3-O-Methylguanosine (BioDeep_00000405680)

   


代谢物信息卡片


Guanosine, 3-O-methyl-

化学式: C11H15N5O5 (297.10731400000003)
中文名称: 3′-O-甲基鸟苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1C(OC(C1O)N2C=NC3=C2N=C(NC3=O)N)CO
InChI: InChI=1S/C11H15N5O5/c1-20-7-4(2-17)21-10(6(7)18)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1

描述信息

Guanosine with the hydrogen on the hydroxyl at position C-3 substituted with a methyl group.
3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator. 3'-O-methylguanosine can inhibit early virus-specific RNA synthesis[1].

同义名列表

3 个代谢物同义名

Guanosine, 3-O-methyl-; 3-O-Methylguanosine; 3'-O-Methylguanosine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adam M Deane, Nam Q Nguyen, Julie E Stevens, Robert J L Fraser, Richard H Holloway, Laura K Besanko, Carly Burgstad, Karen L Jones, Marianne J Chapman, Chris K Rayner, Michael Horowitz. Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. The Journal of clinical endocrinology and metabolism. 2010 Jan; 95(1):215-21. doi: 10.1210/jc.2009-1503. [PMID: 19892837]
  • Marianne J Chapman, Robert J L Fraser, Geoffrey Matthews, Antonietta Russo, Max Bellon, Laura K Besanko, Karen L Jones, Ross Butler, Barry Chatterton, Michael Horowitz. Glucose absorption and gastric emptying in critical illness. Critical care (London, England). 2009; 13(4):R140. doi: 10.1186/cc8021. [PMID: 19712450]
  • Paramjit K Khera, Clinton H Joiner, Anthony Carruthers, Christopher J Lindsell, Eric P Smith, Robert S Franco, Yancey R Holmes, Robert M Cohen. Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation. Diabetes. 2008 Sep; 57(9):2445-52. doi: 10.2337/db07-1820. [PMID: 18591386]
  • R Richard Pencek, Alessandra Bertoldo, Julie Price, Carol Kelley, Claudio Cobelli, David E Kelley. Dose-responsive insulin regulation of glucose transport in human skeletal muscle. American journal of physiology. Endocrinology and metabolism. 2006 Jun; 290(6):E1124-30. doi: 10.1152/ajpendo.00598.2004. [PMID: 16390860]
  • Alessandra Bertoldo, Julie Price, Chet Mathis, Scott Mason, Daniel Holt, Carol Kelley, Claudio Cobelli, David E Kelley. Quantitative assessment of glucose transport in human skeletal muscle: dynamic positron emission tomography imaging of [O-methyl-11C]3-O-methyl-D-glucose. The Journal of clinical endocrinology and metabolism. 2005 Mar; 90(3):1752-9. doi: 10.1210/jc.2004-1092. [PMID: 15613423]
  • Changting Xiao, V Margaret Quinton, John P Cant. Description of glucose transport in isolated bovine mammary epithelial cells by a three-compartment model. American journal of physiology. Cell physiology. 2004 Apr; 286(4):C792-7. doi: 10.1152/ajpcell.00356.2003. [PMID: 14644775]
  • Peter Lange, Elena Gertsen, Ingrid Monden, Jörg Klepper, Konrad Keller. Functional consequences of an in vivo mutation in exon 10 of the human GLUT1 gene. FEBS letters. 2003 Dec; 555(2):274-8. doi: 10.1016/s0014-5793(03)01247-x. [PMID: 14644427]
  • J Kang, E Heart, C K Sung. Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes. American journal of physiology. Endocrinology and metabolism. 2001 Mar; 280(3):E428-35. doi: 10.1152/ajpendo.2001.280.3.e428. [PMID: 11171597]
  • P L Poulsen, L Orskov, T Grøfte, J Møller, J J Holst, O Schmitz, N Møller. Effects of oral glucose on systemic glucose metabolism during hyperinsulinemic hypoglycemia in normal man. Metabolism: clinical and experimental. 2000 Dec; 49(12):1598-603. doi: 10.1053/meta.2000.18558. [PMID: 11145123]
  • K Yamada, L G Tillotson, K J Isselbacher. Regulation of hexose transporters in chicken embryo fibroblasts: stimulation by the phorbol ester TPA leads to increased numbers of functioning transporters. Journal of cellular physiology. 1986 May; 127(2):211-5. doi: 10.1002/jcp.1041270204. [PMID: 3009495]
  • B B Goswami, O K Sharma. Inhibition of vaccinia virus growth and virus-specific RNA synthesis by 3'-O-methyl adenosine and 3'-O-methyl guanosine. Journal of virology. 1983 Mar; 45(3):1164-7. doi: 10.1128/jvi.45.3.1164-1167.1983. [PMID: 6834481]