers After Pediatric Cardiac Surgery: Post Hoc Analysis of Clinical Trial Data. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2021 07; 22(7):e402-e409. doi: 10.1097/pcc.0000000000002712. [PMID: 33739957]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Aslak Widerøe Kristoffersen, Per Kristian Knudsen, Thomas Møller. SARS-CoV-2 infection in an infant with severe dilated cardiomyopathy. Cardiology in the young. 2021 Mar; 31(3):485-487. doi: 10.1017/s1047951120004060. [PMID: 33118485]
  • Densel Arac, Mehmet Fatih Erdi, Fatih Keskin, Mehmet Kenan, Gokhan Cuce, Fatma H Y Aydemir, Onder Guney, Yalçın Kocaogullar. Neuroprotective Effects of Milrinone on Experimental Acute Spinal Cord Injury: Rat Model. World neurosurgery. 2021 03; 147(?):e225-e233. doi: 10.1016/j.wneu.2020.12.021. [PMID: 33316484]
  • Nikita Lomis, Susan Westfall, Dominique Shum-Tim, Satya Prakash. Synthesis and characterization of peptide conjugated human serum albumin nanoparticles for targeted cardiac uptake and drug delivery. PloS one. 2021; 16(9):e0254305. doi: 10.1371/journal.pone.0254305. [PMID: 34591850]
  • Rohan Magoon, ItiShri, Jasvinder Kaur Kohli, Ramesh Kashav. Inhaled milrinone for sick COVID-19 cohort: A pathophysiology driven hypothesis!. Medical hypotheses. 2021 01; 146(?):110441. doi: 10.1016/j.mehy.2020.110441. [PMID: 33308938]
  • Marjolein Blink, Emilie P Buddingh', Luc H P M Filippini, Daniëlle M C Brinkman, Simone A Joosten, Richard H Klein. [COVID-19-associated hyperinflammatory state in a 15-year-old female patient]. Nederlands tijdschrift voor geneeskunde. 2020 10; 164(?):. doi: NULL. [PMID: 33331715]
  • Yixin Han, Rui Hou, Xiaoyu Zhang, Haibo Liu, Yuan Gao, Ximeng Li, Ruijuan Qi, Runlan Cai, Yun Qi. Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages. Biochimica et biophysica acta. Molecular cell research. 2020 10; 1867(10):118766. doi: 10.1016/j.bbamcr.2020.118766. [PMID: 32504661]
  • Shinichi Nakanuma, Hidehiro Tajima, Hiroyuki Takamura, Seisho Sakai, Ryosuke Gabata, Mitsuyoshi Okazaki, Hiroyuki Shinbashi, Yoshinao Ohbatake, Isamu Makino, Hironori Hayashi, Tomoharu Miyashita, Sachio Fushida, Tetsuo Ohta. Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats. Annals of transplantation. 2020 Jul; 25(?):e922306. doi: 10.12659/aot.922306. [PMID: 32661218]
  • Yu-Shan Ren, Lan-Fang Li, Tao Peng, Yu-Jun Tan, Ying Sun, Guo-Liang Cheng, Gui-Min Zhang, Jie Li. The effect of milrinone on mortality in adult patients who underwent CABG surgery: a systematic review of randomized clinical trials with a meta-analysis and trial sequential analysis. BMC cardiovascular disorders. 2020 07; 20(1):328. doi: 10.1186/s12872-020-01598-8. [PMID: 32640988]
  • Shintaro Dobashi, Ippei Watanabe, Rine Nakanishi, Shinji Hisatake, Shunsuke Kiuchi, Takayuki Kabuki, Takashi Oka, Takahiro Fujii, Takanori Ikeda. Comparing the effects of milrinone and olprinone in patients with congestive heart failure. Heart and vessels. 2020 Jun; 35(6):776-785. doi: 10.1007/s00380-019-01543-6. [PMID: 31865433]
  • Lukas Lannemyr, Gudrun Bragadottir, Bengt Redfors, Sven-Erik Ricksten. Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery. Journal of critical care. 2020 06; 57(?):225-230. doi: 10.1016/j.jcrc.2019.12.022. [PMID: 31919012]
  • Katsuyoshi Chiba, Tomomichi Ishizaka, Yu Yoshimatsu, Kei Mikamoto, Yu Maeda, Takuma Iguchi, Makoto Shirai, Takashi Yamaguchi, Koichi Goto, Ken Sakurai, Satoshi Tamai, Hiroko Kataoka, Miki Hasegawa, Kazuhiko Mori. Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys. Journal of pharmacological and toxicological methods. 2020 May; 103(?):106870. doi: 10.1016/j.vascn.2020.106870. [PMID: 32353509]
  • Julie Kelly, Judy Cheng, Rhynn Malloy, Kenneth Lupi. Comparison of Positive Inotropic Agents in the Management of Acute Decompensated Heart Failure. Journal of cardiovascular pharmacology. 2020 05; 75(5):455-459. doi: 10.1097/fjc.0000000000000811. [PMID: 32091426]
  • Amna Qasim, Sunil K Jain. Milrinone Use in Persistent Pulmonary Hypertension of the Newborn. NeoReviews. 2020 03; 21(3):e165-e178. doi: 10.1542/neo.21-3-e165. [PMID: 32123121]
  • Anne Quynh-Nhu Nguyen, André Y Denault, Yves Théoret, Louis P Perrault, France Varin. Inhaled milrinone in cardiac surgical patients: a pilot randomized controlled trial of jet vs. mesh nebulization. Scientific reports. 2020 02; 10(1):2069. doi: 10.1038/s41598-020-58902-x. [PMID: 32034202]
  • Martin Fredholm, Kirsten Jörgensen, Erik Houltz, Sven-Erik Ricksten. Levosimendan or milrinone for right ventricular inotropic treatment?-A secondary analysis of a randomized trial. Acta anaesthesiologica Scandinavica. 2020 02; 64(2):193-201. doi: 10.1111/aas.13486. [PMID: 31556095]
  • Nahmah Kim-Campbell, Catherine Gretchen, Vladimir B Ritov, Patrick M Kochanek, Goundappa K Balasubramani, Elizabeth Kenny, Mahesh Sharma, Melita Viegas, Clifton Callaway, Valerian E Kagan, Hülya Bayír. Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2020 01; 21(1):33-41. doi: 10.1097/pcc.0000000000002036. [PMID: 31305328]
  • Xianyong Liao, Lin Qian, Song Zhang, Xiang Chen, Jing Lei. Network Meta-Analysis of the Safety of Drug Therapy for Cardiogenic Shock. Journal of healthcare engineering. 2020; 2020(?):8862256. doi: 10.1155/2020/8862256. [PMID: 32802302]
  • Christoph P Hornik, Ram Yogev, Peter M Mourani, Kevin M Watt, Janice E Sullivan, Andrew M Atz, David Speicher, Amira Al-Uzri, Michelle Adu-Darko, Elizabeth H Payne, Casey E Gelber, Susan Lin, Barrie Harper, Chiara Melloni, Michael Cohen-Wolkowiez, Daniel Gonzalez. Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents. Journal of clinical pharmacology. 2019 12; 59(12):1606-1619. doi: 10.1002/jcph.1499. [PMID: 31317556]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jaewon Huh, Hyewon Chung, Wonjung Hwang. Comparison of the Effects of Milrinone, Sodium Nitroprusside, and Nitroglycerine for Induced Hypotension in Elderly Patients Undergoing Spine Surgery: A Randomized Controlled Trial. Clinical spine surgery. 2019 10; 32(8):E366-E371. doi: 10.1097/bsd.0000000000000884. [PMID: 31503048]
  • Peta M A Alexander, Ayse Akcan-Arikan, Lara S Shekerdemian. Another Outcome Lost to the Benefits of Levosimendan?. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2019 10; 20(10):992-994. doi: 10.1097/pcc.0000000000002019. [PMID: 31580276]
  • Elin M Thorlacius, Pertti K Suominen, Håkan Wåhlander, Juho Keski-Nisula, Maria Vistnes, Sven-Erik Ricksten, Mats Synnergren, Birgitta S Romlin, Albert Castellheim. The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2019 10; 20(10):947-956. doi: 10.1097/pcc.0000000000002017. [PMID: 31274775]
  • Maarja Hallik, Mari-Liis Ilmoja, Tõnis Tasa, Joseph F Standing, Kalev Takkis, Rūta Veigure, Karin Kipper, Tiiu Jalas, Maila Raidmäe, Karin Uibo, Joel Starkopf, Tuuli Metsvaht. Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2019 07; 20(7):621-629. doi: 10.1097/pcc.0000000000001879. [PMID: 30664589]
  • Tomoyuki Mizuno, Katja M Gist, Zhiqian Gao, Michael F Wempe, Jeffrey Alten, David S Cooper, Stuart L Goldstein, Alexander A Vinks. Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. Clinical pharmacokinetics. 2019 06; 58(6):793-803. doi: 10.1007/s40262-018-0729-3. [PMID: 30607889]
  • Osama Mahmoud Mehanna, Ahmad El Askary, Saad Al-Shehri, Basem El-Esawy. Effect of phosphodiesterase inhibitors on renal functions and oxidant/antioxidant parameters in streptozocin-induced diabetic rats. Archives of physiology and biochemistry. 2018 Dec; 124(5):424-429. doi: 10.1080/13813455.2017.1419267. [PMID: 29271249]
  • Erdal Uysal, Mehmet Dokur, Serdar Altınay, Eyup İlker Saygılı, Kadir Batcıoglu, Mehmet S Ceylan, Hatem Kazımoglu, Burcin A Uyumlu, Mehmet Karadag. Investigation of the Effect of Milrinone on Renal Damage in an Experimental Non-Heart Beating Donor Model. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2018 Oct; 31(5):402-411. doi: 10.1080/08941939.2017.1343880. [PMID: 28708967]
  • Paul Gavra, André Y Denault, Yves Théoret, Louis P Perrault, France Varin. Pharmacokinetics and Pharmacodynamics of Nebulized and Intratracheal Milrinone in a Swine Model of Hypercapnia Pulmonary Hypertension. Journal of cardiothoracic and vascular anesthesia. 2018 10; 32(5):2130-2138. doi: 10.1053/j.jvca.2018.01.031. [PMID: 29525196]
  • Shane Nanayakkara, Vivian Mak, Karina Crannitch, Melissa Byrne, David M Kaye. Extended Release Oral Milrinone, CRD-102, for Advanced Heart Failure. The American journal of cardiology. 2018 09; 122(6):1017-1020. doi: 10.1016/j.amjcard.2018.06.009. [PMID: 30064857]
  • Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, Yasuhide Watanabe, Naoyuki Matsuda, Naoki Yoshimura, Yuichi Hattori. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis. Naunyn-Schmiedeberg's archives of pharmacology. 2018 09; 391(9):1021-1032. doi: 10.1007/s00210-018-1527-z. [PMID: 29922941]
  • Nikita Lomis, Francis Gaudreault, Meenakshi Malhotra, Susan Westfall, Dominique Shum-Tim, Satya Prakash. Novel Milrinone Nanoformulation for Use in Cardiovascular Diseases: Preparation and in Vitro Characterization. Molecular pharmaceutics. 2018 07; 15(7):2489-2502. doi: 10.1021/acs.molpharmaceut.7b00360. [PMID: 28837343]
  • Anna Cavigelli-Brunner, Maja I Hug, Hitendu Dave, Oskar Baenziger, Christoph Buerki, Dominique Bettex, Vincenzo Cannizzaro, Christian Balmer. Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2018 07; 19(7):619-625. doi: 10.1097/pcc.0000000000001533. [PMID: 29538053]
  • Katja M Gist, David S Cooper, Julia Wrona, Sarah Faubel, Christopher Altmann, Zhiqian Gao, Bradley S Marino, Jeffrey Alten, Kristal M Hock, Tomoyuki Mizuno, Alexander A Vinks, Melanie S Joy, Michael F Wempe, Michael R Bennett, Stuart L Goldstein. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Therapeutic drug monitoring. 2018 04; 40(2):186-194. doi: 10.1097/ftd.0000000000000496. [PMID: 29529007]
  • Rabie Soliman, Adel Ragheb. Assessment of the effect of two regimens of milrinone infusion in pediatric patients undergoing fontan procedure: A randomized study. Annals of cardiac anaesthesia. 2018 Apr; 21(2):134-140. doi: 10.4103/aca.aca_160_17. [PMID: 29652273]
  • Mari Sakai, Tokiko Suzuki, Kengo Tomita, Shigeyuki Yamashita, Sailesh Palikhe, Kohshi Hattori, Naoki Yoshimura, Naoyuki Matsuda, Yuichi Hattori. Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation. American journal of physiology. Heart and circulatory physiology. 2017 Jun; 312(6):H1224-H1237. doi: 10.1152/ajpheart.00828.2016. [PMID: 28455289]
  • Maarja Hallik, Tõnis Tasa, Joel Starkopf, Tuuli Metsvaht. Dosing of Milrinone in Preterm Neonates to Prevent Postligation Cardiac Syndrome: Simulation Study Suggests Need for Bolus Infusion. Neonatology. 2017; 111(1):8-11. doi: 10.1159/000447049. [PMID: 27490706]
  • Kimberly I Mills, Aditya K Kaza, Brian K Walsh, Hilary C Bond, Mackenzie Ford, David Wypij, Ravi R Thiagarajan, Melvin C Almodovar, Luis G Quinonez, Christopher W Baird, Sitaram E Emani, Frank A Pigula, James A DiNardo, John N Kheir. Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. Journal of the American Heart Association. 2016 11; 5(11):. doi: 10.1161/jaha.116.003554. [PMID: 27806964]
  • Katja M Gist, Stuart L Goldstein, Melanie S Joy, Alexander A Vinks. Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review. Journal of cardiovascular pharmacology. 2016 Feb; 67(2):175-81. doi: 10.1097/fjc.0000000000000327. [PMID: 26448275]
  • Hai-Ming Tang, Haisong Ju, Shufang Zhao, Carrie LaDuke, Suzette Hahn, James Glick, Cynthia Carey, Gregory S Friedrichs. Translational assessment of cardiac contractility by echocardiography in the telemetered rat. Journal of pharmacological and toxicological methods. 2016 Jan; 77(?):24-32. doi: 10.1016/j.vascn.2015.09.005. [PMID: 26427954]
  • Katja M Gist, Tomoyuki Mizuno, Stuart L Goldstein, Alexander Vinks. Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury. Therapeutic drug monitoring. 2015 Dec; 37(6):792-6. doi: 10.1097/ftd.0000000000000214. [PMID: 25860636]
  • Nicholas A Haglund, Adam Burdorf, Tara Jones, Valerie Shostrom, John Um, Timothy Ryan, Sasha Shillcutt, Patricia Fischer, Zachary L Cox, Eugenia Raichlin, Daniel R Anderson, Brian D Lowes, Ioana Dumitru. Inhaled Milrinone After Left Ventricular Assist Device Implantation. Journal of cardiac failure. 2015 Oct; 21(10):792-7. doi: 10.1016/j.cardfail.2015.04.011. [PMID: 25937146]
  • Jahan Porhomayon, Sina Davari-Farid, Carlos M Li, Pradeep Arora, Leili Pourafkari, Nader D Nader. Intraoperative administration of vasopressin during coronary artery bypass surgery is associated with acute postoperative kidney injury. Journal of critical care. 2015 Oct; 30(5):963-8. doi: 10.1016/j.jcrc.2015.06.013. [PMID: 26183070]
  • Minoru Tagawa, Hitomi Nanba, Hiromi Suzuki, Yuichi Nakamura, Hiroko Uchiyama, Sachie Ochiai, Masahiro Terunuma, Kazuaki Yahata, Tohru Minamino. Ventricular Rhythm and Hypotension in a Patient with Pheochromocytoma-induced Myocardial Damage and Reverse Takotsubo Cardiomyopathy. Internal medicine (Tokyo, Japan). 2015; 54(18):2343-9. doi: 10.2169/internalmedicine.54.4732. [PMID: 26370859]
  • Hamood Al Kindi, Arghya Paul, Zhipeng You, Oleg Nepotchatykh, Adel Schwertani, Satya Prakash, Dominique Shum-Tim. Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction. The Journal of thoracic and cardiovascular surgery. 2014 Nov; 148(5):2316-23. doi: 10.1016/j.jtcvs.2014.07.033. [PMID: 25175952]
  • Paul Gavra, Anne Q-N Nguyen, Yves Theoret, Catherine Litalien, André Y Denault, France Varin. A specific and sensitive HPLC-MS/MS micromethod for milrinone plasma levels determination after inhalation in cardiac patients. Therapeutic drug monitoring. 2014 Oct; 36(5):663-8. doi: 10.1097/ftd.0000000000000072. [PMID: 24690585]
  • Tomasz Urbanowicz, Marcin Ligowski, Estillita Camacho, Maciej Walczak, Ewa Straburzyńska-Migaj, Jadwiga Tomczyk, Marek Jemielity. Effect of milrinone therapy on splanchnic perfusion after heart transplantation. Annals of transplantation. 2014 Sep; 19(?):472-7. doi: 10.12659/aot.890691. [PMID: 25249304]
  • Wonjung Hwang, Eunsung Kim. The effect of milrinone on induced hypotension in elderly patients during spinal surgery: a randomized controlled trial. The spine journal : official journal of the North American Spine Society. 2014 Aug; 14(8):1532-7. doi: 10.1016/j.spinee.2013.09.028. [PMID: 24331842]
  • Paul Gavra, Anne Q N Nguyen, Natasha Beauregard, André Y Denault, France Varin. High-performance liquid chromatography assay using ultraviolet detection for urinary quantification of milrinone concentrations in cardiac surgery patients undergoing cardiopulmonary bypass. Biomedical chromatography : BMC. 2014 Aug; 28(8):1084-9. doi: 10.1002/bmc.3123. [PMID: 24522977]
  • John M Costello, Carolyn Dunbar-Masterson, Catherine K Allan, Kimberlee Gauvreau, Jane W Newburger, Francis X McGowan, David L Wessel, John E Mayer, Joshua W Salvin, Roger E Dionne, Peter C Laussen. Impact of empiric nesiritide or milrinone infusion on early postoperative recovery after Fontan surgery: a randomized, double-blind, placebo-controlled trial. Circulation. Heart failure. 2014 Jul; 7(4):596-604. doi: 10.1161/circheartfailure.113.001312. [PMID: 24906491]
  • Dafni Charisopoulou, Neil Leaver, Nicholas R Banner. Milrinone in advanced heart failure: dose and therapeutic monitor outside intensive care unit. Angiology. 2014 Apr; 65(4):343-9. doi: 10.1177/0003319713485808. [PMID: 23620310]
  • Shih-Min Wang, I-Chun Chen, Yu-Ting Liao, Ching-Chuan Liu. The clinical correlation of regulatory T cells and cyclic adenosine monophosphate in enterovirus 71 infection. PloS one. 2014; 9(7):e102025. doi: 10.1371/journal.pone.0102025. [PMID: 25010330]
  • Winnie Vogt. Evaluation and optimisation of current milrinone prescribing for the treatment and prevention of low cardiac output syndrome in paediatric patients after open heart surgery using a physiology-based pharmacokinetic drug-disease model. Clinical pharmacokinetics. 2014 Jan; 53(1):51-72. doi: 10.1007/s40262-013-0096-z. [PMID: 23839530]
  • Elizabeth Geras-Raaka, Susanne Neumann, Marvin C Gershengorn. Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition. Thyroid : official journal of the American Thyroid Association. 2013 Nov; 23(11):1484-9. doi: 10.1089/thy.2013.0089. [PMID: 23713896]
  • Zachary L Cox, Marion W Calcutt, Thomas B Morrison, Wendell S Akers, Mary Beth Davis, Daniel J Lenihan. Elevation of plasma milrinone concentrations in stage D heart failure associated with renal dysfunction. Journal of cardiovascular pharmacology and therapeutics. 2013 Sep; 18(5):433-8. doi: 10.1177/1074248413489773. [PMID: 23695773]
  • Catherine J Morgan, Peter J Gill, Simon Lam, Ari R Joffe. Peri-operative interventions, but not inflammatory mediators, increase risk of acute kidney injury after cardiac surgery: a prospective cohort study. Intensive care medicine. 2013 May; 39(5):934-41. doi: 10.1007/s00134-013-2849-4. [PMID: 23417202]
  • Mario Di Braccio, Giancarlo Grossi, Maria Grazia Signorello, Giuliana Leoncini, Elena Cichero, Paola Fossa, Silvana Alfei, Gianluca Damonte. Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones. European journal of medicinal chemistry. 2013 Apr; 62(?):564-78. doi: 10.1016/j.ejmech.2013.01.026. [PMID: 23425969]
  • Patrick J McNamara, Sandesh P Shivananda, Mohit Sahni, David Freeman, Anna Taddio. Pharmacology of milrinone in neonates with persistent pulmonary hypertension of the newborn and suboptimal response to inhaled nitric oxide. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2013 Jan; 14(1):74-84. doi: 10.1097/pcc.0b013e31824ea2cd. [PMID: 23132395]
  • Louise Marks, Samantha Borland, Karen Philp, Lorna Ewart, Pierre Lainée, Matthew Skinner, Sarah Kirk, Jean-Pierre Valentin. The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds. Toxicology and applied pharmacology. 2012 Sep; 263(2):171-83. doi: 10.1016/j.taap.2012.06.007. [PMID: 22714037]
  • B Chihoho, A B Sage, R T Smolenski, A Vazir, M L Rose, N R Banner, N V Leaver. A clinical assay for the measurement of milrinone in plasma by HPLC mass spectrometry. Biomedical chromatography : BMC. 2012 May; 26(5):566-70. doi: 10.1002/bmc.1675. [PMID: 21905056]
  • Jeremy Springer, John Azer, Rui Hua, Courtney Robbins, Andrew Adamczyk, Sarah McBoyle, Mary Beth Bissell, Robert A Rose. The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. Journal of molecular and cellular cardiology. 2012 May; 52(5):1122-34. doi: 10.1016/j.yjmcc.2012.01.018. [PMID: 22326431]
  • Evonne Krushansky, Nelson Burbano, Victor Morell, Diego Moguillansky, Yeon Kim, Richard Orr, Constantinos Chrysostomou, Ricardo Munoz. Preoperative management in patients with single-ventricle physiology. Congenital heart disease. 2012 Mar; 7(2):96-102. doi: 10.1111/j.1747-0803.2011.00584.x. [PMID: 22051044]
  • John Wynne, Sara Y Narveson, Laszlo Littmann. Cardiorenal syndrome. Heart & lung : the journal of critical care. 2012 Mar; 41(2):157-60. doi: 10.1016/j.hrtlng.2011.06.001. [PMID: 21784526]
  • Kevin Damman, Adriaan A Voors, Gerjan Navis, Dirk J van Veldhuisen, Hans L Hillege. Current and novel renal biomarkers in heart failure. Heart failure reviews. 2012 Mar; 17(2):241-50. doi: 10.1007/s10741-011-9254-2. [PMID: 21604178]
  • Se-Young Oh, Jong Chan Kim, Yong Seon Choi, Woo Kyung Lee, Yeong-Kyu Lee, Young Lan Kwak. Effects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass. Korean journal of anesthesiology. 2012 Feb; 62(2):148-53. doi: 10.4097/kjae.2012.62.2.148. [PMID: 22379570]
  • Jean Grisouard, Elisa Bouillet, Katharina Timper, Tanja Radimerski, Kaethi Dembinski, Daniel M Frey, Ralph Peterli, Henryk Zulewski, Ulrich Keller, Beat Müller, Mirjam Christ-Crain. Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytes. Innate immunity. 2012 Feb; 18(1):25-34. doi: 10.1177/1753425910386632. [PMID: 21088047]
  • Cai-Rong Yang, Yanchang Wei, Shu-Tao Qi, Lei Chen, Qing-Hua Zhang, Jun-Yu Ma, Yi-Bo Luo, Ya-Peng Wang, Yi Hou, Heide Schatten, Zhong-Hua Liu, Qing-Yuan Sun. The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes. PloS one. 2012; 7(6):e38807. doi: 10.1371/journal.pone.0038807. [PMID: 22685609]
  • Ming Gong, Xue-Zheng Lin, Guang-Tao Lu, Li-Juan Zheng. Preoperative inhalation of milrinone attenuates inflammation in patients undergoing cardiac surgery with cardiopulmonary bypass. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2012; 21(1):30-5. doi: 10.1159/000332411. [PMID: 22024477]
  • U Deniz Dincer. Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?. Diabetes, metabolic syndrome and obesity : targets and therapy. 2012; 5(?):89-99. doi: 10.2147/dmso.s30005. [PMID: 22563249]
  • Petrus R de Jong, Alvin W L Schadenberg, Theo van den Broek, Jeffrey M Beekman, Femke van Wijk, Paul J Coffer, Berent J Prakken, Nicolaas J G Jansen. STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PloS one. 2012; 7(4):e35070. doi: 10.1371/journal.pone.0035070. [PMID: 22506067]
  • Chung-Hung Shih, Ling-Hung Lin, Hsin-Te Hsu, Kuo-Hsien Wang, Chi-Yin Lai, Chien-Ming Chen, Wun-Chang Ko. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):472897. doi: 10.1155/2012/472897. [PMID: 22454667]
  • You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen, Wun-Chang Ko. Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. Journal of biomedical science. 2011 Nov; 18(?):84. doi: 10.1186/1423-0127-18-84. [PMID: 22074248]
  • Raul A Nachar, Erin A Booth, Philippe Friedlich, Matthew Borzage, Sadaf Soleymani, Michael D Wider, Istvan Seri. Dose-dependent hemodynamic and metabolic effects of vasoactive medications in normotensive, anesthetized neonatal piglets. Pediatric research. 2011 Nov; 70(5):473-9. doi: 10.1203/pdr.0b013e31822e178e. [PMID: 21775923]
  • Marco Vinetti, Vincent Haufroid, Arnaud Capron, Jean-François Classen, Sebastien Marchandise, Philippe Hantson. Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms. Clinical toxicology (Philadelphia, Pa.). 2011 Nov; 49(9):865-9. doi: 10.3109/15563650.2011.626421. [PMID: 22077251]
  • Raniah Q Gabr, Marwa E Elsherbiny, Vishwa Somayaji, P Timothy Pollak, Dion R Brocks. A liquid chromatography-mass spectrometry method for nicotine and cotinine; utility in screening tobacco exposure in patients taking amiodarone. Biomedical chromatography : BMC. 2011 Oct; 25(10):1124-31. doi: 10.1002/bmc.1581. [PMID: 21308701]
  • S Devi Chiravuri, Lori Q Riegger, Robert Christensen, Russell R Butler, Shobha Malviya, Alan R Tait, Terri Voepel-Lewis. Factors associated with acute kidney injury or failure in children undergoing cardiopulmonary bypass: a case-controlled study. Paediatric anaesthesia. 2011 Aug; 21(8):880-6. doi: 10.1111/j.1460-9592.2011.03532.x. [PMID: 21306475]
  • Paula Stein, Karen Schindler. Mouse oocyte microinjection, maturation and ploidy assessment. Journal of visualized experiments : JoVE. 2011 Jul; ?(53):. doi: 10.3791/2851. [PMID: 21808228]
  • Charlotte U Andersen, Ole Hilberg, Søren Mellemkjær, Jens E Nielsen-Kudsk, U Simonsen. Apelin and pulmonary hypertension. Pulmonary circulation. 2011 Jul; 1(3):334-46. doi: 10.4103/2045-8932.87299. [PMID: 22140623]
  • Zaccaria Ricci, Rosa Luciano, Isabella Favia, Cristiana Garisto, Maurizio Muraca, Stefano Morelli, Luca Di Chiara, Paola Cogo, Sergio Picardo. High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery. Critical care (London, England). 2011 Jun; 15(3):R160. doi: 10.1186/cc10295. [PMID: 21714857]
  • A Vazir, N Leaver, H Lyster, A Alexanian, P Wilton, N R Banner. Is monitoring milrinone therapy useful in advanced heart failure?. International journal of cardiology. 2011 Jun; 149(3):380-1. doi: 10.1016/j.ijcard.2011.02.068. [PMID: 21450357]
  • T Nishiki, H Kitada, Y Okabe, Y Miura, K Kurihara, S Kawanami, M Tanaka. Effect of milrinone on ischemia-reperfusion injury in the rat kidney. Transplantation proceedings. 2011 Jun; 43(5):1489-94. doi: 10.1016/j.transproceed.2011.03.009. [PMID: 21693223]
  • Won-Sung Kim, Seung-Hoon Baek, Sang Kwon Lee, Tae Yong Jeon, Hee-Young Kim, Sang Wook Shin. Dexmedetomidine does not produce vasocontraction on human isolated gastroepiploic artery. Korean journal of anesthesiology. 2011 Jun; 60(6):428-33. doi: 10.4097/kjae.2011.60.6.428. [PMID: 21738846]
  • Irena Baranowska, Sylwia Magiera, Jacek Baranowski. UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Mar; 879(9-10):615-26. doi: 10.1016/j.jchromb.2011.01.026. [PMID: 21345747]
  • Mohammad Sarraf, Robert W Schrier. Cardiorenal syndrome in acute heart failure syndromes. International journal of nephrology. 2011 Mar; 2011(?):293938. doi: 10.4061/2011/293938. [PMID: 21423563]
  • Ping Zhu, Yu-Guan Wen, Ji-Mei Chen, Jian Zhuang, Zhi-Ling Zhou, Shao-Yi Zheng, Ruo-Bin Wu, Xue-Jun Xiao, Cong Lu, Rui-Xin Fan, Hui-Ming Guo, Xiao-Ping Fan. Determination of olprinone in human plasma utilizing liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2011 Jan; 54(1):198-202. doi: 10.1016/j.jpba.2010.07.016. [PMID: 20728297]
  • Paula Martínez-Santos, Isidre Vilacosta. Cardiorenal syndrome: an unsolved clinical problem. International journal of nephrology. 2011; 2011(?):913029. doi: 10.4061/2011/913029. [PMID: 21660257]
  • Chung-Hung Shih, Tzu-Jung Huang, Chien-Ming Chen, Yun-Lian Lin, Wun-Chang Ko. S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):132374. doi: 10.1093/ecam/nep088. [PMID: 19641087]
  • Massimo Antonelli, Elie Azoulay, Marc Bonten, Jean Chastre, Giuseppe Citerio, Giorgio Conti, Daniel De Backer, Herwig Gerlach, Goran Hedenstierna, Michael Joannidis, Duncan Macrae, Jordi Mancebo, Salvatore M Maggiore, Alexandre Mebazaa, Jean-Charles Preiser, Jerôme Pugin, Jan Wernerman, Haibo Zhang. Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentals. Intensive care medicine. 2011 Jan; 37(1):19-34. doi: 10.1007/s00134-010-2112-1. [PMID: 21203748]
  • Marcelo Eidi Ochiai, Juliano Novaes Cardoso, Kelly Regina Novaes Vieira, Marcelo Villaça Lima, Euler Cristovan Ochiai Brancalhao, Antonio Carlos Pereira Barretto. Predictors of low cardiac output in decompensated severe heart failure. Clinics (Sao Paulo, Brazil). 2011; 66(2):239-44. doi: 10.1590/s1807-59322011000200010. [PMID: 21484040]
  • Farheen Shah-Khan, Marc H Scheetz, Cybele Ghossein. Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity. International journal of nephrology. 2011; 2011(?):436856. doi: 10.4061/2011/436856. [PMID: 21716699]
  • Teresa Bishara, Winnie T W Seto, Angela Trope, Christopher S Parshuram. Use of milrinone in critically ill children. The Canadian journal of hospital pharmacy. 2010 Nov; 63(6):420-8. doi: 10.4212/cjhp.v63i6.960. [PMID: 22479014]
  • S Reddy, A Bahl, K K Talwar. Congestive heart failure in Indians: how do we improve diagnosis & management?. The Indian journal of medical research. 2010 Nov; 132(?):549-60. doi: NULL. [PMID: 21150007]
  • Johan Sällström, Boye L Jensen, Ole Skøtt, Xiang Gao, A Erik G Persson. Neuronal nitric oxide synthase supports Renin release during sodium restriction through inhibition of phosphodiesterase 3. American journal of hypertension. 2010 Nov; 23(11):1241-6. doi: 10.1038/ajh.2010.153. [PMID: 20651700]
  • Gautham Viswanathan, Scott Gilbert. The cardiorenal syndrome: making the connection. International journal of nephrology. 2010 Oct; 2011(?):283137. doi: 10.4061/2011/283137. [PMID: 21151533]
  • James C Coons, Kara M Plauger, Amy L Seybert, George G Sokos. Worsening heart failure in the setting of dronedarone initiation. The Annals of pharmacotherapy. 2010 Sep; 44(9):1496-500. doi: 10.1345/aph.1p075. [PMID: 20628043]
  • Nathan A Pinner, Carrie S Oliphant, Jack P Hopkins. Use of conivaptan for the treatment of symptomatic hyponatremia in a patient with acute decompensated heart failure. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2010 Jun; 67(12):1011-5. doi: 10.2146/ajhp090174. [PMID: 20516472]